Transplantation of adipose tissue derived multilineage progenitor cells via portal vein improved serum levels of mucopolysaccharidosis model mice.
Project/Area Number |
25293229
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Osaka University |
Principal Investigator |
Matsuyama Akifumi 大阪大学, 国際医工情報センター, 招へい教授 (10423170)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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Keywords | 再生医療 / ムコ多糖症 / ライソゾーム病 / 遺伝子疾患 / 脂肪組織由来多系統前駆細胞 / in situ reprogramming / 移植・再生医療 / 再生医学 |
Outline of Final Research Achievements |
The mechanism of this study is in vivo engrafted reprogrammed-hepatocyte from adipse tisse derived multilinage progenitor cell, so called ‘ADMPC’ sustained secrete and supplied lysosomal hydrolase deficient in mucopolysaccharidosis to the whole body.Via the portal vein administration of ADMPC, β-galactosidase that are deficient GM1- gangliosidosis mouse, which is a mucopolysaccharidosis model animal had expressed in the blood, and the effect has been revealed that long-lasting. ADMPC have been induced to differentiate into hepatocytes in the liver, so we proposed the new concept of the "in situ reprogramming". The concept is defferent from "Reprogramming", reprogrammed terminal differentiated cell to pluripotent cells and "direct reprogramming", to differentiate directly to the target cells in vitro gene transfer, so far. We are going to deploy this as in situ stem cell therapy to the treatment.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Platelet-derived growth factor (PDGF)-AA/AB in human serum are potential indicators of the proliferative capacity of human synovial mesenchymal stem cells.2015
Author(s)
Mizuno M, Katano H, Otabe K, Komori K, Matsumoto Y, Fujii S, Ozeki N, Tsuji K, Koga H, Muneta T, Matsuyama A, Sekiya
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Journal Title
Stem Cell Res Ther.
Volume: 10
Issue: 1
Pages: 243-243
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Report of the international conference on regulatory endeavors towards the sound development of human cell therapy products.2015
Author(s)
Hayakawa T., Aoi T., Bravery C., Hoogendoorn K., Knezevic I., Koga J., Maeda D., Matsuyama A., McBlane J., Morio T., Petricciani J., Rao M., Ridgway A., Sato D., Sato Y., Stacey G., Sakamoto N., Trouvin J.H., Umezawa A., Yamato M., Yano K., Yokote H., Yoshimatsu K., Zorzi-Morre P.
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Journal Title
Biologicals
Volume: 43(5)
Pages: 283-97
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Trophic factors from adipose tissue-derived multi-lineage progenitor cells promote cytodifferentiation of periodontal ligament cells.2015
Author(s)
Sawada K., Takedachi M., Yamamoto S., Morimoto C., Ozasa M., Iwayama T., Lee C.M., Okura H., Matsuyama A., Kitamura M., Murakami S.
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Journal Title
Biochem Biophys Res Commun
Volume: Aug 14;464(1)
Issue: 1
Pages: 299-305
DOI
Related Report
Peer Reviewed
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[Presentation] 再生医療とOMICS2016
Author(s)
松山晃文
Organizer
第15回日本再生医療学会総会特別シンポジウム
Place of Presentation
グランキューブ大阪
Year and Date
2016-03-17
Related Report
Invited
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[Presentation] 再生医療推進の課題2015
Author(s)
松山晃文
Organizer
第5回レギュラトリーサイエンス学会学術集会
Place of Presentation
一橋大学一橋講堂
Year and Date
2015-09-04
Related Report
Invited
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