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Molecular Mechanisms of atherosclerotic remodeling in childhood

Research Project

Project/Area Number 25293236
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pediatrics
Research InstitutionYokohama City University

Principal Investigator

YOKOYAMA Utako  横浜市立大学, 医学部, 准教授 (70404994)

Co-Investigator(Kenkyū-buntansha) 市川 泰広  横浜市立大学, 医学部, 助教 (10555121)
Co-Investigator(Renkei-kenkyūsha) SUGIMOTO Yukihiko  熊本大学, 生命科学研究部, 教授 (80243038)
NISHIHARA Hiroshi  北海道大学, 医学研究科, 特任准教授 (50322805)
ARAKAWA Noriaki  横浜市立大学, 生命ナノシステム科学研究科, 助教 (60398394)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords動脈硬化 / 小児 / 内膜肥厚 / リモデリング / 冠動脈 / プロスタグランディンE / 循環器・高血圧 / プロスタグランディン / 生理学
Outline of Final Research Achievements

The process of progression of atherosclerosis during childhood and its molecular mechanisms are not fully understood. We aimed to examine the developmental changes of atherosclerosis using vascular tissue samples ranging in age from 0 to 71 years old. In human coronary arterial smooth muscle cells, prostaglandin E receptor EP4 was highly expressed among EP receptors. Physiological intimal thickening was observed from newborn infants. We analyzed ApoE-/- EP4+/+ and ApoE-/- EP4+/- mice and found that EP4 deficiency inhibited atherosclerotic plaque formation. These data suggested that EP4 contributes to progression of atherosclerotic remodeling from childhood.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (89 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (24 results) (of which Peer Reviewed: 22 results,  Open Access: 20 results,  Acknowledgement Compliant: 6 results) Presentation (57 results) (of which Int'l Joint Research: 3 results,  Invited: 18 results) Book (4 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Enhanced EP4 Expression in a Pulmonary Artery Aneurysm With Dissection in a Patient With Pulmonary Arterial Hypertension2017

    • Author(s)
      S. Akagi, K. Nakamura, U. Yokoyama, S. Kasahara, T. Sarashina, K. Ejiri, H. Ito
    • Journal Title

      Circulation: Cardiovascular Imaging

      Volume: 10 Issue: 2

    • DOI

      10.1161/circimaging.116.005839

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arterial graft with elastic layer structure grown from cells.2017

    • Author(s)
      Yokoyama U, Tonooka Y, Koretake R, Akimoto T, Gonda Y, Saito J, Umemura M, Fujita T, Sakuma S, Arai F, Kaneko M, Ishikawa Y.
    • Journal Title

      Sci Rep

      Volume: 1 Issue: 1 Pages: 140-140

    • DOI

      10.1038/s41598-017-00237-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pathology and Molecular Mechanisms of Coarctation of the Aorta and its Association with the Ductus Arteriosus.2017

    • Author(s)
      Yokoyama U, Ichikawa Y, Minamisawa S, Ishikawa Y
    • Journal Title

      J Physiol Sci.

      Volume: 67 Issue: 2 Pages: 259-270

    • DOI

      10.1007/s12576-016-0512-x

    • NAID

      40021113914

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glutamate promotes contraction of the rat ductus arteriosus.2016

    • Author(s)
      Fujita S, Yokoyama U, Ishiwata R, Aoki R, Nagao K, Masukawa D, Umemura M, Fujita T, Iwasaki S, Nishimaki S, Seki K, Ito S, Goshima Y, Asou T, Masuda M, Ishikawa Y.
    • Journal Title

      Circ J

      Volume: 80 Pages: 2388-2396

    • NAID

      130005433144

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epac1 deficiency attenuated vascular smooth muscle cell migration and neointimal formation.2015

    • Author(s)
      Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, Ishikawa Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 35(12) Issue: 12 Pages: 2617-2625

    • DOI

      10.1161/atvbaha.115.306534

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin E-mediated molecular mechanisms driving remodeling of the ductus arteriosus.2015

    • Author(s)
      Yokoyama U.
    • Journal Title

      Pediatr Int.

      Volume: 57(5) Issue: 5 Pages: 820-827

    • DOI

      10.1111/ped.12769

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through β1- and α1-adrenergic receptor-mediated signaling in mice.2015

    • Author(s)
      Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y.
    • Journal Title

      PLoS One.

      Volume: 23;10(7) Issue: 7 Pages: e0133664-e0133664

    • DOI

      10.1371/journal.pone.0133664

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.2015

    • Author(s)
      Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, SuitaK, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, and Ishikawa Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 458 Issue: 3 Pages: 531-535

    • DOI

      10.1016/j.bbrc.2015.01.149

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach2015

    • Author(s)
      Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65(2) Issue: 2 Pages: 195-200

    • DOI

      10.1007/s12576-014-0354-3

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.2015

    • Author(s)
      TsunematsuT, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, Ishikawa Y.
    • Journal Title

      Biochemical and Biophysical Research Communications (BBRC)

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microfluidic perfusion culture system for multilayer artery tissue models2014

    • Author(s)
      Yuka Yamagishi, Taisuke Masuda, Michiya Matsusaki, Mitsuru Akashi, Utako Yokoyama, Fumihito Arai
    • Journal Title

      Biomicrofluids

      Volume: 8 Issue: 6 Pages: 064113-064113

    • DOI

      10.1063/1.4903210

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3.2014

    • Author(s)
      Tsutsumi YM, Tsutsumi R, Hamaguchi E, Sakai Y, Kasai A, Ishikawa Y, Yokoyama U, Tanaka K.
    • Journal Title

      Cardiovasc Diabetol.

      Volume: VOL.13 Issue: 1 Pages: 132-132

    • DOI

      10.1186/preaccept-1916507751134656

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased serum osmolality promotes ductus arteriosus constriction.2014

    • Author(s)
      Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y.
    • Journal Title

      Cardiovascular Research

      Volume: 104(2) Issue: 2 Pages: 326-36

    • DOI

      10.1093/cvr/cvu199

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses2014

    • Author(s)
      Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 6 Pages: 2785

    • DOI

      10.1172/jci64784

    • URL

      https://localhost/en/publications/36b42ba8-faa2-4af8-8b0f-f7a856c64b49

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8.2014

    • Author(s)
      Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun, AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, and Ishikawa Y.
    • Journal Title

      PLoS ONE.

      Volume: 9 Issue: 3 Pages: e91980-e91980

    • DOI

      10.1371/journal.pone.0091980

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperthermia generated with ferucarbotran (Resovis®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells.2014

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T Fujita T, Yokoyama U, Okumura S, Feng X, Ito K, Miyajima A, Makino A, Iwai M, Eguchi H, I wai T, and Ishikawa Y.
    • Journal Title

      J. Physiol. Sci.

      Volume: 64 Issue: 3 Pages: 177-183

    • DOI

      10.1007/s12576-014-0309-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Store-operated Ca2 entry (SOCE) Regulates Melanoma Proliferation and Cell Migration.2014

    • Author(s)
      Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Lai-Hua Xie LH, Feng X, 1, Itoh K, Makino A, Fujita T, Yokoyama U, Iw atsubo M, Chen S, Goydos JS, I shikawa Y, and Iwatsubo K
    • Journal Title

      PLoS ONE.

      Volume: 9 Issue: 2 Pages: e89292-e89292

    • DOI

      10.1371/journal.pone.0089292

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Geranylgeranylacetone protects the heart via caveloae and caveolin-3.2014

    • Author(s)
      Tsutsumi YM, Tsutsumi R, Hirokawa YT, Sakai Y, Hamaguchi E, Ishikawa Y, Yokoyama U, Kasai A, Kambe N, and Tanaka K.
    • Journal Title

      Life Sciences.

      Volume: 101 Issue: 1-2 Pages: 43-48

    • DOI

      10.1016/j.lfs.2014.02.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-Dimensional Multilayers of Smooth Muscle Cells as a New Experimental Model for Vascular Elastic Fiber Formation Studies.2014

    • Author(s)
      Ishiwata R, Yokoyama U, Matsusaki M, Yoshiya A, Kadowaki K, Ichikaww Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Mitsuru Akashi M, and Ishikawa Y.
    • Journal Title

      Atherosclerosis.

      Volume: 233 Issue: 2 Pages: 590-600

    • DOI

      10.1016/j.atherosclerosis.2014.01.045

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling.2014

    • Author(s)
      Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
    • Journal Title

      Circulation.

      Volume: 129 Issue: 4 Pages: 487-496

    • DOI

      10.1161/circulationaha.113.004726

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 動脈管閉鎖の分子メカニズムと新たな薬物療法の可能性2014

    • Author(s)
      横山詩子
    • Journal Title

      小児科

      Volume: 55 Pages: 11-20

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The prostanoid EP4 receptor and its signaling pathway.2013

    • Author(s)
      Yokoyama U, Iwatsubo K, Umemura M, Fujita T, and Ishikawa Y.
    • Journal Title

      Pharmacol Rev.

      Volume: 65 Issue: 3 Pages: 1010-1052

    • DOI

      10.1124/pr.112.007195

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動脈硬化・動脈瘤病態形成におけるプロスタグランディンE2の役割(The role of prostaglandin E2 in atherosclerosis and aortic aneurysm)2013

    • Author(s)
      横山詩子
    • Journal Title

      血栓と循環

      Volume: 21 Pages: 29-33

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Low-dose Thromboxane A2 Receptor Stimulation Promotes Closure of the Rat Ductus Arteriosus with Minimal Adverse Effects2012

    • Author(s)
      Yokota T, Aida T, Ichikawa Y, Fujita T, Yokoyama U, Minamisawa S
    • Journal Title

      Pediatr Res

      Volume: 72 Issue: 4 Pages: 129-36

    • DOI

      10.1371/journal.pone.0094895

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Oxygenation-induced postnatal remodeling of the ductus arteriosus.2017

    • Author(s)
      Jin MH, Yokoyama U, Ishiwata R, Minamisawa S, Ishikawa Y.
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Human gene analysis identified tissue plasminogen activator as a mediator of disrupting the internal elastic lamina in the ductus arteriosus.2017

    • Author(s)
      Saito J, Yokoyama U, Ishikawa Y.
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] An EP4 antagonist has inhibitory and therapeutic effects on mouse models of abdominal aortic aneurysm.2017

    • Author(s)
      Al Mamun, Yokoyama U, Ishiwata R, Isono O, Nagabukuro H, Ishikawa Y.
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Clinical Course of Pulmonary Artery Aneurysm in Pulmonary Hypertension: Insight into Medical Treatment and Histological Characteristics2017

    • Author(s)
      Akagi S, Nakamura K, Yokoyama U, Sarashina T, Ejiri K, Itoh H.
    • Organizer
      The 81th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Ishikawa Ongakudo, Kanazawa
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Fibulin-1 は平滑筋細胞遊走を介して動脈管内膜肥厚を誘導する2016

    • Author(s)
      伊藤智子, 横山詩子, 益田宗孝, 麻生俊英, 石川義弘
    • Organizer
      第61回日本新生児成育医学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] EP4 signaling in smooth muscle cells attracts inflammatory immune responses in the aorta.2016

    • Author(s)
      Ishiwata R, Yokoyama U, Ichikawa Y, Kurotaki D, Yasuda S, Goda M, Suzuki S, Masuda M, Tamura T, Ishikawa Y.
    • Organizer
      The 89th Scientific Session, American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human Gene Profiling Reveals contribution of Tissue Plasminogen Activator to Intimal Thickening of the Ductus Arteriosus.2016

    • Author(s)
      Saito J, Yokoyama U, Masuda M, Asou T, Ishikawa Y.
    • Organizer
      The 89th Scientific Session, American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fibulin-1 plays a role in smooth muscle cell migration and intimal thickening in the ductus arteriosus.2016

    • Author(s)
      Ito S, Yokoyama U, Yanai C, Masuda M, Asou T, Ishikawa Y.
    • Organizer
      The 89th Scientific Session, American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 組織型プラスミノーゲン活性化因子による動脈管内弾性板の分解2016

    • Author(s)
      齋藤純一, 横山詩子, 石川義弘
    • Organizer
      第15回日本心臓血管発生研究会
    • Place of Presentation
      国立循環器病研究センター(大阪府吹田市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] PGE2-EP4シグナルはfibulin-1を介して動脈管平滑筋遊走を促進する2016

    • Author(s)
      伊藤智子, 横山詩子, 石川義弘
    • Organizer
      第15回日本心臓血管発生研究会
    • Place of Presentation
      国立循環器病研究センター(大阪府吹田市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリング2016

    • Author(s)
      齋藤純一,横山詩子,麻生俊英,石川義弘
    • Organizer
      第52回日本周産期・新生児医学会学術集会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 平滑筋細胞におけるPGE2-EP4シグナルは腹部大動脈瘤の発症を促す2016

    • Author(s)
      石渡 遼, 横山 詩子, 市川 泰弘, 黒滝 大翼, 田村 智彦, 石川 義弘
    • Organizer
      第37回日本循環制御医学会総会
    • Place of Presentation
      ステーションコンファレンス東京(東京都)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of Epac1 in the regulatory mechanisms of vascular smooth muscle cell migration and neointimal formation.2016

    • Author(s)
      Kato Y, Yokoyama U, Ishikawa Y.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Periodic hydrodynamic pressurization promotes layered structure of human arterial smooth muscle cells.2016

    • Author(s)
      Tonooka Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fabrication of layered elastic fibers in rat arterial constructs by periodic hydrodynamic pressurization.2016

    • Author(s)
      Gonda Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血管平滑筋と細胞外基質制御における新たなホスホリパーゼCとサイクリックAMPの役割The roles of phospholipase C and cyclic AMP in regulation of extracellular matrix in vascular smooth muscle cells.2016

    • Author(s)
      Yokoyama U.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市白石区)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Inhibition of PGE2-EP4 Signaling as a PotentialFuture Therapeutic Strategy for Abdominal Aortic Aneurysm.2016

    • Author(s)
      Yokoyama U, Ishiwata R, Ichikawa Y, Yasuda S, Goda M, Suzuki S, Masuda M, Ishikawa Y.
    • Organizer
      The 80th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      仙台国際センター(宮城県仙台市青葉区)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 動脈硬化性疾患に対する薬物治療の開発2016

    • Author(s)
      横山詩子
    • Organizer
      Atherosclerosis and Angiogenesis Research Frontier
    • Place of Presentation
      旭川グランドホテル(北海道旭川市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 早産児の動脈管はなぜ閉じないのか2015

    • Author(s)
      横山詩子
    • Organizer
      第28回北海道新生児談話会
    • Place of Presentation
      北海道大学病院(北海道札幌市北区)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 動脈管閉鎖の分子機序と新たな薬物療法の可能性2015

    • Author(s)
      横山詩子
    • Organizer
      第24回東海新生児研究会
    • Place of Presentation
      名古屋市立大学病院(愛知県名古屋市瑞穂区)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プロスタグランディンE受容体―EP4を標的とした大動脈瘤治療の開発2015

    • Author(s)
      横山詩子
    • Organizer
      岡山心臓血管研究会
    • Place of Presentation
      岡山大学病院(岡山県岡山市北区)
    • Year and Date
      2015-09-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 平滑筋におけるPGE2-EP4シグナルは腹部大動脈瘤の慢性炎症をつかさどる2015

    • Author(s)
      横山詩子、石渡遼、石川義弘
    • Organizer
      第246回生理学東京談話会
    • Place of Presentation
      東邦大学医学部(東京都大田区)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 未熟児動脈管開存症治療におけるアミノ酸輸液組成の重要性 The effect of amino acids on patent ductus arteriosus in preterm infants2015

    • Author(s)
      横山詩子、藤田秀次郎、青木理加、岩崎志穂、麻生俊英、益田宗孝、関和男、石川義弘
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリングGene profiling of the intimal thickness in the human ductus arteriosus2015

    • Author(s)
      齋藤純一、横山詩子、市川泰広、益田宗孝、麻生俊英、石川義弘
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 動脈管分化の分子メカニズム2015

    • Author(s)
      横山詩子
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 平滑筋におけるPGE2-EP4シグナルは腹部大動脈瘤の発症を促進する2015

    • Author(s)
      石渡遼、横山詩子、市川泰弘、石川義弘
    • Organizer
      第132回日本薬理学会関東部会
    • Place of Presentation
      明海大学浦安キャンパス(千葉県浦安市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 動脈管開存症治療における輸液組成の重要性2015

    • Author(s)
      横山詩子
    • Organizer
      神奈川県立こども医療センター第24回心臓血管外科勉強会
    • Place of Presentation
      神奈川県立こども医療センター(神奈川県横浜市南区)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Regulation of collagens in the heart.2015

    • Author(s)
      Yokoyama U.
    • Organizer
      The 79th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Plasminogen activator may promote intimal thickening in the ductus arteriosus.2015

    • Author(s)
      Nicho N, Yokoyama U, Saitoh J, Yanai C, Ichikawa Y, Masuda M, Aso T, Ishikawa Y.
    • Organizer
      The 118th Annual Meeting of the Japan Pediatric Society
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 実験的アプローチによる新たな動脈管開存症治療の開発2015

    • Author(s)
      横山詩子
    • Organizer
      第一回新生児科指導医養成事業による教育セミナー
    • Place of Presentation
      東北大学病院(宮城県仙台市)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Fabrication of tissue-engineered human arterial constructs by cyclic hydrostatic pressure.2015

    • Author(s)
      Tonooka Y, Yokoyama U, Koretake R, Ishiwata R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      The 92th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナノ薄膜技術を用いた高弾性を有する動脈グラフトの作製 Construction of biological elastic vessels by extracellular matrix nanofilm-based cell accumulation technique.2015

    • Author(s)
      Yokoyama U.
    • Organizer
      The 92th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] PGE2-EP4 sigaling promotes vascular intimal thickening via fibulin-1.2015

    • Author(s)
      Yokoyama U, Yanai C, Sato A, Ishikawa Y.
    • Organizer
      The 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Secretome-based identification of PGE2-regulated proteins in human abdominal aortic aneurysm.2015

    • Author(s)
      Ishiwata R, Yokoyama U, Arakawa N, Ishikawa Y.
    • Organizer
      he 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] PGE2-EP4 exerts an anti-fibrotic effect in the heart.2015

    • Author(s)
      Ishiwata R. Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
    • Organizer
      The 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] PGE2-EP4 sigaling in smooth muscle cell plays a role in chronic inflammation of aortic abdominal aneurysm.2015

    • Author(s)
      Yokoyama U, Ichikawa Y, Ishiwata R, Ishikawa Y.
    • Organizer
      The 6th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] プロスタグランディンE-EP4はfibulin-1を介して生理的・病的血管内膜肥厚の形成に関与する Prostaglandin E2-EP4 is involved in physiological and pathological intimal thickening via fibulin-12014

    • Author(s)
      矢内千春、横山詩子、熊谷駿、手島隆之、佐藤綾美、石川義弘
    • Organizer
      第13回日本心臓血管発生研究会
    • Place of Presentation
      磐梯熱海温泉 ホテル 華の湯(福島県郡山市)
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 plays a protective role against cardiac fibrosis.2014

    • Author(s)
      Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      Spain, Barcelona
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 動脈管は面白い2014

    • Author(s)
      横山詩子
    • Organizer
      第24回心研小児科夏季セミナー
    • Place of Presentation
      東京女子医科大学(東京都新宿区)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 仕事の多様化について2014

    • Author(s)
      横山詩子
    • Organizer
      横浜市立大学第2回Joinの会
    • Place of Presentation
      横浜市立大学附属 市民総合医療センター(神奈川県横浜市)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] プロスタグランディンEによる血管弾性線維の制御メカニズム2014

    • Author(s)
      横山詩子
    • Organizer
      東京農工大学 材料健康科学「Cell to Body Dynamicsセミナー」
    • Place of Presentation
      東京農工大学(東京都小金井市)
    • Year and Date
      2014-07-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] グルタミン酸が動脈管閉鎖に及ぼす作用の検討2014

    • Author(s)
      藤田秀次郎、横山詩子、青木理加、岩崎志穂、西巻滋、関和男、横田俊平、石川義弘
    • Organizer
      第50回日本周産期・新生児医学会学術集会
    • Place of Presentation
      シェラトングランデトーキョーベイ(千葉県浦安市)
    • Year and Date
      2014-07-13 – 2014-07-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト大動脈瘤組織におけるPGE2-EP4誘導性分泌タンパク質の網羅的解析2014

    • Author(s)
      石渡遼、横山詩子、荒川憲昭、安田章沢、郷田素彦、鈴木伸一、益田宗孝、石川義弘
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県福岡市)
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nuclear Factor kappa B Inhibition Promotes Closure of the Rat Ductus Arteriosus.2014

    • Author(s)
      Kajimura I, Yokoyama U, Ishikawa Y, Minamisawa S.
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] cAMP reverses the pro-fibrogenic phenotype of cardiac myofibroblasts.2014

    • Author(s)
      Aroonsakool N, Yokoyama U, Lu D, Patel HH, Insel PA.
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prostaglandin E2 receptor EP4 signaling in vascular smooth muscle cells decreases aortic elasticity.2014

    • Author(s)
      Ichikawa Y, Yokoyama U, Ishikawa Y.
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] PGE2-EP4 signaling is a key regulator of cardiovascular stiffness and elasticity2014

    • Author(s)
      Yokoyama U
    • Organizer
      The 91th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Prostaglandin E2 receptor EP4 signaling in vascular smooth muscle cells decreases aortic elasticity2014

    • Author(s)
      Ichikawa Y, Yokoyama U, Ishikawa Y
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      USA San Diego Convention center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2 Receptor EP4 Signaling in Vascular Smooth Muscle Plays a Role in Arterial Elasticity2014

    • Author(s)
      Ichikawa Y, Yokoyama U, Minamisawa S, Ishikawa Y
    • Organizer
      The78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 signaling-induced fibulin-1 may play a role in intimal thickening in the ductus arteriosus2014

    • Author(s)
      Kumagaya S, Yokoyama U, Minamisawa S, Inoue T, Ishikawa Y
    • Organizer
      The 91th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2 Receptor EP4 Signaling in Smooth Muscle Cells Regulates Arterial Elasticity2014

    • Author(s)
      Ichikawa Y, Yokoyama U, Ishikawa Y
    • Organizer
      The 91th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The multiple roles of prostaglandin E and oxygen in the regulation of the ductus arteriosus2013

    • Author(s)
      Yokoyama U, Jin MH, Ishiwata R, Ichikawa Y, Minamisawa S, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都渋谷区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Prostaglandin E2 Receptor EP4 Signaling in Vascular Smooth Muscle Decreased Elasticity of the Aorta2013

    • Author(s)
      Ichikawa Y, Yokoyama U, Iwamoto M, Yokota S, Minamisawa S, Ishikawa Y
    • Organizer
      The 86th Scientific Session, American Heart Association
    • Place of Presentation
      USA Dallas Convention center
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血管弾性線維におけるプロスタグランディンE受容体EP4の役割の検討2013

    • Author(s)
      市川泰広、横山詩子、南沢享、石川義弘
    • Organizer
      第21回 日本血管生物医学会学術集会
    • Place of Presentation
      千里阪急ホテル(大阪府豊中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 signaling promotes secretion of the lipid-relating proteoglycan biglycan in human coronary arteries during development2013

    • Author(s)
      Kumagaya S, Yokoyama U, Sato A, Nishihara H, Inoue T, Minamisawa S, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都渋谷区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 signaling inhibits vascular elastic fiber formation in the ductus arteriosus2013

    • Author(s)
      Ishiwata R, Yokoyama U, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都渋谷区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mouse Overexpressing Prostaglandin E Receptor EP4 in Vascular Smooth Muscle Cells Decreased Elasticity of the Aorta2013

    • Author(s)
      Ichikawa Y, Yokoyama U, Jin MH, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都渋谷区)
    • Related Report
      2013 Annual Research Report
  • [Book] Bioactive Lipid Mediators. Current Reviews and Protocols.2015

    • Author(s)
      Yokoyama U, Ishiwata R, Ishikawa Y.
    • Total Pages
      11
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Etiology and Morphogenesis of Congenital Heart Disease.2015

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y.
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Nanomedicine and Nanotoxicology.2014

    • Author(s)
      Yokoyama U*, Ishikawa Y.
    • Total Pages
      271
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Etiology and Morphogenesis of Congenital Heart Disease2014

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y
    • Total Pages
      5
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Remarks] 横浜市立大学医学部循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 横浜市立大学医学部循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 横浜市立大学医学部循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 動脈硬化を検出するための血中バイオマーカー2017

    • Inventor(s)
      横山詩子、石川義弘、ほか
    • Industrial Property Rights Holder
      横山詩子、石川義弘、ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-16
    • Related Report
      2016 Annual Research Report
    • Overseas

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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