Study for mechanism of maintaining cutaneous homeostasis by HMGB1-induced mesenchymal stem cell mobilization from bone marrow, and application for treating intractable skin diseases.
| Project/Area Number |
25293244
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
Tamai Katsuto 大阪大学, 医学(系)研究科(研究院), 寄付講座教授 (20236730)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | HMGB1 / 骨髄間葉系幹細胞 / 血小板増殖因子受容体 / 表皮水疱症 / 強皮症 / 再生誘導医療 / 間葉系幹細胞 / 生体組織再生 / 皮膚恒常性維持 |
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| Outline of Final Research Achievements |
In this study, we investigated role of HMGB1 for regulating cutaneous homeostasis, and possibility of HMGB1 application for treating intractable skin diseases. In summary, we clarified following mechanisms; 1) necrotic tissue-derived HMGB1 binds to proteoglycan "syndecan" to be pooled on the cell surface and released when injury occurs, 2) released HMGB1 in the circulation binds to the receptor on the cell membrane of bone marrow mesenchymal stem cells (MSCs) and mobilize them into the circulation, 3) the mobilized MSCs in the circulation target the injured/necrotic tissues by SDF-1/CXCR4 axis generated on the vascular endothelial cell surface, and 4) the mobilized MSCs in the injured tissue then suppress inflammation, reduce scar formation, and induce tissue regeneration.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Immune tolerance induction using fetal directed placental injection in rodent models: a murine model.2015
Author(s)
Takahashi, K. Endo, M. Miyoshi, T. Tsuritani, M. Shimazu, Y. Hosoda, H. Saga, K. Tamai, K. Flake, AW. Yoshimatsu, J. Kimura, T.
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Journal Title
PLoS One.
Volume: 10(4)
Issue: 4
Pages: e0123712-e0123712
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Cinnamtannin B-1 Promotes Migration of Mesenchymal Stem Cells and Accelerates Wound Healing in Mice.2015
Author(s)
Fujita K, Kuge K, Ozawa N, Sahara S, Zaiki K, Nakaoji K, Hamada K, Takenaka Y, Tanahashi T, Tamai K, Kaneda Y, Maeda A.
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Journal Title
PLoS One
Volume: Dec 11;10(12)
Issue: 12
Pages: e0144166-e0144166
DOI
Related Report
Open Access
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[Journal Article] Transplanted bone marrow-derived circulating PDGFRα+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.2015
Author(s)
Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath JA, Uitto J, Ishii M, Iizuka H, Kaneda Y.
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Journal Title
Journal of Immunology
Volume: 194(4)
Issue: 4
Pages: 1996-2003
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mallotus philippinensis bark extracts promote preferential migration of mesenchymal stem cells and improve wound healing in mice.2014
Author(s)
Furumoto T, Ozawa N, Inami Y, Toyoshima M, Fujita K, Zaiki K, Sahara S, Akita M, Kitamura K, Nakaoji K, Hamada K, Tamai K, Kaneda Y, Maeda A.
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Journal Title
Phytomedicine.
Volume: 21
Issue: 3
Pages: 247-253
DOI
Related Report
Peer Reviewed
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[Presentation] Transplanted mesenchymal stem cells provide typeVII collagen in the skin of recessive dystrophic epidermolysis bullosa.2013
Author(s)
Tamai K, Iinuma S, Ikawa E, Kikuchi Y, Fujita R, Ishii M, Uitto, J, Kaneda Y.
Organizer
16th annual meeting of American Society of Gene and Cell Therapy,
Place of Presentation
Salt Lake City, USA
Related Report
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