A psychological and neuroimaging study regarding to self in children, adolescents and adults tih autism spectrum disorder

• Project/Area Number: 25293248
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: MUNESUE Toshio 金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA Shigeru 金沢大学, 子どものこころの発達研究センター, 特任教授 (00210633) ; MIURA Yui 金沢大学, 子どものこころの発達研究センター, 特任助教 (40612320) ; KOSAKA Hirotaka 福井大学, 子どものこころの発達研究センター, 特命教授 (70401966) ; SAITOH Daisuke 福井大学, 子どものこころの発達研究センター, 特命准教授 (30390701) ; MORITA Tomoyo 大阪大学, 工学研究科, 特任講師 (60543402) ; KOMEDA Hidetsugu 京都大学, 白眉センター, 特任准教授 (50711595)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
• Keywords: 自閉スペクトラム症 / 自我 / オキシトシン / 臨床試験 / 児童青年精神医学

Outline of Final Research Achievements

We conducted a series of psychological, neuroimaging and psychopharmacological studies focused on self in individuals with autism spectrum disorder (ASD). A result showed that the ventromedial prefrontal cortex, which is likely to be involved in self-related processing, was significantly activated in ASD individuals when they processed autistic characters rather than typically developing characters.

Research Products

• [Journal Article] Atypical development of the central auditory system in young children with Autism spectrum disorder. (2016)
  • Author(s): Yoshimura, Y., Kikuchi, M., Hiraishi, H., Hasegawa, C., Takahashi, T., Remijn, G. B., Oi, M., Munesue, T., Higashida, H., Minabe, Y., Kojima, H.
  • Journal Title: Autism Research Volume: 9(2) Issue: 11 Pages: 1-11
  • DOI: 10.1002/aur.1604
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oxytocin for Male Subjects with Autism Spectrum Disorder and Comorbid Intellectual Disabilities: A Randomized Pilot Study (2016)
  • Author(s): Toshio Munesue, Hiroyuki Nakamura, Mitsuru Kikuchi, Yui Miura, Noriyuki Takeuchi, Tokie Anme, Eiji Nanba, Kaori Adachi, Kiyotaka Tsubouchi, Yoshimichi Sai, Ken-ichi Miyamoto, Shin-ichi Horike, Shigeru Yokoyama, Hideo Nakatani, Yo Niida, Hirotaka Kosaka, Yoshio Minabe and Haruhiro Higashida
  • Journal Title: Frontiers in Psychiatry Volume: 7-2 Pages: 2-2
  • DOI: 10.3389/fpsyt.2016.00002
  • NAID: 120007128509
  • Peer Reviewed / Open Access
• [Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults. (2016)
  • Author(s): Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
  • Journal Title: Molecular Autism Volume: 7 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s13229-016-0083-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhanced brain signal variability in children with autism spectrum disorder during early childhood. (2016)
  • Author(s): Takahashi T, Yoshimura Y, Hiraishi H, Hasegawa C, Munesue T, Higashida H, Minabe Y, Kikuchi M.
  • Journal Title: Hum Brain Mapp. Volume: 37（3） Issue: 3 Pages: 1038-1050
  • DOI: 10.1002/hbm.23089
  • Peer Reviewed / Open Access
• [Journal Article] Reduced long-range functional connectivity in young children with autism spectrum disorder. (2015)
  • Author(s): Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y.
  • Journal Title: Soc Cogn Affect Neurosci. Volume: 10 Issue: 2 Pages: 248-254
  • DOI: 10.1093/scan/nsu049
  • Peer Reviewed / Open Access
• [Journal Article] Association study between the CD157/BST1 gene and autism spectrum disorders in a Japanese population (2015)
  • Author(s): Shigeru Yokoyama, Naila Al Mahmuda, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Masakazu Yamagishi, Haruhiro Higashida
  • Journal Title: Brain Sci Volume: 5 Issue: 2 Pages: 188-200
  • DOI: 10.3390/brainsci5020188
  • Peer Reviewed / Open Access
• [Journal Article] Changes in autistic trait indicators in parents and their children with ASD: A preliminary longitudinal study. (2015)
  • Author(s): Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Higashida H, Oi M, Minabe Y, Asada M.
  • Journal Title: Psychiatry Research Volume: 228 Issue: 3 Pages: 956-957
  • DOI: 10.1016/j.psychres.2015.05.048
  • Peer Reviewed / Open Access
• [Journal Article] Autistic empathy toward autistic others (2015)
  • Author(s): Komeda H, Kosaka H, Saito DN, Mano Y, Jung M, Fujii T, Yanaka HT, Munesue T, Ishitobi M, Sato M, Okazawa H
  • Journal Title: Social cognitive and affective neuroscience Volume: 10 (2) Issue: 2 Pages: 145-52
  • DOI: 10.1093/scan/nsu126
  • Peer Reviewed / Open Access
• [Journal Article] Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits. (2014)
  • Author(s): Jung M, Kosaka H, Saito DN, Ishitobi M, Morita T, Inohara K, Asano M, Arai S, Munesue T, Tomoda A, Wada Y, Sadato N, Okazawa H, Iidaka T
  • Journal Title: Molecular Autism Volume: 5 Issue: 1 Pages: 1-11
  • DOI: 10.1186/2040-2392-5-35
  • Peer Reviewed / Open Access
• [Journal Article] A custom Magnetoencephalography device reveals brain connectivity and high reading/decoding ability in children with autism. (2013)
  • Author(s): Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S., et al., Remijn, G.B., Takahashi, T., Suzuki, M., Higashida, H., Minabe, Y.
  • Journal Title: Scientific Reports Volume: 3 Issue: 1 Pages: 1139-1139
  • DOI: 10.1038/srep01139
  • Peer Reviewed
• [Journal Article] Anterior prefrontal hemodynamic connectivity in conscious 3- to 7-year-old children with typical development and autism spectrum disorder. (2013)
  • Author(s): Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S., et al., Remijn, G.B., Takahashi, T., Suzuki, M., Higashida, H., Minabe, Y.
  • Journal Title: PloSONE Volume: 8 Issue: 2 Pages: 56087-56087
  • DOI: 10.1371/journal.pone.0056087
  • Peer Reviewed
• [Journal Article] Episodic memory retrieval for story characters in high-functioning autism (2013)
  • Author(s): Komeda H, Kosaka H, Saito DN, Inohara K, Munesue T, Ishitobi M, Sato M, Okazawa H.
  • Journal Title: Mol Autism Volume: 4 (1) Issue: 1 Pages: 20-20
  • DOI: 10.1186/2040-2392-4-20
  • NAID: 120005293585
  • Peer Reviewed
• [Journal Article] Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: a case-control study in a Japanese population and functional analysis. (2013)
  • Author(s): Ma WJ, Hashii M, Munesue T, Hayashi K, Yagi K, Yamagishi M, Higashida H, Yokoyama S.
  • Journal Title: Mol Autism Volume: 4 Issue: 1 Pages: 22-22
  • DOI: 10.1186/2040-2392-4-22
  • NAID: 120006325350
  • Peer Reviewed
• [Journal Article] Atypical brain lateralisation in the auditory cortex and language performance in 3- to 7-year-old children with high-functioning autism spectrum disorder : a child-customised magnetoencephalography (MEG) study (2013)
  • Author(s): Y Yoshimura, M Kikuchi, K Shitamichi, S Ueno, T Munesue, Y Ono, T Tsubokawa, Y Haruta, M Oi, Y Niida, GB Remijn, T Takahashi, M Suzuki, H Higashida, Y Minabe
  • Journal Title: Mol Autism Volume: 8巻 Issue: 1 Pages: 38-38
  • DOI: 10.1186/2040-2392-4-38
  • Peer Reviewed
• [Journal Article] The brain's response to the human voice depends on the incidence of autistic traits in the general population (2013)
  • Author(s): Y Yoshimura, M Kikuchi, S Ueno, E Okumura, H Hiraishi, C Hasegawa, G B Remijn, K Shitamichi, T Munesue, T Tsubokawa, H Higashida, Y Minabe
  • Journal Title: PLoS One Volume: 20巻 Issue: 11 Pages: e80126-e80126
  • DOI: 10.1371/journal.pone.0080126
  • Peer Reviewed
• [Presentation] 自閉スペクトラム症におけるオキシトシン (2015)
  • Author(s): 三邉義雄、棟居俊夫
  • Organizer: 第111回日本精神神経学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] 自閉スペクトラム症者への経鼻的オキシトシン継続投与の臨床試験報 (2015)
  • Author(s): 棟居俊夫
  • Organizer: 第111回日本精神神経学会学術総会
  • Place of Presentation: リーガロイヤルホテル大阪
  • Year and Date: 2015-06-04
  • Invited
• [Book] こころの病気を学ぶ (2013)
  • Author(s): 棟居俊夫
  • Total Pages: 268
  • Publisher: シナジー
• [Remarks] 金沢大学子どものこころの発達研究センター
  • URL: http://kodomokokoro.w3.kanazawa-u.ac.jp/