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A psychological and neuroimaging study regarding to self in children, adolescents and adults tih autism spectrum disorder

Research Project

Project/Area Number 25293248
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

MUNESUE Toshio  金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Shigeru  金沢大学, 子どものこころの発達研究センター, 特任教授 (00210633)
MIURA Yui  金沢大学, 子どものこころの発達研究センター, 特任助教 (40612320)
KOSAKA Hirotaka  福井大学, 子どものこころの発達研究センター, 特命教授 (70401966)
SAITOH Daisuke  福井大学, 子どものこころの発達研究センター, 特命准教授 (30390701)
MORITA Tomoyo  大阪大学, 工学研究科, 特任講師 (60543402)
KOMEDA Hidetsugu  京都大学, 白眉センター, 特任准教授 (50711595)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords自閉スペクトラム症 / 自我 / オキシトシン / 臨床試験 / 児童青年精神医学
Outline of Final Research Achievements

We conducted a series of psychological, neuroimaging and psychopharmacological studies focused on self in individuals with autism spectrum disorder (ASD). A result showed that the ventromedial prefrontal cortex, which is likely to be involved in self-related processing, was significantly activated in ASD individuals when they processed autistic characters rather than typically developing characters.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 Other

All Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 9 results) Presentation (2 results) (of which Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Atypical development of the central auditory system in young children with Autism spectrum disorder.2016

    • Author(s)
      Yoshimura, Y., Kikuchi, M., Hiraishi, H., Hasegawa, C., Takahashi, T., Remijn, G. B., Oi, M., Munesue, T., Higashida, H., Minabe, Y., Kojima, H.
    • Journal Title

      Autism Research

      Volume: 9(2) Issue: 11 Pages: 1-11

    • DOI

      10.1002/aur.1604

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxytocin for Male Subjects with Autism Spectrum Disorder and Comorbid Intellectual Disabilities: A Randomized Pilot Study2016

    • Author(s)
      Toshio Munesue, Hiroyuki Nakamura, Mitsuru Kikuchi, Yui Miura, Noriyuki Takeuchi, Tokie Anme, Eiji Nanba, Kaori Adachi, Kiyotaka Tsubouchi, Yoshimichi Sai, Ken-ichi Miyamoto, Shin-ichi Horike, Shigeru Yokoyama, Hideo Nakatani, Yo Niida, Hirotaka Kosaka, Yoshio Minabe and Haruhiro Higashida
    • Journal Title

      Frontiers in Psychiatry

      Volume: 7-2 Pages: 2-2

    • DOI

      10.3389/fpsyt.2016.00002

    • NAID

      120007128509

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults.2016

    • Author(s)
      Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
    • Journal Title

      Molecular Autism

      Volume: 7 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s13229-016-0083-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced brain signal variability in children with autism spectrum disorder during early childhood.2016

    • Author(s)
      Takahashi T, Yoshimura Y, Hiraishi H, Hasegawa C, Munesue T, Higashida H, Minabe Y, Kikuchi M.
    • Journal Title

      Hum Brain Mapp.

      Volume: 37(3) Issue: 3 Pages: 1038-1050

    • DOI

      10.1002/hbm.23089

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced long-range functional connectivity in young children with autism spectrum disorder.2015

    • Author(s)
      Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y.
    • Journal Title

      Soc Cogn Affect Neurosci.

      Volume: 10 Issue: 2 Pages: 248-254

    • DOI

      10.1093/scan/nsu049

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association study between the CD157/BST1 gene and autism spectrum disorders in a Japanese population2015

    • Author(s)
      Shigeru Yokoyama, Naila Al Mahmuda, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Masakazu Yamagishi, Haruhiro Higashida
    • Journal Title

      Brain Sci

      Volume: 5 Issue: 2 Pages: 188-200

    • DOI

      10.3390/brainsci5020188

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in autistic trait indicators in parents and their children with ASD: A preliminary longitudinal study.2015

    • Author(s)
      Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Higashida H, Oi M, Minabe Y, Asada M.
    • Journal Title

      Psychiatry Research

      Volume: 228 Issue: 3 Pages: 956-957

    • DOI

      10.1016/j.psychres.2015.05.048

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autistic empathy toward autistic others2015

    • Author(s)
      Komeda H, Kosaka H, Saito DN, Mano Y, Jung M, Fujii T, Yanaka HT, Munesue T, Ishitobi M, Sato M, Okazawa H
    • Journal Title

      Social cognitive and affective neuroscience

      Volume: 10 (2) Issue: 2 Pages: 145-52

    • DOI

      10.1093/scan/nsu126

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits.2014

    • Author(s)
      Jung M, Kosaka H, Saito DN, Ishitobi M, Morita T, Inohara K, Asano M, Arai S, Munesue T, Tomoda A, Wada Y, Sadato N, Okazawa H, Iidaka T
    • Journal Title

      Molecular Autism

      Volume: 5 Issue: 1 Pages: 1-11

    • DOI

      10.1186/2040-2392-5-35

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A custom Magnetoencephalography device reveals brain connectivity and high reading/decoding ability in children with autism.2013

    • Author(s)
      Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S., et al., Remijn, G.B., Takahashi, T., Suzuki, M., Higashida, H., Minabe, Y.
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1139-1139

    • DOI

      10.1038/srep01139

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior prefrontal hemodynamic connectivity in conscious 3- to 7-year-old children with typical development and autism spectrum disorder.2013

    • Author(s)
      Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S., et al., Remijn, G.B., Takahashi, T., Suzuki, M., Higashida, H., Minabe, Y.
    • Journal Title

      PloSONE

      Volume: 8 Issue: 2 Pages: 56087-56087

    • DOI

      10.1371/journal.pone.0056087

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Episodic memory retrieval for story characters in high-functioning autism2013

    • Author(s)
      Komeda H, Kosaka H, Saito DN, Inohara K, Munesue T, Ishitobi M, Sato M, Okazawa H.
    • Journal Title

      Mol Autism

      Volume: 4 (1) Issue: 1 Pages: 20-20

    • DOI

      10.1186/2040-2392-4-20

    • NAID

      120005293585

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: a case-control study in a Japanese population and functional analysis.2013

    • Author(s)
      Ma WJ, Hashii M, Munesue T, Hayashi K, Yagi K, Yamagishi M, Higashida H, Yokoyama S.
    • Journal Title

      Mol Autism

      Volume: 4 Issue: 1 Pages: 22-22

    • DOI

      10.1186/2040-2392-4-22

    • NAID

      120006325350

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical brain lateralisation in the auditory cortex and language performance in 3- to 7-year-old children with high-functioning autism spectrum disorder : a child-customised magnetoencephalography (MEG) study2013

    • Author(s)
      Y Yoshimura, M Kikuchi, K Shitamichi, S Ueno, T Munesue, Y Ono, T Tsubokawa, Y Haruta, M Oi, Y Niida, GB Remijn, T Takahashi, M Suzuki, H Higashida, Y Minabe
    • Journal Title

      Mol Autism

      Volume: 8巻 Issue: 1 Pages: 38-38

    • DOI

      10.1186/2040-2392-4-38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The brain's response to the human voice depends on the incidence of autistic traits in the general population2013

    • Author(s)
      Y Yoshimura, M Kikuchi, S Ueno, E Okumura, H Hiraishi, C Hasegawa, G B Remijn, K Shitamichi, T Munesue, T Tsubokawa, H Higashida, Y Minabe
    • Journal Title

      PLoS One

      Volume: 20巻 Issue: 11 Pages: e80126-e80126

    • DOI

      10.1371/journal.pone.0080126

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 自閉スペクトラム症におけるオキシトシン2015

    • Author(s)
      三邉義雄、棟居俊夫
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 自閉スペクトラム症者への経鼻的オキシトシン継続投与の臨床試験報2015

    • Author(s)
      棟居俊夫
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      リーガロイヤルホテル大阪
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] こころの病気を学ぶ2013

    • Author(s)
      棟居俊夫
    • Total Pages
      268
    • Publisher
      シナジー
    • Related Report
      2013 Annual Research Report
  • [Remarks] 金沢大学子どものこころの発達研究センター

    • URL

      http://kodomokokoro.w3.kanazawa-u.ac.jp/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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