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Latent neuroinflamation hypothesis on schizoprenia

Research Project

Project/Area Number 25293249
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

IWATA YASUHIDE  浜松医科大学, 医学部附属病院, 講師 (10285025)

Co-Investigator(Kenkyū-buntansha) Mori Norio  浜松医科大学, 医学部, 教授 (00174376)
Ueki Takatoshi  名古屋市立大学, 医学研究科, 教授 (60317328)
Wakuda Tomoyasu  浜松科大学, 医学部, 助教 (80444355)
Yokokura Masamichi  浜松科大学, 医学部, 助教 (00529399)
Takahashi Taro  浜松科大学, 医学部, 助教 (30402358)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords統合失調症 / ミクログリア / NMR / MRI / 予防法 / 神経炎症 / マイクログリア / マーモセット
Outline of Final Research Achievements

In the present study magnetic resonance imaging (MRI) switching probe was newly developed to visualize in vivo under MRI the activity pathological proteinase, which generates soluble fractalkine (FKN) from membrane bound form of FKN. The production of soluble FKN in the co-culture system of neuron and microglia was quantitatively analyzed according to the principle of paramagnetic relaxation, where MRI switching probe was originally designed and synthesized. And here the brain slice culture system derived from rodent model of schizophrenia was used to comprehensively analyze gene expression pattern in microglia at the onset of inflammation. As the results a series of molecules associated with the activation of microglia were identified.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (4 results)

All 2016 2014

All Presentation (4 results) (of which Invited: 2 results)

  • [Presentation] 脳内活性型ミクログリアを指標とした統合失調症の発症前診断システムの構築2016

    • Author(s)
      岩田泰秀
    • Organizer
      第12回統合失調症研究会
    • Place of Presentation
      東京コンファレンスセンター・品川
    • Year and Date
      2016-02-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Function of CD44 in NG2 progenitor cell differentiation and the potential of CD44 as the therapeutic target for multiple sclerosis2014

    • Author(s)
      Takatoshi Ueki, Saki Ide, Moeko Murano, Kumiko Shibasaki, Saori Morikawa, Yasuomi Ouchi
    • Organizer
      米国神経科学会年会
    • Place of Presentation
      Washington DC Conference Center
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microglial activation in first-episode and drug-naïve schizophrenia2014

    • Author(s)
      Yasuhide Iwata, Katsuaki Suzuki, Norio Mori
    • Organizer
      the 29th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Vancouver, British Columbia, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミクログリアを治療標的とした神経変性疾患治療戦略の構築2014

    • Author(s)
      植木孝俊
    • Organizer
      第119回日本解剖学会総会全国学術集会シンポジウム「グリア細胞研究の最前線」
    • Place of Presentation
      栃木県下野市
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-21   Modified: 2019-07-29  

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