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Systematic determination of the neuronal circuit underlying depression and elucidation of the mechanism for neuro-glial injury

Research Project

Project/Area Number 25293252
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

KANBA SHIGENOBU  九州大学, 医学(系)研究科(研究院), 教授 (50195187)

Co-Investigator(Renkei-kenkyūsha) ONITSUKA TOSHIAKI  九州大学, 大学院医学研究院, 准教授 (00398059)
TAKAHIRO KATO  九州大学, 先端融合医療レドックスナビ, 特任助教 (70546465)
KEISUKE MOTOMURA  九州大学, 大学病院, 助教 (60432944)
TOMOFUMI MIURA  九州大学, 大学病院, 助教 (90404053)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywordsうつ病 / 神経炎症 / 動物モデル / ニューロン・グリア相関
Outline of Final Research Achievements

Based on the neuroinflammation hypothesis of depression, we investigated behavior and brain of the mice which were injected with bacterial endotoxin. Despite of transient activation of the microglia, we could not detect persistent alteration of the marker molecules in the astroglia and oligodendroglia. Minocycline, inhibitor of microglial activation, induced depressive behavior in the tail suspension test in the mice. We also developed a new technique for creating induced microglia-like cells from human peripheral blood. In the MRI study, we accumulated diffuse tensor image of the patients with mood disorder. These results added further information regarding possible interaction between neuroinflammation and depression.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report

Research Products

(12 results)

All 2015 2014 2013

All Journal Article Presentation Patent(Industrial Property Rights)

  • [Journal Article] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease2014

    • Author(s)
      Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S
    • Journal Title

      Scientific Reports

      Volume: 4 Pages: 4957-4957

    • Related Report
      2014 Annual Research Report
  • [Journal Article] BDNF induces sustained intracellular Ca2+ elevation through the upregulation of surface TRPC3 channels in rodent microglia2014

    • Author(s)
      Mizoguchi Y*, Kato TA, Seki Y, Ohgidani M, Sagata N, Horikawa H, Yamauchi Y, Sato-Kasai M, Hayakawa K, Inoue R, Kanba S, Monji A
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289(26) Pages: 18549-18555

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia2014

    • Author(s)
      Mizoguchi Y*, Kato TA, Horikawa H, Monji A
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 8 Pages: 370-370

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice2013

    • Author(s)
      小林 祐樹、 佐野 良威、Vannoni Elizabetta、 後藤 大道、 鈴木 瞳、 大葉 敦子、川崎 弘詔、 神庭 重信、 Lipp Hans-Petter、 Murphy Niall P、 Wolfer David P、 糸原 重美
    • Journal Title

      Front Behav Neurosci

      Volume: 7

    • DOI

      10.3389/fnbeh.2013.00017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism for retardation of amyloid fibril formation by sugars in Vλ6 protein.2013

    • Author(s)
      Abe M, Abe Y, Ohkuri T, Mishima T, Monji A, Kanba S, Ueda T.
    • Journal Title

      Protein Sci

      Volume: 22 Pages: 467-474

    • DOI

      10.1002/pro.2228

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immuno-inflammatory, oxidative and nitrosative stress, and neuroprogressive pathways in the etiology, course and treatment of schizophrenia2013

    • Author(s)
      Anderson G, Berk M, Dodd S, Bechter K, Altamura AC, Dell'osso B, Kanba S, Monji A, Fatemi SH, Buckley P, Debnath M, Das UN, Meyer U, Müller N, Kanchanatawan B, Maes M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: Apr

    • DOI

      10.1016/j.pnpbp.2012.10.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurotransmitters, psychotropic drugs and microglia: clinical implications for psychiatry.2013

    • Author(s)
      Kato TA, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S
    • Journal Title

      Curr Med Chem

      Volume: 20(3) Pages: 331-44

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalyticapproach2013

    • Author(s)
      Kato TA, Kanba S
    • Journal Title

      Front Hum Neurosci.

      Volume: 13 Pages: 13-13

    • DOI

      10.3389/fnhum.2013.00013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia2013

    • Author(s)
      Kato TA, Hayakawa K, Monji A, Kanba S
    • Journal Title

      Front Integr Neurosci

      Volume: Jul 15

    • DOI

      10.3389/fnint.2013.00053

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neuronal correlates of antidepressant effect in the forced swim test in mice.2013

    • Author(s)
      Yanagida S, Motomura K, Ohashi A, Hiraoka K, Kanba S.
    • Organizer
      12th World Congress of Biological Psychiatry
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prolonged activation of microglia induced by systemic lipopolysaccharide administration in mice.2013

    • Author(s)
      Ohashi A, Motomura K, Yanagida S, Hiraoka K, Kanba S. June 27, 2013, Kyoto, Japan.
    • Organizer
      12th World Congress of Biological Psychiatry
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] Method of producing microglial cells2015

    • Inventor(s)
      Kato TA,Ohgidani M,Kanba S
    • Industrial Property Rights Holder
      Kato TA,Ohgidani M,Kanba S
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
    • Overseas

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Published: 2013-05-21   Modified: 2019-07-29  

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