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Functional neural network analysis in postnatal development of communication ability

Research Project

Project/Area Number 25293254
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Yokoyama Chihiro  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 (90264754)

Co-Investigator(Renkei-kenkyūsha) Onoe Hirotaka  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (80214196)
Hayashi Takuya  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (50372115)
Research Collaborator Iriki Atsushi  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (70184843)
Kato Masaki  国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (80345016)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords非ヒト霊長類 / 養育環境 / セロトニン / PET / 社会行動 / 神経ネットワーク / 音声コミュニケーション / MRI / fMRI
Outline of Final Research Achievements

We investigated brain mechanisms underlying postnatal development of inter-individual communication ability using common marmosets, a primate species known for human-like social activity. The analyses included quantitative evaluation of social behavior and in vivo brain imaging (PET). Early social deprivation results in social withdrawal accompanied with reduced serotonin transporter availability, but late social environment can be expected to restore such effects. Whole-brain mapping of conspecific call perception revealed that the calls convey information about individual identity and context depending on the flexibility of call usage. These results suggested that humans and marmosets may share some neural basis of inter-individual communication. In addition, we report the usefulness of a recently-developed agonist PET probe for 5-HT1A receptor in common marmosets to investigate serotonin system linked with social behavior.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report

Research Products

(28 results)

All 2016 2015 2014 2013

All Journal Article Presentation

  • [Journal Article] Marmoset Serotonin 5-HT1A Receptor Mapping with a Biased Agonist PET Probe 18F-F13714: Comparison with an Antagonist Tracer 18F-MPPF in Awake and Anesthetized States.2016

    • Author(s)
      Yokoyama C, Mawatari A, Kawasaki A, Takeda C, Onoe K, Doi H, Newman-Tancredi A, Zimmer L, Onoe H.
    • Journal Title

      Int J Neuropsychopharmacol.

      Volume: -

    • DOI
      10.1093/ijnp/pyw079
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 特集 社会認知研究の最近の動向 マーモセットの社会認知とニューロイメージング2016

    • Author(s)
      横山ちひろ
    • Journal Title

      精神医学

      Volume: 58 Issue: 1 Pages: 15-21

    • DOI
      10.11477/mf.1405205092
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Positron emission tomography imaging of the social brain of common marmosets.2015

    • Author(s)
      Yokoyama C, Onoe H.
    • Journal Title

      Neuroscience Research

      Volume: 93 Pages: 82-90

    • DOI
      10.1016/j.neures.2014.12.006
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression2015

    • Author(s)
      Cui, Y., Toyoda, H., Sako, T., Onoe, K., Hayashinaka, E., Wada, Y., Yokoyama, C., Onoe, H., Kataoka, Y., and Watanabe, Y.
    • Journal Title

      Neuroimage

      Volume: 108 Pages: 17-22

    • DOI
      10.1016/j.neuroimage.2014.12.047
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 動物モデルとしてのマーモセットの展望2014

    • Author(s)
      横山ちひろ
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 952-953

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis.2014

    • Author(s)
      Etsuo A. Susaki, Kazuki Tainaka, Dimitri Perrin, Fumiaki Kishino, Takehiro Tawara, Tomonobu M. Watanabe, Chihiro Yokoyama, Hirotaka Onoe, Megumi Eguchi, Shun Yamaguchi, Takaya Abe, Hiroshi Kiyonari, Yoshihiro Shimizu, Atsushi Miyawaki, Hideo Yokota and Hiroki R. Ueda
    • Journal Title

      Cell

      Volume: 157 Pages: 726-739

    • DOI
      10.1016/j.cell.2014.03.042
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] コモンマーモセットの気管内挿管とベンチレーターによるイソフルラン麻酔呼吸管理方法.2016

    • Author(s)
      川崎章宏、横山ちひろ、武田千穂、林拓也
    • Organizer
      第6回日本マーモセット研究会
    • Place of Presentation
      東京大学農学部弥生講堂(東京都・文京区)
    • Year and Date
      2016-12-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] ‘Grayordinate’ pipeline for magnetic resonance imaging of marmoset brain.2016

    • Author(s)
      Hayashi T, Glasser M, Yokoyama C, Ose T, Takeda C, Kawasaki A, Autio J, Van Essen D. A
    • Organizer
      第6回日本マーモセット研究会
    • Place of Presentation
      東京大学農学部弥生講堂(東京都・文京区)
    • Year and Date
      2016-12-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vivo dopamine D2 receptor binding in the brain cortical surface of humans, macaque monkeys and common marmosets.2016

    • Author(s)
      Yokoyama C, Autio J, Ose T, Kawasaki A, Takeda C, Takahashi K, Igesaka A, Doi H, Watanabe Y, Hayashi T.
    • Organizer
      第6回日本マーモセット研究会
    • Place of Presentation
      東京大学農学部弥生講堂(東京都・文京区)
    • Year and Date
      2016-12-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] ‘Grayordinate’ pipeline for magnetic resonance imaging of marmoset brain.2016

    • Author(s)
      Hayashi T, Glasser M, Yokoyama C, Ose T, Takeda C, Kawasaki A, Autio J, Van Essen D. A
    • Organizer
      Annual Meeting of Society for Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo cortical dopamine D2 receptor binding in humans, macaques and marmosets.2016

    • Author(s)
      Yokoyama C, Autio J, Ose T, Kawasaki A, Takeda C, Takahashi K, Igesaka A, Doi H, Watanabe Y, Hayashi T.
    • Organizer
      Annual Meeting of Society for Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuroimaging and social behavior in common marmosets.2016

    • Author(s)
      Yokoyama C.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Influence of early social experience on sociability and brain serotonin function in common marmosets2015

    • Author(s)
      Chihiro Yokoyama, Akihiro Kawasaki, Chiho Takeda, Hirotaka Onoe.
    • Organizer
      SfN's 45th annual meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コモンマーモセットの社会性に関わる脳代謝ネットワーク2015

    • Author(s)
      横山ちひろ、川崎章弘、林拓也、尾上浩隆
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Phee callを用いたMatching-NonMatching課題遂行時のマーモセット神経細胞活動2015

    • Author(s)
      彦坂和雄、田山 久志、彦坂 幸子、横山ちひろ、尾上浩隆
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 18F標識アンタゴニストおよびアゴニストリガンドによるマーモセット脳内セロトニン1A受容体PETイメージング:イソフルラン麻酔の影響について2015

    • Author(s)
      横山ちひろ、川崎章弘、馬渡彩、土居久志、Luc Zimmer、尾上浩隆
    • Organizer
      第10回日本分子イメージング学会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] コモンマーモセットの示す向社会行動と脳内セロトニン神経伝達との関連性2014

    • Author(s)
      横山ちひろ, 川崎章弘, 武田千穂, 尾上浩隆
    • Organizer
      日本人間行動進化学会 第7回大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular imaging of the marmoset brain by positron emission tomography (PET).2014

    • Author(s)
      Chihiro YOKOYAMA
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 社会環境要因による社会行動および脳内セロトニン神経伝達への影響:発達期コモンマーモセットを用いたPET研究2014

    • Author(s)
      横山ちひろ, 川崎章弘, 武田千穂, 尾上浩隆.
    • Organizer
      第4回社会神経科学研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 5-HT1A receptor mapping in the marmoset brain: PET study with an agonist radiotracer 18F-F13714 under conscious and isoflurane anesthetic conditions.2014

    • Author(s)
      Chihiro YOKOYAMA, Akihiro KAWASAKI, Aya MAWATARI, Hisashi DOI, Luc Zimmer, Hirotaka ONOE.
    • Organizer
      27th Annual EANM Congress
    • Place of Presentation
      Gothenburg. Sweden
    • Year and Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早期養育環境が社会行動へ及ぼす影響と脳内セロトニン神経伝達との関連性:コモンマーモセットを用いたPET研究2014

    • Author(s)
      横山ちひろ, 川崎章弘, 武田千穂, 尾上浩隆
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional role of brain aromatase in social behavior: PET study with [11C]cetrozole and [18F]FDG in common marmosets2013

    • Author(s)
      Yokoyama C, Kawasaki A, Hayashi T, Takahashi K, Hosoya T, Watabnabe Y, Onoe H
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Social behavior and the medial cortical structures: PET study in common marmosets.2013

    • Author(s)
      Yokoyama C, Kawasaki A, Hayashi T, Onoe H
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cortical midline network in the brain of marmoset monkeys.2013

    • Author(s)
      Yokoyama C, Kawasaki A, Hayashi T, Onoe H
    • Organizer
      Neural Oscillation Conference 2013
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] Imaging the ‘social brain’ in common marmosets.2013

    • Author(s)
      Yokoyama C
    • Organizer
      Marmoset Neuroscience -Anatomy, Development and Function. Igakuken International Symposium
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cortical midline network in personal traits and context-dependent communicative interaction: PET study with common marmosets.2013

    • Author(s)
      Yokoyama C, Kawasaki A, Hayashi T, Onoe H
    • Organizer
      Neurosience 2013
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Resting state functional connectivity in common marmosets; positron emission tomography study with [18F]fluorodeoxyglucose.2013

    • Author(s)
      Yokoyama C, Kawasaki A, Nakazawa S, Ishibashi F, Hayashi T, Onoe H
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      博多
    • Related Report
      2013 Annual Research Report
  • [Presentation] マーモセットの麻酔方法の実例紹介2013

    • Author(s)
      横山ちひろ
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      博多
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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