Functional neural network analysis in postnatal development of communication ability
| Project/Area Number |
25293254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Yokoyama Chihiro 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 (90264754)
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| Co-Investigator(Renkei-kenkyūsha) |
Onoe Hirotaka 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (80214196)
Hayashi Takuya 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (50372115)
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| Research Collaborator |
Iriki Atsushi 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (70184843)
Kato Masaki 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (80345016)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 非ヒト霊長類 / 養育環境 / セロトニン / PET / 社会行動 / 神経ネットワーク / 音声コミュニケーション / MRI / fMRI |
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| Outline of Final Research Achievements |
We investigated brain mechanisms underlying postnatal development of inter-individual communication ability using common marmosets, a primate species known for human-like social activity. The analyses included quantitative evaluation of social behavior and in vivo brain imaging (PET). Early social deprivation results in social withdrawal accompanied with reduced serotonin transporter availability, but late social environment can be expected to restore such effects. Whole-brain mapping of conspecific call perception revealed that the calls convey information about individual identity and context depending on the flexibility of call usage. These results suggested that humans and marmosets may share some neural basis of inter-individual communication. In addition, we report the usefulness of a recently-developed agonist PET probe for 5-HT1A receptor in common marmosets to investigate serotonin system linked with social behavior.
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression2015
Author(s)
Cui, Y., Toyoda, H., Sako, T., Onoe, K., Hayashinaka, E., Wada, Y., Yokoyama, C., Onoe, H., Kataoka, Y., and Watanabe, Y.
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Journal Title
Neuroimage
Volume: 108
Pages: 17-22
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis.2014
Author(s)
Etsuo A. Susaki, Kazuki Tainaka, Dimitri Perrin, Fumiaki Kishino, Takehiro Tawara, Tomonobu M. Watanabe, Chihiro Yokoyama, Hirotaka Onoe, Megumi Eguchi, Shun Yamaguchi, Takaya Abe, Hiroshi Kiyonari, Yoshihiro Shimizu, Atsushi Miyawaki, Hideo Yokota and Hiroki R. Ueda
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Journal Title
Cell
Volume: 157
Pages: 726-739
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] In vivo dopamine D2 receptor binding in the brain cortical surface of humans, macaque monkeys and common marmosets．2016
Author(s)
Yokoyama C, Autio J, Ose T, Kawasaki A, Takeda C, Takahashi K, Igesaka A, Doi H, Watanabe Y, Hayashi T.
Organizer
第６回日本マーモセット研究会
Place of Presentation
東京大学農学部弥生講堂（東京都・文京区）
Year and Date
2016-12-12
Related Report
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[Presentation] In vivo cortical dopamine D2 receptor binding in humans, macaques and marmosets.2016
Author(s)
Yokoyama C, Autio J, Ose T, Kawasaki A, Takeda C, Takahashi K, Igesaka A, Doi H, Watanabe Y, Hayashi T.
Organizer
Annual Meeting of Society for Neuroscience 2016
Place of Presentation
San Diego, USA
Year and Date
2016-11-16
Related Report
Int'l Joint Research
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