| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Outline of Final Research Achievements |
A new microreactor system using electrochemically concentrated [18F]fluoride was developed for preparation of many useful 18F-labeled probes. Novel approaches were evaluated with re-concentration of a reaction solvent in an evaporation flow chip between microfluidic reactions and on-chip 18F-labeling in an electrochemical flow cell where [18F]fluoride was trapped from a flowing water and then released in an aprotic solvent. However, the results showed they were both not promising methods employed for microfluidic reaction. On the other hand, solid phase extraction was successfully adapted to the present system. As a typical demonstration, a hypoxic cell marker [18F]FRP170 was efficiently and rapidly prepared with high qualities as an injection.
|
