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Development of precise real-time adaptive tumor following beam control for next generation of 4-dimensional image guided radiation therapy

Research Project

Project/Area Number 25293258
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

Homma Noriyasu  東北大学, 医学(系)研究科(研究院), 教授 (30282023)

Co-Investigator(Kenkyū-buntansha) TAKAI Yoshihiro  弘前大学, 大学院医学研究科, 教授 (50107653)
Co-Investigator(Renkei-kenkyūsha) YOSHIZAWA Makoto  東北大学, サイバーサイエンスセンター, 教授 (60166931)
NARITA Yuichiro  弘前大学, 大学院医学研究科, 講師 (30311385)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords画像誘導放射線治療 / 腫瘍追尾照射 / 放射線治療 / 画像計測 / 制御工学
Outline of Final Research Achievements

In radiation therapy, intra-fractional tumor motion significantly limits the efficiency of radiation delivery and brings potential risk for organs around the tumor. Conformable tumor following beam control is an ideal solution for such intra-fractional motion problem. In this study, two key techniques of real-time markerless tumor tracking and motion prediction have been developed for such accurate beam control that can be implemented on radiotherapy instruments widely used in clinic. Experimental results demonstrate that the proposed techniques outperform the conventional methods and more importantly, they can achieve clinically useful performance.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (35 results)

All 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (24 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results) Book (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Czech Technical University in Prague(チェコ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Tracking Tumor Boundary in MV-EPID Images Without Implanted Markers: A Feasibility Study2015

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Yoshihiro Takai, Yuichiro Narita, Makoto Yoshizawa
    • Journal Title

      Medical Physics

      Volume: 42 Issue: 5 Pages: 2510-2523

    • DOI

      10.1118/1.4918578

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice. Scientific Reports2015

    • Author(s)
      S. Kikuta, Y. Nakamura, Y. Yamamura, A. Tamura, N. Homma, Y. Yanagawa, H. Tamura, J. Kasahara, M. Osanai
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 12800-12800

    • DOI

      10.1038/srep12800

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Fast Neural Network Approach to Predict Lung Tumor Motion during Respiration for Radiation Therapy Applications2015

    • Author(s)
      Ivo Bukovsky, Noriyasu Homma, Kei Ichiji, Matous Cejnek, Matous Slama, PeterM. Benes, and Jiri Bila
    • Journal Title

      BioMed Research International

      Volume: 2015 Pages: 1-13

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 肺腫瘍追跡のためのX線画像シーケンスの混合正規分布モデル近似に基づく対象輝度成分抽出2015

    • Author(s)
      澁澤直樹, 市地慶, 張曉勇, 本間経康, 高井良尋, 吉田裕輔, 吉澤誠
    • Journal Title

      信学技報

      Volume: MI2014-110 Pages: 277-282

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A kernel-based method for markerless tumor tracking in kV fluoroscopic images.2014

    • Author(s)
      Zhang X, Homma N, Ichiji K, Abe M, Sugita N, Takai Y, Narita Y, Yoshizawa M.
    • Journal Title

      Phys Med Biol.

      Volume: 7;59 Issue: 17 Pages: 4897-911

    • DOI

      10.1088/0031-9155/59/17/4897

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Faster 1-D Phase-Only Correlation-Based Method for Estimations of Translations, Rotation and Scaling in Images2014

    • Author(s)
      X. Zhang, N. Homma, K. Ichiji, M. Abe, N. Sugita, M. Yoshizawa
    • Journal Title

      IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences

      Volume: E97.A Issue: 3 Pages: 809-819

    • DOI

      10.1587/transfun.E97.A.809

    • NAID

      130003394786

    • ISSN
      0916-8508, 1745-1337
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Time Varying Seasonal Autoregressive Model Based Prediction of Res piratory Motion for Tumor Following Radiotherapy2013

    • Author(s)
      K. Ichiji, N. Homma, M. Sakai, Y. Narita, Y. Takai, X. Zhang, M. Abe, N. Sugita, M. Yoshizawa
    • Journal Title

      Computational and Mathematical Methods in Med icine

      Volume: Vol.2013 Pages: 1-9

    • DOI

      10.1155/2013/390325

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Markerless Lung Tumor Motion Tracking by Dynamic Decomposition of X-ray Image Intensity2013

    • Author(s)
      N. Homma, Y. Takai, H. Endo, K. Ichiji, Y. Narita, X. Zhang, M. Sakai, M. Osanai, M. Abe, N. Sugita, M. Yoshizawa
    • Journal Title

      Journal of Medical Engineering

      Volume: Vol.2013 Pages: 340821-340821

    • DOI

      10.1155/2013/340821

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tumor Motion Tracking Using kV/MV X-ray Fluoroscopy for Adaptive Radiation Therapy2015

    • Author(s)
      張暁勇, 本間経康, 市地慶, 杉田典大, 高井良尋, 吉澤誠
    • Organizer
      SICE システム・情報部門 学術講演会 2015
    • Place of Presentation
      函館アリーナ(函館市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 呼吸性移動時系列の最大リャプノフ指数推定に基づく予測可能性の検討2015

    • Author(s)
      市地慶, 本間経康, 張曉勇, 武田賢, 髙井良尋, 杉田典大, 吉澤誠
    • Organizer
      SICE システム・情報部門 学術講演会 2015
    • Place of Presentation
      函館アリーナ(函館市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Adaptive Classification of EEG for Dementia Diagnosis2015

    • Author(s)
      M. Cejnek, I. Bukovsky, N. Homma, and O. Liska
    • Organizer
      IWCIM 2015
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A REAL-TIME FEATURE-BASED MARKER- LESS TUMOR TRACKING METHOD USING X-RAY IMAGE SEQUENCE FOR RADIOTHERAPY2015

    • Author(s)
      Yusuke Yoshida, Kei Ichiji, Xiaoyong Zhang, Noriyasu Homma, Yoshihiro Takai, Makoto Yoshizawa,
    • Organizer
      IWCIM 2015
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor motion tracking using kV/MV X-ray fluoroscopy for adaptive radiation therapy2015

    • Author(s)
      X. Zhang, N. Homma, K. Ichiji, M. Abe, N. Sugita, I. Bukovsky, Y. Takai, and M. Yoshizawa
    • Organizer
      IWCIM 2015
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マーカレスMLC追尾照射の開発2015

    • Author(s)
      本間 経康
    • Organizer
      がんプロフェッショナル養成推進プラン 東北大学医学物理セミナー
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A Real-Time Homography-Based Tumor Tracking Method for Image-Guided Radiation Therapy2015

    • Author(s)
      張 暁勇,本間 経康,市地 慶,阿部 誠,杉田 典大,髙井 良尋,吉澤 誠
    • Organizer
      第25回インテリジェント・システム・シンポジウム
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤外線深度センサを用いた体表面同時多点の呼吸誘導システムに関する研究2015

    • Author(s)
      塚田 拓也,市地 慶,張 曉勇,本間 経康,髙井 良尋,吉澤 誠
    • Organizer
      第25回インテリジェント・システム・シンポジウム
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] A Real-Time Homography-Based Algorithm for Markerless Deformable Lung Tumor Motion Tracking Using kV X-Ray Fluoroscopy2015

    • Author(s)
      X. Zhang , N. Homma, Y. Takai, K. Ichiji, M. Abe, N. Sugita, M. Yoshizawa
    • Organizer
      AAPM 57th Annual Meeting
    • Place of Presentation
      Anaheim, CA, USA
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 安全で正確な追尾照射が拓く次世代放射線治療~医工連携開発の例2015

    • Author(s)
      本間経康
    • Organizer
      アカデミアから始まる医療機器開発
    • Place of Presentation
      TKP東京駅大手町カンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 放射線治療のための混合正規分布モデルを用いた X 線透視画像シーケンスからの腫瘍輝度成分の抽出・強調2014

    • Author(s)
      澁澤直樹, 市地慶, 張曉勇, 本間経康, 髙井良尋, 吉澤誠
    • Organizer
      計測自動制御学会 東北支部50周年記念学術講演会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] X 線透視画像を用いた特徴点ベースのマーカレス腫瘍位置計測法2014

    • Author(s)
      吉田裕輔, 市地慶, 張曉勇, 本間経康, 髙井良尋, 澁澤直樹, 吉澤誠
    • Organizer
      計測自動制御学会 東北支部50周年記念学術講演会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尾放射線治療における X 線透視画像を用いた腫瘍位置計測法2014

    • Author(s)
      吉田裕輔, 市地慶, 張曉勇, 本間経康, 髙井良尋, 澁澤直樹, 吉澤誠
    • Organizer
      第48回 日本生体医工学会 東北支部大会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 放射線治療のための X 線透視画像シーケンスからの腫瘍輝度成分の分離2014

    • Author(s)
      澁澤直樹, 市地慶, 張曉勇, 本間経康, 髙井良尋, 吉澤誠
    • Organizer
      第48回 日本生体医工学会 東北支部大会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] A Region-Scalable Level Set Method for Tracking Tumor in Megavoltage X-Ray Image Sequences2014

    • Author(s)
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Yoshihiro Takai, Makoto Yoshizawa
    • Organizer
      第48回日本生体医工学会東北支部大会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 汎用機によるリアルタイム腫瘍追尾放射線治療技術開発の試み2014

    • Author(s)
      本間経康
    • Organizer
      がんプロフェッショナル要請基盤推進プラン 東海大学・慶應義塾大学連携事業,医学物理シンポジウム
    • Place of Presentation
      株式会社メディコントレーニングセンター(東京都港区)
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Markerless image-guided tumor following techniques for real-time conformable radiation therapy2014

    • Author(s)
      Noriyasu Homma
    • Organizer
      Forum for Nuclear Cooperation in Asia FY2014 Workshop on Radiation Oncology
    • Place of Presentation
      Hirosaki University, Japan
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tracking Tumor’s Boundary in MV Image Sequences for Image-Guided Radiation Therapy2014

    • Author(s)
      X. Zhang, N. Homma, Y. Narita, Y. Takai, K. Ichiji, M. Abe, N. Sugita, M. Yoshizawa
    • Organizer
      AAPM Annual Meeting
    • Place of Presentation
      Austin, USA
    • Year and Date
      2014-07-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Study of Learning Entropy for Novelty Detection in Lung Tumor Motion Prediction for Target Tracking Radiation Therapy2014

    • Author(s)
      Ivo Bukovsky, Noriyasu Homma, Matous Cejnek, Kei Ichiji
    • Organizer
      IEEE World Congress on Computational Intelligence 2014
    • Place of Presentation
      Beijing, China
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] A Kernel-Based Method for Non-Rigid Tumor Tracking in KV Image Sequence2013

    • Author(s)
      X. Zhang, N. Homma, K. Ichiji, Y. Takai, Y. Narita, M. Abe, N. Sugita, M Yoshizawa
    • Organizer
      American Association of Physicists in Medicine 55th Annual Meeting
    • Place of Presentation
      Indianapolis, IN, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Kernel-Based Method for Real-Time Markerless Tumor Tracking in Fluoroscopic Image Sequence2013

    • Author(s)
      X. Zhang, N. Homma, Y. Takai, N. Yuichiro, K. Ichiji, M. Abe, N. Sugita, M. Yoshizawa
    • Organizer
      SICE Annual Conference 2013
    • Place of Presentation
      Nagoya University, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Moving Object Segmentation in Surveillance Video Based on Adaptive Mixtures2013

    • Author(s)
      X. Zhang, N. Homma, K. Ichiji, M. Abe, N. Sugita, M. Yoshizawa
    • Organizer
      SICE Annual Conference 2013
    • Place of Presentation
      Nagoya University, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] マーカレス動体追尾照射のための汎用型リニアック制御システムの開発に向けて2013

    • Author(s)
      本間 経康、酒井 正夫、張 暁勇、市地 慶、澁澤 直樹、吉田 裕輔、阿部 誠、杉田 典大、吉澤 誠、成田 雄一郎、高井 良尋
    • Organizer
      日本放射線腫瘍学会第26回学術大会
    • Place of Presentation
      ホテル青森(青森市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マーカレス動体追尾照射システムの開発

    • Author(s)
      本間 経康、酒井 正夫、張 暁勇、市地 慶、澁澤 直樹、吉田 裕輔、阿部 誠、杉田 典大、吉澤 誠、成田 雄一郎、高井 良尋
    • Organizer
      第27回日本高精度放射線外部照射研究会
    • Place of Presentation
      学術総合センター(千代田区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Frontiers in Radiation Oncology2013

    • Author(s)
      Kei Ichiji, Noriyasu Homma, Masao Sakai, Makoto Abe, Norihiro Sugita, and Makoto Yoshizawa
    • Total Pages
      216
    • Publisher
      In-Tech
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 画像処理装置,画像処理方法,及び,画像処理プログラム2015

    • Inventor(s)
      本間経康 他8名
    • Industrial Property Rights Holder
      本間経康 他8名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-03-31
    • Related Report
      2014 Annual Research Report
    • Overseas

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Published: 2013-05-21   Modified: 2022-02-01  

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