Space modulated radiotherapy using bio-absorbable spacer
Project/Area Number |
25293265
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kobe University |
Principal Investigator |
SASAKI RYOHEI 神戸大学, 医学部附属病院, 教授 (30346267)
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Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Takumi 神戸大学, 医学(系)研究科(研究院), 准教授 (70379402)
EJIMA Yasuo 神戸大学, 医学部附属病院, 講師 (70423233)
NISHIMURA Hideki 神戸大学, 医学(系)研究科(研究院), 准教授 (80444610)
YOSHIDA Kenji 神戸大学, 医学部附属病院, 講師 (80351906)
MIYAWAKI Daisuke 神戸大学, 医学(系)研究科(研究院), 助教 (30546502)
UEZONO Haruka 神戸大学, 医学(系)研究科(研究院), 研究員 (60546480)
AKASAKA Hiroaki 神戸大学, 医学部附属病院, 助教 (20707161)
MUKUMOTO Naritoshi 神戸大学, 医学部附属病院, その他 (70634278)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
Keywords | スペーサー / 粒子線治療 / 放射線治療 / 粒子線 |
Outline of Final Research Achievements |
Non-woven fabric bioabsorbable spacer consisted of surgical polyglucolic acid (PGA) sutures has been originaly invented. Characteristics and safety was intensively examined,and animal studies were performed without severe toxicity. The ability of the PGA spacer is to keep its thickness more than 85% for 8 weeks. The spacer reduced gradually, however, it did not cause any toxicity. Clinical study has been started to elucidate efficacy and safety of this spacer for particle therapy
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Concomitant chemoradiotherapy for advanced squamous cell carcinoma of temporal bone2016
Author(s)
Shinomiya H, Hasegawa S, Yamashita D, Ejima Y, Kenji Y, Otsuki N, Kiyota N, Sakakibara S, Nomura T, Hashikawa K, Kohmura E, Sasaki R, Nibu KI.
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Journal Title
Head Neck.
Volume: 38 Suppl 1
Issue: S1
DOI
Related Report
Peer Reviewed
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[Journal Article] Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer.2015
Author(s)
6.Fujii O, Demizu Y, Hashimoto N, Takagi M, Terashima K, Mima M, Jin D, Nagano F, Katsui K, Okimoto T, Iwata H, Niwa Y, Yamashita T, Akagi T, Daimon T, Sasaki R, Hishikawa Y, Abe M, Murakami M, Fuwa N.
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Journal Title
Acta Oncol.
Volume: 54(3)
Issue: 3
Pages: 315-321
DOI
Related Report
Peer Reviewed
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[Journal Article] Combined IDH1 mutation and MGMT methylation status on long-term survival of patients with cerebral low-grade glioma.2015
Author(s)
Tanaka K, Sasayama T, Mizukawa K, Takata K, Sulaiman NS, Nishihara M, Kohta M, Sasaki R, Hirose T, Itoh T, Kohmura E.
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Journal Title
Clin Neurol Neurosurg.
Volume: 138
Pages: 37-44
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer.2015
Author(s)
Tamaki Y, Hieda Y, Yoshida R, Yoshizako T, Fuchiwaki T, Aoi N, Sekihara K,Kitajima K, Kawauchi H, Kitagaki H, Sasaki R, Inomata T.
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Journal Title
Nagoya J Med Sci.
Volume: 77(4)
Pages: 585-94
NAID
Related Report
Peer Reviewed
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[Journal Article] Assessment of Parametrial Response by Growth Pattern in Patients With International Federation of Gynecology and Obstetrics Stage IIB and IIIB Cervical Cancer: Analysis of Patients From a Prospective, Multicenter Trial (EMBRACE).2015
Author(s)
17.Yoshida K, Jastaniyah N, Sturdza A, Lindegaard J, Segedin B, Mahantshetty U, Rai B, Jürgenliemk-Schulz I, Haie-Meder C, Sasaki R, Pötter R.
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Journal Title
Int J Radiat Oncol Biol Phys.
Volume: 93(4)
Issue: 4
Pages: 788-796
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.2015
Author(s)
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
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Journal Title
J Clin Invest
Volume: 125
Issue: 4
Pages: 1591-602
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck2014
Author(s)
Masaru Takagi,Yusuke Demizu, Naoki Hashimoto, Masayuki Mima, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Yasue Niwa, Koichi Morimoto, Takashi Akagi, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, and Nobukazu Fuwa
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Journal Title
Radiotherapy and Oncology,
Volume: 113(3)
Issue: 3
Pages: 364-370
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Particle therapy using carbon ions or protons as a definitive therapy for patients with primary sacral chordoma.2014
Author(s)
Mima M, Demizu Y, Jin D, Hashimoto N, Takagi M, Terashima K, Fujii O, Niwa Y, Akagi T, Daimon T, Hishikawa Y, Abe M, Murakami M, Sasaki R, Fuwa N.
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Journal Title
Br J Radiol.
Volume: 87(1033)
Issue: 1033
Pages: 20130512-20130512
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic Value of FDG PET Imaging in Patients with Laryngeal Cancer2014
Author(s)
Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, Sasaki R, Komatsu H, Saito M, Otsuki N, Nibu K, Kiyota N, Minamikawa T, Sugimura K.
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Journal Title
PLoS One
Volume: 9(5)
Issue: 5
Pages: e96999-e96999
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] A Novel Radiosensitizor from the Component of Spinach, MGDG, Induced Apoptosis in the Pancreatic Cancer Cells Combined with Radiation2015
Author(s)
Hiroaki Akasaka, Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Naritoshi Mukumoto, Yoshiro Matsuo, Haruka Uezono, Yoshiyuki Mizushina, Ryohei Sasaki
Organizer
57th Annual Meeting of ASTRO
Place of Presentation
San Antonio, USA
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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[Presentation] Assessment of parametrial response by growth pattern in patients with FIGO stage IIB and IIIB cervical cancer: analysis of a prospective multicentric trial (EMBRACE)2015
Author(s)
Kenji Yoshida, Noha Jastaniyah, Alina Sturdza, Jacob Lindegaard, Barbara Segedin , Umesh Mahantshetty, Firuza Patel, Ina Jürgenliemk-Schulz, Christine Haie-Meder, Ryohei Sasaki, Richard Pötter
Organizer
57th Annual Meeting of ASTRO
Place of Presentation
San Antonio, USA
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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[Presentation] Titanium peroxide nanoparticles, as novel radiosensitizers, enhance antitumor efficacy in pancreatic cancer therapy2015
Author(s)
Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
Organizer
15th International Congress of Radiation Research
Place of Presentation
Kyoto, Japan
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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[Presentation] Assessment of parametrial response by growth pattern in patients with FIGO stage IIB and IIIB cervical cancer: analysis of a prospective multicentric trial (EMBRACE)2015
Author(s)
Kenji Yoshida, Noha Jastaniyah, Alina Sturdza, Jacob Lindegaard, Barbara Segedin , Umesh Mahantshetty, Firuza Patel, Ina Jürgenliemk-Schulz, Christine Haie-Meder, Ryohei Sasaki, Richard Pötter
Organizer
15th International Congress of Radiation Research
Place of Presentation
Kyoto, Japan
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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[Presentation] Titanium peroxide nanoparticles enhance antitumor efficacy through reactive oxygen species in pancreatic cancer radiation therapy2015
Author(s)
Masao Nakayama, Ryohei Sasaki, Toru Mukohara, Chiaki Ogino, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
Organizer
AACR Annual Meeting 2015
Place of Presentation
Philadelphia, USA
Year and Date
2015-04-18
Related Report
Int'l Joint Research
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[Presentation] Efficacy of PGA Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs2014
Author(s)
H Akasaka, R Sasaki, D Miyawaki, N Mukumoto, NS Sulaiman, TY Wang, S Yamada, M Murakami, Y Demizu, T Fukumoto
Organizer
MMND & IPCT 2014
Place of Presentation
Port Douglas, Australia
Year and Date
2014-10-20 – 2014-10-25
Related Report
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[Presentation] Particle Therapy Using Carbon Ions or Protons for Chondrosarcomas:a Single-Institution Retrospective Analysis2014
Author(s)
Y Demizu, M Mima、D Jin, N Hasimoto, M Takagi , F Nagano, K Katsui, K Terashima, O Fujii, T Okimoto, T Yamashita, Y Toyomasu, Y Niwa, R Sasaki, M Murakami, Y Hishikawa, M Abe, N Fuwa
Organizer
The 53th Annual Conference of the Particle Therapy Co-Operative Group
Place of Presentation
Shanghai, China
Year and Date
2014-06-11 – 2014-06-14
Related Report
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[Presentation] スペーサー手術と粒子線照射による腹部・骨盤部悪性腫瘍の治療2013
Author(s)
福本 巧, 木戸 正浩, 武部 敦志, 田中 基文, 蔵満 薫, 木下 秘我, 小松 昇平, 松本 逸平, 味木 徹夫, 出水 祐介, 不破 信和, 佐々木 良平, 具 英成
Organizer
日本癌治療学会
Place of Presentation
京都
Related Report
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