Prediction of outcomes after radiotherapy for the patients with advanced cervical cancer using the molecular technique
Project/Area Number |
25293266
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kansai Medical University |
Principal Investigator |
HARIMA Yoko 関西医科大学, 医学部, 非常勤講師 (80140276)
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Co-Investigator(Renkei-kenkyūsha) |
NAKANO Takashi 群馬大学, 大学院医学系研究科, 教授 (20211427)
OHNO Tatsuya 群馬大学, 重粒子線医学推進機構, 教授 (10344061)
TOITA Takafumi 琉球大学, 医学部, 客員教授 (30237036)
IKUSHIMA Hitoshi 徳島大学, 大学院医歯薬学研究部, 教授 (90202861)
TOKUMARU Sunao 兵庫県立粒子線医療センター, 診療部, 副院長 (90304899)
KANEYASU Yuko 広島大学, 医歯(薬)学総合研究科, 非常勤医師 (90204586)
IKEDA Koshi 関西医科大学, 医学部, 講師 (80288802)
UTSUNOMIYA Keita 関西医科大学, 医学部, 准教授 (20193914)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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Keywords | 放射線 / 子宮頸癌 / 予後予測 / バイオマーカー |
Outline of Final Research Achievements |
We previously identified serum apolipoprotein C-II (ApoC-II) before radiation therapy as a prognostic biomarker for clinical outcomes in patients with locally advanced cervical cancer (Int J Radiat Oncol Biol Phys, 87: 1155-1161, 2013). In 2012, to further assess ApoC-II as a prognostic biomarker in this population, we started a prospective study in cooperation with gynecology tumor group in Japanese Radiation Oncology Study Group (JROSG). One hundred and forty-eight patients in 13 institutions were enrolled. Preliminary results of the study were presented at the 29th Annual Meeting of Japanese Society for Radiation Oncology. Lower serum levels of ApoC-II (<28.5 μg/mL) were significantly associated with shorter pelvic progression-free survival (P=.019). The final results of this study are being analyzed and will be published soon.
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Report
(5 results)
Research Products
(63 results)
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[Journal Article] Recommendations for high-risk clinical target volume definition with computed tomography for three-dimensional image-guided brachytherapy in cervical cancer patients2016
Author(s)
Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Ii, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-ei Noda, Tomoko Kazumoto, Yoko Harima
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Journal Title
J Radiat Res
Volume: 56
Issue: 3
Pages: 1-10
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intra-arterial infusion of thrombin: animal experiments2014
Author(s)
Komemushi A, Kariya S, Nakatani M, Yoshida R, Kono Y, Suzuki S, Kanno S, Ikeda K, Utsunomiya K, Harima Y, Oyamada K, Kamiyoshi T, Miyake T, Sato R, Inoue M, Tanigawa N.
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Journal Title
Minim Invasive Ther Allied Technol
Volume: 23
Pages: 52-54
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Radiation dose of nurses during IR procedures: a controlled trial evaluating operator alerts before nursing tasks2014
Author(s)
Komemushi A, Suzuki S, Sano A, Kanno S, Kariya S, Nakatani M, Yoshida R, Kono Y, Ikeda K, Utsunomiya K, Harima Y, Komemushi S, Tanigawa N.
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Journal Title
J Vasc Interv Radiol
Volume: 25
Pages: 1195-1199
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intra-arterial infusion of thrombin: animal experiments2013
Author(s)
Atsushi Komemushi, Shuji Kariya, Miyuki Nakatani, Rie Yagi, Yumiko Kono, Satoshi Suzuki, Shohei Kanno, Koshi Ikeda, Keita Utsunomiya, Yoko Harima,Kazuhisa Oyamada, Tsuyoshi Kamiyoshi, tsuyoshi Miyake, Ryo Sato, Michito inoue, Noboru Tanigawa
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Journal Title
Minimally Invesive Therapy
Volume: Early Online
Pages: 1-3
Related Report
Peer Reviewed
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[Presentation] Serum ApoC-II as a biomarker in cervical cancer after radiotherapy: A prospective study (JROSG10-4)2016
Author(s)
Yoko Harima, Takuro Ariga, Yuko Kaneyasu, Hitoshi Ikushima, Tatsuya Ohno, Sunao Tokumaru, Shigetoshi Shimamoto, Takeo Takahashi, Tomoko Kazumoto, Noriko Ii, Kayoko Tsujino, Anneyuko I Saito, Takafumi Toita
Organizer
第29回日本放射線腫瘍学会
Place of Presentation
国立京都国際会館、京都
Year and Date
2016-11-25
Related Report
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[Presentation] A multicenter randomized clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer2016
Author(s)
Yoko Harima, Takayuki Ohguri, Hajime Imada, Hideyuki Sakurai, Tatsuya Ohno, Yoshiyuki Hiraki, Koh Tuji, Masahiro Tanaka, Hiromi Terashima
Organizer
12th International Congress of Hyperthermic Oncology
Place of Presentation
InterContinental New Orleans, ニューオリンズ, アメリカ
Year and Date
2016-04-15
Related Report
Int'l Joint Research / Invited
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[Presentation] Feasibility and safety of dexmedetomidine sedation in central venous port placement2015
Author(s)
Atsushi Komemushi , Satoshi Suzuki, Akira Sano, Shuji Kariya, Miyuki Nakatani, Rie Yoshida, Yumiko Kono, Koshi Ikeda, Keita Utsunomiya, Yoko Harima, Noboru Tanigawa
Organizer
ISIR and APCIO 2015
Place of Presentation
シーガイヤ、宮崎
Year and Date
2015-05-28
Related Report
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[Presentation] Feasibility and safety of dexmedetomidine sedation in central venous port placement2015
Author(s)
Atsushi Komemushi , Satoshi Suzuki, Akira Sano, Shuji Kariya, Miyuki Nakatani, Rie Yoshida, Yumiko Kono, Koshi Ikeda, Keita Utsunomiya, Yoko Harima, Noboru Tanigawa
Organizer
第74回日本医学放射線学会
Place of Presentation
パシフィコ横浜、横浜
Year and Date
2015-04-16
Related Report
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[Presentation] Evaluation of an aspiration-type semiautomatic cutting biopsy needle2015
Author(s)
Atsushi Komemushi , Shohei Kanno, Satoshi Suzuki, Akira Sano, Shuji Kariya, Miyuki Nakatani, Rie Yoshida, Yumiko Kono, Takaya Tsuno, Koshi Ikeda, Keita Utsunomiya, Yoko Harima, Sadao Komemushi, Noboru Tanigawa
Organizer
SIR 40th Annual Scientific Meeting
Place of Presentation
World Convention Center、アトランタ、アメリカ
Year and Date
2015-04-01
Related Report
Int'l Joint Research
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[Presentation] Evaluation of an aspiration-type semiautomatic biopsy needle.2014
Author(s)
Atusushi Komemushi, Shohei Kanno, Satoshi Suzuki, Akira Sano, Miyuki Nakatani, Rie Yoshida, Yumiko Kono, Shuji Kariya, Yoko Harima, Noboru Tanigawa,
Organizer
The 73rd Annual Meeting of the Japan Radiological Society
Place of Presentation
パシフィコ横浜(神奈川県・横浜市)
Year and Date
2014-04-10 – 2014-04-13
Related Report
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