| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
In this study, effects of high intensity focused ultrasound (HIFU) combined with photocatalytic titanium dioxide Silica (TiS) nanoparticles on human oral squamous cell line HSC-2 were investigated. Viability of HSC-2 cells after HIFU irradiation with various intensities in the presence or absence of TiS was measured immediately after the exposures in-vitro. Immediate effects of HIFU combined with TiS on solid tumors were also examined by histological study. Cytotoxic effect of HIFU+ TiS in-vitro was significantly higher than that of TiS or HIFU alone with the tendency to increase for higher HIFU intensity, duration, and TiS concentration in the suspension. In-vivo results showed significant necrosis and tissue damage in HIFU and HIFU+ TiS treated samples. However, penetration of TiS nanoparticles into the cell cytoplasm was only observed in HIFU+TiO2 treated tissues.
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