Use of high intensity focused ultrasound and photocatalytic nanoparticles for cancer treatment
Project/Area Number |
25293268
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Fukuoka University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | 超音波 / 酸化チタン / 癌細胞 / 光触媒 / マイクロバブル / チタン |
Outline of Final Research Achievements |
In this study, effects of high intensity focused ultrasound (HIFU) combined with photocatalytic titanium dioxide Silica (TiS) nanoparticles on human oral squamous cell line HSC-2 were investigated. Viability of HSC-2 cells after HIFU irradiation with various intensities in the presence or absence of TiS was measured immediately after the exposures in-vitro. Immediate effects of HIFU combined with TiS on solid tumors were also examined by histological study. Cytotoxic effect of HIFU+ TiS in-vitro was significantly higher than that of TiS or HIFU alone with the tendency to increase for higher HIFU intensity, duration, and TiS concentration in the suspension. In-vivo results showed significant necrosis and tissue damage in HIFU and HIFU+ TiS treated samples. However, penetration of TiS nanoparticles into the cell cytoplasm was only observed in HIFU+TiO2 treated tissues.
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Report
(4 results)
Research Products
(19 results)
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[Presentation] そこまできた超音波治療2015
Author(s)
立花 克郎
Organizer
第26回日本心エコー図学会学術集会
Place of Presentation
北九州国際会議場
Year and Date
2015-03-26 – 2015-03-28
Related Report
Invited
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[Presentation] 分子診断治療の今後の展望2014
Author(s)
立花 克郎
Organizer
第17日本栓子検出と治療学会
Place of Presentation
福岡市
Year and Date
2014-10-04 – 2014-10-05
Related Report
Invited
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