Development of radioprobes by targeted metabotropic glutamate receptor 1 in tumor
| Project/Area Number |
25293269
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
|---|
Principal Investigator |
Ming Rong Zhang 国立研究開発法人量子科学技術研究開発機構, 標識薬剤開発部, 部長 (80443076)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
謝 琳 国立研究開発法人量子科学技術研究開発機構, 分子イメージング研究センター, 研究員 (30623558)
河村 和紀 国立研究開発法人量子科学技術研究開発機構, 分子イメージング研究センター, チームリーダー (50401766)
藤永 雅之 国立研究開発法人量子科学技術研究開発機構, 分子イメージング研究センター, 研究員 (70623726)
山崎 友照 国立研究開発法人量子科学技術研究開発機構, 分子イメージング研究センター, 研究員 (80627563)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | mGluR1 / 腫瘍 / 放射性プローブ / 核医学 |
|---|
| Outline of Final Research Achievements |
Metabotropic glutamate receptor 1(mGluR1) is widely expressed in brain, melanoma and breast cancer. We have developed novel PET probes useful for visualization of mGluR1 in human brain. In the present study, we designed a dozen of novel radioprobes specific for mGluR1 in tumor. Using [18F]FITM, we performed PET imaging of mGluR1 in melanoma and elucidated the relationship between mGluR1 and tumor progress for the first time. Moreover, we conducted therapy study for tumor using [131I]IITM and succeeded in observing the therapeutic effects on tumor.
|
Report
(5 results)
Research Products
(23 results)
-
-
[Journal Article] Dynamic changes in striatal mGluR1 but not mGluR5 during pathological progression of Parkinson's Disease in human alpha-synuclein A53T transgenic rats: A multi-PET imaging study2016
Author(s)
Yamasaki T, Fujinaga M, Kawamura K, Furutsuka K, Nengaki N, Shimoda Y, Shiomi S, Takei M, Hashimoto H, Yui J, Wakizaka H, Hatori A, Xie L, Kumata K, Zhang MR.
-
Journal Title
The Journal of Neuroscience
Volume: 36
Issue: 2
Pages: 375-384
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Synthesis and evaluation of 4-halogeno-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-[11C]methylbenzamide for imaging of metabotropic glutamate 1 receptor in melanoma.2015
Author(s)
Fujinaga M, Xie L, Yamasaki T, Yui J, Shimoda Y, Hatori A, Kumata K, Zhang Y, Nengaki N, Kawamura K, Zhang MR.
-
Journal Title
J Med Chem.
Volume: 58
Issue: 3
Pages: 1513-1523
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Molecular imaging of ectopic metabotropic glutamate 1 receptor in melanoma with a positron emission tomography radioprobe 18 F-FITM.2014
Author(s)
Xie L, Yui J, Fujinaga M, Hatori A, Yamasaki T, Kumata K, Wakizaka H, Furutsuka K, Takei M, Jin ZH, Furukawa T, Kawamura K, Zhang MR.
-
Journal Title
International Journal of Cancer
Volume: in press
Issue: 8
Pages: 1852-1859
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Noninvasive quantification of metabotropic glutamate receptor type 1 with [¹¹C]ITDM: a small-animal PET study.2014
Author(s)
Yamasaki T, Fujinaga M, Yui J, Ikoma Y, Hatori A, Xie L, Wakizaka H, Kumata K, Nengaki N, Kawamura K, Zhang MR.
-
Journal Title
J Cereb Blood Flow Metab.
Volume: 34
Pages: 606-612
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
