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Development of fluorine-18 labeled 4DST derivatives for clinical use

Research Project

Project/Area Number 25293271
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Toyohara Jun  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50425659)

Co-Investigator(Kenkyū-buntansha) 窪田 和雄  一般財団法人脳神経疾患研究所, PETセンター, その他 (40161674)
木村 裕一  近畿大学, 生物理工学部, 教授 (60205002)
Co-Investigator(Renkei-kenkyūsha) ISHIWATA Kiichi  一般社団法人脳神経疾患研究所, 南東北創薬・サイクロトロン研究所, 所長 (50143037)
ISHII Kenji  地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究部長 (10231135)
ODA Keiichi  北海道科学大学, 保険医療学部, 教授 (70224235)
SAKATA Muneyuki  地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (00403329)
NARIAI Tadashi  東京医科歯科大学, 医学部付属病院, 准教授 (00228090)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords核医学 / PET / 放射性医薬品 / 核酸 / 癌 / フッ素 / 腫瘍 / 細胞増殖
Outline of Final Research Achievements

The thymidine derivative 11C-4DST has the potential to visualize in vivo DNA synthesis rates with positron emission tomography (PET). To expand the use of 4DST needs the fluorine-18 version of this compound. In this study, we tried to synthesize the 18F-4DST analogues for practical use of DNA synthesis imaging. The three candidates were selected. The fluoromethyl version of 4DST was not stable and cannot obtained as an purified form. The fluoroethyl version of 4DST can be labeled with using N3-Boc-3',5'-di-O-tolyl-5-tosyloxyethane precursor. However, biodistribution studies did not show tumor selective uptake. The 5-fluoro version of 4DST could be labeled by 18F anion with Cu-mediated nucleophilic fluorination of tin-precursor. However, the yields were very low. The acute toxicity studies indicate 5-fluoro-4DST is acceptable as PET drug for human use. In contrast, 5-fluror-4DST has mutagenic activity in E. Coli as indicated by the Ames study.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (82 results)

All 2017 2016 2015 2014 2013

All Journal Article (24 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 24 results,  Acknowledgement Compliant: 9 results,  Open Access: 7 results) Presentation (56 results) (of which Int'l Joint Research: 19 results,  Invited: 11 results) Book (2 results)

  • [Journal Article] Synthesis and basic evaluation of 7α-(3-[18F]fluoropropyl)-testosterone and 7α-(3-[18F]fluoropropyl)-dihydrotestosterone.2017

    • Author(s)
      Okamoto M, Naka K, Ishiwata K, Shimizu I, Toyohara J
    • Journal Title

      Ann. Nucl. Med

      Volume: 31 Issue: 1 Pages: 53-62

    • DOI

      10.1007/s12149-016-1130-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Determination of radionuclides and radiochemical impurities produced by in-house cyclotron irradiation and subsequent radiosynthesis of PET tracers.2017

    • Author(s)
      Ishiwata K, Hayashi K, Sakai M, Kawaguchi S, Hasegawa H, Toyohara J.
    • Journal Title

      Ann. Nucl. Med.

      Volume: 31 Issue: 1 Pages: 84-92

    • DOI

      10.1007/s12149-016-1134-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term cilostazol administration ameliorates memory decline in senescence-accelerated mouse prone 8 (SAMP8) through a dual effect on cAMP and blood-brain barrier.2017

    • Author(s)
      Yanai S, Toyohara J, Ishiwata K, Ito H, Endo S.
    • Journal Title

      Neuropharmacology

      Volume: 116 Pages: 246-259

    • DOI

      10.1016/j.neuropharm.2016.12.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central μ-opioidergic system activation evoked by heavy and severe-intensity cycling exercise in humans: a pilot study using positron emission tomography with 11C-carfentanil.2017

    • Author(s)
      Hiura M, Sakata M, Ishii K, Toyohara J, Oda K, Nariai T, Ishiwata K.
    • Journal Title

      Int. J. Sports Med.

      Volume: 38 Issue: 01 Pages: 19-26

    • DOI

      10.1055/s-0042-114779

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of imaging using 11C-ITMM and 18F-FDG for the detection of cerebellar ataxia.2017

    • Author(s)
      Ishibashi K, Miura Y, Toyohara J, Ishii K, Ishiwata K.
    • Journal Title

      J. Neurol. Sci.

      Volume: 375 Pages: 97-102

    • DOI

      10.1016/j.jns.2017.01.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers2017

    • Author(s)
      Sakata M, Ishibashi K, Imai M, Wagatsuma K, Ishii K, Hatano K, Ishiwata K, Toyohara J.
    • Journal Title

      EJNMMI Res.

      Volume: 7 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s13550-017-0271-6

    • NAID

      120007134889

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Age and gender effects of 11C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants.2017

    • Author(s)
      Sakata M, Toyohara J, Ishibashi K, Wagatsuma K, Ishii K, Zhang MR, Ishiwata K
    • Journal Title

      Neurobiol Aging.

      Volume: 55 Pages: 72-77

    • DOI

      10.1016/j.neurobiolaging.2017.03.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of peri-implant bone metabolism under immediate loading using high-resolution Na18F-PET.2017

    • Author(s)
      Matsuo Y, Ogawa T, Yamamoto M, Shibamoto A, Saenz JR, Yokoyama M, Kanda Y, Toyohara J, Sasaki K.
    • Journal Title

      Clin. Oral Investig.

      Volume: 印刷中 Issue: 6 Pages: 2029-2037

    • DOI

      10.1007/s00784-016-1992-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Initial evaluation of a novel adenosine A2A receptor ligand, 11C-preladenant, in healthy human subjects2017

    • Author(s)
      Sakata M, Ishibashi K, Imai M, Wagatsuma K, Ishii K, Zhou X, de Vries EFJ, Elsinga PH, Ishiwata K, Toyohara J.
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 58 Issue: 9 Pages: 1464-1470

    • DOI

      10.2967/jnumed.116.188474

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Optimization of the alkyl side chain length of fluorine-18-labeled 7α-alkyl-fluoroestradiol.2016

    • Author(s)
      Okamoto M, Shibayama H, Naka K, Kitagawa Y, Ishiwata K, Shimizu I, Toyohara J.
    • Journal Title

      Nucl. Med. Biol.

      Volume: 43 Issue: 8 Pages: 512-519

    • DOI

      10.1016/j.nucmedbio.2016.05.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Preclinical and the first-in-man studies on [11C]CB184 for imaging 18 kDa translocator protein by positron emission tomography2016

    • Author(s)
      J.Toyohara, M. Sakata, K. Hatano, S. Yanai, S. Endo, K. Ishibashi, K. Wagatsuma, K. Ishii and K. Ishiwata
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 30 Issue: 8 Pages: 534-543

    • DOI

      10.1007/s12149-016-1094-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of DNA synthesis with carbon-11-labeled 4-thiothymidine.2016

    • Author(s)
      Toyohara J.
    • Journal Title

      World J. Radiol.

      Volume: 8 Issue: 9 Pages: 799-808

    • DOI

      10.4329/wjr.v8.i9.799

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Importance of P-gp PET imaging in pharmacology.2016

    • Author(s)
      Toyohara J.
    • Journal Title

      Curr. Pharm. Des.

      Volume: 22 Issue: 38 Pages: 5830-5863

    • DOI

      10.2174/1381612822666160804092258

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relationship between type 1 metabotropic glutamate receptors and cerebellar ataxia.2016

    • Author(s)
      Ishibashi K, Miura Y, Ishikawa K, Zhang MR, Toyohara J, Ishiwata K, Ishii K.
    • Journal Title

      J Neurol.

      Volume: 263 Issue: 11 Pages: 2179-2187

    • DOI

      10.1007/s00415-016-8248-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] (R)-[11C]Emopamil as a novel tracer for imaging enhanced P-glycoprotein function. (R)-[11C]Emopamil as a novel tracer for imaging enhanced P-glycoprotein function.2016

    • Author(s)
      Jun Toyohara, Mayumi Okamoto, Hiroki Aramaki, Yuto Zaitsu, Isao Shimizu, Kiichi Ishiwata.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 43 Issue: 1 Pages: 52-63

    • DOI

      10.1016/j.nucmedbio.2015.09.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Correlation of 4′-[methyl-11C]-thiothymidine uptake with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas in comparison with 11C-methionine uptake2016

    • Author(s)
      Kenichi Tanaka, Yuka Yamamoto, Yukito Maeda, Hiroyuki Yamamoto, Nobuyuki Kudomi, Nobuyuki Kawai, Jun Toyohara, Yoshihiro Nishiyama
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 30 Issue: 2 Pages: 89-96

    • DOI

      10.1007/s12149-015-1035-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of 4DST and FDG PET/CT imaging for advanced renal cell carcinoma: preliminary study.2016

    • Author(s)
      Minamimoto R, Nakaigawa R, Nagashima Y, Toyohara J, Ueno D, Namura K, Nakajima K, Yao M, and Kubota K,
    • Journal Title

      Abode Radiol

      Volume: 41 Issue: 3 Pages: 521-530

    • DOI

      10.1007/s00261-015-0601-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of dosimetry between PET/CT and PET alone using 11C-ITMM.2015

    • Author(s)
      Ito K, Sakata M, Oda K, Wagatsuma K, Toyohara J, Ishibashi K, Ishii K, Ishiwata K.
    • Journal Title

      Australas Phys. Eng. Sci. Med.

      Volume: 39 Issue: 1 Pages: 177-186

    • DOI

      10.1007/s13246-015-0419-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of (11)C-4'-thiothymidine, (11)C-methionine, and (18)F-FDG PET/CT for the detection of active lesions of multiple myeloma.2015

    • Author(s)
      Okasaki M, Kubota K, Minamimoto R, Miyata Y, Morooka M, Ito K, Ishiwata K, Toyohara J, Inoue T, Hirai R, Hagiwara S, Miwa A.
    • Journal Title

      Ann Nucl Med

      Volume: 29 Issue: 3 Pages: 224-232

    • DOI

      10.1007/s12149-014-0931-9

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro analysis of transport and metabolism of 4'-thiothymidine in human tumor cells.2015

    • Author(s)
      Plotnik DA, Wu S, Linn GR, Yip FCT, Comandante NL, Kroc KA, Toyohara J, and Schwartz JL.
    • Journal Title

      Nucl Med Biol

      Volume: 42 Issue: 5 Pages: 470-474

    • DOI

      10.1016/j.nucmedbio.2014.12.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Synthesis and evaluation of 7α-(3-[18F]fluoropropyl) estradiol.2015

    • Author(s)
      2.Mayumi Okamoto, Kyosuke Naka, Yuya Kitagawa, Kiichi Ishiwata, Mitsuyoshi Yoshimoto, Isao Shimizu, Jun Toyohara.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 42 Issue: 7 Pages: 590-597

    • DOI

      10.1016/j.nucmedbio.2015.03.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Volumetric comparison 4'-[methyl-11C]-thiothymidine with 18F-FDG PET/CT in patients with advanced head and neck squamous cell carcinoma2015

    • Author(s)
      Ito K, Yokoyama J, Miyata Y, Toyohara J, Okasaki M, Minamimoto R, Morooka M, Ishiwata K, Kubota K
    • Journal Title

      Nucl Med Commun

      Volume: 36 Pages: 219-225

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of 4'-[methyl-11C]thiothymidine (11C-4DST) and 3'-deoxy-3'-[18F]fluorothymiein (18F-FLT) PET/CT in human brain glioma imaging2015

    • Author(s)
      Toyota Y, Miyake K, Kawai N, Hatakeyama, T, Yamamoto Y, Toyohara J, NIshiyama Y, Tamiya T
    • Journal Title

      EJNMMI Research

      Volume: 5 Pages: 7-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pilot study of 4'-[methyl-11C]-thothymidine PET/CT for detection of regional lymph node metastasis in non-small cell lung cancer.2014

    • Author(s)
      Minamimoto R, Toyohara J, Ito H, Seike A, Miyata Y, Morooka M, Okasaki M, Nakajima K, Ito K, Ishiwata K and Kubota K
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging Research

      Volume: 4 Issue: 1 Pages: 10-10

    • DOI

      10.1186/2191-219x-4-10

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Imaging of adenosine A2A receptors in a healthy human brain by positron emission tomography with [11C]preladenant.2017

    • Author(s)
      Toyohara J, Sakata M, Ishibashi K, Wagatsuma K, Ishii K, Zhou X, de Vries EFJ, Elsinga PH, Ishiwata K.
    • Organizer
      Molecular imaging agents in medicine
    • Place of Presentation
      Groningen (The Netherlands)
    • Year and Date
      2017-02-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Is tau accumulation detectable before neuronal injury markers? Analysis from tau PET imaging with [C-11]PBB3 in clinical variations of Alzheimer’s disease.2017

    • Author(s)
      Imai M, Ishii K, Tanaka M, Ishibashi K, Wagatsuma K, Tago T, Toyohara J, Maruno H, Murayama S, Shimada H, Higuchi M, Suhara T.
    • Organizer
      Human Amyloid Imaging 2017
    • Place of Presentation
      Miami Beach (USA)
    • Year and Date
      2017-01-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳機能イメージングのための新規PETトレーサーの開発2017

    • Author(s)
      豊原潤
    • Organizer
      Neurovascular Unit 研究会
    • Place of Presentation
      慶應義塾大学医学部(東京都-信濃町)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] mGluR1 PET imaging in medial temporal lobe epilepsy patients with hippocampal sclerosis.2016

    • Author(s)
      Inaji M, Hayashi S, Nariai T, Wagatsuma K、Toyohara J, Ishii K, Maehara T.
    • Organizer
      AES annual meeting
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PETイメージングを活用した運動負荷時の脳機能解析:脳血流と神経受容体計測の実際2016

    • Author(s)
      日浦幹夫、成相直、牟田光孝、稲次基希、豊原潤、石井賢二、石橋賢士、我妻慧、坂田宗之、織田圭一、石渡喜一、前原健寿
    • Organizer
      第59回日本脳循環代謝学会学術総会
    • Place of Presentation
      あわぎんホール(徳島県-徳島市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 孤発性脊髄小脳変性症における代謝型グルタミン酸受容体1型イメージング2016

    • Author(s)
      石橋賢士、三浦義治、石川欽也、張明栄、豊原潤、石渡喜一、石井賢二
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] [C-11]ITMM PETを用いた未治療パーキンソン病における代謝型グルタミン酸受容体1型密度の検討―第一報―2016

    • Author(s)
      三品雅洋、鈴木正彦、石井賢二、坂田宗之、我妻慧、石橋賢士、豊原潤、張明栄、木村和美、石渡喜一
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳FDG画像を用いた認知症鑑別診断における機械学習から得られる画像指標と認知機能との関係2016

    • Author(s)
      坂田宗之、王小宇、石井賢二、木村裕一、我妻慧、石橋賢士、豊原潤、矢田紀子、眞鍋佳嗣
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規アデノシンA2A受容体イメージング剤11C-Preladenantの初期臨床評価2016

    • Author(s)
      豊原潤、坂田宗之、石橋賢士、我妻慧、周小云、ドフリースエリク、エルシンガフィリップ、石渡喜一、石井賢二
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] [18F]FBPA注射液の製造法の改善検討2016

    • Author(s)
      林薫平、酒井昌成、石渡喜一、渡辺利光、フランシスコゲラ、豊原潤
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 消化管癌における11C-4DST PETと18F-FDG PETの比較2016

    • Author(s)
      安賀文俊、福田有子、山本由佳、田中賢一、小野優子、山本浩之、豊原潤、西山佳宏
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 臨床応用を目指したPET薬剤の次世代化2016

    • Author(s)
      豊原潤、多湖哲郎、坂田宗之、石橋賢士、我妻慧、石渡喜一、石井賢二
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新規TSPOイメージング剤11C-CB184の初期臨床評価2016

    • Author(s)
      豊原潤、坂田宗之、石橋賢士、我妻慧、籏野健太郎、石渡喜一、石井賢二
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 頭頸部癌の放射線化学療法前後における11C-4DST PETと18F-FDG PETの比較2016

    • Author(s)
      三田村克哉、山本由佳、則兼敬志、星川広史、豊原潤、西山佳宏
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 治療前神経膠腫における11C-4DST PETと造影MRIの比較2016

    • Author(s)
      福田有子、田中賢一、山本由佳、則兼敬志、畠山哲宗、山本浩之、久富信之、豊原潤
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 11C-4DSTと18F-FDGにおける食道癌の描出能に関する比較検討2016

    • Author(s)
      堀田昌利、南本亮吾、豊原潤、諸岡都、亀山征史、中島和彦、野原京子、山田和彦、窪田和雄
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県-名古屋市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 4'-[methyl-11C]thiothymidine positron emission tomography in patients with newly diagnosed glioma.2016

    • Author(s)
      Fukuda Y, Tanaka K, Yamamoto Y, Hatakeyama T, Kudomi N, Toyohara J, Nishiyama Y.
    • Organizer
      EANM'16
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prognostic value of 4'-[methyl-11C]-thiothymidine PET in a patients with newly diagnosed glioma.2016

    • Author(s)
      Yamamoto Y, Tanaka K, Mitamura K, Norikane T, Fukuda Y, Hatakeyama T, Yamamoto H, Toyohara J, Nishiyama Y.
    • Organizer
      EANM'16
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] First-in-human studies of imidazopyridineacetamide, [11C]CB184, as a novel 18 kDa translocator protein seeker.2016

    • Author(s)
      Toyohara J, Sakata M, Ishibashi K, Wagatsuma K, Hatano K, Ishiwata K, Ishii K.
    • Organizer
      EANM'16
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] mGluR1 PET imaging of mTLE patients with HS2016

    • Author(s)
      Inaji M, Hayashi S, Nariai T, Wagatsuma K, Toyohara J, Ishii K, Maehara T.
    • Organizer
      第50回日本てんかん学会学術集会
    • Place of Presentation
      グランシップ(静岡県-静岡市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 基礎研究と臨床研究は両立できる2016

    • Author(s)
      豊原潤
    • Organizer
      PETサマーセミナー2016
    • Place of Presentation
      ANAクラウンプラザホテル熊本ニュースカイ(熊本県-熊本市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Clinical impact of amyloid PET with [C-11]Pittsburgh Compound B on the diagnosis of early onset dementias.2016

    • Author(s)
      Ishii K, Ishibashi K, Sakata M, Wagatsuma K, Toyohara J, Murayama S.
    • Organizer
      AAIC2016 Alzheimer’s Association International Conference
    • Place of Presentation
      Tronto (Canada)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regional cerebral blood flow following a single bout aerobic exercise: PET and TCD studies.2016

    • Author(s)
      Muta A, Hiura M, Nariai T, Maehara T, Sakata M. Oda K, Toyohara J, Ishiwata K, Ishii K.
    • Organizer
      OHBM 2016 Annual Meeting
    • Place of Presentation
      Geneva (Switzerland)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Density of metabotropic glutamate receptors subtype 1 in de novo patients with Parkinson’s disease using 11C-ITMM PET.2016

    • Author(s)
      Mishina M, Suzuki M, Ishii K, Sakata M, Wagatsuma K, Ishibashi K, Toyohara J, Zhang MR, Kimura K, Ishiwata K.
    • Organizer
      The MDS 20th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Berlin (Germany)
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preclinical and a first-in man studes on [11C]CB184 for imaging 18 kDa translocator protein by positron emission tomography.2016

    • Author(s)
      Toyohara J, Sakata M, Ishibashi K, Wagatsuma K, Hatano K, Yanai S, Endo S, Ishii K, Ishiwata K.
    • Organizer
      SNMMI 2016 Annual Meeting
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation of intratumor textual heterogeneity on 4'-[methyl-11C]thiothymidine PET/CT with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas.2016

    • Author(s)
      Yamamoto Y, Mitamura K, Maeda Y, Hatakeyama T, Yamamoto H, Kudomi N, Toyohara J, Nishiyama Y.
    • Organizer
      SNMMI 2016 Annual Meeting
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prospective comparison of 11C-4DST, 18F-FDG PET/CT and whole-body MRI in the patients with multile myeloma.2016

    • Author(s)
      Minamimoto R, Toyohara J, Okasaki M, Morooka M, Miyata Y, Kameyama M, Hotta M, Nakajima K, Miwa A, Kubota K.
    • Organizer
      SNMMI 2016 Annual Meeting
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preclinical and first-in-man studies of imidazopyridine acetamide, [11C]CB184, as a novel 18 kDa translator protein seeker.2016

    • Author(s)
      Toyohara J, Sakata M, Ishibashi K, Wagatsuma K, Hatano K, Yanai S, Endo S, Ishii K, and Ishiwata K.
    • Organizer
      SNMMI 2016 Annual Meeting
    • Place of Presentation
      Sandiego
    • Year and Date
      2016-06-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エオジン好性核内封入体病における機能画像・髄液バイオマーカーの検討2016

    • Author(s)
      仙石錬平、渋川茉莉、本山りえ、森本悟、砂川昌子、金田大太、仁科裕史、豊原潤、藤ヶ崎純子、石井賢二、金丸和富、村山繁雄
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県-神戸市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] PET薬剤製造の基礎-アミロイドPET薬剤等を作るために必要な知識-2016

    • Author(s)
      豊原潤
    • Organizer
      第16回日本核医学会春季大会
    • Place of Presentation
      大阪国際交流センター(大阪府-大阪市)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳卒中慢性期における有酸素運動が脳血流量とμオピオイド受容体に及ぼす影響; 至適運動療法の検討2016

    • Author(s)
      日浦幹夫、成相直、石井賢二、坂田宗之、豊原潤、織田圭一、石渡喜一
    • Organizer
      第41回日本脳卒中学会総会
    • Place of Presentation
      ロイトン札幌(北海道-札幌市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] (R)-[11C]emopamil as a novel tracer for imaging enhanced P-glycoprotein function.2015

    • Author(s)
      Toyohara J, Aramaki H, Zaitsu Y, Okamoto M, Hosokawa S, Shimizu I, and Ishiwata K.
    • Organizer
      JCSRC2015
    • Place of Presentation
      Chiba (Japan)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] P糖たんぱく質の機能亢進を画像化するPET薬剤としての(R)-[11C]emopamilの基礎評価2015

    • Author(s)
      豊原潤、岡本真由美、荒牧光紀、財津優人、清水功雄、石渡喜一
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      新宿(東京)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] (R)-[11C]emopamil as a novel tracer for imaging enhanced P^glycoprotein function in the brain.2015

    • Author(s)
      Toyohara J, Okamoto M, Aramaki H, Zaitsu Y, Shimizu I, Hosokawa S, and Ishiwata K.
    • Organizer
      EANM'15
    • Place of Presentation
      Hamburg (Germany)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 7alpha-(3-[18F]fluoropropyl)testosteroneの開発2015

    • Author(s)
      中喬介、清水功雄、岡本真由美、石渡喜一、豊原潤
    • Organizer
      第15回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都(京都)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞増殖能イメージングトレーサー(がん)2015

    • Author(s)
      豊原潤
    • Organizer
      PETサマーセミナー2015 in 東京ベイ
    • Place of Presentation
      舞浜(千葉)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] [18F:Flutemetamol製造施設認証に必要な条件:TMIGのケース2015

    • Author(s)
      豊原潤
    • Organizer
      PETサマーセミナー2015 in 東京ベイ
    • Place of Presentation
      舞浜(千葉)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Comparison of 4DST and FDG PET/CT imaging for advanced clear cell renal cell carcinoma.2015

    • Author(s)
      MInamimoto R, Nakaigawa N, Toyohara J, Nagashima Y, Miata Y, Okazaki M, Morooka M, Nakajima K, Sunaoka F, and Kubota K.
    • Organizer
      SNMMI 2015 Annual Meeting
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation of 11C-4DST and 11C-MET uptake on Pet with tumor grade and Ki-67 immunohistochemistry in patients with newly diagnosed gliomas.2015

    • Author(s)
      Tanaka K, Yamamoto Y, Hatakeyama T, Yamamoto H, Toyohara J, and Nishiyama Y.
    • Organizer
      SNMMI 2015 Annual Meeting
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential alteration of neuronal network with FDG-PET in Alzheimer's disease and dementia with Lewy bodies.2015

    • Author(s)
      Yamamoto Y, Tanaka K, Hatakeyama T, Yamamoto H, Toyohara J, Murano H, and Ishii K.
    • Organizer
      SNMMI 2015 Annual Meeting
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structure activity relationships of 18F-labeled 7alpha-alkyl-estradiol derivatives.2015

    • Author(s)
      Toyohara J, Okamoto M, Shibayama H, Naka K, Kitagawa Y, Ishiwata K, and Shimizu I.
    • Organizer
      ISRS 2015
    • Place of Presentation
      Missouri (USA)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PET薬剤製造の基礎ーFDG以外の薬剤を作るために必要な基礎知識ー2015

    • Author(s)
      豊原潤
    • Organizer
      第15回日本核医学会春季大会
    • Place of Presentation
      船堀(東京)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 放射性フッ素18標識7alpha-alkyl-estradiol誘導体の構造活性相関2015

    • Author(s)
      豊原潤、岡本真由美、芝山啓允、中喬介、北川雄也、石渡喜一、清水功雄
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 4'-[Methyl-11C]thiothymidine PET for proliferation imaging in head and neck squamous cell carcinoma: comparison with 18F-FDG PET2014

    • Author(s)
      Yamamoto Y, Tanaka K, Hoshikawa H, Toyohara J, Nishiyama Y
    • Organizer
      100th Scientific Assembly and Annual Meeting, Radiological Society of North America
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-30 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 放射性薬剤入門ー構成から管理まで2014

    • Author(s)
      豊原潤
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Evaluation of [11C]CB184 for imaging and quantification of neuroinflammation i n rat model of helped encephalitis2014

    • Author(s)
      Garcia DV, de Vries EJF, Hatano K, Toyohara J, Ishiwata K, Dierckx RAJO, Doorduin J
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Gothenburg
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒトを対象としたPET分子イメージング2014

    • Author(s)
      豊原潤
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      町田
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 7α-[18F]Estradiolの構造活性相関研究2014

    • Author(s)
      芝山啓允、中喬介、北川雄也、岡本真由美、豊原潤、石渡喜一、清水功雄
    • Organizer
      第14回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 光学活性11C-Emopamilの標識合成と基礎評価2014

    • Author(s)
      荒牧光紀、財津優人、岡本真由美、清水功雄、石渡喜一、豊原潤
    • Organizer
      第14回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 4'-[Methyl-11C]thiothymidine PET for proliferation imaging in gastrointestinal cancer: comparison with 18F-FDG PET2014

    • Author(s)
      Yamamoto Y, Tanaka K, Toyohara J, NIshiyama Y
    • Organizer
      11th Congress of the World Federation of Nuclear Medicine and Biology
    • Place of Presentation
      Cancun
    • Year and Date
      2014-08-27 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of 4'-[methyl-11C]thiothymidine (4DST) and FDG PET/CT for early therapy monitoring of advanced non small cell lung cancer2014

    • Author(s)
      Minamimoto R, Toyohara J, Miyata Y, Okasaki M, Morooka M, Nakajima K, Ishiwata K, Kubota K
    • Organizer
      60th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
    • Place of Presentation
      St. Louis
    • Year and Date
      2014-06-07 – 2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 11C-4DST PET for proliferation imaging in patients with newly diagnosed high-grade gliomas: comparison with 18F-FLT PET2014

    • Author(s)
      Yamamoto Y, Kawai N, Yamamoto H, Maeda Y, Toyohara J, Nishiyama Y
    • Organizer
      60th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
    • Place of Presentation
      St. Louis
    • Year and Date
      2014-06-07 – 2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Imaging of DNA synthesis rate of malignant brain tumor with a newly developed PET molecular imaging probe 11C-4DST.2013

    • Author(s)
      Hayashi S, Inaji M, Nariai T, Tanaka Y, Maehara T, Oda K, Sakata M, Toyohara J, Ishiwata K and Ishii K
    • Organizer
      15th WFNS World Congress of Neurosurgery
    • Place of Presentation
      Seoul
    • Related Report
      2013 Annual Research Report
  • [Presentation] The potential of proliferation imaging by 4'-[methyl-11C]thiothymidine (4DST) PET/CT for nodal staging of non-small cell lung cancer.2013

    • Author(s)
      Minamimoto R, Toyohara J, Morooka M, Miyata Y, Okasaki M, Nakajima K, Mitsumoto T, Sunaoka F, Ishiwata K and Kubota K
    • Organizer
      60th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Vancouver
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diagnostic and prognostic value of nodal staging by 4'-[methyl-11C]-thiothymidine (4DST) PET/CT in non small cell lung cancer.2013

    • Author(s)
      Minamimoto R, Ishiwata K, Nakajima K, Okazaki M, Miyata Y, Morooka M, Toyohara J and Kubota K
    • Organizer
      99th Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Place of Presentation
      Chicago
    • Related Report
      2013 Annual Research Report
  • [Presentation] 11C-4DSTを用いたDNA合成の分子イメージング2013

    • Author(s)
      豊原潤
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] PET and SPECT of Neurobiological Systems2014

    • Author(s)
      Toyohara J, Sakata M and Ishiwata K
    • Total Pages
      600
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] Tumors of the Central Nervous System2013

    • Author(s)
      Nariai T, Inaji M, Sakata M and Toyohara J
    • Total Pages
      500
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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