Repair method of steatotic grafts aiming to resolve the organ shortage
Project/Area Number |
25293272
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
Taketomi Akinobu 北海道大学, 大学院医学研究科, 教授 (70363364)
Fukai Moto 北海道大学, 大学院医学研究科, 特任助教 (60374344)
Kimura Taichi 北海道大学, 大学院医学研究科, 特任助教 (90435959)
Nishikawa Yuji 旭川医科大学, 医学部, 教授 (90208166)
Ohsawa Ikuro 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究副部長 (30343586)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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Keywords | 移植・再生医療 / 虚血再灌流 / 臓器保存 / 脂肪肝 / 肝臓 |
Outline of Final Research Achievements |
We succeeded to obtain the "Proof of Concept" that combined therapy against the marginal grafts, including steatosis and DCD liver, could reduce ischemia and reperfusion injury. Using novel preservation solution, perfusate for machine perfusion, and hydrogen gas, graft weight gain and intrahepatic resistance during CS , HOPE and/or reperfusion were well controlled. Although bile production was not fully resucitated in DCD graft subjected to extended cold preservation, it would be resolved by perfusion from the artery. We believe that our method would become a choice to utilize the marginal grafts, and thereby resolving, at least to some extent, organshortage.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Hydrogen sulfide augments survival signals in warm ischemia and reperfusion of the mouse liver.2015
Author(s)
Shimada S, Fukai M, Wakayama K, Ishikawa T, Kobayashi N, Kimura T, Yamashita K, Kamiyama T, Shimamura T, Taketomi A, Todo S
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Journal Title
Surg Today
Volume: 45
Pages: 892-903
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Establishment of educational program for multiorgan procurement from deseased donors.2014
Author(s)
Taniguchi M, Furukawa H, Kawai T, Morikawa H, Morozumi K, Goto M, Kondo T, Aikawa A, Ito T, Takahara S, Nio M, Kokudo N, Uemoto S, Fukushima N, Yoshida K, Kenmochi T, Date H, Ono M, Eguchi S, Shimamura T, Mizuta K, Yoshizumi T, Ueno T.
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Journal Title
Transplant Proc.
Volume: 46
Pages: 1071-3
Related Report
Peer Reviewed
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[Presentation] Successful Withdrawal of Immunosuppression by a Cell Therapy Using Donor Ag-pulsed Tregs in Living Donor Liver Transplantation: An Update on Clinical Trial.2014
Author(s)
Kenichiro Yamashita, Masaki Zaitsu, Akihisa Nagatsu, Ryoichi Goto, Tetsu Oura, Masaaki Watanabe, Takeshi Aoyagi, Tomomi Suzuki, Tsuyoshi Shimamura, Toshiya Kamiyama, Norihiro Sato, Junichi Sugita, Kanako Hatanaka, Hisashi Bashuda, Ko Okumura, Satoru Todo.
Organizer
The 2014 Joint International Congress of ILTS, ELITA & LICAGE
Place of Presentation
Queen ElizabethⅡ Conference Centre(London, United Kingdom)
Year and Date
2014-06-04
Related Report
Int'l Joint Research
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[Presentation] Preoperative Prediction of Short-Term Prognosis after Adult-to-Adult Living Donor Liver Transplantation: A Way to Zero-Mortality.2014
Author(s)
Tsuyoshi Shimamura, Masato Fujiyoshi, Tomomi Suzuki, Kenichiro Yamashita, Takeshi Aoyagi, Ryoichi Goto, Toru Takahashi, Yasuyuki Koshizuka, Masahiko Taniguchi, Hiroyuki Furukawa, Satoru Todo.
Organizer
The 2014 Joint International Congress of ILTS, ELITA & LICAGE
Place of Presentation
Queen ElizabethⅡ Conference Centre(London, United Kingdom)
Year and Date
2014-06-04
Related Report
Int'l Joint Research
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[Presentation] Heavy Water and Hydrogen Gas Confer Protection Against Hepatic Cold Ischemia and Reperfusion Injury in Isolated Perfused Rat Liver
Author(s)
Shimada S, Fukai M, Wakayama K, Yamashita K, Taniguchi M, Suzuki T, Shimamura T, Kamiyama T, Furukawa F, Todo S, Taketomi A.
Organizer
American Transplant Congress 2013
Place of Presentation
Washington State Convention & Trade Center(Seattle, USA)
Related Report
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[Presentation] Heavy Water and Hydrogen Gas Ameliorates Cold Preservation and Reperfusion Injury in Rat Liver
Author(s)
Shimada S, Fukai M, Wakayama K, Yamashita K, Taniguchi M, Suzuki T, Shimamura T, Kamiyama T, Furukawa F, Todo S, Taketomi A.
Organizer
International Congress of European Society for Organ Transplantation
Place of Presentation
Austria Center Vienna(Vienna, Austria)
Related Report
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[Presentation] 低温下でエネルギー産生を賦活化させる新しい方法~有効性と普遍性
Author(s)
深井原, 若山顕治, 山下健一郎, 廣方玄太郎, 谷口雅彦, 古川博之, 島田慎吾, 小倉正臣, 鈴木友己, 嶋村剛, 尾崎倫孝, 神山俊哉, 藤堂省
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡国際会議場(福岡市)
Related Report
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