| Project/Area Number |
25293272
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Taketomi Akinobu 北海道大学, 大学院医学研究科, 教授 (70363364)
Fukai Moto 北海道大学, 大学院医学研究科, 特任助教 (60374344)
Kimura Taichi 北海道大学, 大学院医学研究科, 特任助教 (90435959)
Nishikawa Yuji 旭川医科大学, 医学部, 教授 (90208166)
Ohsawa Ikuro 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究副部長 (30343586)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 移植・再生医療 / 虚血再灌流 / 臓器保存 / 脂肪肝 / 肝臓 |
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| Outline of Final Research Achievements |
We succeeded to obtain the "Proof of Concept" that combined therapy against the marginal grafts, including steatosis and DCD liver, could reduce ischemia and reperfusion injury. Using novel preservation solution, perfusate for machine perfusion, and hydrogen gas, graft weight gain and intrahepatic resistance during CS , HOPE and/or reperfusion were well controlled. Although bile production was not fully resucitated in DCD graft subjected to extended cold preservation, it would be resolved by perfusion from the artery. We believe that our method would become a choice to utilize the marginal grafts, and thereby resolving, at least to some extent, organshortage.
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