Development of organ regeneration and transplantation of functional pancreas from iPS cells
| Project/Area Number |
25293277
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 祥介 奈良県立医科大学, 医学部, 教授 (00142381)
植田 剛 奈良県立医科大学, 医学部, 助教 (40526810)
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| Research Collaborator |
NAKAMOTO Takahiro
KASUDA Shogo
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 再生医療 / 糖尿病 / iPS細胞 / 移植医療 / 膵臓 / 臓器再生 |
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| Outline of Final Research Achievements |
We aimed to induce organ regeneration of "iPanc" from "iGut" by using iPS cells. For clinical application, we tried to induce iPanc by using human iPS cells, but failed to induce human iPanc. We found that mouse iPS-derived heart (iHeart) and iGut have temperature-sensitive ability in motion, which were decreased under 35℃ and failed to move under 30℃. Now we are establishing iPS cells from mouse insulin promotor (MIP)-green fluorescence protein (GFP) mouse. Our results would provide useful information for organ regenerative medicine of iPanc from iGut.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice.2016
Author(s)
Cavelti-Weder C, Li W, Zumsteg A, Stemman-Andersen M, Zhang Y, Yamada T, Wang M, Lu J, Jermendy A, Bee YM, Bonner-Weir, S, Weir GC, Zhou Q.
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Journal Title
Diabetologia
Volume: 59
Issue: 3
Pages: 522-532
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.2014
Author(s)
Li W, Cavelti-Weder C, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D, Meissner A, Weir G, Zhou Q.
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Journal Title
Nature Biotechnology
Volume: 32
Issue: 12
Pages: 1223-1230
DOI
Related Report
Peer Reviewed / Open Access
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