The newly invented murine pancreatic cancer model associated with pancreatic developmental master gene Pdx1
| Project/Area Number |
25293282
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
Masui Toshihiko 京都大学, 医学(系)研究科(研究院), 助教 (20452352)
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| Co-Investigator(Kenkyū-buntansha) |
UEMOTO SHINJI 京都大学, 医学研究科, 教授 (40252449)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAGUCHI YOSHIYA 京都大学, 医学研究科, 教授 (60359792)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 膵発癌 / 非自律的増殖 / pdx1 / 膵癌 / epigenetic / 膵発生 / Pdx1 / 発癌 |
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| Outline of Final Research Achievements |
In this project, we tried to elucidate the function of pancreatic developmental master gene Pdx1 in the pancreatic carcinogenesis, since there are many common characteristics in the behavior of the cancer cells and of the developmental cells. We knockout pdx1 expression in the genetic manipulated murine pancreatic cancer model and found an exaggeration of the tumor development contrary to our preliminary results. Surprisingly, this phenomenon was observed not only in the knockout cells with K-ras or p53 mutations but also in the genetically normal cells, which indicates the non-autonomous development of cancer cells from normal tissue. We are now seeking the factors inducing this non-autonomous development.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice.2016
Author(s)
Kodama S, Nakano Y, Hirata K, Furuyama K, Horiguchi M, Kuhara T, Masui T, Kawaguchi M, Gannon M, Wright CV, Uemoto S, Kawaguchi Y.
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Journal Title
Sci Rep.
Volume: 18
Issue: 1
Pages: 110-110
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations.2015
Author(s)
Sawai Y, Kodama Y, Shimizu T, Ota Y, Maruno T, Eso Y, Kurita A, Shiokawa M, Tsuji Y, Uza N, Matsumoto Y, Masui T, Uemoto S, Marusawa H, Chiba T.
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Journal Title
Cancer Res.
Volume: 15
Issue: 16
Pages: 32923301-32923301
DOI
Related Report
Peer Reviewed
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[Journal Article] Non-functioning pancreatic neuroendocrine tumor accompanied with multiple liver metastases: remorseful case and literature review.2014
Author(s)
Hori T, Takaori K, Kawaguchi M, Ogawa K, Masui T, Ishii T, Nagata H, Narita M, Kodama Y, Uza N, Uemoto S.
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Journal Title
JOP
Volume: 15(6)
Pages: 622-625
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term survival after resection of pancreatic ductal adenocarcinoma with para-aortic lymph node metastasis : case report2013
Author(s)
Masui T, Kubota T, Aoki K, Nakanishi Y, Miyamoto T, Nagata J, Morino K, Fukugaki A, Takamura M, Sugimoto S, Onuma H, Tokuka A.
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Journal Title
World J Surg Oncol
Volume: 11(1)
Issue: 1
Pages: 195-195
DOI
Related Report
Peer Reviewed
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