Development of a novel therapeutic approach based on the mechanism of tumor dissemination
| Project/Area Number |
25293286
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HARADA YUI 九州大学, 薬学研究院, 助教 (00608507)
SAITO SATORU 九州大学, 薬学研究院, 学術研究員 (50634193)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
|---|
| Keywords | 腹膜播種 / 悪性腫瘍 / 治療抵抗性 / スフェロイド / CXCR4 / Sp1 / がん / がん幹細胞 |
|---|
| Outline of Final Research Achievements |
Peritonitis carcinomatosa is an advanced and intractable state of gastrointestinal and ovarian cancer, where mechanistic elucidation might enable the development of more effective therapies. Peritoneal dissemination of this type of malignancy has been generally thought to initiate from "milky spots" of primitive lymphoid tissues in the peritoneal cavity. Spheroid formation strongly induced the expression of CXCR4 in an Sp1-dependent manner to promote niche-directed metastasis. Notably, disrupting sphere forma- tion or inhibiting Sp1 activity was sufficient to suppress tumor dissemination and potentiated chemosensitivity to 5-fluoro-uracil. Our findings illuminate mechanisms of peritoneal cancer dissemination and highlight the Sp1/CXCR4/CXCL12 signaling axis as a rational target for the development of therapeutics to manage this intractable form of malignancy.
|
Report
(4 results)
Research Products
(19 results)
-
[Journal Article] Peritoneal dissemination requires an Sp1-dependent CXCR4/CXCL12 signaling axis and extracellular matrix-directed spheroid formation2016
Author(s)
*Kasagi Y, *Harada Y, Morodomi Y, Iwai T, Saito S, Yoshida K, Oki E, Saeki H, Ohgaki K, Sugiyama M, Onimaru M, Maehara Y, Yonemitsu Y.
-
Journal Title
Cancer Research.
Volume: 76
Pages: 347-357
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy: a multicenter analysis.2014
Author(s)
Kobayashi M, Shimodaira S, Nagai K, Ogasawara M, Takahashi H, Abe H, Tanii M, Okamoto M, Tsujitani S, Yusa S, Ishidao T, Kishimoto J, Shibamoto Y, Nagaya M, Yonemitsu Y.
-
Journal Title
Cancer Immunology, Immunotherapy
Volume: 印刷中
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Dendritic cell-based immunotherapy targeting synthesized peptides for advanced biliary tract cancer2013
Author(s)
Kobayashi M, Sakabe T, Abe H, Tanii M, Takahashi H, Chiba A, Yanagida E,Shibamoto Y, Ogasawara M, Tsujitani S, Koido S, Nagai K, Shimodaira S, Okamoto M,Yonemitsu Y, Suzuki N, Nagaya M; DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT).
-
Journal Title
J Gastrointest Surg
Volume: 17(9)
Issue: 9
Pages: 1609-17
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Eur J Cancer2013
Author(s)
Hidenori Takahashi
-
Journal Title
10.1016/j.ejca.2012.11.005
Volume: 49
Issue: 4
Pages: 852-859
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Patent(Industrial Property Rights)] NK細胞の調整方法2013
Inventor(s)
米満吉和、原田結、齊藤智、石田尾武文、矢崎雄一郎
Industrial Property Rights Holder
米満吉和、原田結、齊藤智、石田尾武文、矢崎雄一郎
Industrial Property Rights Type
特許
Industrial Property Number
2013-107568
Filing Date
2013-05-22
Related Report
