Refractory cancer therapy development by cancer microenvironment elucidation and new drug delivery system based on autophagy
| Project/Area Number |
25293287
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
NAGAI Eishi 九州大学, 医学(系)研究科(研究院), 准教授 (30264021)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masao 九州大学, 医学研究院, 教授 (30163570)
MAEYAMA Ryo 九州大学, 医学研究院, 共同研究員 (10611668)
OHUCHIDA Kenoki 九州大学, 大学病院, 助教 (20452708)
NAKATA Kohei 九州大学, 大学病院, 特別教員 (30419569)
MIYASAKA Yoshihiro 九州大学, 医学研究院, 助教 (40507795)
TOMA Hiroki 九州大学, 医学研究院, 共同研究員 (80437780)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | オートファジー / 癌微小環境 / 膵臓癌 |
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| Outline of Final Research Achievements |
In pancreatic cancer, cancer microenvironment composed of fibroblasts and extracellular matrix play an important role in invasion, metastasis, and anti-cancer drug resistant. We studied relationship of cancer microenvironment and autophagy that has been shown greatly involved in the carcinogenesis and progress of cancer.
We found that autophagy of pancreatic stellate cells established from pancreatic cancer resections are enhanced compared to normal fibroblasts. Further, we reported that suppressing autophagy of pancreatic stellate cells decreased invasion and migration ability of pancreatic cancer cells in the indirect co-culture with pancreatic stellate cells. In addition, we reported that hypoxia, which is one of the major inducer of autophagy, promoted the migration of pancreatic cancer cells through the remodeling of extracellular matrix produced by pancreatic stellate cells.
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Report
(4 results)
Research Products
(19 results)
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[Presentation] 低酸素下膵星細胞による癌間質マトリックス・リモデリングは膵癌浸潤能を増強する2016
Author(s)
佐田政史, 大内田研宙, 阿部俊也, 遠藤翔, 肥川和寛, 奥村隆志, 千々岩芳朗, 吉田真樹, 堀岡宏平, 森山大樹, 宮坂義浩, 大塚隆生, 植木隆, 永井英司, 水元一博, 小田義直, 中村雅史
Organizer
第116回日本外科学会定期学術集会
Place of Presentation
大阪市
Year and Date
2016-04-16
Related Report
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[Presentation] 膵癌腹膜播種形成を導く腹膜中皮細胞の新たな役割～防御から促進へ～2016
Author(s)
阿部俊也, 大内田研宙,遠藤翔, 肥川和寛, 千々岩芳朗, 吉田真樹, 奥村隆志, 堀岡宏平, 佐田政史, 大塚隆生, 植木隆, 永井英司, 水元一博, 中村雅史
Organizer
第116回日本外科学会定期学術集会
Place of Presentation
大阪市
Year and Date
2016-04-16
Related Report
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[Presentation] 膵周囲脂肪組織は膵癌細胞の遊走・浸潤能を増強し，局所浸潤に関与する2016
Author(s)
奥村隆志, 大内田研宙, 武居晋、中山宏道、阿部俊也, 遠藤翔, 肥川和寛,,千々岩芳朗, 吉田真樹, 鄭彪、佐田政史、堀岡宏平、森山大樹,三好圭、 宮坂義浩, 真鍋達也、大塚隆生, 植木隆, 永井英司, 水元一博, 中村雅史
Organizer
第116回日本外科学会定期学術集会
Place of Presentation
大阪市
Year and Date
2016-04-16
Related Report
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[Presentation] 膵癌におけるCD110の臨床的意義と癌進展におけるその役割2016
Author(s)
厳子龍、大内田研宙、鄭彪、 堀岡宏平, 佐田政史、奥村隆志、千々岩芳朗, 吉田真樹、遠藤翔、肥川和寛, 阿部俊也,中山宏道、武居晋、森山大樹、宮坂義浩, 大塚隆生, 植木隆, 永井英司, 水元一博, 中村雅史
Organizer
第116回日本外科学会定期学術集会
Place of Presentation
大阪市
Year and Date
2016-04-16
Related Report
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[Presentation] Pancreatic Stellate Cells Lead and Promote the Local Invasion of Cancer Cells, by Physically Remodeling the Extracellular Matrix with Collagen Fiber Alignment in Pancreatic Cancer2015
Author(s)
Koikawa K, Ohuchida K, Sada M, Abe T, Endo S, Horioka K, Moriyama T, Miyasaka Y, Ohtsuka T, Ohuchida R, Ueki T, Nagai E, Mizumoto K, Nakamura M
Organizer
American Pancreatic Association 46th Annual Meeting
Place of Presentation
San Diego(USA)
Year and Date
2015-11-04
Related Report
Int'l Joint Research
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