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Challenge of iPS-induced gut (iGut) regeneration and transplantation as a novel treatment strategy against inflammatory bowel diseases

Research Project

Project/Area Number 25293291
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionNara Medical University

Principal Investigator

Nakajima Yoshiyuki  奈良県立医科大学, 医学部, 教授 (00142381)

Co-Investigator(Kenkyū-buntansha) YAMADA Takatsugu  奈良県立医科大学, 医学部, 講師 (20316061)
UEDA Takeshi  奈良県立医科大学, 医学部, 助教 (40526810)
Research Collaborator NAKAMOTO Takayuki  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
KeywordsiPS細胞 / 再生医療 / 移植医療 / 難治性腸疾患 / 臓器再生
Outline of Final Research Achievements

We succeeded organ regeneration of iGut from mouse iPS cells and challenged the improvement of environment of culture to induce human iGut from human iPS cells. Firstly, we introduced apoptosis inhibitory factor and non-feeder culture system to maintain a large amount of human iPS cells. Secondly, we succeeded to induce efficiently stable embryoid bodies by using a novel three-dimensional culture system. These findings have proved the specific environment of culture characteristic to different species of iPS cell/iGut, and proposed significant way to the clinical application. We will present widely our powerful results and develop our works as a novel treatment strategy against inflammatory bowel diseases in the future.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (14 results)

All 2016 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] iPS細胞と腸疾患―臓器としての腸管の再生―2016

    • Author(s)
      山田高嗣、、植田剛、中島祥介
    • Journal Title

      G.I. Research

      Volume: 24 Pages: 48-55

    • Related Report
      2015 Annual Research Report
  • [Journal Article] iPS細胞による消化管再生2014

    • Author(s)
      山田高嗣、中島祥介
    • Journal Title

      Journal of Gastrointestinal Research

      Volume: 22 Pages: 185-192

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.2014

    • Author(s)
      Li W, Cavelti-Weder C, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D, Meissner A, Weir G, Zhou Q.
    • Journal Title

      Nature Biotechnology

      Volume: 32 Pages: 1223-1230

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] iPS細胞技術による消化管臓器の作製2014

    • Author(s)
      山田高嗣、中島祥介
    • Journal Title

      Journal of Gastrointestinal Research

      Volume: 22 Pages: 185-192

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 消化管領域におけるiPS細胞の応用2014

    • Author(s)
      山田高嗣、中島祥介
    • Journal Title

      Annual Review 消化器 2013

      Volume: 22 Pages: 7-13

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 腸管再生医療-iPS細胞から腸管の臓器再生-2013

    • Author(s)
      山田高嗣、植田剛、中島祥介
    • Journal Title

      Journal of Gastrointestinal Research

      Volume: 21 Pages: 166-170

    • Related Report
      2013 Annual Research Report
  • [Presentation] iPS細胞/リプログラミング技術を応用した臓器再生医療-新しい外科学の創造2016

    • Author(s)
      山田高嗣、、植田剛、中本貴透、Gordon Weir、中島祥介
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Organ regenerative medicine of "iGut" from iPS cells and "new islets" using reprogramming technology.2016

    • Author(s)
      Yamada T, Ueda T, Nakamoto T, Zhou Q, Gordon Weir, Nakajima Y.
    • Organizer
      CiRA/ISSCR International Symposium 2016
    • Place of Presentation
      京都
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 本邦報告例集積からみたクローン病合併直腸肛門部癌の特徴 cancer surveillanceに向けた検討2014

    • Author(s)
      植田 剛, 小山 文一, 中川 正, 中村 信治, 錦織 直人, 井上 隆, 川崎 敬次郎, 尾原 伸作, 中本 貴透, 藤井 久男, 中島 祥介
    • Organizer
      第69回日本大腸肛門病学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Organ regeneration of functional gut (iGut) from mouse iPS cells2014

    • Author(s)
      Yamada T, Ueda T, Nakamoto T, Nakajima Y.
    • Organizer
      The 12th Annual Meeting of the International Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Vancouver, BC, Canada
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] iPS細胞からの臓器分化誘導2014

    • Author(s)
      中島祥介
    • Organizer
      第10回 日本消化管学会総会学術集会
    • Place of Presentation
      福島
    • Related Report
      2013 Annual Research Report
  • [Presentation] iPS細胞からのiGutの作製2014

    • Author(s)
      中島祥介、植田 剛、山田高嗣
    • Organizer
      第100回 日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vitro reprogramming of adult pancreatic duct cells to insulin-producing beta cells by defined transcription factors.2013

    • Author(s)
      Yamada T, Cavelti-Weder C, Guo L, Sharma A, Li W, Zhou Q, Bonner-Weir S, Weir GC.
    • Organizer
      11th Annual Meeting of the International Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Boston, MA USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gut organ regeneration from ES cells and iPS cells

    • Author(s)
      Yamada T and Nakajima Y.
    • Organizer
      Memorial Lecture for the 20th Saichi Nakajima Researcher’s Award
    • Place of Presentation
      奈良
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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