Challenge of iPS-induced gut (iGut) regeneration and transplantation as a novel treatment strategy against inflammatory bowel diseases
Project/Area Number |
25293291
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Nara Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YAMADA Takatsugu 奈良県立医科大学, 医学部, 講師 (20316061)
UEDA Takeshi 奈良県立医科大学, 医学部, 助教 (40526810)
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Research Collaborator |
NAKAMOTO Takayuki
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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Keywords | iPS細胞 / 再生医療 / 移植医療 / 難治性腸疾患 / 臓器再生 |
Outline of Final Research Achievements |
We succeeded organ regeneration of iGut from mouse iPS cells and challenged the improvement of environment of culture to induce human iGut from human iPS cells. Firstly, we introduced apoptosis inhibitory factor and non-feeder culture system to maintain a large amount of human iPS cells. Secondly, we succeeded to induce efficiently stable embryoid bodies by using a novel three-dimensional culture system. These findings have proved the specific environment of culture characteristic to different species of iPS cell/iGut, and proposed significant way to the clinical application. We will present widely our powerful results and develop our works as a novel treatment strategy against inflammatory bowel diseases in the future.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.2014
Author(s)
Li W, Cavelti-Weder C, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D, Meissner A, Weir G, Zhou Q.
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Journal Title
Nature Biotechnology
Volume: 32
Pages: 1223-1230
Related Report
Peer Reviewed
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[Presentation] 本邦報告例集積からみたクローン病合併直腸肛門部癌の特徴 cancer surveillanceに向けた検討2014
Author(s)
植田 剛, 小山 文一, 中川 正, 中村 信治, 錦織 直人, 井上 隆, 川崎 敬次郎, 尾原 伸作, 中本 貴透, 藤井 久男, 中島 祥介
Organizer
第69回日本大腸肛門病学会学術集会
Place of Presentation
横浜
Year and Date
2014-11-07 – 2014-11-08
Related Report
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