Novel treatment method for extensive myocardial infarction with ventricular assist device using an electrocardiography-synchronized rotational speed control

• Project/Area Number: 25293294
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Osaka University (2018); Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2013-2017)
• Principal Investigator: Takashi Nishimura 大阪大学, 医学系研究科, 特任准教授(常勤) (80433655)
• Co-Investigator(Kenkyū-buntansha): 巽 英介 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00216996) ; 許 俊鋭 東京大学, 医学部附属病院, 研究員 (30153232)
• Project Period (FY): 2013-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 補助人工心臓 / 心拍同期制御 / Bridge to Recovery / 広範囲心筋梗塞 / 制御 / 心不全 / 右心不全 / von Willebrand factor / 冠動脈外科学 / 心拍同期制御システム

Outline of Final Research Achievements

Effects of an electrocardiography-synchronized rotational speed control of continuous flow ventricular assist device for extensive myocardial infarction were clarified. Severe mitral valve regurgitation which accompanying with massive myocardial infarction can be controlled by this system using reduction of left ventricular end-diastolic pressure. Also found damage to momentary high rotation by blood caused by the electrocardiography-synchronized rotational speed control system that does not negatively affect to the coagulation system. Local dyssynchrony caused by massive myocardial infarction can treated by this system and the cardiac output will be recovered. These various effects through massive myocardial infarction revealed that can more effectively treated by an electrocardiography-synchronized rotational speed control of continuous flow ventricular assist device.

Academic Significance and Societal Importance of the Research Achievements

本研究によって明らかにされた定常流ポンプの自己心拍同期制御の広範囲心筋梗塞に及ぼす影響は、今後、極めて死亡率の高い本疾患の死亡率を軽減せしめる可能性を有するのみならず、本疾患に伴う心不全を軽減させて社会復帰にまで導く可能性もある。今回明らかにした効果をより詳細に検討することによって、重症心不全治療戦略全体に影響を与える可能性もある。

Research Products

• [Journal Article] Miniaturized centrifugal ventricular assist device for bridge to decision: preclinical chronic study in a bovine model. (2019)
  • Author(s): Shimamura J, Mizuno T, Takewa Y, Tsukiya T, Naito N, Akiyama D, Iiduka K, Katagiri N, Nishimura T, Ono M, Tatsumi E.
  • Journal Title: Artif Organs. Volume: 印刷中 Issue: 9 Pages: 821-827
  • DOI: 10.1111/aor.13459
  • Peer Reviewed / Open Access
• [Journal Article] Accurate Method of Quantification of Aortic Insufficiency During Left Ventricular Assist Device Support by Thermodilution Analysis: Proof of Concept and Validation by a Mock Circulatory System. (2018)
  • Author(s): Akiyama D, Nishimura T, Sumikura H, Iizuka K, Mizuno T, Tsukiya T, Takewa Y, Ono M, Tatsumi E.
  • Journal Title: Artif Organs. Volume: 42(10) Issue: 10 Pages: 954-960
  • DOI: 10.1111/aor.13158
  • Peer Reviewed
• [Journal Article] Rotational speed modulation used with continuous-flow left ventricular assist device provides good pulsatility. (2018)
  • Author(s): Naito N, Nishimura T, Iizuka K, Takewa Y, Umeki A, Ando M, Ono M, Tatsumi E.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 26(1) Issue: 1 Pages: 119-123
  • DOI: 10.1093/icvts/ivx236
• [Journal Article] Novel Rotational Speed Modulation System Used With Venoarterial Extracorporeal Membrane Oxygenation. (2017)
  • Author(s): Naito N, Nishimura T, Iizuka K, Fujii Y, Takewa Y, Umeki A, Ando M, Ono M, Tatsumi E.
  • Journal Title: Ann Thorac Surg. Volume: 104（5） Pages: 1488-1495
  • Peer Reviewed
• [Journal Article] Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device (2017)
  • Author(s): Date K, Nishimura T, Arakawa M, Takewa Y, Kishimoto S, Umeki A, Ando M, Mizuno T, Tsukiya T, Ono M, Tatsumi E
  • Journal Title: JOURNAL OF ARTIFICIAL ORGANS Volume: 20(1) Issue: 1 Pages: 18-25
  • DOI: 10.1007/s10047-016-0920-y
  • Peer Reviewed
• [Journal Article] Shifting the pulsatility by increasing the change in rotational speed for a rotary LVAD using a native heart load control system. (2016)
  • Author(s): Date K, Nishimura T, Takewa Y, Kishimoto S, Arakawa M, Umeki A, Ando M, Mizuno T, Tsukiya T, Ono M, Tatsumi E.
  • Journal Title: JOURNAL OF ARTIFICIAL ORGANS Volume: online Issue: 4 Pages: 315-321
  • DOI: 10.1007/s10047-016-0906-9
  • Peer Reviewed / Open Access
• [Journal Article] What Is the Optimal Setting for a Continuous-Flow Left Ventricular Assist Device in Severe Mitral Regurgitation? (2016)
  • Author(s): Naito N, Nishimura T, Takewa Y, Kishimoto S, Date K, Umeki A, Ando M, Ono M, Tatsumi E
  • Journal Title: Artificial Organs Volume: 未定 Issue: 11 Pages: 1039-1045
  • DOI: 10.1111/aor.12702
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pulsatile support using a rotary left ventricular assist device with an electrocardiography-synchronized rotational speed control mode for tracking heart rate variability (2016)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Fujii Y, Date K, Kyo S, Adachi H, Tatsumi E
  • Journal Title: JOURNAL OF ARTIFICIAL ORGANS Volume: 19(2) Issue: 2 Pages: 204-207
  • DOI: 10.1007/s10047-015-0875-4
  • Peer Reviewed
• [Journal Article] Influence of a rotational speed modulation system used with an implantable continuous-flow left ventricular assist device (EVAHEART) on von Willebrand factor dynamics (2016)
  • Author(s): Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, and Eisuke Tatsumi
  • Journal Title: Artif. Organs Volume: 未定 Issue: 9 Pages: 877-883
  • DOI: 10.1111/aor.12666
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Novel control system to prevent right ventricular failure induced by rotary blood pump (2016)
  • Author(s): 荒川衛 西村隆 武輪能明 巽英介
  • Journal Title: 人工臓器 Volume: 45（1） Pages: 18-25
• [Journal Article] Effects of feeding state on anticoagulation in adult goats treated with warfarin (2016)
  • Author(s): Date K, Kishimoto S, Fujii Y, Togo K, Kakut Y, Mizuno T, Tsukiya T, Takewa Y, Nishimura T, Ono M, Tatsumi E
  • Journal Title: JOURNAL OF ARTIFICIAL ORGANS Volume: online Issue: 3 Pages: 301-304
  • DOI: 10.1007/s10047-016-0885-x
  • Peer Reviewed / Open Access
• [Journal Article] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models (2015)
  • Author(s): 梅木昭秀、西村 隆、武輪能明、安藤政彦、荒川 衛、岸本祐一郎、築谷朋典、水野敏秀、許 俊鋭、小野 稔、妙中義之、巽 英介
  • Journal Title: 人工臓器 Volume: 44（1） Pages: 12-13
• [Journal Article] Influence of a novel electrocardiogram-synchronized rotational-speed-change system of an implantable continuous-flow left ventricular assist device (EVAHEART) on hemolytic performance (2014)
  • Author(s): Kishimoto, S; Date, K; Arakawa, M; Takewa, Y; Nishimura, T; Tsukiya, T; Mizuno, T; Katagiri, N; Kakuta, Y; Ogawa, D; Nishimura, M; Tatsumi, E
  • Journal Title: JOURNAL OF ARTIFICIAL ORGANS Volume: 17 Issue: 4 Pages: 373-377
  • DOI: 10.1007/s10047-014-0787-8
  • Peer Reviewed / Open Access
• [Journal Article] Novel control system to prevent right ventricular failure induced by rotary blood pump (2014)
  • Author(s): Arakawa, M; Nishimura, T; Takewa, Y; Umeki, A; Ando, M; Kishimoto, Y; Fujii, Y; Kyo, S; Adachi, H; Tatsumi, E
  • Journal Title: JOURNAL OF ARTIFICIAL ORGANS Volume: 17 Issue: 2 Pages: 134-141
  • DOI: 10.1007/s10047-014-0757-1
  • Peer Reviewed / Open Access
• [Journal Article] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model. (2014)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Adachi H, Tatsumi E.
  • Journal Title: J Thorac Cardiovasc Surg. Volume: Epub ahead of print Issue: 2 Pages: 1-10
  • DOI: 10.1016/j.jtcvs.2013.12.049
  • Peer Reviewed / Open Access
• [Journal Article] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model (2014)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Adachi H, Tatsumi E.
  • Journal Title: J Thorac Cardiovasc Surg. Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Novel control system to prevent right ventricular failure induced by rotary blood pump. (2014)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Fujii Y, Kyo S, Adachi H, Tatsumi E
  • Journal Title: J Artif Organs. Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Preparation of an autologous heart valve with a stent (stent-biovalve) using the stent eversion method (2014)
  • Author(s): Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Moriwaki T, Yamanami M, Oie T, Tatsumi E, Uechi M, Nakayama Y
  • Journal Title: J Biomed Mater Res B Appl Biomater Volume: Dec 9 Issue: 5 Pages: 1-10
  • DOI: 10.1002/jbm.b.33086
  • Peer Reviewed
• [Journal Article] In vitro evaluation of a novel autologous aortic valve (Biovalve) with a pulsatile circulation circuit (2014)
  • Author(s): Sumikura H, Nakayama Y, Ohmuma K, Takewa Y, Tastumi E
  • Journal Title: Artif Organs Volume: (in press) Issue: 4 Pages: 282-9
  • DOI: 10.1111/aor.12173
  • Peer Reviewed
• [Journal Article] Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat (2013)
  • Author(s): Kishimoto Y1, Takewa Y, Arakawa M, Umeki A, Ando M, Nishimura T, Fujii Y, Mizuno T, Nishimura M, Tatsumi E
  • Journal Title: J Artif Organs. Volume: 16(2) Issue: 2 Pages: 129-37
  • DOI: 10.1007/s10047-012-0685-x
  • Peer Reviewed
• [Journal Article] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models. (2013)
  • Author(s): Umeki A1, Nishimura T, Takewa Y, Ando M, Arakawa M, Kishimoto Y, Tsukiya T, Mizuno T, Kyo S, Ono M, Taenaka Y, Tatsumi E
  • Journal Title: J Artif Organs. Volume: 16(2) Issue: 2 Pages: 119-28
  • DOI: 10.1007/s10047-012-0682-0
  • Peer Reviewed
• [Journal Article] In vivo evaluation of an in-body, tissue-engineered, completely autologous valved conduit (biovalve type VI) as an aortic valve in a goat model (2013)
  • Author(s): Takewa Y, Yamanami M, Kishimoto Y, Arakawa M, Kanda K, Matsui Y, Oie T, Ishibashi-Ueda H, Tajikawa T, Ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y
  • Journal Title: J Artif Organs Volume: 25 Issue: 2 Pages: 176-184
  • DOI: 10.1007/s10047-012-0679-8
  • Peer Reviewed
• [Journal Article] Hyperoxic condition promotes an inflammatory response during cardiopulmonary bypass in a rat model. (2013)
  • Author(s): Fujii Y, Shirai M, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.
  • Journal Title: Artif Organs. Volume: 37(12) Issue: 12 Pages: 1034-40
  • DOI: 10.1111/aor.12125
  • Peer Reviewed
• [Journal Article] Early clinical outcomes of new pediatric extracorporeal life support system (Endumo (2000) in neonates and infants. (2013)
  • Author(s): Hoashi T1, Kagisaki K, Yamashita K, Tatsumi E, Nishigaki T, Yoshida K, Hayashi T, Ichikawa H
  • Journal Title: J Artif Organs. Volume: 16(3) Issue: 3 Pages: 267-72
  • DOI: 10.1007/s10047-013-0713-5
  • Peer Reviewed
• [Journal Article] Development and evaluation of endurance test system for ventricular assist devices (2013)
  • Author(s): Sumikura H1, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mukaibayashi H, Katano K, Tatsumi E.
  • Journal Title: J Artif Organs Volume: 16(2) Issue: 2 Pages: 138-48
  • DOI: 10.1007/s10047-013-0687-3
  • Peer Reviewed
• [Presentation] Electrocardiogram-synchronized rotational speed modulation system can reduce the recirculation due to aortic insufficiency in LVAD support (2018)
  • Author(s): Akiyama D, Nishimura T, Iizuka K, Mizuno T, Tsukiya T, Takewa Y, Ono M, Tatsumi E
  • Organizer: International Society for Heart and Lung Transplantation Annual Meeting and Scientific Sessions (38)
  • Int'l Joint Research
• [Presentation] Electrocardiogram-synchronized rotational speed modulation system can reduce the recirculation due to aortic insufficiency in left ventricular assist device support (2018)
  • Author(s): Iizuka K, Akiyama D, Mizuno T, Tsukiya T, Takewa Y, Nishimura T, Tatsumi E
  • Organizer: Annual European Society for Artificial Organs Congress (45)
  • Int'l Joint Research
• [Presentation] Native heart load control system (NHLCS) for continuous-flow LVAD: a comprehensive review and updates (2018)
  • Author(s): Nishimura T, Shimamura J, Akiyama D, Iizuka K, Naito N, Date K, Umeki A, Ando M, Kishimoto S, Kishimoto Y, Arakawa M, Mizuno T., Tsukiya T, Takewa Y, Ono M, Tatsumi E
  • Organizer: Annual meeting of Japanese society for Artificial Organs
  • Invited
• [Presentation] ECG-synchronized rotational speed change system has preventive effect on right heart failure during continuous-flow left ventricular assist device support (2017)
  • Author(s): Akiyama D, Nishimura T, Tatsumi E
  • Organizer: ASAIO 63th annual conference
  • Int'l Joint Research
• [Presentation] Control of LVADs: Native Heart Load Control System. (2017)
  • Author(s): Nishimura T
  • Organizer: The 44th ESAO and 7th IFAO-Congress
  • Int'l Joint Research / Invited
• [Presentation] ECG-synchronized rotational speed change system has preventive effect on right heart failure during continuous-flow left ventricular assist device support (2017)
  • Author(s): Akiyama D, Nishimura T, Tatsumi E
  • Organizer: The 44th ESAO and 7th IFAO-Congress
  • Int'l Joint Research
• [Presentation] Development of accurate quantification method of aortic insufficiency during LVAD by thermodilution technique (2017)
  • Author(s): Akiyama D, Nishimura T, Tatsumi E
  • Organizer: The 2017 ISMCS conference
  • Int'l Joint Research
• [Presentation] The current situation of NHLCS (2017)
  • Author(s): Nishimura T, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Kishimoto S, Date K, Naito N, Akiyama D, Iizuka K, Tatsumi E
  • Organizer: The 2017 ISMCS conference
  • Int'l Joint Research / Invited
• [Presentation] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムがvon Willebrand factorに及ぼす影響 (2015)
  • Author(s): 内藤敬嗣，西村 隆，岸本 諭，水野敏秀，武輪能明，樋口（江浦）由佳，小亀浩市，宮田敏行，小野 稔，巽 英介
  • Organizer: 第53回日本人工臓器学会大会
  • Place of Presentation: 東京ドームホテル、東京都文京区
  • Year and Date: 2015-11-19
• [Presentation] 定常流型左室補助人工心臓を用いた自己心拍同期システムの冠血流量の増加効果と左室仕事量の軽減効果 (2015)
  • Author(s): 荒川 衛，西村 隆，武輪能明，梅木昭秀，安藤政彦，岸本祐一郎，岸本 諭，藤井 豊，安達秀雄，巽 英介
  • Organizer: 第53回日本人工臓器学会大会
  • Place of Presentation: 東京ドームホテル、東京都文京区
  • Year and Date: 2015-11-19
• [Presentation] What is an optimal setting of continuous-flow left ventricular assist device for severe mitral regurgitation? (2015)
  • Author(s): Naito N, Nishimura T, Kishimoto S, Takewa Y, Ono M, Tatsumi E
  • Organizer: American Heart Association Scientific Sessions 2015
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Continuous-flow LVAD control with cardiac cycle synchronization (2015)
  • Author(s): Nishimura T, Naito N, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Date K, Tatsumi E
  • Organizer: Annual Conference of the Asia-Pacific Society for Artificial Organs
  • Place of Presentation: Gangwondo, Korea
  • Year and Date: 2015-10-25
  • Int'l Joint Research / Invited
• [Presentation] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムが僧帽弁閉鎖不全症に及ぼす影響 (2015)
  • Author(s): 内藤敬嗣，西村 隆，武輪能明，岸本 諭，伊達数馬，梅木昭秀，安藤政彦，小野 稔，巽 英介
  • Organizer: 第68回日本胸部外科学会定期学術集会
  • Place of Presentation: 神戸ポートピアホテル、兵庫県神戸市
  • Year and Date: 2015-10-17
• [Presentation] Influence of a rotational speed modulation of an implantable continuous-flow left ventricular assist device (EVAHEART) on von Willebrand's factor dynamics (2015)
  • Author(s): Naito N, Nishimura T, Kishimoto S, Mizuno T, Takewa Y, Ehara-Higuchi Y, Kokame K, Ono M, Tatsumi E
  • Organizer: 23rd Annual Congress of the International Society for Rotary Blood Pump (23)
  • Place of Presentation: Dubrovnik, Croaria
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] Control of mitral regurgitation by a continuous-flow left ventricular assist device with a native heart control system (2015)
  • Author(s): Naito N, Nishimura T, Kishimoto S, Takewa Y, Ono M, Tatsumi E
  • Organizer: ASAIO 61th annual conference
  • Place of Presentation: chicago, USA
  • Year and Date: 2015-06-25
  • Int'l Joint Research
• [Presentation] Cotrol of left ventricular load and pulsatility by a continuous flow left ventricular assist device with a Native Heart Load Control System in a chronic awake phase (2014)
  • Author(s): Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi
  • Organizer: 2014 AHA scientific sessions
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 定常流型左室補助人工心臓に用いる自己心拍数同期回転数制御システムが術後慢性期に心拍数に及ぼす影響 (2014)
  • Author(s): 伊達 数馬、西村 隆、武輪 能明、岸本 諭、荒川 衛、梅木 昭秀、安藤 雅彦、水野 敏秀、築谷 朋典、小野 稔、巽 英介
  • Organizer: 日本人工臓器学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] What is the optimal difference of the change in the rotational speed with a rotary LVAD by a Native Heart Load Control System? (2014)
  • Author(s): Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi
  • Organizer: 22nd congress of ISRBP
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] The comparison between synchronization and non-synchronization with cardiac beat under pulsatile mode with a rotary LVAD by a Native Heart Load Control System (2014)
  • Author(s): Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Minoru Ono, Eisuke Tatsumi
  • Organizer: 41st annual ESAO congress
  • Place of Presentation: Roma, Italy
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a Native Heart Load Control System in chronic awake phase (2014)
  • Author(s): Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi
  • Organizer: ASAIO 60th annual conference
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2014-06-18 – 2014-06-21
• [Presentation] Development of a tissue-compatible apical inflow cannula for an implantable (2013)
  • Author(s): Mizuno T, Tsukiya T, Takewa Y, Tatsumi E
  • Organizer: 33th International Society for Heart and Lung Transplantation Annual Meeting and Scientific Sessions
  • Place of Presentation: モントリオール
• [Presentation] Development of a novel autologous valve with a stent (Biovalve stent) for transcatheter implantation (2013)
  • Author(s): Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Kishimoto S, Atsuta Y, Ohnuma K, Sumikura H, Mizuno T, Kanda K, Tajikawa T, Taenaka Y, Tatsumi E
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] In vivo evaluation of the percutaneous site of VAD system (2013)
  • Author(s): Atsuta Y, Mizuno T, Takewa Y, Tsukiya T, Kakuta Y, Katagiri N, Ohnuma K, Sumikura H, Fujii Y, Arakawa M, Togo K, Kishimoto S, Tatsumi E
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] Media coverage of revised act on organ transplantation in Japan (2013)
  • Author(s): Nakada H, Tatsumi E, Muto K, Taenaka Y
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] Enchantment of the myocardial perfusion by a novel cardiac cycle-synchronized rotation control mode in a continuous-flow in chronic ischemic heart failure model (2013)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Date K, Atsuta Y, Fujii Y, Kishimoto S, Kyo S, Adachi H, Tatsumi E
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] Hydrogen gas suppresses systemic inflammatory response during cardiopulmonary bypass in a rat model (2013)
  • Author(s): Fujii Y, Tatsumi E, Shirai M, Takewa Y, Taenaka Y
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] A proposal of flexible control algorithm for artificial heart based on stochastic method (2013)
  • Author(s): Ohnuma K, Sumikura H, Homma A, Tsukiya T, Mizuno T, Takewa Y, Akagawa E, Fukui Y, Tatsumi E
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] In vitro and in vivo evaluation of a compact wearable pneumatic drive unit for a ventricular assist device (2013)
  • Author(s): Sumikura H, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mizuno T, Tsukiya T, Katagiri N, Kakuta Y, Mukaibayashi H, Katano K, Kojma K, Fukui Y, Tatsumi E
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] Pathological observation in the goat following prolonged venoarterial bypass using an extracoporeal membrane oxygenation (2013)
  • Author(s): Mizuno T, Katagiri N, Tsukiya T, Takewa Y, Tatsumi E,
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] Practical operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation (2013)
  • Author(s): Togo K, Takawa Y, Mizuno T, Tsukiya T, Atsuta Y, Arakawa M, Kishinmoto S, Katagiri N, Kakuta Y, Fujii Y, Sumikura H, Ohnuma K, Taenaka Y, MiyamotoY, Tatsumi E
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] Evaluation of long-term durability of an antithrombogenic-coated ECMO system with Gyro pump (2013)
  • Author(s): Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Kobara D, Yanagisono Y, Taenaka Y
  • Organizer: 59th American Society for Artificial Internal Organs
  • Place of Presentation: シカゴ
• [Presentation] The effect or continuous-flow LVAD control with cardiac cycle synchronization (2013)
  • Author(s): Nishimura T, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Date K, Tatsumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] Long-term evaluation of a durable and thrombo-resistant ECMO system consisting of BIOCUBE6000 and SOFTLINE coated RATAFLOW (2013)
  • Author(s): Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Atsuta Y, Kato Y, Taenaka Y
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] Ethical issues of clinical trials of artificial hearts: past ,present, and future (2013)
  • Author(s): Nakada H, Matsui K, Aizawa K, Muto K, Tatsumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] Field investigation of the approaches to promote the development of orphan medical devices in the United States (2013)
  • Author(s): Ohya T, Akagawa E, Tatsumi E, Taenaka Y
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] Hyperoxia condition promotes an inflammatory response during extracorporeal circulation in a rat model (2013)
  • Author(s): Fujii Y, Tatsumi E, Shirai M, Takewa Y, Taenaka Y
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] Pathological changes in cardio-pulmonary tissue of the goat following prolonged venoarterial ECMO (2013)
  • Author(s): Mizuno T, Katagiri N, Tsukiya T, Takewa Y, Tatsumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] The safe program for a newly developed electrocardiogram-synchronized rotational speed control mode with continuous-flow left ventricular assist device (2013)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Fujii Y, Kyo S, Adachi H, Tatsumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] A non-invasive assessment of cardiac function during continuous-flow LVAD support by HRV analysis (2013)
  • Author(s): Kishimoto S, Kishimoto Y, Ohnuma K, Arakawa M, Date K, Takewa Y, Nishimura M, Tatsumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] The potentially of non-synchronized pulsatile mode with a rotary LVAD by a native heart load control system (2013)
  • Author(s): Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] Motor performance of magnetically levitated paediatric VAD (2013)
  • Author(s): Omori N, Masuzawa T, Osa M, Tatsumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] Assessment of the cannula exit site infection in two different configuration, porous material coverd vs non-coverd tube (2013)
  • Author(s): Mizuno T, Takewa Y, Tsukiya T, Yanagisono Y, Kobara, Taenaka Y, Tasumi E
  • Organizer: 第51回日本人工臓器学会大会/第５回 International Federation for Artificial Organs
  • Place of Presentation: 横浜
• [Presentation] The titanium mesh shows great biocompatibility with regenerated endothelial cells on the surface (2013)
  • Author(s): Miyamoto T, Nishinaka T, Suzuki K, Mizuno T, Tatsumi E, Yamazaki K
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] In vitro evaluation of the hydrodynamically levitated centrifugal blood pump as a extracorporeal ventricular assist device (2013)
  • Author(s): Tsukiya T, Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Hoshi H, Okubo T, Tatsumi E, Taenaka Y
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] Long-term durability test of the developing axial-flow ventricular assist devices under pulsatile (2013)
  • Author(s): Nishida M, Kosaka R, Maruyama O, Yamane T, Okubo T, Hoshi H, Osada T, Tatsumi E, Taenaka Y
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] Optimization of ACT for in vitro antithrombogenic evaluation of a continuous flow pump (2013)
  • Author(s): Maruyama O, Kosaka R, Nishida M, Yamane T, Tatsumi E, Taenaka Y
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] Longtime pulsatile control using a rotary blood pump with a newly developed electrocardiogram synchronized rotational speed control system (2013)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Yamazaki K, Kyo S, Adachi H, Tatsumi E
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] The difference between front load and delay load in the pulsatile mode with a rotary LVAD by a native heart load control system (2013)
  • Author(s): Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] Chronic animal test of the SUNMEDICAL EVAHEART with titanium meshed inflow cannula in accordance with good laboratory practice (2013)
  • Author(s): Mizuno T, Kitano T, Miyakoshi T, Tokuno T, Tsukiya T, Nishinaka T, Yamazaki K, Tatsumi E
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] The establishement of the quantitative evaluation standard for the anatomical adaptability of the ventricular assist device (2013)
  • Author(s): Homma A, Mita Y, Ohgoe Y, Nishinaka T, Tatsumi E, Taenaka Y, Fukui Y
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] Evaluation of long-term durability of a T-NCVC coated ECMO system with GYRO pump for cardiopulmonary support use (2013)
  • Author(s): Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Kobara D, Yanaginoso Y, Taenaka Y
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation and decarboxylation (2013)
  • Author(s): Togo K, Takewa Y, Tsukiya T, Mizuno T, Katagiri N, Atsuta Y, Fujii Y, Kishimoto S, Date K, Sumikura H, Ohnuma K, Kakuta Y, Miyamoto Y, Tatsumi E
  • Organizer: 21th International Society for Rotary Blood Pumps
  • Place of Presentation: 横浜
• [Presentation] Development of a novel autologous valve with stent (Biovalave stent) for TAVI (2013)
  • Author(s): Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Ohnuma K, Sumikura H, Tajikawa T, Kanada K, Taenaka Y, Tatsumi E
  • Organizer: Heart Valve Society of America 7th Biennial congress
  • Place of Presentation: ベニス
• [Presentation] Systemic application of a completely autologous valved conduit (BIOVALVE Type VIII) prepared by in body tissue architecture tchnology in a goat model (2013)
  • Author(s): Nakayama Y, Takewa Y, Sumikura H, Yamanami M, Ohnuma K, Kanda K, Tatsumi E
  • Organizer: Heart Valve Society of America 7th Biennial congress
  • Place of Presentation: ベニス
• [Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation (2013)
  • Author(s): Togo K, Atsuta Y, Fujii Y, Kakuta Y, Katagiri N, Kishimoto Y, Miyamoto T, Mizuno T, Ohnuma K, Sumikura H, Taenaka Y, Takewa Y, Tatsumi E, Tsukiya T
  • Organizer: 40th European Society for Artificial Organs
  • Place of Presentation: グラスゴー
• [Presentation] Evaluation of novel autologous heart valve (Biovalve Stent) for transcatheter aortic valve implantation (2013)
  • Author(s): Takewa Y, Kanada K, Nakayama Y, Sumikura H, Taenaka Y, Tajikawa T, Tatsumi E, Yamanami M
  • Organizer: 40th European Society for Artificial Organs
  • Place of Presentation: グラスゴー
• [Presentation] Can human biotubes be used as artificial vascular grafts? (2013)
  • Author(s): Nakayama Y, Takewa Y, Kaneko T, Yamanami M, Mizuno T, Kwajiri H, Okumura N, Hanada S, Kanda K, Tatsumi E
  • Organizer: 40th European Society for Artificial Organs
  • Place of Presentation: グラスゴー
• [Presentation] Novel stent eversion method for the preparation of autologous valve with stent (Stent-Biovalve) (2013)
  • Author(s): Mizuno T, Takewa Y, Sumikura H, Omura T, Tsujinaka T, Yamanami M, Tatsumi E, Nakayama Y
  • Organizer: 40th European Society for Artificial Organs
  • Place of Presentation: グラスゴー
• [Presentation] 動圧軸受を応用した長期使用血液ポンプの研究開発 (2013)
  • Author(s): 築谷朋典、巽英介、妙中義之
  • Organizer: 日本機械学会 第91期流体工学部門講演会
  • Place of Presentation: 九州