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Novel treatment method for extensive myocardial infarction with ventricular assist device using an electrocardiography-synchronized rotational speed control

Research Project

Project/Area Number 25293294
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionOsaka University (2018)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2013-2017)

Principal Investigator

Takashi Nishimura  大阪大学, 医学系研究科, 特任准教授(常勤) (80433655)

Co-Investigator(Kenkyū-buntansha) 巽 英介  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00216996)
許 俊鋭  東京大学, 医学部附属病院, 研究員 (30153232)
Project Period (FY) 2013-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords補助人工心臓 / 心拍同期制御 / Bridge to Recovery / 広範囲心筋梗塞 / 制御 / 心不全 / 右心不全 / von Willebrand factor / 冠動脈外科学 / 心拍同期制御システム
Outline of Final Research Achievements

Effects of an electrocardiography-synchronized rotational speed control of continuous flow ventricular assist device for extensive myocardial infarction were clarified. Severe mitral valve regurgitation which accompanying with massive myocardial infarction can be controlled by this system using reduction of left ventricular end-diastolic pressure. Also found damage to momentary high rotation by blood caused by the electrocardiography-synchronized rotational speed control system that does not negatively affect to the coagulation system. Local dyssynchrony caused by massive myocardial infarction can treated by this system and the cardiac output will be recovered. These various effects through massive myocardial infarction revealed that can more effectively treated by an electrocardiography-synchronized rotational speed control of continuous flow ventricular assist device.

Academic Significance and Societal Importance of the Research Achievements

本研究によって明らかにされた定常流ポンプの自己心拍同期制御の広範囲心筋梗塞に及ぼす影響は、今後、極めて死亡率の高い本疾患の死亡率を軽減せしめる可能性を有するのみならず、本疾患に伴う心不全を軽減させて社会復帰にまで導く可能性もある。今回明らかにした効果をより詳細に検討することによって、重症心不全治療戦略全体に影響を与える可能性もある。

Report

(7 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (84 results)

All 2019 2018 2017 2016 2015 2014 2013

All Journal Article (25 results) (of which Peer Reviewed: 22 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (59 results) (of which Int'l Joint Research: 11 results,  Invited: 4 results)

  • [Journal Article] Miniaturized centrifugal ventricular assist device for bridge to decision: preclinical chronic study in a bovine model.2019

    • Author(s)
      Shimamura J, Mizuno T, Takewa Y, Tsukiya T, Naito N, Akiyama D, Iiduka K, Katagiri N, Nishimura T, Ono M, Tatsumi E.
    • Journal Title

      Artif Organs.

      Volume: 印刷中 Issue: 9 Pages: 821-827

    • DOI

      10.1111/aor.13459

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accurate Method of Quantification of Aortic Insufficiency During Left Ventricular Assist Device Support by Thermodilution Analysis: Proof of Concept and Validation by a Mock Circulatory System.2018

    • Author(s)
      Akiyama D, Nishimura T, Sumikura H, Iizuka K, Mizuno T, Tsukiya T, Takewa Y, Ono M, Tatsumi E.
    • Journal Title

      Artif Organs.

      Volume: 42(10) Issue: 10 Pages: 954-960

    • DOI

      10.1111/aor.13158

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rotational speed modulation used with continuous-flow left ventricular assist device provides good pulsatility.2018

    • Author(s)
      Naito N, Nishimura T, Iizuka K, Takewa Y, Umeki A, Ando M, Ono M, Tatsumi E.
    • Journal Title

      Interact Cardiovasc Thorac Surg.

      Volume: 26(1) Issue: 1 Pages: 119-123

    • DOI

      10.1093/icvts/ivx236

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Journal Article] Novel Rotational Speed Modulation System Used With Venoarterial Extracorporeal Membrane Oxygenation.2017

    • Author(s)
      Naito N, Nishimura T, Iizuka K, Fujii Y, Takewa Y, Umeki A, Ando M, Ono M, Tatsumi E.
    • Journal Title

      Ann Thorac Surg.

      Volume: 104(5) Pages: 1488-1495

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device2017

    • Author(s)
      Date K, Nishimura T, Arakawa M, Takewa Y, Kishimoto S, Umeki A, Ando M, Mizuno T, Tsukiya T, Ono M, Tatsumi E
    • Journal Title

      JOURNAL OF ARTIFICIAL ORGANS

      Volume: 20(1) Issue: 1 Pages: 18-25

    • DOI

      10.1007/s10047-016-0920-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shifting the pulsatility by increasing the change in rotational speed for a rotary LVAD using a native heart load control system.2016

    • Author(s)
      Date K, Nishimura T, Takewa Y, Kishimoto S, Arakawa M, Umeki A, Ando M, Mizuno T, Tsukiya T, Ono M, Tatsumi E.
    • Journal Title

      JOURNAL OF ARTIFICIAL ORGANS

      Volume: online Issue: 4 Pages: 315-321

    • DOI

      10.1007/s10047-016-0906-9

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] What Is the Optimal Setting for a Continuous-Flow Left Ventricular Assist Device in Severe Mitral Regurgitation?2016

    • Author(s)
      Naito N, Nishimura T, Takewa Y, Kishimoto S, Date K, Umeki A, Ando M, Ono M, Tatsumi E
    • Journal Title

      Artificial Organs

      Volume: 未定 Issue: 11 Pages: 1039-1045

    • DOI

      10.1111/aor.12702

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pulsatile support using a rotary left ventricular assist device with an electrocardiography-synchronized rotational speed control mode for tracking heart rate variability2016

    • Author(s)
      Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Fujii Y, Date K, Kyo S, Adachi H, Tatsumi E
    • Journal Title

      JOURNAL OF ARTIFICIAL ORGANS

      Volume: 19(2) Issue: 2 Pages: 204-207

    • DOI

      10.1007/s10047-015-0875-4

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of a rotational speed modulation system used with an implantable continuous-flow left ventricular assist device (EVAHEART) on von Willebrand factor dynamics2016

    • Author(s)
      Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, and Eisuke Tatsumi
    • Journal Title

      Artif. Organs

      Volume: 未定 Issue: 9 Pages: 877-883

    • DOI

      10.1111/aor.12666

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel control system to prevent right ventricular failure induced by rotary blood pump2016

    • Author(s)
      荒川衛 西村隆 武輪能明 巽英介
    • Journal Title

      人工臓器

      Volume: 45(1) Pages: 18-25

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Effects of feeding state on anticoagulation in adult goats treated with warfarin2016

    • Author(s)
      Date K, Kishimoto S, Fujii Y, Togo K, Kakut Y, Mizuno T, Tsukiya T, Takewa Y, Nishimura T, Ono M, Tatsumi E
    • Journal Title

      JOURNAL OF ARTIFICIAL ORGANS

      Volume: online Issue: 3 Pages: 301-304

    • DOI

      10.1007/s10047-016-0885-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models2015

    • Author(s)
      梅木昭秀、西村 隆、武輪能明、安藤政彦、荒川 衛、岸本祐一郎、築谷朋典、水野敏秀、許 俊鋭、小野 稔、妙中義之、巽 英介
    • Journal Title

      人工臓器

      Volume: 44(1) Pages: 12-13

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Influence of a novel electrocardiogram-synchronized rotational-speed-change system of an implantable continuous-flow left ventricular assist device (EVAHEART) on hemolytic performance2014

    • Author(s)
      Kishimoto, S; Date, K; Arakawa, M; Takewa, Y; Nishimura, T; Tsukiya, T; Mizuno, T; Katagiri, N; Kakuta, Y; Ogawa, D; Nishimura, M; Tatsumi, E
    • Journal Title

      JOURNAL OF ARTIFICIAL ORGANS

      Volume: 17 Issue: 4 Pages: 373-377

    • DOI

      10.1007/s10047-014-0787-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel control system to prevent right ventricular failure induced by rotary blood pump2014

    • Author(s)
      Arakawa, M; Nishimura, T; Takewa, Y; Umeki, A; Ando, M; Kishimoto, Y; Fujii, Y; Kyo, S; Adachi, H; Tatsumi, E
    • Journal Title

      JOURNAL OF ARTIFICIAL ORGANS

      Volume: 17 Issue: 2 Pages: 134-141

    • DOI

      10.1007/s10047-014-0757-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model.2014

    • Author(s)
      Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Adachi H, Tatsumi E.
    • Journal Title

      J Thorac Cardiovasc Surg.

      Volume: Epub ahead of print Issue: 2 Pages: 1-10

    • DOI

      10.1016/j.jtcvs.2013.12.049

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model2014

    • Author(s)
      Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Adachi H, Tatsumi E.
    • Journal Title

      J Thorac Cardiovasc Surg.

      Volume: Epub ahead of print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel control system to prevent right ventricular failure induced by rotary blood pump.2014

    • Author(s)
      Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Fujii Y, Kyo S, Adachi H, Tatsumi E
    • Journal Title

      J Artif Organs.

      Volume: Epub ahead of print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of an autologous heart valve with a stent (stent-biovalve) using the stent eversion method2014

    • Author(s)
      Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Moriwaki T, Yamanami M, Oie T, Tatsumi E, Uechi M, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: Dec 9 Issue: 5 Pages: 1-10

    • DOI

      10.1002/jbm.b.33086

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro evaluation of a novel autologous aortic valve (Biovalve) with a pulsatile circulation circuit2014

    • Author(s)
      Sumikura H, Nakayama Y, Ohmuma K, Takewa Y, Tastumi E
    • Journal Title

      Artif Organs

      Volume: (in press) Issue: 4 Pages: 282-9

    • DOI

      10.1111/aor.12173

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat2013

    • Author(s)
      Kishimoto Y1, Takewa Y, Arakawa M, Umeki A, Ando M, Nishimura T, Fujii Y, Mizuno T, Nishimura M, Tatsumi E
    • Journal Title

      J Artif Organs.

      Volume: 16(2) Issue: 2 Pages: 129-37

    • DOI

      10.1007/s10047-012-0685-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models.2013

    • Author(s)
      Umeki A1, Nishimura T, Takewa Y, Ando M, Arakawa M, Kishimoto Y, Tsukiya T, Mizuno T, Kyo S, Ono M, Taenaka Y, Tatsumi E
    • Journal Title

      J Artif Organs.

      Volume: 16(2) Issue: 2 Pages: 119-28

    • DOI

      10.1007/s10047-012-0682-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo evaluation of an in-body, tissue-engineered, completely autologous valved conduit (biovalve type VI) as an aortic valve in a goat model2013

    • Author(s)
      Takewa Y, Yamanami M, Kishimoto Y, Arakawa M, Kanda K, Matsui Y, Oie T, Ishibashi-Ueda H, Tajikawa T, Ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y
    • Journal Title

      J Artif Organs

      Volume: 25 Issue: 2 Pages: 176-184

    • DOI

      10.1007/s10047-012-0679-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperoxic condition promotes an inflammatory response during cardiopulmonary bypass in a rat model.2013

    • Author(s)
      Fujii Y, Shirai M, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.
    • Journal Title

      Artif Organs.

      Volume: 37(12) Issue: 12 Pages: 1034-40

    • DOI

      10.1111/aor.12125

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early clinical outcomes of new pediatric extracorporeal life support system (Endumo (2000) in neonates and infants.2013

    • Author(s)
      Hoashi T1, Kagisaki K, Yamashita K, Tatsumi E, Nishigaki T, Yoshida K, Hayashi T, Ichikawa H
    • Journal Title

      J Artif Organs.

      Volume: 16(3) Issue: 3 Pages: 267-72

    • DOI

      10.1007/s10047-013-0713-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of endurance test system for ventricular assist devices2013

    • Author(s)
      Sumikura H1, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mukaibayashi H, Katano K, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: 16(2) Issue: 2 Pages: 138-48

    • DOI

      10.1007/s10047-013-0687-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Electrocardiogram-synchronized rotational speed modulation system can reduce the recirculation due to aortic insufficiency in LVAD support2018

    • Author(s)
      Akiyama D, Nishimura T, Iizuka K, Mizuno T, Tsukiya T, Takewa Y, Ono M, Tatsumi E
    • Organizer
      International Society for Heart and Lung Transplantation Annual Meeting and Scientific Sessions (38)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrocardiogram-synchronized rotational speed modulation system can reduce the recirculation due to aortic insufficiency in left ventricular assist device support2018

    • Author(s)
      Iizuka K, Akiyama D, Mizuno T, Tsukiya T, Takewa Y, Nishimura T, Tatsumi E
    • Organizer
      Annual European Society for Artificial Organs Congress (45)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Native heart load control system (NHLCS) for continuous-flow LVAD: a comprehensive review and updates2018

    • Author(s)
      Nishimura T, Shimamura J, Akiyama D, Iizuka K, Naito N, Date K, Umeki A, Ando M, Kishimoto S, Kishimoto Y, Arakawa M, Mizuno T., Tsukiya T, Takewa Y, Ono M, Tatsumi E
    • Organizer
      Annual meeting of Japanese society for Artificial Organs
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ECG-synchronized rotational speed change system has preventive effect on right heart failure during continuous-flow left ventricular assist device support2017

    • Author(s)
      Akiyama D, Nishimura T, Tatsumi E
    • Organizer
      ASAIO 63th annual conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of LVADs: Native Heart Load Control System.2017

    • Author(s)
      Nishimura T
    • Organizer
      The 44th ESAO and 7th IFAO-Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ECG-synchronized rotational speed change system has preventive effect on right heart failure during continuous-flow left ventricular assist device support2017

    • Author(s)
      Akiyama D, Nishimura T, Tatsumi E
    • Organizer
      The 44th ESAO and 7th IFAO-Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of accurate quantification method of aortic insufficiency during LVAD by thermodilution technique2017

    • Author(s)
      Akiyama D, Nishimura T, Tatsumi E
    • Organizer
      The 2017 ISMCS conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The current situation of NHLCS2017

    • Author(s)
      Nishimura T, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Kishimoto S, Date K, Naito N, Akiyama D, Iizuka K, Tatsumi E
    • Organizer
      The 2017 ISMCS conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムがvon Willebrand factorに及ぼす影響2015

    • Author(s)
      内藤敬嗣,西村 隆,岸本 諭,水野敏秀,武輪能明,樋口(江浦)由佳,小亀浩市,宮田敏行,小野 稔,巽 英介
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル、東京都文京区
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 定常流型左室補助人工心臓を用いた自己心拍同期システムの冠血流量の増加効果と左室仕事量の軽減効果2015

    • Author(s)
      荒川 衛,西村 隆,武輪能明,梅木昭秀,安藤政彦,岸本祐一郎,岸本 諭,藤井 豊,安達秀雄,巽 英介
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル、東京都文京区
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] What is an optimal setting of continuous-flow left ventricular assist device for severe mitral regurgitation?2015

    • Author(s)
      Naito N, Nishimura T, Kishimoto S, Takewa Y, Ono M, Tatsumi E
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Continuous-flow LVAD control with cardiac cycle synchronization2015

    • Author(s)
      Nishimura T, Naito N, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Date K, Tatsumi E
    • Organizer
      Annual Conference of the Asia-Pacific Society for Artificial Organs
    • Place of Presentation
      Gangwondo, Korea
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムが僧帽弁閉鎖不全症に及ぼす影響2015

    • Author(s)
      内藤敬嗣,西村 隆,武輪能明,岸本 諭,伊達数馬,梅木昭秀,安藤政彦,小野 稔,巽 英介
    • Organizer
      第68回日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸ポートピアホテル、兵庫県神戸市
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Influence of a rotational speed modulation of an implantable continuous-flow left ventricular assist device (EVAHEART) on von Willebrand's factor dynamics2015

    • Author(s)
      Naito N, Nishimura T, Kishimoto S, Mizuno T, Takewa Y, Ehara-Higuchi Y, Kokame K, Ono M, Tatsumi E
    • Organizer
      23rd Annual Congress of the International Society for Rotary Blood Pump (23)
    • Place of Presentation
      Dubrovnik, Croaria
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of mitral regurgitation by a continuous-flow left ventricular assist device with a native heart control system2015

    • Author(s)
      Naito N, Nishimura T, Kishimoto S, Takewa Y, Ono M, Tatsumi E
    • Organizer
      ASAIO 61th annual conference
    • Place of Presentation
      chicago, USA
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cotrol of left ventricular load and pulsatility by a continuous flow left ventricular assist device with a Native Heart Load Control System in a chronic awake phase2014

    • Author(s)
      Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi
    • Organizer
      2014 AHA scientific sessions
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 定常流型左室補助人工心臓に用いる自己心拍数同期回転数制御システムが術後慢性期に心拍数に及ぼす影響2014

    • Author(s)
      伊達 数馬、西村 隆、武輪 能明、岸本 諭、荒川 衛、梅木 昭秀、安藤 雅彦、水野 敏秀、築谷 朋典、小野 稔、巽 英介
    • Organizer
      日本人工臓器学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] What is the optimal difference of the change in the rotational speed with a rotary LVAD by a Native Heart Load Control System?2014

    • Author(s)
      Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi
    • Organizer
      22nd congress of ISRBP
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] The comparison between synchronization and non-synchronization with cardiac beat under pulsatile mode with a rotary LVAD by a Native Heart Load Control System2014

    • Author(s)
      Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Minoru Ono, Eisuke Tatsumi
    • Organizer
      41st annual ESAO congress
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a Native Heart Load Control System in chronic awake phase2014

    • Author(s)
      Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi
    • Organizer
      ASAIO 60th annual conference
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of a tissue-compatible apical inflow cannula for an implantable2013

    • Author(s)
      Mizuno T, Tsukiya T, Takewa Y, Tatsumi E
    • Organizer
      33th International Society for Heart and Lung Transplantation Annual Meeting and Scientific Sessions
    • Place of Presentation
      モントリオール
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of a novel autologous valve with a stent (Biovalve stent) for transcatheter implantation2013

    • Author(s)
      Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Kishimoto S, Atsuta Y, Ohnuma K, Sumikura H, Mizuno T, Kanda K, Tajikawa T, Taenaka Y, Tatsumi E
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo evaluation of the percutaneous site of VAD system2013

    • Author(s)
      Atsuta Y, Mizuno T, Takewa Y, Tsukiya T, Kakuta Y, Katagiri N, Ohnuma K, Sumikura H, Fujii Y, Arakawa M, Togo K, Kishimoto S, Tatsumi E
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Media coverage of revised act on organ transplantation in Japan2013

    • Author(s)
      Nakada H, Tatsumi E, Muto K, Taenaka Y
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enchantment of the myocardial perfusion by a novel cardiac cycle-synchronized rotation control mode in a continuous-flow in chronic ischemic heart failure model2013

    • Author(s)
      Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Date K, Atsuta Y, Fujii Y, Kishimoto S, Kyo S, Adachi H, Tatsumi E
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hydrogen gas suppresses systemic inflammatory response during cardiopulmonary bypass in a rat model2013

    • Author(s)
      Fujii Y, Tatsumi E, Shirai M, Takewa Y, Taenaka Y
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] A proposal of flexible control algorithm for artificial heart based on stochastic method2013

    • Author(s)
      Ohnuma K, Sumikura H, Homma A, Tsukiya T, Mizuno T, Takewa Y, Akagawa E, Fukui Y, Tatsumi E
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vitro and in vivo evaluation of a compact wearable pneumatic drive unit for a ventricular assist device2013

    • Author(s)
      Sumikura H, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mizuno T, Tsukiya T, Katagiri N, Kakuta Y, Mukaibayashi H, Katano K, Kojma K, Fukui Y, Tatsumi E
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pathological observation in the goat following prolonged venoarterial bypass using an extracoporeal membrane oxygenation2013

    • Author(s)
      Mizuno T, Katagiri N, Tsukiya T, Takewa Y, Tatsumi E,
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Practical operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation2013

    • Author(s)
      Togo K, Takawa Y, Mizuno T, Tsukiya T, Atsuta Y, Arakawa M, Kishinmoto S, Katagiri N, Kakuta Y, Fujii Y, Sumikura H, Ohnuma K, Taenaka Y, MiyamotoY, Tatsumi E
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Evaluation of long-term durability of an antithrombogenic-coated ECMO system with Gyro pump2013

    • Author(s)
      Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Kobara D, Yanagisono Y, Taenaka Y
    • Organizer
      59th American Society for Artificial Internal Organs
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effect or continuous-flow LVAD control with cardiac cycle synchronization2013

    • Author(s)
      Nishimura T, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Date K, Tatsumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Long-term evaluation of a durable and thrombo-resistant ECMO system consisting of BIOCUBE6000 and SOFTLINE coated RATAFLOW2013

    • Author(s)
      Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Atsuta Y, Kato Y, Taenaka Y
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ethical issues of clinical trials of artificial hearts: past ,present, and future2013

    • Author(s)
      Nakada H, Matsui K, Aizawa K, Muto K, Tatsumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Field investigation of the approaches to promote the development of orphan medical devices in the United States2013

    • Author(s)
      Ohya T, Akagawa E, Tatsumi E, Taenaka Y
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hyperoxia condition promotes an inflammatory response during extracorporeal circulation in a rat model2013

    • Author(s)
      Fujii Y, Tatsumi E, Shirai M, Takewa Y, Taenaka Y
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pathological changes in cardio-pulmonary tissue of the goat following prolonged venoarterial ECMO2013

    • Author(s)
      Mizuno T, Katagiri N, Tsukiya T, Takewa Y, Tatsumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] The safe program for a newly developed electrocardiogram-synchronized rotational speed control mode with continuous-flow left ventricular assist device2013

    • Author(s)
      Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Fujii Y, Kyo S, Adachi H, Tatsumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] A non-invasive assessment of cardiac function during continuous-flow LVAD support by HRV analysis2013

    • Author(s)
      Kishimoto S, Kishimoto Y, Ohnuma K, Arakawa M, Date K, Takewa Y, Nishimura M, Tatsumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] The potentially of non-synchronized pulsatile mode with a rotary LVAD by a native heart load control system2013

    • Author(s)
      Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Motor performance of magnetically levitated paediatric VAD2013

    • Author(s)
      Omori N, Masuzawa T, Osa M, Tatsumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Assessment of the cannula exit site infection in two different configuration, porous material coverd vs non-coverd tube2013

    • Author(s)
      Mizuno T, Takewa Y, Tsukiya T, Yanagisono Y, Kobara, Taenaka Y, Tasumi E
    • Organizer
      第51回日本人工臓器学会大会/第5回 International Federation for Artificial Organs
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] The titanium mesh shows great biocompatibility with regenerated endothelial cells on the surface2013

    • Author(s)
      Miyamoto T, Nishinaka T, Suzuki K, Mizuno T, Tatsumi E, Yamazaki K
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vitro evaluation of the hydrodynamically levitated centrifugal blood pump as a extracorporeal ventricular assist device2013

    • Author(s)
      Tsukiya T, Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Hoshi H, Okubo T, Tatsumi E, Taenaka Y
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Long-term durability test of the developing axial-flow ventricular assist devices under pulsatile2013

    • Author(s)
      Nishida M, Kosaka R, Maruyama O, Yamane T, Okubo T, Hoshi H, Osada T, Tatsumi E, Taenaka Y
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimization of ACT for in vitro antithrombogenic evaluation of a continuous flow pump2013

    • Author(s)
      Maruyama O, Kosaka R, Nishida M, Yamane T, Tatsumi E, Taenaka Y
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Longtime pulsatile control using a rotary blood pump with a newly developed electrocardiogram synchronized rotational speed control system2013

    • Author(s)
      Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Yamazaki K, Kyo S, Adachi H, Tatsumi E
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] The difference between front load and delay load in the pulsatile mode with a rotary LVAD by a native heart load control system2013

    • Author(s)
      Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chronic animal test of the SUNMEDICAL EVAHEART with titanium meshed inflow cannula in accordance with good laboratory practice2013

    • Author(s)
      Mizuno T, Kitano T, Miyakoshi T, Tokuno T, Tsukiya T, Nishinaka T, Yamazaki K, Tatsumi E
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] The establishement of the quantitative evaluation standard for the anatomical adaptability of the ventricular assist device2013

    • Author(s)
      Homma A, Mita Y, Ohgoe Y, Nishinaka T, Tatsumi E, Taenaka Y, Fukui Y
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Evaluation of long-term durability of a T-NCVC coated ECMO system with GYRO pump for cardiopulmonary support use2013

    • Author(s)
      Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Kobara D, Yanaginoso Y, Taenaka Y
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation and decarboxylation2013

    • Author(s)
      Togo K, Takewa Y, Tsukiya T, Mizuno T, Katagiri N, Atsuta Y, Fujii Y, Kishimoto S, Date K, Sumikura H, Ohnuma K, Kakuta Y, Miyamoto Y, Tatsumi E
    • Organizer
      21th International Society for Rotary Blood Pumps
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of a novel autologous valve with stent (Biovalave stent) for TAVI2013

    • Author(s)
      Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Ohnuma K, Sumikura H, Tajikawa T, Kanada K, Taenaka Y, Tatsumi E
    • Organizer
      Heart Valve Society of America 7th Biennial congress
    • Place of Presentation
      ベニス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Systemic application of a completely autologous valved conduit (BIOVALVE Type VIII) prepared by in body tissue architecture tchnology in a goat model2013

    • Author(s)
      Nakayama Y, Takewa Y, Sumikura H, Yamanami M, Ohnuma K, Kanda K, Tatsumi E
    • Organizer
      Heart Valve Society of America 7th Biennial congress
    • Place of Presentation
      ベニス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation2013

    • Author(s)
      Togo K, Atsuta Y, Fujii Y, Kakuta Y, Katagiri N, Kishimoto Y, Miyamoto T, Mizuno T, Ohnuma K, Sumikura H, Taenaka Y, Takewa Y, Tatsumi E, Tsukiya T
    • Organizer
      40th European Society for Artificial Organs
    • Place of Presentation
      グラスゴー
    • Related Report
      2013 Annual Research Report
  • [Presentation] Evaluation of novel autologous heart valve (Biovalve Stent) for transcatheter aortic valve implantation2013

    • Author(s)
      Takewa Y, Kanada K, Nakayama Y, Sumikura H, Taenaka Y, Tajikawa T, Tatsumi E, Yamanami M
    • Organizer
      40th European Society for Artificial Organs
    • Place of Presentation
      グラスゴー
    • Related Report
      2013 Annual Research Report
  • [Presentation] Can human biotubes be used as artificial vascular grafts?2013

    • Author(s)
      Nakayama Y, Takewa Y, Kaneko T, Yamanami M, Mizuno T, Kwajiri H, Okumura N, Hanada S, Kanda K, Tatsumi E
    • Organizer
      40th European Society for Artificial Organs
    • Place of Presentation
      グラスゴー
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel stent eversion method for the preparation of autologous valve with stent (Stent-Biovalve)2013

    • Author(s)
      Mizuno T, Takewa Y, Sumikura H, Omura T, Tsujinaka T, Yamanami M, Tatsumi E, Nakayama Y
    • Organizer
      40th European Society for Artificial Organs
    • Place of Presentation
      グラスゴー
    • Related Report
      2013 Annual Research Report
  • [Presentation] 動圧軸受を応用した長期使用血液ポンプの研究開発2013

    • Author(s)
      築谷朋典、巽英介、妙中義之
    • Organizer
      日本機械学会 第91期流体工学部門講演会
    • Place of Presentation
      九州
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2020-03-30  

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