Development of regenerative therapy for cardiovascular organ from induced pluripotent stem cells using new tissue engineering
| Project/Area Number |
25293298
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Nakayama Kouichi 佐賀大学, 医学部, 教授 (50420609)
Itoh Manabu 佐賀大学, 医学部, 助教 (50555084)
Noguchi Ryo 佐賀大学, 医学部, 助教 (70530187)
Node Kouichi 佐賀大学, 医学部, 教授 (80359950)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 再生医療 / 組織工学 / 心筋再生 / 血管再生 / 心臓血管外科 |
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| Outline of Final Research Achievements |
We developed a novel method to create scaffold-free tissue from spheroid using a robotics system. This system enables the creation of pre-designed three-dimensional structures using a computer controlled system. In this research, we introduced induced pluripotent stem cell technology into our three-dimensional system, established a model for building the myocardium and the vascular structure using cells derived from human iPS, and carried out functional analysis. For the purpose of upsizing and high functionality of the tissue, a bioreactor was developed in which tissues can be cultured over the long term within a more physiological environment. The manufacture of a structure that was implantable for the short term in an animal (mini-swine) was successful.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] The effectiveness of using a bio-3D printer in the development of a scaffold-free regenerative vascular graft.2015
Author(s)
Itoh M, Mukae Y, Matsubayashi K, Kawakatsu M, Furukawa K, Uchihashi K, Toda S, Oyama J, Node K, Nakayama K, Morita S.
Organizer
TERMIS World Congres
Place of Presentation
Boston
Year and Date
2015-09-08
Related Report
Int'l Joint Research
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[Presentation] ヒトiPS細胞由来心筋細胞凝集塊の機能的解析2015
Author(s)
迎 洋輔, 伊藤 学, 野口 亮, 諸隈宏之, 古賀秀剛, 柚木純二, 蒲原啓司, 古川浩二郎, 中山功一, 野出孝一, 森田茂樹
Organizer
第14回再生心臓血管外科治療研究会
Place of Presentation
京都
Year and Date
2015-02-16
Related Report
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[Presentation] 新規組織工学技術による次世代型小口径人工血管の開発2014
Author(s)
伊藤 学, 野口 亮, 山元博文, 佐藤 久, 諸隈宏之, 柚木純二, 蒲原啓司, 古川浩二郎, 中山功一, 尾山純一, 野出孝一, 森田茂樹
Organizer
第42回日本血管外科学会学術総会
Place of Presentation
青森
Year and Date
2014-05-22
Related Report
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