| Project/Area Number |
25293301
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Masayoshi 京都府立医科大学, 医学系研究科, 教授 (10379232)
OKUMURA Meinoshin 大阪大学, 医学系研究科, 教授 (40252647)
FUNAKI SOuichirou 大阪大学, 医学系研究科, 講師 (50465241)
SHINTANI Yasushi 大阪大学, 医学系研究科, 准教授 (90572983)
舟木 壮一郎 大阪大学, 医学(系)研究科(研究院), 助教 (50464251)
中桐 伴行 大阪大学, 医学(系)研究科(研究院), 研究員 (70528710)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 肺癌 / 循環癌細胞 / 手術 / 再発 / 多施設共同研究 / 遊離癌細胞 / 外科的治療 / 上皮間葉移行 / 再発制御 / 外科治療 / 転移 / 微小環境 |
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| Outline of Final Research Achievements |
Clinical implication of isolated tumor cells (ITC) in surgical cases of lung cancer were demonstrated using samples of extracted tumor cells at the surgical margin, circulating tumor cells in the blood drained pulmonary vein of the resected lung lobe and peripheral arterial blood. In detail, it is revealed that the morphology of ITC was associated with severity of stromal reaction which is a surrogate marker of epithelial-mesenchymal transition and the degree of tumor malignancy. In addition, cancer cell dislodgement by surgical manipulation is demonstrate and this phenomenon is confirmed in a multicenter prospective study.
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