| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
We observed that cognitive impairment after bilateral common carotid artery stenosis (BCAS), as a model of vascular dementia, was more marked in angiotensin type 2 (AT2) receptor knockout (KO) mice compared with that in wild-type (WT) mice, and that the overexpression of AT2 receptor interacting protein (ATIP) could protect cognitive impairment after BCAS. We also reported that angiotensin converting enzyme (ACE2) KO mice exhibited significant impairment of spatial cognitive function. These results suggest that protective arm of renin-angiotensin system (RAS) could attenuate cognitive decline after ischemic brain damage. Moreover, we proposed a new mechanism by which ATIP could plays an important roles in neurons and vascular smooth muscle cells as transcription factor as a member of protective arm of RAS.
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