Identification of glioma oncoantigens for the development of the vaccine
| Project/Area Number |
25293313
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
Toda Masahiro 慶應義塾大学, 医学部, 准教授 (20217508)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Kazunari 慶應義塾大学, 医学部, 教授 (70166940)
SAITO Katsuya 慶應義塾大学, 医学部, 助教 (60464963)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 脳腫瘍 / 免疫療法 / Oncoantigen / glioma / 神経膠腫 |
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| Outline of Final Research Achievements |
Oncoantigen are tumor antigens required for the neoplastic process and when cancer vaccine against oncoantigen, the chance that escape immune recognition to tumor should be reduced. In order to identify oncoantigens against glioma, we performed the comparative gene expression analysis of gliomas and also gene expression analysis of known oncoantigens against other cancers in gliomas. Then, functional analysis of oncoantigen candidates selected was performed in glioma cells. We succeeded in identify two oncoantigens against glioma that are expressed highly in malignant glioma tissues, glioma cell lines, and glioma stem cells isolated from glioma patients. These oncoantigens were shown to be involved in the growth of glioma by gene knockdown experiments. Furthermore, in a mouse in vivo glioma model, the gene knockdown of the oncoantigen showed a significant therapeutic effect. We plan to perform an immunotherapy using the oncoantigen identified for the treatment of malignant gliomas.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53.2015
Author(s)
Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K, Toda M.
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Journal Title
Cancer Res
Volume: なし
Issue: 9
Pages: 1011-1011
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] ペプチドワクチンの臨床経験2015
Author(s)
戸田正博
Organizer
第10回信濃町脳腫瘍セミナー
Place of Presentation
慶應義塾大学病院新教育研究棟講堂（東京都新宿区）
Year and Date
2015-02-07
Related Report
Invited
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