| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
We have reported that the absence of locally produced BMP7 had no effect on limb bone and joint formation and the process of fracture healing in the postnatal animals. Here, to evaluate the physiological roles of endogenous BMP7 in postnatal joint homeostasis, we performed detailed analyses on the knee joint of these mice. Histological analyses showed that the absence of locally produced BMP7 reduced proteoglycan contents in articular cartilage starting at 8 weeks of age. Loss of BMP7 did not affect survival of articular cartilage cells, but resulted in their reduced expression of aggrecan and enhanced expression of matrix metalloprotease 13. We also found extensive synovial hyperplasia and enhanced expression of the inflammatory cytokine, Activin, in the synovial membrane in the absence of BMP7. These data suggest that local production of BMP7 is prerequisite for postnatal synovial joint homeostasis and loss of BMP7 may involve in osteoarthritic changes in adult synovial joints.
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