| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Heterotypic ossification (HO) is an event that forms bone in mesenchymal tissues such as skeletal muscle, tendon, and ligament. Previously, it has been shown that growth factors such as bone morphogenetic protein (BMP), and artificial bone scaffold can induce HO, However, the molecular mechanisms and cell-of-origin of the HO is not fully elucidated. In this grant, we used patient-specific iPSCs generated from fibrodysplasia ossificans progressive (FOP-iPSCs) and mutation-corrected FOP-iPSCs (rescued FOP-iPSCs) as genetically-matched control cells, and analyze the molecular mechanisms underlying HO.
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