Analysis of fibrodysplasia ossificans progressive by using iPSCs
| Project/Area Number |
25293320
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Ikeya Makoto 京都大学, iPS細胞研究所, 准教授 (20442923)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOGUCHIDA Junya 京都大学, 再生医科学研究所, 教授 (40273502)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Hidetoshi 京都大学, ips細胞研究所, 准教授 (80528745)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
|---|
| Keywords | 異所性骨化 / 進行性骨化性線維異形成症 |
|---|
| Outline of Final Research Achievements |
Heterotypic ossification (HO) is an event that forms bone in mesenchymal tissues such as skeletal muscle, tendon, and ligament. Previously, it has been shown that growth factors such as bone morphogenetic protein (BMP), and artificial bone scaffold can induce HO, However, the molecular mechanisms and cell-of-origin of the HO is not fully elucidated. In this grant, we used patient-specific iPSCs generated from fibrodysplasia ossificans progressive (FOP-iPSCs) and mutation-corrected FOP-iPSCs (rescued FOP-iPSCs) as genetically-matched control cells, and analyze the molecular mechanisms underlying HO.
|
Report
(4 results)
Research Products
(30 results)
-
[Journal Article] Neofunction of ACVR1 in Fibrodysplasia Ossificance Progressiva2016
Author(s)
Hino K, Ikeya M, Horigome K, Matsumoto Y, Ebise H, Nishio M, Sekiguchi K, Shibata M, Nagata S, Matsuda S, Toguchida J
-
Journal Title
Proc Natl Acad Sci USA
Volume: 112
Issue: 50
Pages: 15438-15443
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
[Journal Article] Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.2014
Author(s)
Fukuta M, Nakai Y, Kirino K, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M, Ikeya M, Toguchida J.
-
Journal Title
PLOS ONE
Volume: 9
Issue: 12
Pages: e112291-e112291
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.2013
Author(s)
Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC.
-
Journal Title
Orphanet J Rare Dis.
Volume: 8
Issue: 1
Pages: 190-190
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Application of iPS cells for a rare and intractable disease involving mesenchymal tissues
Author(s)
Yoshihisa Matsumoto, Makoto Ikeya, Edward Hsiao, Christopher R. Schlieve, Akira Nasu, Isao Asaka, Takanobu Otsuka, Bruce R. Conklin, Junya Toguchida
Organizer
The 8th Combined Meeting of Orthopaedic Research Societies (CORS)
Place of Presentation
Congress Center of San Servolo(San Servolo, Venice, Italy)
Related Report
-
-
-
-
-
