| Project/Area Number |
25293323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
Ozaki Toshifumi 岡山大学, 医歯(薬)学総合研究科, 教授 (40294459)
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| Co-Investigator(Kenkyū-buntansha) |
KUNISADA TOSHIYUKI 岡山大学, 医歯(薬)学総合研究科, 准教授 (80346428)
FUJIWARA TOSHIYOSHI 岡山大学, 医歯(薬)学総合研究科, 教授 (00304303)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUMATSU TAKAYUKI 岡山大学, 大学病院, 助教 (20432651)
TAKEDA KEN 岡山大学, 医歯(薬)学総合研究科, 助教 (70614923)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | ウイルス治療 / 骨軟部肉腫 / p53 / 化学療法 / 放射線療法 / 骨・軟部肉腫 / 骨肉腫 / ウイルス療法 / p５３ |
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| Outline of Final Research Achievements |
Despite major advances in the treatment of bone and soft tissue sarcomas, some patients show a poor response to chemotherapy and radiotherapy, leading to a poor prognosis. We recently developed the p53-expressing oncolytic adenovirus, OBP-702. And we confirmed OBP-702 effectively killed human osteosarcoma cells. In the present study, we evaluated the efficacy of combined treatment with OBP-702 and chemotherapy or radiotherapy on human bone and soft tissue sarcoma cells. OBP-702 enhanced the anti-tumor effect of chemotherapy and radiotherapy.
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