p53-expressing oncolytic adenovirus enhances the anti-tumor effect of chemotherapy and radiotherapy
Project/Area Number |
25293323
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Okayama University |
Principal Investigator |
Ozaki Toshifumi 岡山大学, 医歯(薬)学総合研究科, 教授 (40294459)
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Co-Investigator(Kenkyū-buntansha) |
KUNISADA TOSHIYUKI 岡山大学, 医歯(薬)学総合研究科, 准教授 (80346428)
FUJIWARA TOSHIYOSHI 岡山大学, 医歯(薬)学総合研究科, 教授 (00304303)
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Co-Investigator(Renkei-kenkyūsha) |
FURUMATSU TAKAYUKI 岡山大学, 大学病院, 助教 (20432651)
TAKEDA KEN 岡山大学, 医歯(薬)学総合研究科, 助教 (70614923)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
|
Keywords | ウイルス治療 / 骨軟部肉腫 / p53 / 化学療法 / 放射線療法 / 骨・軟部肉腫 / 骨肉腫 / ウイルス療法 / p53 |
Outline of Final Research Achievements |
Despite major advances in the treatment of bone and soft tissue sarcomas, some patients show a poor response to chemotherapy and radiotherapy, leading to a poor prognosis. We recently developed the p53-expressing oncolytic adenovirus, OBP-702. And we confirmed OBP-702 effectively killed human osteosarcoma cells. In the present study, we evaluated the efficacy of combined treatment with OBP-702 and chemotherapy or radiotherapy on human bone and soft tissue sarcoma cells. OBP-702 enhanced the anti-tumor effect of chemotherapy and radiotherapy.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] Combination treatment with doxorubicin and tumor-specific p53-expressing oncolytic adenovirus in doxorubicin-resistant osteosarcoma cells2016
Author(s)
Kazuhisa Sugiu, Hiroshi Tazawa, Joe Hasei, Shuhei Osaki, Yasuaki Yamakawa, Toshinori Omori, Tadashi Komatsubara, Kouji Uotani, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki
Organizer
Orthopaedic Research Society 2016 Annual Meeting
Place of Presentation
Orland, Florida
Year and Date
2016-03-05
Related Report
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[Presentation] Telomerase-dependent oncolytic adenovirus sensitizes human osteosarcoma cells to chemotherapy through Mcl-1 downregulation2014
Author(s)
Osaki S, Omori T, Tazawa H,Hasei J, Yamakawa Y, SasakiT, Kunisada T, Urata Y, Ozaki T, Fujiwara T
Organizer
Annual Meeting of American Association for Cancer Research
Place of Presentation
San Diego, California, USA
Year and Date
2014-04-05 – 2014-04-09
Related Report
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