Development of new treatments using pro-angiogenic and tissue-specific microRNAs for the injury of musculoskeletal and nerve tissue
| Project/Area Number |
25293324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMEI NAOSUKE 広島大学, 病院(医), 講師 (70444685)
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| Co-Investigator(Kenkyū-buntansha) |
OCHI MITSUO 広島大学, その他部局等, 学長 (70177244)
MIYAKI SHIGERU 広島大学, 病院, 講師 (10392490)
NAKASA TOMOYUKI 広島大学, 病院, 病院助教 (60467769)
ISHIKAWA MASAKAZU 広島大学, 医歯薬保健学研究院, 助教 (60372158)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 脊椎脊髄病学 / 筋・神経病学 / 運動器外傷学 / 関節病学 / 再生医学 / 脊髄脊髄病学 |
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| Outline of Final Research Achievements |
The administration of miR-210 to the mouse spinal cord injury model promoted angiogenesis and astrogliosis, and improved functional recovery after spinal cord injury compared with the non-injected controls. Additionally, the administration of miR-145 to the same model improved functional recovery and inhibited the expression of semaphorin 3A.
An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. The administration of miR-210 to the rat calcaneal tendon injury model promoted the repair of a calcaneal tendon at early phase follow injury.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Administration of microRNA-210 promotes spinal cord regeneration in mice2014
Author(s)
Ujigo S, Kamei N, Hadoush H, Fujioka Y, Miyaki S, Nakasa T, Tanaka N, Nakanishi K, Eguchi A, Sunagawa T, Ochi M
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Journal Title
Spine
Volume: 39
Issue: 14
Pages: 1099-1107
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 血管再生による神経再生2014
Author(s)
亀井直輔，越智光夫
Organizer
第25回日本末梢神経学会学術集会
Place of Presentation
ホテルルビノ京都堀川（京都市上京区）
Year and Date
2014-08-29 – 2014-08-31
Related Report
Invited
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