Elucidation of novel cell communications in skeletal muscle tissue

• Project/Area Number: 25293326
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Saitama Medical University
• Principal Investigator: KATAGIRI TAKENOBU 埼玉医科大学, 医学部, 教授 (80245802)
• Co-Investigator(Kenkyū-buntansha): Jimi Eijiro 九州歯科大学, 歯学部, 教授 (40276598)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: 骨格筋 / 異所性骨化 / 炎症 / 細胞内シグナル / 運動器 / 骨組織 / 軟骨 / 骨 / 分化 / BMP / 筋 / シグナル伝達 / 生理活性物質 / 細胞

Outline of Final Research Achievements

In some pathological conditions, skeletal muscle tissues show heterotopic ossification. Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification in skeletal muscle due to a genetic mutation of ALK2, a BMP type I receptor. We found that Smad9 has unique functions among substrates of BMP receptors, such as Smad1 and Smad5. A component of NFkB signaling, p65, suppressed the Smad-dependent BMP activity by direct interaction with Smad4. Mutant ALK2 identified in patients with FOP were synergistically activated by BMP type II receptors in a kinase activity-dependent manner. These results suggest that the heterotopic ossification caused by muscle trauma in FOP might be induced by ligands activated indirectly by inflammatory reactions in the skeletal muscle.

Research Products

• [Int'l Joint Research] オックスフォード大学(英国)
• [Journal Article] A door opens for fibrodysplasia ossificans progressiva. (2016)
  • Author(s): Katagiri T.
  • Journal Title: Trends in Biochemical Sciences Volume: 41 Issue: 2 Pages: 119-121
  • DOI: 10.1016/j.tibs.2015.11.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 進行性骨化性線維異形成症（FOP）と骨免疫学 (2016)
  • Author(s): 片桐岳信
  • Journal Title: Clinical Calcium Volume: 26 Pages: 39-46
• [Journal Article] 進行性骨化性線維異形成症. (2015)
  • Author(s): 片桐岳信、大手聡、塚本翔、倉谷麻衣、町谷亜位子
  • Journal Title: The BONE Volume: 29 Pages: 309-316
  • Acknowledgement Compliant
• [Journal Article] Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptor (2015)
  • Author(s): Fujimoto M, Ohte S, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Suda N, Katagiri T
  • Journal Title: Mol Endocrinol Volume: 29 Issue: 1 Pages: 140-152
  • DOI: 10.1210/me.2014-1301
  • Peer Reviewed / Open Access
• [Journal Article] Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century? (2015)
  • Author(s): Katagiri T, Osawa K, Tsukamoto, Fujimoto M, Miyamoto A, Mizuta T.
  • Journal Title: Jpn Dent Sci Rev Volume: 51 Issue: 2 Pages: 42-50
  • DOI: 10.1016/j.jdsr.2014.09.004
  • NAID: 50009645833
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The p65 subunit of NF-κB suppresses BMP2-induced bone formation by inhibiting Smad DNA binding via an interaction with Smad4 (2014)
  • Author(s): Hirata-Tsuchiya S, Fukushima H, Katagiri T, Ohte S, Shin M, Nagano K, Aoki K, Morotomi T, Sugiyama G, Doi T, Takeuchi H, Ohya K, Terashita M, Hirata M, Kitamura C, Jimi E.
  • Journal Title: Mol Endocrinol Volume: 28 Issue: 9 Pages: 1460-1470
  • DOI: 10.1210/me.2014-1094
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling. (2014)
  • Author(s): Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Machiya A, Jimi E, Kokabu S, Katagiri T.
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 7596-7596
  • DOI: 10.1038/srep07596
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2. (2014)
  • Author(s): Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T.
  • Journal Title: Biochmical and Biophysical Research Communications Volume: 455 Issue: 3-4 Pages: 347-352
  • DOI: 10.1016/j.bbrc.2014.11.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling (2014)
  • Author(s): Kokabu S, Sato T, Ohte S, Enoki Y, Okubo M, Katagiri T, Rosen V, Yoda T.
  • Journal Title: Federation of European Biochemical Societies letters Volume: 588 Issue: 4 Pages: 614-619
  • DOI: 10.1016/j.febslet.2013.12.031
  • Peer Reviewed
• [Journal Article] TGF-βファミリーから見える骨と筋の新しい接点. (2014)
  • Author(s): 片桐岳信、塚本翔、大澤賢次
  • Journal Title: 実験医学別冊 Volume: 32 Pages: 1010-1016
• [Journal Article] ACVR1 (587T＞C) mutation in a variant form of fibrodysplasia ossificans progressiva: Second report. (2014)
  • Author(s): Nakahara Y, Katagiri T, Ogata N, Haga N
  • Journal Title: Am J Med Genet A Volume: Jan;164A(1) Issue: 1 Pages: 220-224
  • DOI: 10.1002/ajmg.a.36219
  • Peer Reviewed
• [Journal Article] The unique activity of bone morphogenetic proteins in bone: a critical role of the Smad signaling pathway (2013)
  • Author(s): Katagiri T, Tsukamoto S.
  • Journal Title: Biological Chemistry Volume: 394 Issue: 6 Pages: 703-714
  • DOI: 10.1515/hsz-2012-0310
  • Peer Reviewed
• [Journal Article] TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells (2013)
  • Author(s): Kokabu S, Nguyen T, Ohte S, Sato T, Katagiri T, Yoda T, Rosen V.
  • Journal Title: Biochemical and biophysical research communications Volume: 438 Issue: 1 Pages: 205-210
  • DOI: 10.1016/j.bbrc.2013.07.054
  • Peer Reviewed
• [Journal Article] 進行性骨化性線維異形成症（FOP） (2013)
  • Author(s): 片桐岳信
  • Journal Title: Bone Joint Nerve Volume: 3 Pages: 53-60
• [Presentation] A role of FKBP12 in signal transduction of mutant ALK2 responsible for fibrodysplasia ossificans progressiva and diffuse intrinsic pontine glioma. (2016)
  • Author(s): Machiya A, Fujimoto M, Ohte S, Tsukamoto S, Osawa K, Kuratani M, Bullock AN, Suda N, Katagiri T.
  • Organizer: BMP Signaling in Cancer.
  • Place of Presentation: St. Catharine's College（ケンブリッジ、イギリス）
  • Year and Date: 2016-03-15
  • Int'l Joint Research
• [Presentation] TGF-β signaling suppresses chondrocyte differentiation. (2016)
  • Author(s): Tsukamoto S, Ohte S, Sekine N, Kuratani M, Machiya A, Katagiri T.
  • Organizer: Gordon Research Conference on Bones & Teeth.
  • Place of Presentation: Hotel Galves (ガルベストン、テキサス州、アメリカ)
  • Year and Date: 2016-02-17
  • Int'l Joint Research
• [Presentation] Establishment and characterization of Tet-On C2C12 cell lines that express mutant ALK2 responsible for fibrodysplasia ossificans progressiva. (2016)
  • Author(s): Katagiri T, Ohte Tsukamoto S, Yoneyama K, Kuratani M, Machiya A.
  • Organizer: Gordon Research Conference on Bones & Teeth.
  • Place of Presentation: Hotel Galves (ガルベストン、テキサス州、アメリカ)
  • Year and Date: 2016-02-15
  • Int'l Joint Research
• [Presentation] 骨格筋組織における異所性骨形成 (2015)
  • Author(s): 片桐岳信
  • Organizer: 九州大学口腔細胞工学セミナー
  • Place of Presentation: 九州大学（福岡県福岡市）
  • Year and Date: 2015-12-09
  • Invited
• [Presentation] 進行性骨化性線維異形成症（FOP）における筋損傷後の骨化の誘発 (2015)
  • Author(s): 倉谷麻衣、町谷亜位子、藤本舞、大澤賢次、塚本翔、大手聡、片桐岳信
  • Organizer: 精神・神経疾患研究開発費「筋ジストロフィーモデル動物を用いた新たな治療法の開発」班班会議
  • Place of Presentation: 国立精神・神経医療研究センター 神経研究所教育研究棟ユニバーサルホール（東京都小平市）
  • Year and Date: 2015-12-08
  • Invited
• [Presentation] 進行性骨化性線維異形成症における変異ALK2の活性化機序. (2015)
  • Author(s): 倉谷麻衣、町谷亜位子、藤本舞、塚本翔、大手聡、片桐岳信.
  • Organizer: 第3回若手による骨格筋細胞研究会
  • Place of Presentation: 九州大学（福岡県福岡市）
  • Year and Date: 2015-11-24
• [Presentation] 進行性骨化性線維異形成症におけるFKBP12の役割. (2015)
  • Author(s): 町谷亜位子、藤本舞、須田直人、片桐岳信.
  • Organizer: 第74回日本矯正歯科学会大会
  • Place of Presentation: 福岡国際会議場 (福岡県福岡市)
  • Year and Date: 2015-11-18
• [Presentation] Establishment and characterization of C2C12 cells expressing human ALK2 under control of Tet-On system. (2015)
  • Author(s): Ohte S, Yoneyama K, Tsukamoto S, Kuratani M, MacHiya A, Katagiri T
  • Organizer: Australian New Zealand Bone & Mineral Society (ANZBMS) Annual Meeting 2015
  • Place of Presentation: Hotel Grand Chancellor (Hobart, Tasmania, Australia)
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] A role of FKBP12 in activation of mutant ALK2 responsible for fibrodysplasia ossificans progressiva (FOP). (2015)
  • Author(s): Machiya A, Fujimoto M, Ohte S, Tsukamoto S, Suda N, Katagiri T
  • Organizer: Australian New Zealand Bone & Mineral Society (ANZBMS) Annual Meeting 2015
  • Place of Presentation: Hotel Grand Chancellor (Hobart, Tasmania, Australia)
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] TGF-βファミリーによる運動器の制御 (2015)
  • Author(s): 片桐岳信
  • Organizer: 第13回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉医科大学創立30周年記念講堂（埼玉県日高市）
  • Year and Date: 2015-10-30
  • Invited
• [Presentation] 筋分化におけるTGF-βファミリーシグナル分子の発現. (2015)
  • Author(s): 倉谷麻衣、町谷亜位子、塚本翔、大手聡、片桐岳信
  • Organizer: 第13回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉医科大学創立30周年記念講堂（埼玉県日高市）
  • Year and Date: 2015-10-30
• [Presentation] 進行性骨化性線維異形成症（FOP）の骨化シグナル活性化機構におけるFKBP12とII型BMP受容体の役割. (2015)
  • Author(s): 町谷亜位子、藤本舞、大手聡、塚本翔、倉谷麻衣、須田直人、片桐岳信
  • Organizer: 第13回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉医科大学創立30周年記念講堂（埼玉県日高市）
  • Year and Date: 2015-10-30
• [Presentation] TGF-βシグナルによる軟骨細胞の分化調節機構の解析. (2015)
  • Author(s): 塚本翔、大手聡、関根典子、倉谷麻衣、町谷亜位子、片桐岳信.
  • Organizer: 第13回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉医科大学創立30周年記念講堂（埼玉県日高市）
  • Year and Date: 2015-10-30
• [Presentation] Role of FKBP12 in signal transduction by mutant ALK2 responsible for fibrodysplasia ossificans progressiva. (2015)
  • Author(s): Machiya A, Fujimoto M, Tsukamoto S, Kuratani M, Ohte S, Suda N, Katagiri T
  • Organizer: American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting
  • Place of Presentation: Seattle Convention Center (Seattle, Washington, USA)
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] TLE3による筋分化調節機構 (2015)
  • Author(s): 古株章一郎、中富千尋、浦田真梨子、松原琢磨、片桐岳信、自見英治郎
  • Organizer: 第57回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市)
  • Year and Date: 2015-09-13
• [Presentation] 進行性骨化性線維異形成症（FOP）のALK2変異体の活性化機構におけるFKBP12とBMP II型受容体の役割. (2015)
  • Author(s): 町谷亜位子、藤本舞、須田直人、片桐岳信
  • Organizer: 第57回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市)
  • Year and Date: 2015-09-12
• [Presentation] FOPの最前線 (2015)
  • Author(s): 片桐岳信
  • Organizer: J-FOP患者家族会交流会
  • Place of Presentation: ホテルグランドヒル市ヶ谷（東京都新宿区）
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] 生理的および病的骨形成のメカニズム (2015)
  • Author(s): 片桐岳信
  • Organizer: 第33回日本骨代謝学会学術集会 Meet the Expert 6
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-07-24
  • Invited
• [Presentation] BMPと骨形成 (2015)
  • Author(s): 片桐岳信
  • Organizer: 第33回日本骨代謝学会学術集会 学術賞受賞講演
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-07-23
  • Invited
• [Presentation] TLE3はMyoDの転写活性を調節する. (2015)
  • Author(s): 古株章一郎、佐藤毅、榎木祐一郎、片桐岳信、自見英治郎
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-07-23
• [Presentation] 進行性骨化性線維異形成症（FOP）のALK2変異体活性化におけるFKBP12の役割. (2015)
  • Author(s): 町谷亜位子、藤本舞、塚本翔、大澤賢次、大手聡、須田直人、片桐岳信
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-07-23
• [Presentation] Recent topics on fibrodysplasia ossificans progressiva. (2015)
  • Author(s): Katagiri T
  • Organizer: Seminar (Sapienza University of Rome)
  • Place of Presentation: Sapienza University of Rome（ローマ、イタリア）
  • Year and Date: 2015-06-19
  • Int'l Joint Research / Invited
• [Presentation] Molecular mechanisms of the activation of mutant ALK2. (2015)
  • Author(s): Katagiri T
  • Organizer: 9th International Meeting on FOP
  • Place of Presentation: ローマ、イタリア
  • Year and Date: 2015-03-20
  • Invited
• [Presentation] 進行性骨化性線維異形成症（FOP）におけるBMPシグナルの活性化機序 (2014)
  • Author(s): 藤本舞、大手聡、塚本翔、水田誉人、宮本阿礼、大澤賢次、片桐岳信
  • Organizer: 筋ジストロフィーモデル動物を用いた新たな治療法の開発 平成26年度研究班会議
  • Place of Presentation: 東京都千代田区、JA共済ビル カンファレンスホール
  • Year and Date: 2014-12-03
  • Invited
• [Presentation] Establishment of a novel model of chondrogenesis using murine ES cells carrying FOP-associated ALK2 (2014)
  • Author(s): Katagiri T
  • Organizer: 1st FOP Drug Development Forum
  • Place of Presentation: ボストン、アメリカ
  • Year and Date: 2014-11-20
  • Invited
• [Presentation] Musculoskeletal system and the TGF-β family. (2014)
  • Author(s): Katagiri T
  • Organizer: 12th RCGM International Symposium of Academic Frontier
  • Place of Presentation: 埼玉県日高市、埼玉医科大学創立30周年記念講堂
  • Year and Date: 2014-11-01
  • Invited
• [Presentation] Smad9 is a new type of transcriptional repressor in BMP signaling (2014)
  • Author(s): Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T
  • Organizer: 12th RCGM International Symposium of Academic Frontier
  • Place of Presentation: 埼玉県日高市、埼玉医科大学創立30周年記念講堂
  • Year and Date: 2014-10-31 – 2014-11-01
• [Presentation] Chondrogenic differentiation of murine embryonic stem cells carrying an active form of ALK2 (2014)
  • Author(s): Fujimoto M, Ohte S, Shin M, Yoneyama K, Mizuta T, Osawa K, Tsukamoto S, Miyamoto A, Okuda A, Suda N, Katagiri T
  • Organizer: 12th RCGM International Symposium of Academic Frontier
  • Place of Presentation: 埼玉県日高市、埼玉医科大学創立30周年記念講堂
  • Year and Date: 2014-10-31 – 2014-11-01
• [Presentation] Smad8はBMPシグナルの新しいタイプの制御因子である (2014)
  • Author(s): 片桐岳信、藤本舞、大澤賢次、自見英治郎、古株彰一郎
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡県福岡市、福岡国際会議場
  • Year and Date: 2014-09-27
• [Presentation] Tet-offシステムを用いたBMP受容体ALK2発現ES細胞の樹立と機能解析 (2014)
  • Author(s): 藤本舞、大澤賢次、宮本阿礼、古株彰一郎、須田直人、片桐岳信
  • Organizer: 第56回歯科基礎医学会学術大会・総会
  • Place of Presentation: 福岡県福岡市、福岡国際会議場
  • Year and Date: 2014-09-27
• [Presentation] Establishment of a novel model of chondrogenesis using murine ES cells carrying mutant ALK2 and more... (2014)
  • Author(s): Katagiri T
  • Organizer: 10th International Conference on BMPs
  • Place of Presentation: ベルリン、ドイツ
  • Year and Date: 2014-09-19
  • Invited
• [Presentation] Smad8 is a novel regulator of BMP signaling. (2014)
  • Author(s): Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T
  • Organizer: 10th International Conference on BMPs
  • Place of Presentation: ベルリン、ドイツ
  • Year and Date: 2014-09-16 – 2014-09-20
• [Presentation] Smad8 negatively regulates BMP signaling in a dominant negative fashion (2014)
  • Author(s): Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T
  • Organizer: 2014 ASBMR Annual Meeting
  • Place of Presentation: ヒューストン、アメリカ
  • Year and Date: 2014-09-13
• [Presentation] Establishment and characterization of a novel Tet-Off embryonic stem cell lines carrying ALK2 (2014)
  • Author(s): Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Tsukamoto S, Miyamoto A, Mizuta T, Kokabu S, Okuda A, Suda N, Katagiri T
  • Organizer: 2014 ASBMR Annual Meeting
  • Place of Presentation: ヒューストン、アメリカ
  • Year and Date: 2014-09-13
• [Presentation] Smad8による新たなBMPシグナルの制御機構 (2014)
  • Author(s): 塚本翔、水田誉人、藤本舞、大手聡、大澤賢次、宮本阿礼、米山克美、村田栄子、自見英治郎、古株彰一郎、片桐岳信
  • Organizer: 第21回BMP研究会
  • Place of Presentation: 大阪府大阪市、大阪大学中之島センター メモリアルホール
  • Year and Date: 2014-07-26
• [Presentation] A novel regulation of BMP signaling by Smad8 (2014)
  • Author(s): Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T
  • Organizer: FASEB Science Research Conferences on Skeletal Muscle Satellite and Stem Cells
  • Place of Presentation: スティームボート・スプリングズ、アメリカ
  • Year and Date: 2014-07-20 – 2014-07-25
• [Presentation] Establishment of a novel model for chondrogenic differentiation using murine embryonic stem cells carrying mutant ALK2 (2014)
  • Author(s): Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Tsukamoto S, Miyamoto A, Mizuta T, Kokabu S, Okuda A, Suda N, Katagiri T
  • Organizer: FASEB Science Research Conferences on Skeletal Muscle Satellite and Stem Cells
  • Place of Presentation: スティームボート・スプリングズ、アメリカ
  • Year and Date: 2014-07-20 – 2014-07-25
• [Presentation] Molecular mechanisms of activation of mutant ALK2 (2014)
  • Author(s): Katagiri T
  • Organizer: 8th International Meeting on FOP
  • Place of Presentation: ジェノア、イタリア
  • Year and Date: 2014-04-04
  • Invited
• [Presentation] 進行性骨化性線維異形成症の典型症例および亜型症例から同定されたALK2受容体はII型受容体に対する感受性が異なる. (2013)
  • Author(s): 藤本舞、大手聡、塚本翔、宮本阿礼、古株彰一郎、須田直人、片桐岳信
  • Organizer: 第31回日本骨代謝学会学術集会
  • Place of Presentation: 神戸市、兵庫県
• [Presentation] Mutant ALK2 receptors identified in patients with a typical and a variant fibrodysplasia ossificans progressiva show different sensitivities to type II receptors. (2013)
  • Author(s): Mai Fujimoto, Satoshi Ohte, Sho Tsukamoto, Arei Miyamoto, Naoto Suda, Takenobu Katagiri
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
  • Place of Presentation: 神戸市、兵庫県
• [Presentation] 非典型的な進行性骨化性線維異形成症で見出されたALK2変異体の解析. (2013)
  • Author(s): 藤本舞、大手聡、塚本翔、宮本阿礼、古株彰一郎、大澤賢次、須田直人、片桐岳信
  • Organizer: 第20回BMP研究会
  • Place of Presentation: 浜松市、静岡県
• [Presentation] 骨芽細胞におけるBMP3の発現はWntシグナルにより制御される. (2013)
  • Author(s): 古株彰一郎、佐藤毅、依田哲也、片桐岳信、Vicki Rosen
  • Organizer: 第20回BMP研究会
  • Place of Presentation: 浜松市、静岡県
• [Presentation] Smad8はBMPシグナルを抑制的に調節する. (2013)
  • Author(s): 片桐岳信、藤本舞、古株彰一郎、自見英治郎、大澤賢次
  • Organizer: 第55回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岡山市、岡山県
• [Presentation] 進行性骨化性線維異形成症から同定された 2 種類の ALK2 変異体は II 型受容体に対する感受性が異なる. (2013)
  • Author(s): 藤本舞、大澤賢次、古株彰一郎、須田直人、片桐岳信
  • Organizer: 第55回歯科基礎医学会学術大会・総会
  • Place of Presentation: 岡山市、岡山県
• [Presentation] Smad8 is a Novel Type Regulator of BMP Signaling. (2013)
  • Author(s): Sho Tsukamoto, Satoshi Ohte, Mai Fujimoto, Takato Mizuta, Arei Miyamoto, Kenji Osawa, Shoichiro Kokabu, Eiko Murata, Eijiro Jimi, Takenobu Katagiri
  • Organizer: 2013 ASBMR Symposium： Cutting Edge Discoveries in Muscle Biology, Disease and Therapeutics
  • Place of Presentation: ボルチモア、メリーランド州、アメリカ
• [Presentation] Smad8 is a Novel Type Regulator of BMP Signaling. (2013)
  • Author(s): Sho Tsukamoto, Satoshi Ohte, Mai Fujimoto, Takato Mizuta, Arei Miyamoto, Kenji Osawa, Shoichiro Kokabu, Eiko Murata, Eijiro Jimi, Takenobu Katagiri
  • Organizer: 2013 ASBMR Annual Meeting
  • Place of Presentation: ボルチモア、メリーランド州、アメリカ
• [Presentation] BMP3 Expression by Osteoblasts Is Regulated by Canonical Wnt Signaling. (2013)
  • Author(s): Shoichiro Kokabu, Laura Gamer, Jonathan Lowery, Tsuyoshi Sato, Tetsuya Yoda, Takenobu Katagiri, Vicki Rosen
  • Organizer: 2013 ASBMR Annual Meeting
  • Place of Presentation: ボルチモア、メリーランド州、アメリカ
• [Presentation] 典型的および非典型的な進行性骨化性線維異形成症例から同定された変異ALK2の機能解析 (2013)
  • Author(s): 藤本舞、片桐岳信、須田直人
  • Organizer: 第72回日本矯正歯科学会大会
  • Place of Presentation: 松本市、長野県
• [Presentation] 転写因子Smad8によるBMPシグナル調節機構の解明. (2013)
  • Author(s): 塚本翔、水田誉人、大澤賢次、藤本舞、宮本阿礼、片桐岳信
  • Organizer: 第11回RCGMフロンティアシンポジウム
  • Place of Presentation: 日高市、埼玉県
• [Presentation] TGF-βのI型受容体における活性化機序の解析. (2013)
  • Author(s): 水田誉人、塚本翔、藤本舞、宮本阿礼、大澤賢次、片桐岳信
  • Organizer: 第11回RCGMフロンティアシンポジウム
  • Place of Presentation: 日高市、埼玉県
• [Presentation] 進行性骨化性線維異形成症(FOP)におけるALK2変異体の活性化メカニズムの解析. (2013)
  • Author(s): 藤本舞、塚本翔、大澤賢次、宮本阿礼、水田誉人、須田直人、片桐岳信
  • Organizer: 第11回RCGMフロンティアシンポジウム
  • Place of Presentation: 日高市、埼玉県
• [Presentation] FOPの変異ALK2は異所性骨化を誘導する. (2013)
  • Author(s): 大澤賢次、宮本阿礼、塚本翔、藤本舞、水田誉人、片桐岳信
  • Organizer: 第11回RCGMフロンティアシンポジウム
  • Place of Presentation: 日高市、埼玉県
• [Presentation] マウス骨格筋由来細胞によるALK2(R206H)の新しい解析法の樹立. (2013)
  • Author(s): 宮本阿礼、大澤賢次、塚本翔、藤本舞、水田誉人、片桐岳信
  • Organizer: 第11回RCGMフロンティアシンポジウム
  • Place of Presentation: 日高市、埼玉県
• [Book] Novel in vitro models to study osteogenesis and chondrogenesis for human skeletal disorders. In Bone Morphogenetic Proteins: Systems Biology Regulators. Sampath TK and Vukicevic S, editors. (2016)
  • Author(s): Katagiri T
  • Total Pages: 20
  • Publisher: Springer, London
• [Book] Bone Morphogenetic Proteins. In The TGF-β Family. Miyazono K and Derynck R, editors. (2016)
  • Author(s): Katagiri T and Watabe T
  • Total Pages: 30
  • Publisher: Cold Spring Harbor Press, New York
• [Book] Ligand–Receptor Interactions and Their Implications in Delivering Certain Signaling for Bone Regeneration. In A Tissue Regeneration Approach to Bone and Cartilage Repair, Mechanical Engineering Series (2015)
  • Author(s): Katagiri T, Tsukamoto S, Osawa K, and Kokabu S.
  • Total Pages: 15
  • Publisher: Springer, London
• [Remarks] 埼玉医科大学ゲノム医学研究センター
  • URL: http://www.saitama-med.ac.jp/genome/
• [Remarks] 埼玉医科大学 ゲノム医学研究センター 病態生理部門
  • URL: http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html
• [Remarks] 埼玉医科大学ゲノム医学研究センター 病態生理部門
  • URL: http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html