Thermoregulation by stress hormones during perioperative period

• Project/Area Number: 25293328
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Kagoshima University
• Principal Investigator: Kanmura Yuichi 鹿児島大学, 医歯学域医学系, 教授 (30211189)
• Co-Investigator(Kenkyū-buntansha): KUWAKI Tomoyuki 鹿児島大学, 医歯学域医学系, 教授 (80205260) ; HASEGAWA Maiko 鹿児島大学, 医歯学域医学系, 准教授 (20516637)
• Research Collaborator: KASHIWADANI Hideki ; KUSUMOTO Ikue ; KUROKI Chiharu ; YAMAGUCHI Keiji ; TASHIRO Shogo ; YAMAGUCHI Ran ; KAJIYA Katsuko
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 防御反応 / オレキシン / 周術期管理 / 遺伝子改変マウス / 体温調節 / ストレス / TRPA1 / 呼吸調節 / 循環調節 / シバリング / 低体温 / ストレスホルモン

Outline of Final Research Achievements

The aim of this study was to reveal possible modification by stress hormones of thermoregulation during perioperative period. From clinical and experimental studies, we found that orexin is critically important for thermoregulation during perioperative period. We conclude that we should pay special attention to keep body temperature of narcolepsy patients who lack orexin within a normal range to avoid aversive side effects from anesthesia.

Research Products

• [Journal Article] Pituitary and adenylate cyclase-activating polypeptode type 1 receptor signaling evokes long-lasting nociceptive behavior through the activation of spinal astrocytes in mice， (2016)
  • Author(s): Ohnou T, Yokai M, Hasegawa-Moriyama M, Shimizu T, Inoue K, Kambe Y, Kanmura Y, Miyata A
  • Journal Title: Journal of Phamacological Sciences Volume: 1 Issue: 4 Pages: 1-10
  • DOI: 10.1016/j.jphs.2016.01.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Atrial natriuretic peptide attenuation of renal ischemia-reperfusion injuryafter major surgery (2016)
  • Author(s): Moriyama T, Kanmura Y, Lindahl SG
  • Journal Title: Journal Surgical Research Volume: 201 Issue: 1 Pages: 213-218
  • DOI: 10.1016/j.jss.2015.10.036
  • Peer Reviewed
• [Journal Article] オレキシンと睡眠障害 (2016)
  • Author(s): 桑木共之
  • Journal Title: The Lung Perspectives Volume: 22 Pages: 82-87
  • Peer Reviewed
• [Journal Article] Effects of glucose load on catabolism during propofol-based anesthesia with remifentanil in patients with diabetes Mellitus : A prospective randomized trail (2015)
  • Author(s): Yamada T, Hasegawa-Moriyama M, Nakahara M, Matsunaga A, Kanmura Y
  • Journal Title: Open Journal of Anesthesiology Volume: 5 Issue: 09 Pages: 197-205
  • DOI: 10.4236/ojanes.2015.59036
  • Peer Reviewed / Open Access
• [Journal Article] Effective method of continuous rocuronium administration based on effectsite concentrations using a pharmacokinetic/pharmacodynamic model during propofol-remifentanil anesthesia (2015)
  • Author(s): Moriyama T, Matsunaga A, Nagata O, Enohata K, Kamikawaji T, Uchino E, Kanmura Y
  • Journal Title: Journal of Anesthesia Volume: 29 Issue: 4 Pages: 593-599
  • DOI: 10.1007/s00540-015-1991-2
  • Peer Reviewed
• [Journal Article] The effects of glucose load on catabolism during remifentanil-based anesthesia in patients with diabetes mellitus : A prospective randomized trail (2015)
  • Author(s): Hasegawa-Moriyama M, Nakahara M, Saito T, Yamada T, Mukaihara K, Masuda M, Matsunaga A, Kanmura Y
  • Journal Title: Open Journal of Anesthesiology Volume: 5 Issue: 07 Pages: 155-162
  • DOI: 10.4236/ojanes.2015.57028
  • Peer Reviewed / Open Access
• [Journal Article] Resolution of Inflammation by Resolvin D1 Is Essential for Peroxisome Proliferator-activated Receptor-γ-mediated Analgesia during Postincisional Pain Development in Type 2 Diabetes (2015)
  • Author(s): Saito T, Hasegawa-Moriyama M, Kurimoto T, Yamada T, Inada E, Kanmura Y
  • Journal Title: Anesthesiology Volume: 123 Issue: 6 Pages: 1420-1434
  • DOI: 10.1097/aln.0000000000000892
  • NAID: 40021011554
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intermittent but not sustained hypoxia activates orexin-containing neurons in mice. (2015)
  • Author(s): Keiji Yamaguchi, Takahiro Futatsuki, Jumpei Ushikai, Chiharu Kuroki, Toshiaki Minami, Yasuyuki Kakihana, Tomoyuki Kuwaki
  • Journal Title: Resp Physiol Neurobiol Volume: 206 Pages: 11-14
  • DOI: 10.1016/j.resp.2014.11.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A role for orexin neurons in thermoregulation under pressure (2015)
  • Author(s): Kuwaki Tomoyuki
  • Journal Title: Temperature Volume: 2 Issue: 3 Pages: 379-391
  • DOI: 10.1080/23328940.2015.1066921
  • Peer Reviewed
• [Journal Article] 呼吸・循環測定実験 (2015)
  • Author(s): 桑木共之
  • Journal Title: 呼吸 Volume: 34 Pages: 589-595
  • Peer Reviewed
• [Journal Article] オレキシンによる睡眠覚醒と循環の調節 (2015)
  • Author(s): 桑木共之
  • Journal Title: 細胞 Volume: 47 Pages: 332-335
  • Peer Reviewed
• [Journal Article] 酸素および刺激ガスセンサーとしてのTRPA1チャンネルの役割 (2015)
  • Author(s): 桑木共之
  • Journal Title: 九州高気圧環境医学会誌 Volume: 15 Pages: 1-6
  • Peer Reviewed
• [Journal Article] オプトジェネティクスを用いた自律神経機能を制御する神経回路の研究 (2015)
  • Author(s): 楠本-吉田郁恵、生駒葉子、桑木共之
  • Journal Title: 自律神経 Volume: 52 Pages: 270-274
  • Peer Reviewed
• [Journal Article] Perfusion index as a possible predictor for postanesthetic shivering. (2014)
  • Author(s): Kuroki C, Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y, Kuwaki T.
  • Journal Title: J Anesth. Volume: 28 Issue: 1 Pages: 19-25
  • DOI: 10.1007/s00540-013-1658-9
  • Peer Reviewed / Open Access
• [Presentation] Peripheral nerve block with ropivacaine accelerates acute inflammation wound healing process in incised tissue of mice (2015)
  • Author(s): T. Yamada, M. Hasegawa-Moriyama, T. Kurimoto, T. Saito, Y. Kanmura
  • Organizer: Anesthesiology 2015
  • Place of Presentation: San Diego Convention Center（米国サンディエゴ）
  • Year and Date: 2015-10-26
  • Int'l Joint Research
• [Presentation] The efffects of glucose load on catabolism during remifentanil-based anesthesia in patients with diabetes (2015)
  • Author(s): Y. Tanaka, M. Hasegawa-Moriyama, M. Nakahara, T. Saito, K. Mukaihara, A. Matsunaga, M. Masuda, Y. Kanmura
  • Organizer: Anesthesiology 2015
  • Place of Presentation: San Diego Convention Center（米国サンディエゴ）
  • Year and Date: 2015-10-25
  • Int'l Joint Research
• [Presentation] Orexin neurons serve as a pivotal link between behavior and autonomic functions. (2015)
  • Author(s): Tomoyuki Kuwaki
  • Organizer: International Society for Autonomic Neuroscience 2015
  • Place of Presentation: Stresa（Italy)
  • Year and Date: 2015-09-26
  • Int'l Joint Research / Invited
• [Presentation] A pivotal role of orexin (hypocretin) neurons in stress-induced thermogenesis (2015)
  • Author(s): Tomoyuki Kuwaki
  • Organizer: International Stress and Behavior Society (ISBS) 5th International Regional Neuroscience and Biological Psychiatry Conference
  • Place of Presentation: Courtyard Miami Downtown Hotel（米国フロリダ）
  • Year and Date: 2015-07-22
  • Int'l Joint Research
• [Presentation] 睡眠時の呼吸調節について (2015)
  • Author(s): 桑木共之
  • Organizer: 日本睡眠学会第40回定期学術集会
  • Place of Presentation: 栃木県総合文化センター（栃木県宇都宮市）
  • Year and Date: 2015-07-02
  • Int'l Joint Research / Invited
• [Presentation] Trigeminal TRPA1 contributes to irritant-induced respiratory slowing (2015)
  • Author(s): Tomoyuki Kuwaki & Keiichi Inui
  • Organizer: NIPS international workshop 2015 "TRPs and SOCs ~Unconventional Ca2+ Physiology~"
  • Place of Presentation: 自然科学研究機構生理学研究所（愛知県岡崎市）
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] The accuracy of stroke volume index measurament obtained with the fourth generation FloTrac-Vigileo and new LiDCOrapid an the time of system vascular resistance variation (2015)
  • Author(s): K.Matsuo, T. Imabayashi, T. Harazono, S. Iwagawa, A. Matsunaga, Y. Kanmura
  • Organizer: Euroanaesthesia 2015
  • Place of Presentation: Berlin(Germany)
  • Year and Date: 2015-06-01
  • Int'l Joint Research
• [Presentation] Perioperative ultrasound-guided truncal blocks improve early recovery after urgent abdominal surgery (2015)
  • Author(s): S. Hagihara, T. Ueno, J. Hamasaki, S. Yamaguchi, T. Arimura, Y. Kanmura
  • Organizer: Euroanaesthesia 2015
  • Place of Presentation: Berlin(Germany)
  • Year and Date: 2015-05-31
  • Int'l Joint Research
• [Presentation] 間欠的低酸素刺激はオレキシン神経を活性化する (2015)
  • Author(s): 山口桂司、二木貴弘、牛飼純平、黒木千晴、桑木共之
  • Organizer: 第8回桜ヶ丘地区（基礎系）研究会
  • Place of Presentation: 鹿児島大学桜ヶ丘キャンパス（鹿児島市）
  • Year and Date: 2015-01-28
• [Presentation] Role of orexin neurons in the regulation of thermogenesis (2014)
  • Author(s): Tomoyuki KUWAKI
  • Organizer: 5th International Symposium on physiology and pharmacology on temperature regulation
  • Place of Presentation: Sukuza（South Africa）
  • Year and Date: 2014-09-07 – 2014-09-12
  • Invited
• [Presentation] 睡眠・覚醒に伴う呼吸調節の変化 (2014)
  • Author(s): 桑木共之
  • Organizer: 日本睡眠学会第39回定期学術集会
  • Place of Presentation: 徳島県郷土文化会館（徳島市）
  • Year and Date: 2014-07-03 – 2014-07-04
  • Invited
• [Presentation] 痛みに対する新たな治療戦略：バイオマーカーから薬物治療、遺伝子、再生治療まで (2014)
  • Author(s): 長谷川麻衣子、桑木共之、上村裕一
  • Organizer: 日本麻酔科学会第61回学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-05-15 – 2014-05-17
• [Remarks]
  • URL: http://www.kufm.kagoshima-u.ac.jp/~physiol1/