The research to explore novel effect of anesthetic agents with comprehensive behavioral test battery

• Project/Area Number: 25293330
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: GOTO Takahisa 横浜市立大学, 医学(系)研究科(研究院), 教授 (00256075)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI Tomoyuki 横浜市立大学, 医学部, 助教 (30580724) ; UCHIMOTO Kazuhiro 横浜市立大学, 医学研究科, 客員講師 (50710951) ; TAKASE Kenkichi 自治医科大学, 医学部, 教授 (80381474)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 行動テストバッテリー / 麻酔薬 / 吸入麻酔 / 行動実験 / テストバッテリー

Outline of Final Research Achievements

Besides the sedative effect of anesthetic agents, they exert adverse effect on post-anesthetic cognition. However other effects but sedation of anesthetic agents can be converted into positive effects in the another paradigm. We established comprehensive behavioral test battery to examine the effect of anesthetic agents on higher brain function. 1)exposure to isoflurane disrupts attention function. 2)exposure to desflurane shows no effect on higher brain function. 3)exposure to sevoflurane induces anti-depressive phenotype.

Research Products

• [Journal Article] Postanesthetic Effects of Isoflurane on Behavioral Phenotypes of Adult Male C57BL/6J Mice (2015)
  • Author(s): Yonezaki K*, Uchimoto K*, Miyazaki T*, Asakura A, Kobayashi A, Takase K, Goto T
  • Journal Title: PLoS One. Volume: 25
  • Peer Reviewed / Open Access / Acknowledgement Compliant