• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clarification of microRNA functional networks and development of novel tools for diagnosis and treatment of castration-resistant prostate cancer

Research Project

Project/Area Number 25293333
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Urology
Research InstitutionChiba University

Principal Investigator

Ichikawa Tomohiko  千葉大学, 医学(系)研究科(研究院), 教授 (20241953)

Co-Investigator(Kenkyū-buntansha) SEKI NAOHIKO  千葉大学, 大学院医学研究院, 准教授 (50345013)
SAKAMOTO SHINICHI  千葉大学, 大学院医学研究院, 助教 (70422235)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords前立腺癌 / 癌抑制 / 転移抑制 / 去勢抵抗性 / マイクロRNA / マイクロRNA
Outline of Final Research Achievements

We constructed the microRNA (miRNA) expression signature of castration-resistant prostate cancer (CRPC) using clinical specimens, and investigated the functional significance of tumor-suppressive miRNAs. We further investigated oncogenes regulated by the tumor-suppressive miRNAs. We have revealed that miR-221/222, miR-29s, miR-218, miR-224, miR-23b/27b/24, miR-26a/b, miR-205, and miR-223 function as tumor suppressors in prostate cancer. We have also identified the genes regulated by those miRNAs.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (33 results)

All 2016 2015 2014 2013 Other

All Journal Article (21 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 21 results,  Open Access: 11 results,  Acknowledgement Compliant: 9 results) Presentation (10 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer2016

    • Author(s)
      Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, Seki N.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 1 Pages: 84

    • DOI

      10.1111/cas.12842

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma2016

    • Author(s)
      Kurozumi A, Kato M, Goto Y, Matsushita R, Nishikawa R, Okato A, Fukumoto I, Ichikawa T, Seki N.
    • Journal Title

      Int J Oncol

      Volume: 48 Issue: 5 Pages: 1837

    • DOI

      10.3892/ijo.2016.3440

    • URL

      https://pure.teikyo.jp/en/publications/2e4d8748-5839-4705-8fb9-449cb38b1380

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Validation of active surveillance criteria for pathologically insignificant prostate cancer in Asian men2016

    • Author(s)
      Yamada Y, Sakamoto S, Sazuka T, Goto Y, Kawamura K, Imamoto T, Nihei N, Suzuki H, Akakura K, Ichikawa T.
    • Journal Title

      Journal of Urology

      Volume: 23 Issue: 1 Pages: 49

    • DOI

      10.1111/iju.12952

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Low serum dehydroepiandrosterone examined by liquid chromatography-tandem mass spectrometry correlates with poor prognosis in hormone-naïve prostate cancer.2016

    • Author(s)
      Miyoshi Y, Uemura H, Umemoto S, Sakamaki K, Taguri M, Suzuki K, Shibata Y, Masumori N, Ichikawa T, Mizokami A, Sugimura Y, Nonomura N, Sakai H, Honma S, Harada M, Kubota Y.
    • Journal Title

      Prostate

      Volume: 76 Issue: 4 Pages: 376-382

    • DOI

      10.1002/pros.23129

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer2015

    • Author(s)
      Nishikawa R, Goto Y, Kurozumi A, Matsushita R, Enokida H, Kojima S, Naya Y, Nakagawa M, Ichikawa T, Seki N
    • Journal Title

      Int J Urol

      Volume: 22 Issue: 9 Pages: 867

    • DOI

      10.1111/iju.12829

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer2015

    • Author(s)
      Kato M, Goto Y, Matsushita R, Kurozumi A, Fukumoto I, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, Seki N.
    • Journal Title

      International Journal of Oncology

      Volume: 47 Issue: 2 Pages: 710

    • DOI

      10.3892/ijo.2015.3043

    • URL

      https://pure.teikyo.jp/en/publications/cadcc8b8-f9f2-4a5d-87f3-fec7805bb4a9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MicroRNA expression signature of castration-resistant prostate cancer: The microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker2015

    • Author(s)
      Goto Y, Kojima S, Nishikawa R, Kurozumi A, Kato M, Enokida H, Matsushita R, Yamazaki K, Ishida Y, Nakagawa M, Naya Y, Ichikawa T, Seki N
    • Journal Title

      Br J Cancer

      Volume: 113 Issue: 7 Pages: 1055

    • DOI

      10.1038/bjc.2015.300

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells2015

    • Author(s)
      Xu M, Sakamoto S, Matsushima J, Kimura T, Ueda T, Mizokami A, Kanai Y, Ichikawa T.
    • Journal Title

      J Urol

      Volume: 195 Issue: 5 Pages: 1588-1597

    • DOI

      10.1016/j.juro.2015.11.071

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nadir Testosterone after Long-Term Followup Predicts Prognosis in Patients with Prostate Cancer Treated with Combined Androgen Blockade.2015

    • Author(s)
      Kamada S, Sakamoto S, Ando K, Muroi A, Fuse M, Kawamura K, Imamoto T, Suzuki H, Nagata M, Nihei N, Akakura K, Ichikawa T.
    • Journal Title

      Journal of Urology

      Volume: 194 Issue: 5 Pages: 1264-70

    • DOI

      10.1016/j.juro.2015.03.120

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prospective evaluation of the safety of transrectal ultrasound-guided transperineal prostate biopsy based on adverse events.2015

    • Author(s)
      Namekawa T, Fukasawa S, Komaru A, Kobayashi M, Imamura Y, Ohzeki T, Takagi K, Sato Y, Akakura K, Ichikawa T, Ueda T.
    • Journal Title

      Int J Clin Oncol

      Volume: 20 Issue: 6 Pages: 1185-1191

    • DOI

      10.1007/s10147-015-0831-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional significance of aberrantly expressed microRNAs in prostate cancer2015

    • Author(s)
      Goto Y, Kurozumi A, Enokida H, Ichikawa T, Seki N.
    • Journal Title

      Int J Urol

      Volume: 22 Issue: 3 Pages: 242

    • DOI

      10.1111/iju.12700

    • URL

      https://pure.teikyo.jp/en/publications/9272cd56-977d-4487-a79e-d78247e4fd5b

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer.2014

    • Author(s)
      Goto Y, Kojima S, Nishikawa R, Enokida H, Chiyomaru T, Kinoshita T, Nakagawa M, Naya Y, Ichikawa T, Seki N.
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 7748-7759

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer2014

    • Author(s)
      Nishikawa R, Goto Y, Kojima S, Enokida H, Chiyomaru T, Kinoshita T, Sakamoto S, Fuse M, Nakagawa M, Naya Y, Ichikawa T, Seki N
    • Journal Title

      Int J Oncol.

      Volume: 45 Issue: 1 Pages: 401

    • DOI

      10.3892/ijo.2014.2437

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer2014

    • Author(s)
      Nishikawa R, Goto Y, Sakamoto S, Chiyomaru T, Enokida H, Kojima S, Kinoshita T, Yamamoto N, Nakagawa M, Naya Y, Ichikawa T, Seki N.
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 7 Pages: 802

    • DOI

      10.1111/cas.12441

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer2014

    • Author(s)
      Goto Y, Nishikawa R, Kojima S, Chiyomaru T, Enokida H, Inoguchi S, Kinoshita T, Fuse M, Sakamoto S, Nakagawa M, Naya Y, Ichikawa T, Seki N.
    • Journal Title

      FEBS Lett.

      Volume: 588 Issue: 10 Pages: 1973

    • DOI

      10.1016/j.febslet.2014.04.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of J-CAPRA Score for High-risk Prostate Cancer Patients Treated with Carbon Ion Radiotherapy Plus Androgen Deprivation Therapy.2014

    • Author(s)
      Akakura K, Tsuji H, Suzuki H, Ichikawa T, Ishikawa H, Okada T, Kamada T, Harada M, Tsujii H, Shimazaki J.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 44 Issue: 4 Pages: 360-5

    • DOI

      10.1093/jjco/hyu006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel.2014

    • Author(s)
      Endo T, Kamiya N, Suzuki H, Oka R, Lee F-C, Utsumi T, Yano M, Kamijima S, Kawamura K, Imamoto T, Ichikawa T.
    • Journal Title

      World J Clin Urol

      Volume: 3 Issue: 2 Pages: 139-143

    • DOI

      10.5410/wjcu.v3.i2.139

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients.2014

    • Author(s)
      Miyoshi Y, Uemura H, Umemoto S, Sakamaki K, Morita S, Suzuki K, Shibata Y, Masumori N, Ichikawa T, Mizokami A, Sugimura Y, Nonomura N, Sakai H, Honma S, Harada M, Kubota Y.
    • Journal Title

      BMC Cancer

      Volume: Sep 26 Issue: 1 Pages: 717-717

    • DOI

      10.1186/1471-2407-14-717

    • NAID

      120006986365

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The tumor-suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOLM1 in prostate cancer2014

    • Author(s)
      Kojima S, Enokida H, Yoshino H, Itesako T, Chiyomaru T, Kinoshita T, Fuse M, Nishikawa R, Goto Y, Naya Y, Nakagawa M, Seki N.
    • Journal Title

      J Hum Genet.

      Volume: 59 Issue: 2 Pages: 78

    • DOI

      10.1038/jhg.2013.121

    • NAID

      40019987497

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of nomogram to non-steroidal antiandrogen sequential alternation in prostate cancer for predictive model.2014

    • Author(s)
      Kamiya N, Suzuki H, Nishimura K, Fujii M, Okegawa T, Matsuda T, Morita T, Takihana Y, Ozono S, Namiki M, Matsubara A, Ichikawa T, Miki T.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 44 Issue: 3 Pages: 263-269

    • DOI

      10.1093/jjco/hyt230

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of preoperative detection for apex prostate cancer by transrectal biopsy2013

    • Author(s)
      Sazuka T, Imamoto T, Namekawa T, Utsumi T, Yanagisawa M, Kawamura K, Kamiya N, Suzuki H, Ueda T, Ota S, Nakatani Y, Ichikawa T:
    • Journal Title

      Prostate Cancer

      Volume: - Pages: 1-6

    • DOI

      10.1155/2013/705865

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Targeting multiple functions of E3 ubiquitin ligase-1 (WWP1) signaling by miR-452 inhibits cancer cell migration and invasion in prostate cancer.2015

    • Author(s)
      Goto Y, Kurozumi A, Nishikawa R, Kato M, Sakamoto S, Kojima S, Naya Y Enokida H, Nakagawa M, Ichikawa T, Seki N.
    • Organizer
      AUA annual meeting 2015
    • Place of Presentation
      New Orleans Morial Convention Center, New Orleans, 米国 ルイジアナ州
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting TPD52 in prostate cancer.2014

    • Author(s)
      Goto Y, Nishikawa R, Kojima S, Sakamoto S, Kawamura K, Imamoto T, Chiyomaru T, Enokida H, Kinoshita T, Naya Y, Nakagawa M, Ichikawa T, Seki N.
    • Organizer
      American Urological Association annual meeting 2014
    • Place of Presentation
      米国フロリダ州オーランド市 Orange County Convention Center
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] The functional significance and its regulated molecular targets of microRNA-23b/27b/24-1 cluster in prostate cancer.2014

    • Author(s)
      Goto Y, Nishikawa R, Kojima S, Sakamoto S, Kawamura K, Imamoto T, Chiyomaru T, Enokida H, Kinoshita T, Naya Y, Nakagawa M, Ichikawa T, Seki N.
    • Organizer
      American Urological Association annual meeting 2014
    • Place of Presentation
      米国フロリダ州オーランド市 Orange County Convention Center
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Validation of active surveillance criteria for pathological insignificant prostate cancer in Japanese men.2014

    • Author(s)
      Yamada Y, Sakamoto S, Sazuka T, Goto Y, Kaga M, Yanagisawa M, Kawamura K, Kamiya N, Imamoto T, Nihei N, Suzuki H, Ichikawa T.
    • Organizer
      American Urological Association annual meeting 2014
    • Place of Presentation
      米国フロリダ州オーランド市 Orange County Convention Center
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 複数の癌抑制型microRNAによって制御されるGOLM1は前立腺癌の新規癌遺伝子である2014

    • Author(s)
      五島悠介、西川里佳、坂本信一、千代丸 剛、榎田英樹、小島聡子、中川昌之、納谷幸男、市川智彦、関 直彦
    • Organizer
      第23回泌尿器科分子・細胞研究会
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌抑制型microRNAによって制御されるGOLM1は前立腺癌の新規癌遺伝子である2014

    • Author(s)
      西川里佳、五島悠介、坂本信一、千代丸 剛、榎田英樹、小島聡子、中川昌之、納谷幸男、市川智彦、関 直彦
    • Organizer
      第23回泌尿器科分子・細胞研究会
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 前立腺癌における必須アミノ酸トランスポーターLAT1の機能解析2014

    • Author(s)
      徐 旻憓、坂本信一、五島悠介、西川里佳、巣山貴仁、川村幸治、今本 敬、二瓶直樹、金井好克、市川智彦
    • Organizer
      第23回泌尿器科分子・細胞研究会
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Amino Acid Transporter LAT1 is a Significant Promoter of Prostate Cnacer2014

    • Author(s)
      Sakamoto S, Xu M-H, Yamada Y, Sato H, Higuchi K, Kaga M, Yanagisawa M, Kawamura K, Imamoto T, Nihei N, Kanai Y, Ichikawa T.
    • Organizer
      The 4th Congress of Asian Pacific Prostate Society
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tumor suppressive microRNA-218 inhibites cancer cell migration and invasion via targeting LASP1 in prostate cancer2014

    • Author(s)
      Nishikawa R, Goto Y, Kinoshita T, Sakamoto S, Chiyomaru T, Enokida H, Kojima S, Nakagawa M, Naya Y, Ichikawa T, Seki N.
    • Organizer
      AACR 2014 annual meeting
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌抑制型microRNAが制御する前立腺癌転移機構の解明2013

    • Author(s)
      五島悠介、西川里佳、坂本信一、小島聡子、市川智彦、関 直彦
    • Organizer
      第29回前立腺シンポジウム
    • Place of Presentation
      東京コンファレンスセンター品川(東京都港区)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院泌尿器科学

    • URL

      http://www.m.chiba-u.ac.jp/class/urology/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院 泌尿器科学 教室業績一覧 2013年度

    • URL

      http://www.m.chiba-u.ac.jp/class/urology/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi