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Pathophysiology and classification of interstitial cystitis

Research Project

Project/Area Number 25293334
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Urology
Research InstitutionThe University of Tokyo

Principal Investigator

Homma Yukio  東京大学, 医学部附属病院, 教授 (40165626)

Co-Investigator(Kenkyū-buntansha) NIIMI Aya  東京大学, 医学部附属病院, 助教 (00376451)
NOMIYA Akira  東京大学, 医学部附属病院, 登録診療員 (30372379)
IGAWA Yasuhiko  東京大学, 医学部, 特任教授 (40159588)
YAMADA Yukio  東京大学, 医学部附属病院, 助教 (80302743)
MORIKAWA Teppei  東京大学, 医学部附属病院, 講師 (80451772)
相澤 直樹  東京大学, 医学部附属病院, 助教 (80595257)
西松 寛明  東京大学, 医学部附属病院, 准教授 (60251295)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords間質性膀胱炎 / 病型分類 / ハンナ型 / 非ハンナ型 / 泌尿器科学 / 排尿機能学
Outline of Final Research Achievements

The purpose of this study is to classify the clinical subtypes of interstitial cystitis and to investigate specific findings for each subtype, in terms of clinical, pathological,and molecular biological characteristics.We have been proposing that interstitial cystitis is clissified into 3 groups; Hunner type, non Hunner type and Hypersenesitive Bladder.
We reported difference between each subtype in terms of clinical featurs, as well as pathological findings. We believe this classification enables health care providers to chose optimal treatment, according to the subtypes.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (28 results)

All 2015 2014 2013 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] Hydrodistension with or without fulguration of hunner lesions for interstitial cystitis: Long-term outcomes and prognostic predictors.2015

    • Author(s)
      Niimi A, Nomiya A, Yamada Y, Suzuki M, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.
    • Journal Title

      Neurourology and Urodynamics

      Volume: e-pub Issue: 8 Pages: 965-9

    • DOI

      10.1002/nau.22837

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Botulinum toxin type A injection for refractory interstitial cystitis: A randomized comparative study and predictors of treatment response.2015

    • Author(s)
      Akiyama Y, Nomiya A, Niimi A, Yamada Y, Fujimura T, Nakagawa T, Fukuhara H, Kume H, Igawa Y, Homma Y.
    • Journal Title

      International Journal of Urology

      Volume: 22(9) Pages: 835-841

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional roles of bladder α1-adrenoceptors in the activation of single-unit primary bladder afferent activity in rats.2015

    • Author(s)
      Aizawa N, Sugiyama R, Ichihara K, Fujimura T, Fukuhara H, Homma Y, Igawa Y.
    • Journal Title

      BJU Int.

      Volume: in press Issue: 6 Pages: 993-1001

    • DOI

      10.1111/bju.13313

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo and in vitro functional characteristics of the bladder in mice lacking Transient Receptor Potential Melastatin 2 (TRPM2) channel2014

    • Author(s)
      Jun Kamei, Naoki Aizawa, Takayuki Nakagawa, Hiroki Ito, Rino Sugiyama, Yoshiyuki Akiyama, Aya Niimi,Shuji Kaneko, Yukio Homma, Yasuhiko Igawa
    • Journal Title

      NEUROUROLOGY AND URODYNAMICS.

      Volume: 33 Pages: 724-725

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat.2014

    • Author(s)
      Aizawa, N., Hedlund, P., Füllhase, C., Ito, H., Homma, Y., & Igawa, Y
    • Journal Title

      The Journal of urology

      Volume: 192 Pages: 956-963

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct evidence for contribution of muscarinic receptors to the facilitation of primary bladder mechanosensitive C-fiber afferents in the rat.2014

    • Author(s)
      Aizawa N., Ito H., Sugiyama R., Kamei J., Akiyama YFujimura T, Suzuki M, Homma Y, Igawa Y
    • Journal Title

      NEUROUROLOGY AND URODYNAMICS

      Volume: 33 Pages: 736-737

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Inhibitory Effect of Imidafenacin and 5-Hydroxymethyl Tolterodine on Capsaicin-Sensitive C-Fibers of the Primary Bladder Mechanosensitive Afferent Nerves in the Rat2014

    • Author(s)
      Aizawa N, Ito H, Sugiyama R, Fujimura T, Suzuki M, Fukuhara H, Homma Y, and Igawa Y.
    • Journal Title

      Journal of Urology

      Volume: E-pub

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocturia in men: a chaotic condition dominated by nocturnal polyuria2014

    • Author(s)
      Fujimura T, Yamada Y, Sugihara T, Azuma T, Suzuki M, Fukuhara H, Nakagawa T, Kume H, Igawa Y, Homma Y
    • Journal Title

      International journal of Urology

      Volume: E-pub

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypersensitive bladder: A solution to confused terminology and2014

    • Author(s)
      Homma Y
    • Journal Title

      International journal of Urology

      Volume: 21 Pages: 43-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OAB symptoms: assessment and discriminator for etiopathology2014

    • Author(s)
      Homma Y
    • Journal Title

      Curr Opin Urol

      Volume: 24 Pages: 345-51

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis.2013

    • Author(s)
      Homma Y, Nomiya A, Tagaya M, Oyama T, Takagaki K, Nishimatsu H, Igawa Y.
    • Journal Title

      J Urol.

      Volume: 190(5) Issue: 5 Pages: 1925-1931

    • DOI

      10.1016/j.juro.2013.05.049

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On- and post-treatment symptom relief by repeated instillations of heparin and alkalized lidocaine in interstitial cystitis.2013

    • Author(s)
      Nomiya A, Naruse T, Niimi A, Nishimatsu H, Kume H, Igawa Y, Homma Y.
    • Journal Title

      International Journal of Urology

      Volume: 刊行予定 Issue: 11 Pages: 1118-1122

    • DOI

      10.1111/iju.12120

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypersensitive bladder: towards clear taxonomy surrounding interstitial cystitis.2013

    • Author(s)
      Homma Y
    • Journal Title

      International Journal of Urology

      Volume: 20(8) Issue: 8 Pages: 742-743

    • DOI

      10.1111/iju.12143

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ③EFFICACY AND SAFETY OF ORAL STEROID TREATMENT FOR INTERSTITIAL CYSTITIS2015

    • Author(s)
      Yamada Y, Niimi A, Nomiya A, Akiyama Y, Igawa Y, Homma Y
    • Organizer
      International Continence Society
    • Place of Presentation
      Palais des Congrès(Montreal, Canada)
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 難治性過活動膀胱/間質性膀胱炎に対する治療2015

    • Author(s)
      新美文彩
    • Organizer
      第80回日本泌尿器科学会東部総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-25 – 2015-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] シンポジウム「難治性過活動膀胱/間質性膀胱炎に対する治療」「間質性膀胱炎に対する膀胱水圧拡張術及びボツリヌストキシン注入療法」2015

    • Author(s)
      新美 文彩
    • Organizer
      第80回日本泌尿器科学会東部総会
    • Place of Presentation
      京王プラザホテル(東京、新宿区)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ⑳間質性膀胱炎に対するアプローチでゲフィチニブ長期治療継続が可能となった進行肺腺癌の1例2015

    • Author(s)
      野宮明
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      京王プラザホテル札幌(北海道、札幌)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 過活動膀胱とその類似疾患―尿意切迫か尿意亢進か2015

    • Author(s)
      新美 文彩
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      京王プラザホテル札幌(北海道、札幌)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A PROSPECTIVE RANDOMIZED CONTROL TRIAL OF BOTULINUM TOXIN A (BOTOX A) INJECTION FOR INTERSTITIAL CYSTITIS2014

    • Author(s)
      Akiyama Y, Nomiya A, Niimi A, Yamada Y, Suzuki M, Fujimura T, Igawa Y, Homma Y
    • Organizer
      International Continence Society Annual Meeting
    • Place of Presentation
      Rio De Janeiro, Brazil
    • Year and Date
      2014-10-20 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] A SURVEY ON CLINICAL PRACTICE OF INTERSTITIAL CYSTITIS IN JAPAN2014

    • Author(s)
      Homma Y, Yamada Y, Igawa Y, Nomiya A, Ito T, Tomoe H, Takei M, Ueda T
    • Organizer
      International Continence Society Annual Meeting
    • Place of Presentation
      Rio De Janeiro, Brazil
    • Year and Date
      2014-10-20 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] URINARY IMMUNOGLOBULIN CONCENTRATION IS NOT INCREASED IN INTERSTITIAL CYSTITIS2014

    • Author(s)
      Yamada Y, Suzuki M, Saito Y, Nomiya A, Niimi A, Igawa Y, Homma Y
    • Organizer
      International Continence Society Annual Meeting
    • Place of Presentation
      Rio De Janeiro, Brazil
    • Year and Date
      2014-10-20 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Outcomes of hydrodistension with or without fulguration for interstitial cystitis and risk factors predicting therapeutic failure2014

    • Author(s)
      Niimi A, Nomiya A, Yamada Y, Azuma T, Suzuki M, Fujimura T, Nakagawa T, Fukuhara H, Kume H, Igawa Y, Homma Y
    • Organizer
      International Continence Society Annual Meeting
    • Place of Presentation
      Rio De Janeiro, Brazil
    • Year and Date
      2014-10-20 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヤングリサーチャーズセミナー:糖尿病モデルラット2014

    • Author(s)
      新美文彩
    • Organizer
      日本性機能学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 指定ワークショップ 間質性膀胱炎に対する局所治療のアウトカム2014

    • Author(s)
      新美文彩
    • Organizer
      日本泌尿器科学会第102回総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] EXPRESSION OF AND LOCALIZATION OF ESTROGEN RECEPTOR BETA IN IC/PBS BLADDER2013

    • Author(s)
      Niimi A, Matsuzawa Y, Nomiya A, Igawa Y, Homma Y
    • Organizer
      43rd Annual Meeting of the International Continence Society
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cystoscopif findings and Hydrodistension

    • Author(s)
      Niimi A, Homma Y
    • Organizer
      8th Pan-pacific continence society meeting
    • Place of Presentation
      Busan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ワークショップ:間質性膀胱炎の局所療法:ヘパリンリドカイン療法の維持療法

    • Author(s)
      新美文彩、野宮明、山田幸央、井川靖彦、本間之夫
    • Organizer
      第02回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Book] LUTS診療ロードマップ2015

    • Author(s)
      山田幸央、新美文彩、本間之夫
    • Total Pages
      277
    • Publisher
      メジカルビュー
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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