Comprehensive study on control of chronic antibody-mediated rejection after renal transplantation

• Project/Area Number: 25293335
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Aichi Medical University (2015); Nagoya University
• Principal Investigator: KOBAYASHI Takaaki 愛知医科大学, 医学部, 教授 (70314010)
• Co-Investigator(Kenkyū-buntansha): IWASAKI Kenta 愛知医科大学, 医学部, 准教授 (10508881) ; MIWA Yuko 愛知医科大学, 医学部, その他 (90572941) ; MARUYAMA Shoichi 名古屋大学, 大学院医学系研究科, 准教授 (10362253) ; ONISHI Akira 日本大学, 生物資源科学部, 教授 (30414890) ; OGAWA Haruko 帯広畜産大学, 学内共同利用施設等, 教授 (10400079) ; HANEDA Masataka 名古屋大学, 大学院医学系研究科, 寄附講座講師 (50436995)
• Research Collaborator: KUZUYA Takafumi ; MATSUDA Yoshiko ; YAMAMOTO Takayuki ; HIRAMITSU Takahisa ; Ashimine Satoshi ; INANAGA Yukiko ; HORIMI Kosei ; KITAHATA Nana ; LIU DaGe ; KUSHIHARA Hideyuki ; KURATA Yoko ; OKADA Manabu ; MATSUOKA Yutaka
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 移植・再生医療 / 腎移植 / 慢性抗体関連型拒絶反応 / 免疫学 / マイクロアレイ / シグナル伝達 / クローンブタ

Outline of Final Research Achievements

Donor specific HLA antibody (DSA)-induced chronic antibody-mediated rejection (CAMR) is an obstacle to long-term graft survival. Approximately 40% of renal transplant recipient with de novo DSA without graft dysfunction demonstrated biopsy-proven subclinical CAMR, and failed to respond to anti-rejection therapy such as anti-CD20 monoclonal antibody and double filtration plasmapheresis.
miR-142-5p and miR-486-5p in peripheral blood mononuclear cells were associated with DSA production and CAMR, respectively. DSA with high complement binding ability showed high risk of CAMR. Anti-A/B antibody, mTOR inhibitor and AMPK activator had protective function against HLA antibody-induced, complement-dependent cytotoxicity. Action at an early stage when immune response starts to move towards DSA production would be essential to control CAMR after kidney transplantation. Furthermore, development of innovative anti-CAMR therapy is necessary.

Research Products

• [Journal Article] De novo anti-HLA DSA characteristics and subclinical antibody-mediated kidney allograft injury. (2016)
  • Author(s): Yamamoto T, Watarai Y, Takeda A, Tsujita M, Hiramitsu T, Goto N, Narumi S, Katayama A, Morozumi K, Uchida K, Kobayashi T.
  • Journal Title: Transplantation Volume: 未定
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Changes in ABCB1 mRNA expression in peripheral blood cells before and after renal transplantation. (2016)
  • Author(s): Kushihara H, Kuzuya T, Miwa Y, Iwasaki K, Haneda M, Watarai Y, Uchida K, Yamada K, Kobayashi T.
  • Journal Title: Biological Pharmaceutical Bulletin Volume: 未定
  • NAID: 130005160773
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MiR-142-5p, miR-182, and miR-486-5p as a biomarker for early detection of chronic antibody-mediated rejection in kidney transplantation. (2016)
  • Author(s): Iwasaki K, Yamamoto T, Inanaga Y, Hiramitsu T, Miwa Y, Haneda M, Narumi S, Watarai Y, Katayama A, Uchida K, Kobayashi T.
  • Journal Title: Biomarker Insights Volume: 未定
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Association of Dialysis Duration with Outcomes after Transplantation in a Japanese Cohort. (2016)
  • Author(s): Goto N, Okada M, Yamamoto T, Tsujita M, Narumi S, Katayama A, Kobayashi T, Uchida K, Watarai Y.
  • Journal Title: Clin J Am Soc Nephrol. Volume: 11 Issue: 3 Pages: 497-504
  • DOI: 10.2215/cjn.08670815
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Current status of pig kidney xenotransplantation (2015)
  • Author(s): Iwase H, Kobayashi T.
  • Journal Title: International Journal of Surgery Volume: 23 Part B Pages: 229-233
  • DOI: 10.1016/j.ijsu.2015.07.721
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Functional Difference between Membrane-Bound and Soluble Human Thrombomodulin. (2015)
  • Author(s): Miwa Y, Yazaki S, Iwamoto M, Suzuki S, Iwasaki K, Haneda M, Yamamoto K, Maruyama S, Onishi A, Kobayashi T.
  • Journal Title: Transplantation Volume: 99 Issue: 4 Pages: 702-709
  • DOI: 10.1097/tp.0000000000000571
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A proliferation-inducing ligand sustains the proliferation of human naive (CD27－) B cells and mediates their differentiation into long-lived plasma cells in vitro via transmembrane activator and calcium modulator and cyclophilin ligand interactor and B-cell mature antigen. (2015)
  • Author(s): Yoshiko Matsuda, Masataka Haneda, Kenji Kadomatsu, Takaaki Kobayashi
  • Journal Title: Cellular Immunology Volume: 295 Issue: 2 Pages: 127-136
  • DOI: 10.1016/j.cellimm.2015.02.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Encephalitis Due to Human Herpesvirus-6B in Pancreas After Kidney (PAK) Transplantation (2014)
  • Author(s): Yamamoto T, Watarai Y, Goto N, Horikoshi Y, Yamada S, Yasui K, Tsujita M, Hiramitsu T, Narumi S, Katayama A, Uchida K, Kobayashi T.
  • Journal Title: Transplant Infectious Disease Volume: 16 Issue: 5 Pages: 853-858
  • DOI: 10.1111/tid.12270
  • Peer Reviewed
• [Journal Article] Influence of olive-derived hydroxytyrosol on the toll-like receptor 4-dependent inflammatory response of mouse peritoneal macrophages (2014)
  • Author(s): Takeda Y,Bui VN,Iwasaki K,Kobayashi T,Ogawa H,Imai K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 446巻 Issue: 4 Pages: 1225-1230
  • DOI: 10.1016/j.bbrc.2014.03.094
  • Peer Reviewed
• [Journal Article] Neither pre-transplant rituximab nor splenectomy affects de novo HLA antibody production after renal transplantation (2014)
  • Author(s): Satoshi Ashimine, Yoshihiko Watarai, Takayuki Yamamoto, Takahisa Hiramitsu, Makoto Tsujita, Koji Nanmoku, Norihiko Goto, Asami Takeda, Akio Katayama, Kazuharu Uchida and Takaaki Kobayashi
  • Journal Title: Kidney International Volume: 85 Issue: 2 Pages: 425-430
  • DOI: 10.1038/ki.2013.291
  • Peer Reviewed
• [Journal Article] Comparative analysis of drug action on B-cell proliferation and differentiation for mycophenolic acid, everolimus, and prednisolone. (2014)
  • Author(s): Haneda M, Owaki M, Kuzuya T, Iwasaki K, Miwa Y, Kobayashi T.
  • Journal Title: Transplantation. Volume: 97 Issue: 11 Pages: 405-412
  • DOI: 10.1097/01.tp.0000441826.70687.f6
  • Peer Reviewed
• [Journal Article] Acute antibody-mediated rejection possibly due to anti-hman leukocyte antigen DQB1 antibodies after renal transplantation - case report (2014)
  • Author(s): S. Yamanaga, Y. Watarai, A. Takeda, T. Yamamoto, T. Hiramitsu, M. Tsujita, N. Goto, K. Uchida, A. Katayama, K. Morozumi, T. Kobayashi
  • Journal Title: Transplantation Proceedings Volume: 46 Issue: 2 Pages: 640-643
  • DOI: 10.1016/j.transproceed.2013.11.012
  • Peer Reviewed
• [Journal Article] Frequent development of subclinical chronic antibody-mediated rejection within 1 year after renal transplantation with pre-transplant positive donor-specific antibodies and negative CDC crossmatches (2013)
  • Author(s): Shigeyoshi Yamanaga,Yoshihiko Watarai,Takayuki Yamamoto,Makoto Tsujita,Takahisa Hiramitsu,Koji Nanmoku,Norihiko Goto,Asami Takeda,Kunio Morozumi,Akio Katayama,Hiroh Saji,Kazuharu Uchida,and Takaaki Kobayashi
  • Journal Title: Human Immunology Volume: 74巻 Issue: 9 Pages: 1111-1118
  • DOI: 10.1016/j.humimm.2013.06.022
  • Peer Reviewed
• [Journal Article] AMP-activated protein kinase as a promoting factor, but complement and thrombin as limiting factors for acquisition of cytoprotection: implications for induction of accommodation. (2013)
  • Author(s): Iwasaki K, Miwa Y, Haneda M, Kuzuya T, Ogawa H, Onishi A, Kobayashi T.
  • Journal Title: Transpl Int. Volume: 26 Issue: 11 Pages: 1138-1148
  • DOI: 10.1111/tri.12186
  • Peer Reviewed
• [Presentation] ABO incompatibility and graft accommodation: Potential strategy to prevent acute/chronic antibody mediated rejection (2015)
  • Author(s): T. Kobayashi
  • Organizer: ABO-I and anti-HLA hyperimmune patient, Pre-Meeting Symposia, 2015 IPITA-IXA-CTS Joint Congress
  • Place of Presentation: Melbourne (Australia)
  • Year and Date: 2015-11-15
  • Int'l Joint Research / Invited
• [Presentation] 異種移植と免疫順応 (2015)
  • Author(s): 岩﨑研太、三輪祐子、大西彰、小林孝彰
  • Organizer: 第42回 日本臓器保存生物医学会
  • Place of Presentation: いわて県民情報交流センター（岩手県盛岡市）
  • Year and Date: 2015-11-13
• [Presentation] Tfh依存性活性化B細胞をターゲットとした新しい免疫モニタリングの可能性 (2015)
  • Author(s): 岩﨑研太、北畑奈々 、山本貴之、平光高久、三輪祐子、羽根田正隆、片山昭男 、山上孝子 、鳴海俊治、渡井至彦、武田朝美、堀見孔星、松岡裕、打田和治、 小林孝彰
  • Organizer: 第51回 日本移植学会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-10-01
• [Presentation] ヒト型トロンボモジュリンを発現するcloned pig作成における適正な発現レベルの検討 (2015)
  • Author(s): 三輪祐子、岩﨑研太、鈴木俊一、岩元正樹、大西彰、小林孝彰
  • Organizer: 第51回 日本移植学会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-10-01
• [Presentation] 移植後BKウイルス感染症のモニタリング (2015)
  • Author(s): 堀見孔星、松岡裕、小林孝彰、岩﨑研太、打田和治、三輪祐子
  • Organizer: 第51回 日本移植学会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-10-01
• [Presentation] 当科における生体腎移植後の感染症性合併症の現状と今後の展望：PD studyの意義について (2015)
  • Author(s): 松岡裕、小林孝彰、堀見孔星、岩﨑研太、打田和治、三輪祐子
  • Organizer: 第51回 日本移植学会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-10-01
• [Presentation] 腎移植後ドナー特異HLA抗体と慢性抗体関連型拒絶反応の関係～診断から治療まで～ (2015)
  • Author(s): 山本貴之、渡井至彦、武田朝美、黒木聖久、坂本慎太郎、二村健太、永井崇敬、岡田学、辻田誠、平光高久、後藤憲彦、鳴海俊治、小林孝彰
  • Organizer: 第51回 日本移植学会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-10-01
• [Presentation] Rituximab sparing protocol for patients with low titers in ABO incompatible kidney transplantation (2015)
  • Author(s): S. Narumi, Y. Watarai, N. Goto, T. Hiramitsu, M, Tsujita, T. Yamamoto, M. Okada, K. Itoh, K. Futamura, T. Kobayashi
  • Organizer: 17th Congress of the European Society for Organ Transplantation
  • Place of Presentation: Brussels (Belgium)
  • Year and Date: 2015-09-13
  • Int'l Joint Research
• [Presentation] Safety and efficacy of low dose and very low dose extended -release tacrolimus/MMF in de novo kidney transplant recipients (2015)
  • Author(s): S. Narumi, Y. Watarai, N. Goto, T. Hiramitsu, M, Tsujita, T. Yamamoto, M. Okada, K. Itoh, K. Futamura, T. Kobayashi
  • Organizer: 17th Congress of the European Society for Organ Transplantation
  • Place of Presentation: Brussels (Belgium)
  • Year and Date: 2015-09-13
  • Int'l Joint Research
• [Presentation] HLA抗体スクリーニング精度の比較検討 (2015)
  • Author(s): 堀見孔星、黒木聖久、坂本慎太郎、渡井至彦、岩﨑研太、打田和治、小林孝彰
  • Organizer: 第24回 日本組織適合性学会
  • Place of Presentation: ホテルレイクビュー水戸（茨城県水戸市）
  • Year and Date: 2015-09-10
• [Presentation] De Novo DSA Would Not Necessarily Cause Graft Rejection After Renal Transplantation: Characteristics of DSA Developing Biopsy-Proven Chronic Antibody-Mediated Rejection (2015)
  • Author(s): T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, H. Takahisa, N. Goto, S. Narumi, T. Kobayashi.
  • Organizer: ATC (American Transplant Congress) 2015
  • Place of Presentation: Philadelphia (USA)
  • Year and Date: 2015-05-02
  • Int'l Joint Research
• [Presentation] Favorable Results of ABO Incompatible Renal Transplantation Without B Cell Targeted Therapy: Advantages and Disadvantages of Rituximab Pretreatment (2015)
  • Author(s): M. Okada, K. Futamura, K. Itou, T. Yamamoto, T. Hiramitsu, M. Tsujita, N. Goto, S. Narumi, Y. Watarai, A. Katayama, K. Uchida, T. Kobayashi.
  • Organizer: ATC (American Transplant Congress) 2015
  • Place of Presentation: Philadelphia (USA)
  • Year and Date: 2015-05-02
  • Int'l Joint Research
• [Presentation] Clinical Significance of Estimated DSA MFI Values at 1,000 C1q MFI for Differentiation Between Harmful and Harmless DSA (2015)
  • Author(s): K. Horimi, T. Akaza, K. Kuroki, S. Sakamoto, Y. Matsuoka, Y. Watarai, S. Narumi, A. Katayama, K. Uchida, T. Kobayashi.
  • Organizer: ATC (American Transplant Congress) 2015
  • Place of Presentation: Philadelphia (USA)
  • Year and Date: 2015-05-02
  • Int'l Joint Research
• [Presentation] Impacts of Mycophenolate Mofetile Addition to Very Low Exposure Everolimus and Calcineurine Inhibitor Based Immunosuppression in De Novo Kidney Transplantation. (2015)
  • Author(s): Y. Watarai, M. Okada, K. Futamura, K. Ito, T. Yamamoto, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, T. Kobayashi.
  • Organizer: ATC (American Transplant Congress) 2015
  • Place of Presentation: Philadelphia (USA)
  • Year and Date: 2015-05-02
  • Int'l Joint Research
• [Presentation] Efficacy of Rituximab Sparing Protocol for ABO Incompatible Renal Transplant in Patients With Low Titers. (2015)
  • Author(s): S. Narumi, Y. Watarai, N. Goto, T. Hiramitsu, T. Yamamoto, M. Tsujita, M. Okada, K. Futamura, A. Takeda, T. Kobayashi.
  • Organizer: ATC (American Transplant Congress) 2015
  • Place of Presentation: Philadelphia (USA)
  • Year and Date: 2015-05-02
  • Int'l Joint Research
• [Presentation] Non-Gal異種抗体はERKを介して内皮細胞を活性化する (2015)
  • Author(s): 岩﨑研太、稲永由紀子、三輪祐子、羽根田正隆、大西彰、小川晴子、小林孝彰
  • Organizer: 第17回日本異種移植研究会
  • Place of Presentation: 自治医科大学 地域医療情報研修センター (栃木県下野市)
  • Year and Date: 2015-03-14
• [Presentation] ブタ血管内皮細胞における適正なヒト型トロンボモジュリンの発現レベルの検討 (2015)
  • Author(s): 三輪祐子、岩﨑研太、羽根田正隆、鈴木俊一、岩元正樹、大西彰、小林孝彰
  • Organizer: 第17回日本異種移植研究会
  • Place of Presentation: 自治医科大学 地域医療情報研修センター (栃木県下野市)
  • Year and Date: 2015-03-14
• [Presentation] 異種移植の現状と課題 (2015)
  • Author(s): 小林孝彰
  • Organizer: 平成26年度獣医学術学会年次大会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2015-02-13 – 2015-02-15
  • Invited
• [Presentation] Lessons from ABO-incompatible and DSA positive renal transplantation: Potential strategy to overcome chronic antibody mediated rejection (2014)
  • Author(s): Takaaki Kobayashi
  • Organizer: The 2014 Fall Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2014-11-06
  • Invited
• [Presentation] Can human thrombomodulin make a major contribution to xenograft survival ? (2014)
  • Author(s): Takaaki Kobayashi
  • Organizer: 3rd Symposium of East Asia Xenotransplantation Association
  • Place of Presentation: Changsha (China)
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] ブタ脂肪由来間葉系幹細胞はブタCD8+T細胞増殖を増強する (2014)
  • Author(s): 稲永由紀子、岩﨑研太、安藤麻子、大西彰、丸山彰一、小林孝彰
  • Organizer: 第２３回日本組織適合性学会
  • Place of Presentation: 長崎大学良順会館(長崎県長崎市)
  • Year and Date: 2014-09-13 – 2014-09-15
• [Presentation] C1q binding assay と腎移植後慢性抗体関連型拒絶反応との関連の検討 (2014)
  • Author(s): 堀見孔星、黒木聖久、坂本慎太郎、渡井至彦、打田和治、小林孝彰
  • Organizer: 第２３回日本組織適合性学会
  • Place of Presentation: 長崎大学良順会館(長崎県長崎市)
  • Year and Date: 2014-09-13 – 2014-09-15
• [Presentation] 抗A/B抗体はIFNγ刺激で誘導される内皮細胞上HLA発現を制御する (2014)
  • Author(s): 岩﨑研太、三輪祐子、羽根田正隆、小林孝彰
  • Organizer: 第２３回日本組織適合性学会
  • Place of Presentation: 長崎大学良順会館(長崎県長崎市)
  • Year and Date: 2014-09-13 – 2014-09-15
• [Presentation] ABO血液型不適合移植はGraft Accommodationを促進するか？抗HLA抗体による慢性抗体関連型拒絶反応に与える影響 (2014)
  • Author(s): 岩﨑研太、三輪祐子、羽根田正隆、片山昭男、鳴海俊治、渡井至彦、武田朝美、小林孝彰
  • Organizer: 第５０回日本移植学会総会
  • Place of Presentation: 京王プラザ(東京都新宿区)
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] 腎移植後慢性抗体関連型拒絶反応（Subclinical）とde novo DSAの関係及びSubclinical CAMRに対する治療介入の試み (2014)
  • Author(s): 山本貴之、渡井至彦、小林孝彰、武田朝美、黒木聖久、岡田学、辻田誠、平光高久、後藤憲彦、鳴海俊治、打田和治
  • Organizer: 第５０回日本移植学会総会
  • Place of Presentation: 京王プラザ(東京都新宿区)
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] ヒト末梢血メモリーB細胞の安定増殖培養法の試み (2014)
  • Author(s): 羽根田正隆、松田佳子、三輪祐子、岩崎研太、小林孝彰
  • Organizer: 第５０回日本移植学会総会
  • Place of Presentation: 京王プラザ(東京都新宿区)
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] ABO不適合腎移植におけるリスク因子の総合解析：IgM, IgGサブクラスおよびドナー抗原量の解析 (2014)
  • Author(s): 三輪祐子、山本貴之、岩﨑研太、羽根田正隆、後藤憲彦、渡井至彦、武田朝美、両角國男、 丸山彰一、小林孝彰
  • Organizer: 第５０回日本移植学会総会
  • Place of Presentation: 京王プラザ(東京都新宿区)
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] Follicular Helper T cell (Tfh) に対する免疫抑制剤の影響(セッション名：免疫抑制剤) (2014)
  • Author(s): 北畑奈々、岩﨑研太、三輪裕子、羽根田正隆、葛谷孝文、小林孝彰
  • Organizer: 第５０回日本移植学会総会
  • Place of Presentation: 京王プラザ(東京都新宿区)
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] In vitroにおける末梢血Ｂ細胞から形質細胞分化誘導の試みー抗体関連型拒絶反応制御を目指してー (2014)
  • Author(s): 松田佳子、羽根田正隆、三輪祐子、岩﨑研太、小林孝彰
  • Organizer: 第５０回日本移植学会総会
  • Place of Presentation: 京王プラザ(東京都新宿区)
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] Efficacy and Safety of Everolimus Based Immunosuppression On De Novo Kidney Transplantation With 5 Years Follow-Up Especially in Protocol Biopsy Findings and Donor Specific Antibody Production. (2014)
  • Author(s): S. Narumi, Y. Watarai, N. Goto, T. Hiramitsu, M. Tsujita,1 T. Yamamoto, A. Takeda, K. Morozumi, T. Kobayashi.
  • Organizer: WTC 2014 (World Transplant Congress)
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-07-26 – 2014-07-31
• [Presentation] Lower Incidence of Cytomegalovirus Infection With Everolimus Based Immunosuppression Versus Mycophenolate in De Novo Renal Transplants With 5 Years Follow-Up. (2014)
  • Author(s): N. Goto, Y. Watarai, S. Narumi, T. Yamamoto, M. Tsujita, T. Hiramitsu, A. Takeda, K. Morozumi, T. Kobayashi.
  • Organizer: WTC 2014 (World Transplant Congress)
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-07-26 – 2014-07-31
• [Presentation] Proteinuria and Histopathological Change of Everolimus Based Immunosuppression On De Novo Kidney Transplantation With 5 Years Follow-Up in Protocol Biopsies. (2014)
  • Author(s): A. Takeda, Y. Watarai, S. Narumi, T. Yamamoto, M. Tsujita, T. Hiramitsu, N. Goto, K. Horike, T. Kobayashi, K. Morozumi.
  • Organizer: WTC 2014 (World Transplant Congress)
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-07-26 – 2014-07-31
• [Presentation] Changes in Non-Donor-Specific Antibodies After Human Leukocyte Antigen-Incompatible Renal Transplantation Would Also Be Worthy of Attention. (2014)
  • Author(s): S. Yamanaga, M. Toyoda, Y. Hidaka, Y. Watarai, A. Takeda, K. Morozumi, A. Katayama, K. Uchida, S. Uekihara, I. Seishi, T. Kobayashi.
  • Organizer: WTC 2014 (World Transplant Congress)
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-07-26 – 2014-07-31
• [Presentation] Early Diagnosis and Treatment for Biopsy-Proven Subclinical Chronic Antibody Mediated Rejection After Renal Transplantation. (2014)
  • Author(s): T. Yamamoto, Y. Watarai, T. Kobayashi, A. Takeda, M. Tsujita, H. Takahisa, N. Goto, S. Narumi, K. Morozumi, K. Uchida.
  • Organizer: WTC 2014 (World Transplant Congress)
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-07-26 – 2014-07-31
• [Presentation] HLA Specificity and Titer Rather Than Complement Fixing Ability of DSA Would Influence the Incidence of Chronic Antibody Mediated Rejection. (2014)
  • Author(s): T. Yamamoto, Y. Watarai, K. Kuroki, S. Sakamoto, M. Hiramatsu, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, K. Uchida, T. Kobayashi.
  • Organizer: WTC 2014 (World Transplant Congress)
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-07-26 – 2014-07-31
• [Presentation] ABO-Incompatible Transplantation Might Have the Potential to Reduce Anti-HLA Class II DR-Mediated CAMR. (2014)
  • Author(s): K. Iwasaki, J. Ping, Y. Miwa, M. Haneda, T. Kobayashi.
  • Organizer: WTC 2014 (World Transplant Congress)
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-07-26 – 2014-07-31
• [Presentation] DSA陽性腎移植とsubclinical AMR (2014)
  • Author(s): 山永成美、豊田麻里子、武田朝美、両角國男、渡井至彦、片山昭男、打田和治、小林孝彰
  • Organizer: 47回日本臨床腎移植学会
  • Place of Presentation: 奈良100年会館、奈良
• [Presentation] 腎移植後慢性抗体関連型拒絶反応に対する早期診断、治療の試み (2014)
  • Author(s): 山本貴之、渡井至彦、小林孝彰、武田朝美、黒木聖久、西平守邦、日高祐嗣、辻田誠、平光高久、後藤憲彦、片山昭男、鳴海俊治、両角國男、打田和治
  • Organizer: 47回日本臨床腎移植学会
  • Place of Presentation: 奈良100年会館、奈良
• [Presentation] Analysis of donor ABO antigen expression in ABO incompatible kidney transplantation (2013)
  • Author(s): Yuko Miwa, Takayuki Yamamoto, Yoshimi Shintoku, Kenta Iwasaki, Masataka Haneda,Norihiko Goto, Yoshihiko Watarai, Asami Takeda, Kunio Morozumi, Yuriko Sawa, Shoichi Maruyama,Kazuharu Uchida, Takaaki Kobayashi
  • Organizer: Congress of Asian Society of Transplantation (CAST) 2013
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Japan)
• [Presentation] Reduced expression of complement regulatory protein, CD59, by anti-HLA class II DR antibody binding to endothelial cells: Implication for blockade in graft accommodation (2013)
  • Author(s): Kenta Iwasaki, Jing Ping, Miwa Yuko, Haneda Masataka, Kuzuya Takafumi, Ogawa Haruko, Onishi Akira, Kobayashi Takaaki
  • Organizer: Congress of Asian Society of Transplantation (CAST) 2013
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Japan)
• [Presentation] Significance of miRNA expression profiling of peripheral blood mononuclear cells for early diagnosis of chronic antibody-mediated rejection (2013)
  • Author(s): Kenta Iwasaki, Jing Ping, Yamamoto Takayuki, Miwa Yuko, Haneda Masataka, Watarai Yoshihiko, Katayama Akio, Uchida Kazuharu, Kobayashi Takaaki
  • Organizer: Congress of Asian Society of Transplantation (CAST) 2013
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Japan)
• [Presentation] Implication of complement reguｌatory proteins and AMP-reguLated kinase for graft accommodation (2013)
  • Author(s): Kenta Iwasaki, Jing Ping, Yuko Miwa, Masataka Haneda, Akira Onishi, Fumiaki Nakashima, Takaaki Kobayashi
  • Organizer: International Xenotransplantation Association (IXA) 2013
  • Place of Presentation: Osaka International Convention Center (Osaka, Japan)
• [Presentation] Porcine adipose-derived MSC might have a risk of enhancing T cell response, unlike human, mouse or rat MSC (2013)
  • Author(s): Yukiko Inanaga, Kenta Iwasaki, Yuko Miwa, Masataka Haneda, Akira Onishi, Shoichi Maruyama, Asako Ando, Takaaki Kobayashi
  • Organizer: International Xenotransplantation Association (IXA) 2013
  • Place of Presentation: Osaka International Convention Center (Osaka, Japan)
• [Presentation] 移植後のHLA抗体モニタリングは慢性抗体関連型拒絶反応の早期診断・治療に有効か？ (2013)
  • Author(s): 山本貴之、渡井至彦、辻田誠、平光高久、後藤憲彦、鳴海俊治、黒木聖久、武田朝美、両角國男、小林孝彰、打田和治
  • Organizer: 49回日本移植学会総会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] De novo DSA 陽性症例の病理組織学的検討：慢性活動性抗体関連型拒絶反応の診断はどこから可能か？ (2013)
  • Author(s): 武田朝美、山本貴之、平光高久、後藤憲彦、渡井至彦、小林孝彰、両角國男
  • Organizer: 49回日本移植学会総会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] 液性拒絶反応における血管内皮細胞の役割と凝固制御の意義 (2013)
  • Author(s): 三輪祐子、山本貴之、岩﨑研太、羽根田正隆、後藤憲彦、渡井至彦、武田朝美、丸山彰一、小林孝彰
  • Organizer: 49回日本移植学会総会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] HLA-DR 抗体接着はSD59の発現を減少させる (2013)
  • Author(s): 岩﨑研太、荊萍、中島文明、三輪祐子、羽根田正隆、小林孝彰
  • Organizer: 49回日本移植学会総会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] ブタ脂肪由来間葉系幹細胞の MHC Class I・II の発現と免疫調節機能 (2013)
  • Author(s): 稲永由紀子、岩崎研太、安藤麻子、大西彰、丸山彰一、小林孝彰
  • Organizer: 22回日本組織適合性学会大会
  • Place of Presentation: コラッセふくしま、福島