| Project/Area Number |
25293337
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAMASUNA Ryoichi 産業医科大学, 医学部, 准教授 (30189609)
高橋 聡 札幌医科大学, 医学部, 教授 (30332919)
福田 和正 産業医科大学, 医学部, 講師 (40389424)
庄 武彦 産業医科大学, 医学部, 助教 (30613632)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Satoshi 札幌医科大学, 医学部, 教授 (30332919)
FUKUDA Kazumasa 産業医科大学, 医学部, 講師 (40389424)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 尿道炎 / 病原性 / M. genitalium / clone library / 口腔内細菌 / T. vaginalis / クロンライブラリ法 / 細菌叢検索 / 淋菌 / M.genitalium / 口腔細菌 / oral sex / うがい液 / 非淋菌性尿道炎 / クラミジア / マイコプラズマ / ウレアプラズマ / トリコモナス / ウイルス / 男性 / 咽頭感染 / 薬剤感受性 |
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| Outline of Final Research Achievements |
From the specimens of male urethritis, many kinds of microorganisms are detected, but the pathogenicities of microorganisms except for N. gonorrhoeae or C. trachomatis has not been determined.
As the new approach, the clone library method was used for analysis of microorganisms of urethritis. This method added quantitative concept to qualitative PCR methods. By this method, the pathogenicities of N. gonorrhoeae adn M. genitalium to the male urethra was confirmed. In addition, it was found that H. influenzae and N. meningitidis would be possible pathogens for male urethritis.
By the examination of microorganisms in the oral cavities of patients with male urethritis, it was found that causative bacteria of male urethritis and bacteria of the resident flora in the vagina were detected in the oral cavities of male patients. these indicated that oral sex is closely related to STIs. When we treat male urethritis, we have to eradicate microorganisms in both the urethra and oral cavities.
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