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Epidemiological and therapeutical study of pathogens associated to non-gonococcal urethritis

Research Project

Project/Area Number 25293337
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Urology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

MATSUMOTO TETSURO  産業医科大学, 医学部, 名誉教授 (50150420)

Co-Investigator(Kenkyū-buntansha) HAMASUNA Ryoichi  産業医科大学, 医学部, 准教授 (30189609)
高橋 聡  札幌医科大学, 医学部, 教授 (30332919)
福田 和正  産業医科大学, 医学部, 講師 (40389424)
庄 武彦  産業医科大学, 医学部, 助教 (30613632)
Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Satoshi  札幌医科大学, 医学部, 教授 (30332919)
FUKUDA Kazumasa  産業医科大学, 医学部, 講師 (40389424)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords尿道炎 / 病原性 / M. genitalium / clone library / 口腔内細菌 / T. vaginalis / クロンライブラリ法 / 細菌叢検索 / 淋菌 / M.genitalium / 口腔細菌 / oral sex / うがい液 / 非淋菌性尿道炎 / クラミジア / マイコプラズマ / ウレアプラズマ / トリコモナス / ウイルス / 男性 / 咽頭感染 / 薬剤感受性
Outline of Final Research Achievements

From the specimens of male urethritis, many kinds of microorganisms are detected, but the pathogenicities of microorganisms except for N. gonorrhoeae or C. trachomatis has not been determined.
As the new approach, the clone library method was used for analysis of microorganisms of urethritis. This method added quantitative concept to qualitative PCR methods. By this method, the pathogenicities of N. gonorrhoeae adn M. genitalium to the male urethra was confirmed. In addition, it was found that H. influenzae and N. meningitidis would be possible pathogens for male urethritis.
By the examination of microorganisms in the oral cavities of patients with male urethritis, it was found that causative bacteria of male urethritis and bacteria of the resident flora in the vagina were detected in the oral cavities of male patients. these indicated that oral sex is closely related to STIs. When we treat male urethritis, we have to eradicate microorganisms in both the urethra and oral cavities.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (27 results)

All 2016 2015 2014 2013

All Journal Article (14 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] The first report: an analysis of bacterial flora of the first voided urine specimens of patients with male urethritis using the 16S ribosomal RNA gene-based clone library method2016

    • Author(s)
      C. You, R. Hamasuna, M. Ogawa, K. Fukuda, T. Hachisuga, T. Matsumoto, H. Taniguchi
    • Journal Title

      Microbial Pathogenesis

      Volume: 95 Pages: 95-100

    • DOI

      10.1016/j.micpath.2016.02.022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-20132015

    • Author(s)
      R. Hamasuna, M. Yasuda, K. Ishikawa, S. Uehara, H. Hayami, S. Takahashi, T. Matsumoto, S. Yamamoto, S. Minamitani, A. Watanabe, S. Iwata, M. Kaku, J. Kadota, K. Sunagawa, J. Sato, H. Hanaki, T. Tsukamoto, et al
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 21 Issue: 5 Pages: 340-345

    • DOI

      10.1016/j.jiac.2015.01.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The obstructive pyelonephritis due to urolithiasis in Japan: diagnosis, treatment and prognosis2015

    • Author(s)
      Hamasuna R, Takahashi S, Nagae H, Kubo T, Yamamoto S. Arakawa S, Matsumoto T.
    • Journal Title

      International Journal of Urology.

      Volume: 22 Issue: 3 Pages: 294-300

    • DOI

      10.1111/iju.12666

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腰痛を伴う感染症ー尿路性器に関連する感染症2015

    • Author(s)
      濵砂良一,岩隈景子,西井久枝
    • Journal Title

      Infection Front

      Volume: 33 Pages: 5-7

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 特集:泌尿器科外来パーフェクトガイドー誰にでも使える! 1.尿路・性器の感染症<腎周囲感染症と周辺疾患> 3. 腎周囲膿瘍2015

    • Author(s)
      濵砂良一,西井久枝
    • Journal Title

      臨床泌尿器科

      Volume: 69

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 特集:泌尿器科外来パーフェクトガイドー誰にでも使える! 1.尿路・性器の感染症<腎周囲感染症と周辺疾患> 3. 急性単純性膀胱炎2015

    • Author(s)
      濵砂良一
    • Journal Title

      臨床泌尿器科

      Volume: 69 Pages: 32-35

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 臨床に役立つ前立腺炎 慢性前立腺炎/慢性骨盤痛症候群2015

    • Author(s)
      濵砂良一
    • Journal Title

      Prostate Journal

      Volume: 2 Pages: 145-149

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 耐性病原体 up-to-date~耐性メカニズムから治療戦略まで~II耐性病原体 2グラム陰性菌 (6)セフトリアキソン耐性淋菌2014

    • Author(s)
      濵砂良一・松本哲朗・大西真
    • Journal Title

      化学療法の領域

      Volume: 30 S-1 Pages: 1005-1016

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Identification of treatment strategies for Mycoplasma genitalium-related urethritis in male patients by culturing and antimicrobial susceptibility testing2013

    • Author(s)
      Ryoichi Hamasuna
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 19 Issue: 1 Pages: 1-11

    • DOI

      10.1007/s10156-012-0487-3

    • NAID

      10031155812

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycoplasma genitalium in male urethritis-diagnosis and treatment in Japan2013

    • Author(s)
      Ryoichi Hamasuna
    • Journal Title

      Internationl Journal of Urology

      Volume: 20 Issue: 7 Pages: 676-684

    • DOI

      10.1111/iju.12152

    • NAID

      10031190513

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 泌尿器科診療 ベストNAVI 尿路・性器の感染症 性感染症 淋菌感染症2013

    • Author(s)
      濵砂良一
    • Journal Title

      臨床泌尿器科

      Volume: 67 Pages: 188-190

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 新興・再興感染症 uo to date~Emerging and re-memerging infectious diseases~ I細菌感染症  12. 薬剤耐性淋菌2013

    • Author(s)
      濵砂良一・松本哲朗・村谷哲郎
    • Journal Title

      化学療法の領域

      Volume: 29 Pages: 1007-1015

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 治療薬 淋菌感染症に対する治療薬 セフトリアキソン2013

    • Author(s)
      濵砂良一
    • Journal Title

      感染症内科

      Volume: 1 Pages: 408-414

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 泌尿器科診療 ベストNAVI 尿路・性器の感染症 性感染症 クラミジア感染症2013

    • Author(s)
      濵砂良一
    • Journal Title

      臨床泌尿器科

      Volume: 67 Pages: 193-195

    • Related Report
      2013 Annual Research Report
  • [Presentation] The detection of pathogens for non-gonococcal urethritis from the oral cavity of patients with male urethritis2016

    • Author(s)
      Hamasuna R, Le PT, Matsumoto M, Fujimoto H, Matsumoto T
    • Organizer
      17th IUSTI World Congress
    • Place of Presentation
      Marrakesh, Morroco
    • Year and Date
      2016-05-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] STI診断におけるマルチプレックスPCRの有用性2015

    • Author(s)
      濵砂良一
    • Organizer
      第28回 日本性感染症学会学術大会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オーラルセックスと感染症・・・すでに常識なのか2015

    • Author(s)
      濵砂良一
    • Organizer
      第16回 JFS 性科学セミナー
    • Place of Presentation
      埼玉県県民健康センター,浦和、埼玉
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ANALYSIS OF BACTERIAL FLORA OF THE URINE SPECIMENS FROM MALE PATIENTS WITH URETHRITIS BY THE CLONE LIBRARY METHOD BASED ON THE 16S RRNA GENE2015

    • Author(s)
      R. Hamasuna, CL You, K. Fukuda,N. Fujimoto, T. Hachisuga, T. Matsumoto,H. Taniguchi
    • Organizer
      2015 World STI & HIV Congress and Australasian HIV&AIDS Conference
    • Place of Presentation
      Brisben, Australia
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 注射用キノロン薬(pazufloxacin)の急性前立腺炎および急性精巣上体炎に対する臨床効果2015

    • Author(s)
      濵砂良一・岩隈景子・守屋良介・長谷川孝高・武内照生・廣田賀之・富崎一向・松本博臣・西井久枝・吉田毅・藤本直浩・松本哲朗
    • Organizer
      第103回 日本泌尿器科学会総会
    • Place of Presentation
      ホテル金沢日航、金沢、石川
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Symposium 9 Urogenital Infections; Risk factors for sexually transmitted Diseases2015

    • Author(s)
      R. Hamasuna
    • Organizer
      The 7th International Ongress of the Asia Pacific Society of Infection Control
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Recent advancement in genitourinary tract infection/inflammation:Asian guideline on sexually transmitted diseases2015

    • Author(s)
      R. Hamasuna
    • Organizer
      43rd General scientific meeting of the Taiwanese Association of Andrology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-03-07 – 2015-03-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Symposium 13 , Asian Pacific :Regional guideline for management of STI: UAA/AAUS guideline-preliminary recommendation for treatment of urethritis2014

    • Author(s)
      R. Hamasuna, M. Yasuda, S. Takahashi, G. Lee, S. Guputa
    • Organizer
      18th IUSTI Asian-Pacific Conferenc
    • Place of Presentation
      Bankok , Thailand
    • Year and Date
      2014-11-11 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Symposium 14, Pharyngeal STI, Sexual behaviors and pharyngeal infection2014

    • Author(s)
      R. Hamasuna、T.Matsumoto
    • Organizer
      18th IUSTI Asian-Pacific Conferenc
    • Place of Presentation
      Bankok , Thailand
    • Year and Date
      2014-11-11 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] New issues in adolescent Urology (II). “STIs in Japanese adolescents”2013

    • Author(s)
      R.Hamasuna
    • Organizer
      15rd Annual Congress od Asian-Pacific Association of Pediatric Urologists
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mycoplasma and ureaplasma infection, What new? Pathogenicity of Mycoplasma genitalium in men2013

    • Author(s)
      R.Hamasuna
    • Organizer
      28th International Congress of Chemotherapy and Infection
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Antimicrobial activity of sitafloxacin against fluoroquinolone-resistant Neisseria gonorrhoeae2013

    • Author(s)
      R. Hamasuna, T. Sho, M. Matsumoto, M. Matsumoto
    • Organizer
      28th International Congress of Chemotherapy and Infection
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Unique activity of sitafloxacin, one of newer fluoroquinolones, against ciprofloxacin-resistant N. gonorrhoeae2013

    • Author(s)
      R. Hamasuna, T. Sho, M. Matsumotom, T. Matsumoto
    • Organizer
      STI &AIDS World Congress 2013
    • Place of Presentation
      Viena, Austlia
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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