Exploit of novel preeclampsia model mice by a simple intervention, and elucidation of mechanism of onset of it
| Project/Area Number |
25293342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
KUMASAWA KEIICHI 大阪大学, 医学(系)研究科(研究院), 助教 (90444546)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Tadashi 大阪大学, 大学院医学系研究科, 教授 (90240845)
NAKAMURA Hitomi 大阪大学, 大学院医学系研究科, 助教 (80467571)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 妊娠高血圧症候群 / 胎盤特異的遺伝子導入 |
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| Outline of Final Research Achievements |
We performed novel intervention Z to pregnant mice at embryonic 10 day. The mice revealed preeclamptic phenotype. The intervention Z did not increase abortion rate. However the placenta was accompanied with hypoxia, which is usual in preeclamsia.
Four days after the intervention, blood pressure began to elevate. And after delivery the blood pressure recovered to the non-pregnant level. This phenotype mimicked the human preeclampsia. Additionally using the angiogenic factor W, we succeeded in the amelioration of hypertensive phenotype induced induced by the intervention Z.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Novel Nonsense Mutation in the NLRP7 Gene Assiciated with Recurrent Hydatidiform Mole.2016
Author(s)
Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K.
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Journal Title
Gynecol Obstet Invest
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Drug repositioning for preeclampsia therapeutics by in vitro screening: phosphodiesterase-5 inhibitor vardenafil restores endothelial dysfunction via induction of placental growth factor2015
Author(s)
Kakigano, A. Tomimatsu, T. Mimura, K. Kanayama, T. Fujita, S. Minato, K. Kumasawa, K. Taniguchi, Y. Kanagawa, T. Endo, M. Ishihara, T. Namba, T. Mizushima, T. Kimura, T.
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Journal Title
Reproductive Sciences
Volume: 10
Issue: 10
Pages: 1272-80
DOI
Related Report
Peer Reviewed
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[Journal Article] Disease flare-ups and obstetric outcomes in pregnant women with systemic lupus erythematosus2013
Author(s)
Takahashi, K. Mimura, K. Kanagawa, T. Kinugasa-Taniguchi, Y. Endo, M. Matsuzaki, S. Kumasawa, K. Hashimoto, K. Tomimatsu, T. Kimura, T.
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Journal Title
Hypertens Res Pregnancy
Volume: 2
Pages: 1-5
NAID
Related Report
Peer Reviewed
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[Presentation] Development of a new local drug delivery system for the uterus using bio-nanocapsule2015
Author(s)
Koizumi, K. Nakamura, H. Matsuzaki, T. Kuroda, S. Yasui, Y. Furuya, K. Miyake, T. Takiuchi, T. Kumasawa, K. Kimura, T.
Organizer
American Society for Reproductive Medicine 2015 Annual Meeting
Place of Presentation
Baltimore, U.S.A.
Year and Date
2015-10-19
Related Report
Int'l Joint Research
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