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Novel therapeutic strategy targeting ovarian cancer stem cells and their niche

Research Project

Project/Area Number 25293344
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKumamoto University

Principal Investigator

Katabuchi Hidetaka  熊本大学, 大学院生命科学研究部(医), 教授 (90224451)

Co-Investigator(Kenkyū-buntansha) TASHIRO HIRONORI  熊本大学, 医学部附属病院, 特任准教授 (70304996)
MOTOHARA TAKESHI  熊本大学, 大学院生命科学研究部, 助教 (10457591)
TAKAISHI KIYOMI  熊本大学, 医学部附属病院, 助教 (00601303)
SAKAGUCHI ISAO  熊本大学, 医学部附属病院, 助教 (40448527)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords卵巣癌 / 癌幹細胞 / CD44 / 上皮性卵巣癌 / 卵巣表層上皮 / 卵巣癌治療 / 卵巣癌モデル
Outline of Final Research Achievements

To investigate the role of cancer stem cell marker CD44 variant 6 (CD44v6) in the development of distant metastasis in patients with epithelial ovarian cancer. The association between the expression of CD44v6 and distant metastasis was evaluated based on immunohistochemical analysis. Distant metastasis-free survival was compared between the CD44v6-high and -low groups. At the time of ovarian cancer diagnosis, distant metastasis occurred in 13 of 53 patients in the CD44v6-high group and 17 of 133 patients in the CD44v6-low group. The median metastasis-free survival after stage I-III ovarian cancer diagnosis was 19.5 months in the CD44v6-high group and 39.5 months in the CD44v6-low group. Multivariate analysis demonstrated that CD44v6 expression was an independent risk factor for distant metastatic recurrence. In conclusion, CD44v6 represents an important predictor of distant metastasis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Invited: 2 results)

  • [Journal Article] CD44 variant 6 as a predictive biomarker for distant metastasis in patients with epithelial ovarian cancer.2016

    • Author(s)
      11.Motohara T, Fujimoto K, Tayama S, Narantuya D, Guo J, Sakaguchi I, Tashiro H, Katabuchi H.
    • Journal Title

      Epub ahead of print

      Volume: Epub ahead of print

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer.2015

    • Author(s)
      Tjhay F, Motohara T, Tayama S, Narantuya D, Fujimoto K, Guo J, Sakaguchi I, Honda R, Tashiro H, Katabuchi H.
    • Journal Title

      Cancer Sci

      Volume: 106 Issue: 10 Pages: 1421-1428

    • DOI

      10.1111/cas.12765

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Low-grade漿液性腺癌の臨床病理・ゲノムと治療法.2015

    • Author(s)
      本原 剛志, 坂口 勲, 片渕秀隆.
    • Journal Title

      臨婦産.

      Volume: 69 Pages: 118-123

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 卵巣癌2014

    • Author(s)
      永瀬 智、片渕 秀隆、八重樫伸生
    • Journal Title

      診療ガイドライン Up-To-Date 2014-2015

      Volume: なし Pages: 833-838

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice.2014

    • Author(s)
      Matsuo Y, Tashiro H, Yanai H, Moriya T, Katabuchi H.
    • Journal Title

      Med Mol Morphol.

      Volume: e-Pub Issue: 3 Pages: 146-154

    • DOI

      10.1007/s00795-014-0090-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 正常大卵巣に局在し抗NMDA受容体脳炎を惹起した成熟嚢胞性奇形腫の1例.2014

    • Author(s)
      田山 親吾, 田代 浩徳, 本原 剛志, 山口 宗影, 本原 研一, 大場 隆, 片渕 秀隆.
    • Journal Title

      日婦腫瘍会誌.

      Volume: 32 Pages: 257-262

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-grade漿液性腺癌の病態と治療.2014

    • Author(s)
      本原 剛志, 片渕秀隆
    • Journal Title

      産婦の実際.

      Volume: 63 Pages: 959-965

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of concurrent benign metastasizing leiomyoma in the lung and retroperitoneum, with a focus on its etiology.2014

    • Author(s)
      Tohya T, Tajima T, Takeshita Y, Ito K, Kuriwaki K, Katabuchi H.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40 Pages: 2010-2013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Relationship Between Estrogen and Genes in the Molecular Pathogenesis of Endometrial Carcinoma2014

    • Author(s)
      Hironori Tashiro, Hidetaka Katabuchi
    • Journal Title

      Current Obstetrics and Gynecology Reports

      Volume: 3 Pages: 9-17

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling.2013

    • Author(s)
      Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M, Komohara Y.
    • Journal Title

      Oncology Letters

      Volume: 6 Pages: 1619-1623

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013

    • Author(s)
      Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
    • Journal Title

      Cancer Res

      Volume: 73(6) Issue: 6 Pages: 1855-1866

    • DOI

      10.1158/0008-5472.can-12-3609-t

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] CD44 variant 6 is associated with peritoneal metastasis and poor prognosis in advanced ovarian cancer patients.2015

    • Author(s)
      Takeshi Motohara, Shingo Tayama, Isao Sakaguchi, Hironori Tashiro, Hidetaka Katabuchi.
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 卵巣癌におけるEpCAM陽性細胞は抗アポトーシス作用を介した抗がん剤治療抵抗性を有する2014

    • Author(s)
      田山 親吾、本原 剛志、坂口 勲、田代 浩徳、片渕 秀隆
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-24 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 卵巣癌幹細胞および癌幹細胞ニッチを標的した新規治療戦略2014

    • Author(s)
      本原 剛志
    • Organizer
      第26回女性医学講座
    • Place of Presentation
      熊本市
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 卵巣癌幹細胞および癌幹細胞ニッチとして機能する骨盤腹膜を標的とした新たな治療戦略2014

    • Author(s)
      本原 剛志
    • Organizer
      第66回 日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Epithelial cell adhesion molecule, a potential marker of cancer stem cell, is associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer2013

    • Author(s)
      Tayama S., Motohara T., Katabuchi H.
    • Organizer
      The 99th Annual Congress of Korean Society of Obstetrics and Gynecology
    • Place of Presentation
      Grand Hilton,Seoul,Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Epithelial cell adhesion molecule, a potential marker of cancer stem cell, is associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer

    • Author(s)
      Tayama S., Motohara T., Tjhay F., Narantuya D., Takaishi K., Tashiro T., Katabuchi H.
    • Organizer
      The 4th Asan-Kumamoto Joint Symposium
    • Place of Presentation
      阿蘇リゾートグランヴィリオホテル、Kumamoto, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Survival impact of wide resection of the pelvic peritoneum in patients with epithelial ovarian cancer:Towards the development of novel surgical strategies for the removal of ovarian cancer stem cells and their niche

    • Author(s)
      Motohara T., Tayama S., Saito F., Tjhay F., Takaishi K., Sakaguchi I., Tashiro H., Katabuchi K.
    • Organizer
      The 4th Asan-Kumamoto Joint Symposium
    • Place of Presentation
      阿蘇リゾートグランヴィリオホテル、Kumamoto, Japan
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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