Novel therapeutic strategy targeting ovarian cancer stem cells and their niche
| Project/Area Number |
25293344
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TASHIRO HIRONORI 熊本大学, 医学部附属病院, 特任准教授 (70304996)
MOTOHARA TAKESHI 熊本大学, 大学院生命科学研究部, 助教 (10457591)
TAKAISHI KIYOMI 熊本大学, 医学部附属病院, 助教 (00601303)
SAKAGUCHI ISAO 熊本大学, 医学部附属病院, 助教 (40448527)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 卵巣癌 / 癌幹細胞 / CD44 / 上皮性卵巣癌 / 卵巣表層上皮 / 卵巣癌治療 / 卵巣癌モデル |
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| Outline of Final Research Achievements |
To investigate the role of cancer stem cell marker CD44 variant 6 (CD44v6) in the development of distant metastasis in patients with epithelial ovarian cancer. The association between the expression of CD44v6 and distant metastasis was evaluated based on immunohistochemical analysis. Distant metastasis-free survival was compared between the CD44v6-high and -low groups. At the time of ovarian cancer diagnosis, distant metastasis occurred in 13 of 53 patients in the CD44v6-high group and 17 of 133 patients in the CD44v6-low group. The median metastasis-free survival after stage I-III ovarian cancer diagnosis was 19.5 months in the CD44v6-high group and 39.5 months in the CD44v6-low group. Multivariate analysis demonstrated that CD44v6 expression was an independent risk factor for distant metastatic recurrence. In conclusion, CD44v6 represents an important predictor of distant metastasis.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013
Author(s)
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
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Journal Title
Cancer Res
Volume: 73(6)
Issue: 6
Pages: 1855-1866
DOI
Related Report
Peer Reviewed
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