Role of Vasopressin-Aquaporin2 System in the Formation of Endolymphatic Hydrops
| Project/Area Number |
25293346
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kobe University (2016)
The University of Tokyo (2013-2015) |
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Principal Investigator |
Kakigi Akinobu 神戸大学, 医学(系)研究科(研究院), 特命教授 (60243820)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA SHINJI 東京大学, 先端科学技術センター, 教授 (40239968)
SAKAMOTO TAKASHI 東京大学, 医学部附属病院, 講師 (50323548)
EGAMI NAOYA 東京大学, 医学部附属病院, 講師 (10505895)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Keywords | メニエール病 / 抗利尿ホルモン / アクアポリン / 内リンパ水腫 / OCT / イソソルビド / 耳鼻咽喉科 / 耳科学 / 水チャネル |
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| Outline of Final Research Achievements |
Meniere’s disease（MD）is histologically characterized by endolymphatic hydrops in the inner ear. The mechanisms underlying overaccumulation of endolymph still remain an enigma. There is considerable evidence that water homeostasis in the inner ear is regulated partly via the vasopressin-aquaporin2 (VP-AQP2) system, suggesting that endolymphatic hydrops, a morphological characteristic of Meniere’s disease, may reflect the mal-regulation of the VP-AQP2 system in inner ear fluid.
In this study, we revealed the existence of AQP2 in the stria vascularis. Moreover, administration of vasopressin type2 receptor agonist induced formation of endolymphatic hydrops. We observed this phenomenon using OCT in vivo. Further, we observed the decompression effect of isosorbide on endolymphatic hydrops by OCT in vivo. These results seem to be useful to understand the underlining mechanisms of formation of endolymphatic hydrops.
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Report
(5 results)
Research Products
(14 results)
