| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Outline of Final Research Achievements |
Meniere’s disease（MD）is histologically characterized by endolymphatic hydrops in the inner ear. The mechanisms underlying overaccumulation of endolymph still remain an enigma. There is considerable evidence that water homeostasis in the inner ear is regulated partly via the vasopressin-aquaporin2 (VP-AQP2) system, suggesting that endolymphatic hydrops, a morphological characteristic of Meniere’s disease, may reflect the mal-regulation of the VP-AQP2 system in inner ear fluid.
In this study, we revealed the existence of AQP2 in the stria vascularis. Moreover, administration of vasopressin type2 receptor agonist induced formation of endolymphatic hydrops. We observed this phenomenon using OCT in vivo. Further, we observed the decompression effect of isosorbide on endolymphatic hydrops by OCT in vivo. These results seem to be useful to understand the underlining mechanisms of formation of endolymphatic hydrops.
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