• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the role of biological defense mechanisms by the intracellular proteolysis systems in damages of the inner ear

Research Project

Project/Area Number 25293347
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

Iwasaki Shinichi  東京大学, 医学部附属病院, 准教授 (10359606)

Co-Investigator(Kenkyū-buntansha) 吉川 弥生  東京大学, 医学部附属病院, 病院診療医 (00452350)
樫尾 明憲  東京大学, 医学部附属病院, 助教 (20451809)
中島 敏明  獨協医科大学, 医学部, 教授 (50227790)
藤本 千里  東京大学, 医学部附属病院, 助教 (60581882)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords脳・神経 / 内耳 / タンパク質 / オートファジー / プロテアソーム / 有毛細胞
Outline of Final Research Achievements

To investigate the role of the intracellular proteolysis systems in damages in the inner ear, we analyzed the roles of the ubiquitin-proteasome system and the autophagy-lysosome system.
To investigate the role of the autophagy-lysosome system in the inner ear, we generated mice deficient in a gene essential for autophagy (Atg5) in hair cells in the inner ear. Deletion of Atg5 resulted in hair cell degeneration and profound congenital hearing loss. To investigate the role of the ubiquitin-proteasome system in the inner ear, we analyzed the effect of proteasome inhibitor (MG-132) in cultured inner ear cells under oxidative damage. The low concentration of proteasome inhibitor had some protective effect, but it had toxic effect in the higher concentration.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (32 results)

All 2017 2016 2015 2014 2013

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (15 results) (of which Int'l Joint Research: 5 results,  Invited: 8 results)

  • [Journal Article] Autophagy is essential for hearing in mice.2017

    • Author(s)
      Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N, Yamasoba T.
    • Journal Title

      Cell Death Dis

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice.2017

    • Author(s)
      Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, Yamasoba T
    • Journal Title

      Neurosci Lett

      Volume: 642 Pages: 123-128

    • DOI

      10.1016/j.neulet.2017.02.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of peripheral vestibular dysfunction on dynamic postural stability measured by the functional reach test and timed up and go test.2017

    • Author(s)
      Nishi T, Kamogashira T, Fujimoto C, Kinoshita M, Egami N, Sugasawa K, Yamasoba T, Iwasaki S*
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress.2017

    • Author(s)
      Kamogashira T, Hayashi K, Fujimoto C, Iwasaki S, Yamasoba T.
    • Journal Title

      Aging Mechanisms Dis

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Noisy Galvanic Vestibular Stimulation on Ocular Vestibular-Evoked Myogenic Potentials to Bone-Conducted Vibration2017

    • Author(s)
      Iwasaki S, Karino S, Kamogashira T, Togo F, Fujimoto C, Yamamoto Y, Yamasoba T
    • Journal Title

      Front Neurol

      Volume: 8 Pages: 26-26

    • DOI

      10.3389/fneur.2017.00026

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of vestibular organs in idiopathic sudden hearing loss with vertigo: An analysis using oVEMP and cVEMP testing.2015

    • Author(s)
      Fujimoto C, Egami N, Kinoshita M, Sugasawa K, Yamasoba T, Iwasaki S.
    • Journal Title

      Clin Neurophysiol.

      Volume: 126 Issue: 5 Pages: 1033-8

    • DOI

      10.1016/j.clinph.2014.07.028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.2015

    • Author(s)
      Yoshimoto R, Iwasaki S*, Takago H, Nakajima T, Sahara Y, Kitamura K.
    • Journal Title

      Neuroscience

      Volume: 284 Pages: 632-642

    • DOI

      10.1016/j.neuroscience.2014.10.034

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting round window niche visibility via the facial recess using high-resolution computed tomography.2015

    • Author(s)
      Kashio A, Sakamoto T, Karino S, Kakigi A, Iwasaki S, Yamasoba T.
    • Journal Title

      Otol Neurotol.

      Volume: 36 Issue: 1 Pages: e18-e23

    • DOI

      10.1097/mao.0000000000000644

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical characteristics of patients with abnormal ocular/cervical vestibular evoked myogenic potentials in the presence of normal caloric responses.2015

    • Author(s)
      Iwasaki S, Fujimoto C, Kinoshita M, Kamogashira T, Egami N, Yamasoba T.
    • Journal Title

      Ann Otol Rhinol Laryngol.

      Volume: 124(6) Issue: 6 Pages: 458-465

    • DOI

      10.1177/0003489414564997

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of center-of-pressure power spectrum in foam posturography.2015

    • Author(s)
      Fujimoto C, Egami N, Demura S, Yamasoba T, Iwasaki S.
    • Journal Title

      Neurosci Lett.

      Volume: 585 Pages: 92-7

    • DOI

      10.1016/j.neulet.2014.11.033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dizziness and imbalance in the elderly: Age-related decline in the vestibular system.2015

    • Author(s)
      Iwasaki S, Yamasoba T.
    • Journal Title

      Aging Dis

      Volume: 6 Issue: 1 Pages: 38-47

    • DOI

      10.14336/ad.2014.0128

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental changes in the protective effect of exogenous brain-derived neurotrophic factor and neurotrophin-3 against ototoxic drugs in cultured rat vestibular ganglion.2014

    • Author(s)
      Inoue A, Iwasaki S, Fujimoto C, Nakajima T, Yamasoba T
    • Journal Title

      Cell Tissue Res

      Volume: 356 Issue: 2 Pages: 299-308

    • DOI

      10.1007/s00441-014-1813-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fujimoto C, Yamasoba T, Iwasaki S. Idiopathic latent vestibulopathy: a clinical entity as a cause of chronic postural instability.2014

    • Author(s)
      Fujimoto C, Yamasoba T, Iwasaki S.
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 272 Issue: 1 Pages: 43-49

    • DOI

      10.1007/s00405-013-2834-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Noisy vestibular stimulation improves body balance in bilateral vestibulopathy.2014

    • Author(s)
      Iwasaki S, Yamamoto Y, Togo F, Kinoshita M, Yoshifuji Y, Fujimoto C, Yamasoba T.
    • Journal Title

      Neurology

      Volume: 82 Issue: 11 Pages: 969-975

    • DOI

      10.1212/wnl.0000000000000215

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ocular vestibular evoked myogenic potentials in response to air-conducted sound and bone-conducted vibration in vestibular schwannoma2013

    • Author(s)
      Kinoshita M, Iwasaki S, Fujimoto C, Inoue A, Egami N, Chihara Y, Ushio M, Yamasoba T
    • Journal Title

      Otol Neurotol

      Volume: 34 Pages: 1342-1348

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of a first-generation H1-antihistamine on postural control: a preliminary study in healthy volunteers2013

    • Author(s)
      Chihara Y, Sato Y, Ohtani M, Fujimoto C, Hayashi T, Nishijima H, Yagi M, Iwasaki S.
    • Journal Title

      Exp Brain Res

      Volume: 231 Pages: 257-266

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ocular vestibular evoked myogenic potential elicited from binaural air-conducted stimulations: clinical feasibility in patients with peripheral vestibular dysfunction2013

    • Author(s)
      Iwasaki S, Egami N, Inoue A, Kinoshita M, Fujimoto C, Murofushi T, Yamasoba T.
    • Journal Title

      Acta Otolaryngol

      Volume: 133 Issue: 7 Pages: 1342-1348

    • DOI

      10.3109/00016489.2013.767476

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 経皮的ノイズ前庭電気刺激が歩行に及ぼす影響:両側前庭障害症例の検討2016

    • Author(s)
      岩﨑真一、藤本千里、木下淳、江上直也、鴨頭輝、牛尾宗貴、菅澤恵子、山岨達也
    • Organizer
      第117回日本耳鼻咽喉科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2016 Annual Research Report
  • [Presentation] VEMP (Basic)-The neural basis of vestibular evoked myogenic potentials. Characteristics of oVEMPs in response to air-conducted sound and bone-conducted vibration.2016

    • Author(s)
      Iwasaki S
    • Organizer
      29th Barany Society Meeting
    • Place of Presentation
      Grand InterContinental Seoul (Seoul, Korea)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of noisy galvanic vestibular stimulation on locomotion in patients with bilateral vestibular dysfunction2016

    • Author(s)
      Iwasaki S, Fujimoto C, Egami N, Kinoshita M, Kamogashira T, Yamasoba T.
    • Organizer
      2016 Annual CORLAS Meeting
    • Place of Presentation
      Bordeaux, France
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ノイズ電気刺激を利用した両側前庭障害患者の体平衡機能改善2016

    • Author(s)
      岩﨑真一
    • Organizer
      第75回日本めまい平衡医学会総会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Probing vestibular function from postural stability.2015

    • Author(s)
      Iwasaki S
    • Organizer
      13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery,
    • Place of Presentation
      学術総合センター(東京)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 経皮的ノイズ前庭電気刺激が歩行に及ぼす影響の検討2015

    • Author(s)
      岩﨑真一、藤本千里、木下淳、江上直也、牛尾宗貴、鴨頭輝、西敏子、菅澤恵子、山岨達也
    • Organizer
      第74回日本めまい平衡医学会総会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of noisy galvanic vestibular stimulation on ocular vestibular evoked myogenic potential to bone-conducted vibration.2015

    • Author(s)
      Iwasaki S, Kamogashira T, Karino S, Fujimoto C, Yamasoba T.
    • Organizer
      2015 Annual CORLAS Meeting
    • Place of Presentation
      Palace Hotel (San Francisco, USA)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] めまい・平衡機能の老化への対策と積極的介入治療2015

    • Author(s)
      岩﨑真一
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical usefulness of ocular vestibular evoked myogenic potentials (oVEMPs) and cervical vestibular evoked myogenic potentials (cVEMPs)2014

    • Author(s)
      Iwasaki S
    • Organizer
      Joint meeting of Japan Society for Equilibrium Research and The Korean Balance Society
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 経皮的ノイズ前庭電気刺激が前庭誘発眼筋電位(oVEMP)に及ぼす影響2014

    • Author(s)
      岩﨑真一、狩野章太郎、鴨頭輝、木下淳、藤本千里、山岨達也
    • Organizer
      第24回日本耳科学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高齢者のめまい:診断と治療2014

    • Author(s)
      岩﨑真一
    • Organizer
      長崎めまい講演会2014
    • Place of Presentation
      長崎
    • Year and Date
      2014-07-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高齢者のめまいとその対策2014

    • Author(s)
      岩﨑真一
    • Organizer
      第16回 山形めまい研究会
    • Place of Presentation
      山形
    • Year and Date
      2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Idiopathic bilateral vestibulopathy: Entity or misdiagnose?2013

    • Author(s)
      Iwasaki S
    • Organizer
      29th Politzer Society Meeting
    • Place of Presentation
      Antalya, Turkey (Susesi Hotel)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 温度刺激検査正常で、oVEMP, cVEMPのみが異常を呈するめまい症齢の検討2013

    • Author(s)
      岩﨑真一、牛尾宗貴、江上直也、藤本千里、木下淳、井上亜希、菅澤恵子、山岨達也
    • Organizer
      第114回日本耳鼻咽喉科学会総会
    • Place of Presentation
      札幌 (ロイトン札幌)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 経皮的ノイズ前庭電気刺激による体平衡機能改善の試み:両側末梢前庭障害患者における検討2013

    • Author(s)
      岩崎真一、木下淳、江上直也、藤本千里、牛尾宗貴、山岨達也
    • Organizer
      第23回日本耳科学会総会
    • Place of Presentation
      宮崎 (フェニックス シーガイア リゾート)
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi