Treatment strategy for intractable upper airway diseases concerning gene-polymorphism-related molecules and local basophils.
Project/Area Number |
25293348
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | University of Fukui |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SAKASHITA Masafumi 福井大学, 医学部, 助教 (40555455)
IMOTO Yoshimasa 福井大学, 医学部附属病院, 助教 (50418703)
TOMITA Kaori 福井大学, 医学部, 特別研究員 (30444227)
TAKABAYASHI Tetsuji 福井大学, 医学部附属病院, 講師 (70397272)
FUJIEDA Shigeharu 福井大学, 医学部, 教授 (30238539)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
Keywords | 好塩基球 / 花粉症 / 好酸球性副鼻腔炎 / 好酸球 / 肥満細胞 / 気管支喘息 / 好酸球鼻副鼻腔炎 / 鼻副鼻腔炎 / アレルギー性鼻炎 / アレルギー / 副鼻腔炎 / 好塩基性細胞 |
Outline of Final Research Achievements |
The intractable upper airway diseases including Japanese Cedar Pollinosis and eosinophilic chronic rhinosinusitis have been focused on. We have identified the phenotype of pollinosis refractory to sublingual immunotherapy. The antigen-induced expression level of CD203c on basophils from the patients with pollinosis was a more objective and reliable biomarker. The antigen- induced production of IL-4 increased in the basophilic cell line that was over-expressed by the gene-polymorphism-related molecules ORMDL3. Dectin-1 recognizes β-glucan, and dectin-1-mediated signaling stimulated gene expression of IL-4 through Syk in the basophilic cell line. Chronic rhinosinusitis without nasal polyps had increased levels of type 2 mediators, including IL-5, IL-13, eotaxin-2, and MCP-4. Aspirin-exacerbated respiratory disease had elevated protein levels of ECP, GM-CSF, and MCP-1, as well as decreased tissue plasminogen activator.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Guiding principles of sublingual immunotherapy for allergic rhinitis in Japanese patients.2016
Author(s)
Masuyama K, Goto M, Takeno S, Ohta N, Okano M, Kamijo A, Suzuki M, Terada T, Sakurai D, Horiguchi S, Honda K, Matsune S, Yamada T, Sakashita M, Yuta A, Fuchiwaki T, Miyanohara I, Nakayama T, Okamoto Y, Fujieda S.
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Journal Title
Auris Nasus Larynx.
Volume: 43(1)
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen2015
Author(s)
Imoto Y, Takabayashi T, Sakashita M, Tokunaga T, Ninomiya T, Ito Y, Narita N, Yamada T, Fujieda S
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Journal Title
Immun Inflamm Dis
Volume: 3
Issue: 3
Pages: 300-308
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease2015
Author(s)
Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, Takabayashi T, Norton JE, Hulse KE, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Kato A, Harris KE, Carter RG, Fujieda S, Kern RC, Schleimer RP
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Journal Title
Am J Respir Crit Care Med
Volume: 192
Issue: 6
Pages: 682-694
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC Study.2015
Author(s)
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Yamada K, Okano M, Ohtori N, Yoshikawa M, et al
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Journal Title
Allergy
Volume: Epub ahead of print
Issue: 8
Pages: 995-1003
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Factors associated with the development and remission of allergic diseases in an epidemiological survey of high school students in Japan.2015
Author(s)
Tokunaga T, Ninomiya T, Osawa Y, Imoto Y, Ito Y, Takabayashi T, Narita N, Kijima A, Murota H, Katayama I, Fujieda S.
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Journal Title
Am J Rhinol Allergy.
Volume: 29
Issue: 2
Pages: 94-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Novel IL36RN gene mutation revealed by analysis of 8 Japanese patients with generalized pustular psoriasis.2014
Author(s)
Hayashi M, Nakayama T, Hirota T, Saeki H, Nobeyama Y, Ito T, Umezawa Y, Fukuchi O, Yanaba K, Kikuchi S, Nakagawa H, Tsunemi Y, Shibata S, Sato S, Tada Y, Miyatake A, Fujieda S, Tamari M.
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Journal Title
J Dermatol Sci.
Volume: 76
Pages: 267-9
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Japanese Guideline for Allergic Rhinitis 20142014
Author(s)
Okubo K, Kurono Y, Fujieda S, Ogino S, Uchio E, Odajima H, Takenaka H; Japanese Society of Allergology.
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Journal Title
Allergology International
Volume: 63
Issue: 3
Pages: 357-375
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Guiding principles of subcutaneous immunotherapy for allergic rhinitis in Japan.2014
Author(s)
Okamoto Y, Ohta N, Okano M, Kamijo A, Gotoh M, Suzuki M, Takeno S, Terada T, Hanazawa T, Horiguchi S, Honda K, Matsune S, Yamada T, Yuta A, Nakayama T, Fujieda S.
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Journal Title
Auris Nasus Larynx.
Volume: 41
Pages: 1-5
Related Report
Peer Reviewed
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[Presentation] アレルギー性鼻炎のフェノタイプ2014
Author(s)
山田武千代
Organizer
第一回総合アレルギー講習会
Place of Presentation
横浜(パシフィコ横浜会議センター)
Year and Date
2014-12-20 – 2014-12-21
Related Report
Invited
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[Presentation] 舌下免疫療法の基礎と実際2014
Author(s)
山田武千代
Organizer
第3回日本アレルギー学会舌下免疫療法講習会
Place of Presentation
東京(東京国際フォーラム)
Year and Date
2014-07-26
Related Report
Invited
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[Presentation] 鼻閉と咳嗽との関連2014
Author(s)
山田武千代
Organizer
第26回日本アレルギー学会春季臨床大会
Place of Presentation
京都(国立京都国際会館)
Year and Date
2014-05-10 – 2014-05-11
Related Report
Invited
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