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Elucidation of regulatory mechanism of neurovascular coupling interaction in retinal circulation and clinical application for early diagnosis of diabetic retinopathy

Research Project

Project/Area Number 25293352
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionAsahikawa Medical College

Principal Investigator

NAGAOKA Taiji  旭川医科大学, 医学部, 准教授 (00333691)

Co-Investigator(Kenkyū-buntansha) 横田 陽匡  旭川医科大学, 医学部, 助教 (60431417)
大谷 真一  旭川医科大学, 大学病院, その他 (70548841)
高橋 淳士  旭川医科大学, 医学部, 助教 (90422047)
善岡 尊文  旭川医科大学, 大学病院, その他 (20548854)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords網膜微小循環 / 糖尿病網膜症 / 神経-血管連関 / 網膜循環調節 / 神経血管連関 / 一酸化窒素 / 網膜血流 / 微小循環
Outline of Final Research Achievements

We have revealed that 1) retinal glial cells may be involved with the retinal neurovascular coupling during systemic hyperoxia 2) EDHF may be involved with histamine-induced vasodilation in retinal porcine arterioles 3) habitual smoking may have some influences on retinal circulation in patients with diabetic retinopathy.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (30 results)

All 2016 2015 2014 2013 Other

All Journal Article (24 results) (of which Peer Reviewed: 24 results,  Open Access: 3 results,  Acknowledgement Compliant: 11 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] Glial Endothelin-1 Regulates Retinal Blood Flow during Hyperoxia in Cats.2016

    • Author(s)
      Song YS, Nagaoka T, Yoshioka T, Ono S, Wada T, Nakabayashi S, Tani T, Yoshida A
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 11 Issue: 11 Pages: 4962-4969

    • DOI

      10.1167/iovs.16-19599

    • NAID

      120006343723

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor2016

    • Author(s)
      Otani S, Nagaoka T, Omae T, Tanano I, Kamiya T, Ono S, Hein TW, Kuo L, Yoshida A
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 11 Issue: 11 Pages: 4791-4798

    • DOI

      10.1167/iovs.15-19038

    • NAID

      120006325061

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of Habitual Cigarette Smoking on Retinal Circulation in Patients With Type 2 Diabetes.2016

    • Author(s)
      Tsuneaki Omae Taiji Nagaoka Akitoshi Yoshida
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57 Issue: 3 Pages: 1345-51

    • DOI

      10.1167/iovs.15-18813

    • NAID

      120006346197

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Retinal Circulation Using Segmental-Scanning Doppler Optical Coherence Tomography in Anesthetized Cats.2016

    • Author(s)
      Nagaoka T, Tani T, Song YS, Yoshioka T, Ishibazawa A, Nakabayashi S, Akiba M, Yoshida A.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57(7) Pages: 2936-2941

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characteristics of Retinal Neovascularization in Proliferative Diabetic Retinopathy Imaged by Optical Coherence Tomography Angiography.2016

    • Author(s)
      Ishibazawa A, Nagaoka T, Yokota H, Takahashi A, Omae T, Song YS, Takahashi T, Yoshida A.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57(14) Pages: 6247-6255

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] En face Swept-Source Optical Coherence Tomographic Analysis of X-linked Juvenile Retinoschisis.2016

    • Author(s)
      Ono S, Takahashi A, Mase T, Nagaoka T, Yoshida A.
    • Journal Title

      Am J Ophthalmol Case Rep.

      Volume: 2 Pages: 30-32

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Systemic Risk Factors in Bilateral Proliferative Diabetic Retinopathy Requiring Vitrectomy.2016

    • Author(s)
      Song YS, Nagaoka T*, Omae T, Yokota H, Takahashi A, Yoshida A.
    • Journal Title

      Retina.

      Volume: 36(7) Pages: 1309-1313

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Radial Peripapillary Capillary Network Visualized Using Wide-Field Montage Optical Coherence Tomography Angiography.2016

    • Author(s)
      Mase T, Ishibazawa A, Nagaoka T, Yokota H, Yoshida A.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57(9)

    • NAID

      120005822574

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Short-term effect of intravitreal ranibizumab therapy on macular edema after branch retinal vein occlusion.2016

    • Author(s)
      Minami Y, Nagaoka T, Ishibazawa A, Yoshida A.
    • Journal Title

      Retina.

      Volume: 36(9) Pages: 1726-1732

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuroprotective effect of Water-dispersible hesperetin in retinal ischemia reperfusion injury.2016

    • Author(s)
      Shimouchi A, Yokota H, Ono S, Matsumoto C, Tamai T, Takumi H, Narayanan SP, Kimura S, Kobayashi H, Caldwell RB, Nagaoka T, Yoshida A.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 60(1) Pages: 51-61

    • NAID

      210000170569

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enhanced Vitreous Imaging Optical Coherence Tomography in Primary Macular Holes.2016

    • Author(s)
      Takahashi A, Nagaoka T, Yoshida A.
    • Journal Title

      Int Ophthalmol.

      Volume: 36(3) Pages: 355-363

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] En-face Optical Coherence Tomography Angiography of Neovascularization Elsewhere in hemi Central Retinal Vein Occlusion.2015

    • Author(s)
      Sogawa K, Nagaoka T, Ishibazawa A, Takahashi A, Tani T, Yoshida A.
    • Journal Title

      Int Med Case Rep J

      Volume: 8 Pages: 263-266

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Choroidal thickness evaluation before and after hemodialysis in patients with and without diabetes.2015

    • Author(s)
      Ishibazawa A, Nagaoka T, Minami Y, Kitahara M, Yamashita T, Yoshida A.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 56(11) Pages: 6534-6541

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Intravitreal Rho kinase inhibitor Ripasudil (K-115) on feline retinal microcirculation.2015

    • Author(s)
      Nakabayashi S, Kawai M, Yoshioka T, Song YS, Tani T, Yoshida A, Nagaoka T.
    • Journal Title

      Exp Eye Res.

      Volume: 139 Pages: 132-135

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of the Corneal Sub-Basal Whorl-Like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients with Diabetes.2015

    • Author(s)
      Utsunomiya T, Nagaoka T, Hanada K, Omae T, Yokota H, Abiko A, Haneda M, Yoshida A.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 56(9) Pages: 5417-5423

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between Retinal Blood Flow and Serum Adiponectin Concentrations in Patients with Type 2 Diabetes Mellitus.2015

    • Author(s)
      Omae T, Nagaoka T, Yoshida A.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 56(6) Pages: 4143-4149

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasodilatory mechanisms of unoprostone isoprophyl in isolated porcine retinal arterioles.2015

    • Author(s)
      Tanano I, Nagaoka T*, Ono S, Omae T, Otani S, Yoshida A.
    • Journal Title

      Mol Vis.

      Volume: 21 Pages: 699-705

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study.2015

    • Author(s)
      Ishibazawa A, Nagaoka T, Takahashi A, Omae T, Tani T, Sogawa K, Yokota H, Yoshida A.
    • Journal Title

      Am J Ophthalmol.

      Volume: 160(1) Pages: 35-44

    • NAID

      120005837998

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anteroposterior tortuosity of the retinal vein at anterovenous crossings in healthy subjects.2015

    • Author(s)
      Sogawa K, Nagaoka T, Tani T, Yoshida A.
    • Journal Title

      Curr Eye Res

      Volume: 40(10) Pages: 1040-1045

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Glial Cells in Regulating Retinal Blood Flow during Flicker-Induced Hyperemia in Cats.2015

    • Author(s)
      10. Song YS, Nagaoka T*, Yoshioka T, Nakabayashi S, Tani T, Yoshida A.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 56(12) Pages: 7551-7559

    • NAID

      120005753770

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Neuronal Nitric Oxide Synthase in Regulating Retinal Blood Flow during Flicker-Induced Hyperemia in Cats2015

    • Author(s)
      Yoshioka T, Nagaoka T, Yoshida A
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 56 Issue: 5 Pages: 3113-3113

    • DOI

      10.1167/iovs.14-15854

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mechanisms Responsible for Autoregulation of Retinal Blood Flow in Response to Reductions in Ocular Perfusion Pressure in Cats: Comparison of the Effects of Increased Intraocular Pressure and Systemic Hypotension.2014

    • Author(s)
      Tani T, Nagaoka T, Nakabayashi S, Yoshioka T, Yoshida A.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 55 Issue: 1 Pages: 360-367

    • DOI

      10.1167/iovs.13-12591

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in Retinal Blood Flow in Patients with Macular Edema Secondary to Branch Retinal Vein Occlusion Before and After Intravitreal Injection of Bevacizmab2014

    • Author(s)
      Nagaoka T, Sogawa K, Yoshida A.
    • Journal Title

      Retina

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between retinal fractal dimensions and retinal circulation in patients with type 2 diabetes mellitus.2013

    • Author(s)
      Nagaoka T, Yoshida A.
    • Journal Title

      Current Eye Research

      Volume: 38 Issue: 11 Pages: 1148-1152

    • DOI

      10.3109/02713683.2013.805232

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of Glial Cells in Regulating Retinal Blood Flow during Flicker-induced Hyperemia and Systemic Hyperoxia-induced Hyporemia in Cats2016

    • Author(s)
      NAGAOKA T.
    • Organizer
      2016 European Association for Vision and Eye Research Annual Meeting
    • Place of Presentation
      Nice, Paris
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ドップラーOCT血流計による網膜血流測定~ネコ眼での検討~2013

    • Author(s)
      長岡泰司、谷智文、善岡尊文、中林征吾、十川健司、佐藤栄一、吉田晃敏
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ドップラー法を用いた眼循環測定2013

    • Author(s)
      長岡泰司
    • Organizer
      第30回日本眼循環学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 眼循環測定の近未来2013

    • Author(s)
      長岡泰司
    • Organizer
      日本臨床眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 旭川医科大学眼科学教室ホームページ

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/ophtha/member/nagaoka_t.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 旭川医科大学眼科学教室ホームページ

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/ophtha/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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