Development of three-dimensional optical biopsy using Doppler and polarization sensitive optical coherence tomography
Project/Area Number |
25293353
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
平岡 孝浩 筑波大学, 医学医療系, 講師 (30359575)
加治 優一 筑波大学, 医学医療系, 准教授 (50361332)
安野 嘉晃 筑波大学, 数理物質科学研究科(系), 講師 (10344871)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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Keywords | 光干渉断層計 / OCT / 眼科疾患 / 偏光 / polarization / birefringence / 複屈折 / 偏光感受性 / 偏光位相差 / 血管イメージング |
Outline of Final Research Achievements |
Optical coherence tomography (OCT) is an instrument widely used in Ophthalmology, which uses near infrared rays and investigates ocular structure in detail. We developed new generation of OCT, polarization sensitive OCT which has several new functions. By detecting and analyzing the polarization caused by the ocular tissues, the new OCT can assess the internal quality and strength of ocular tissues. We tested the safety and effectiveness of this device in normal human subjects and then applied it to several ocular diseases and pathologies such as corneal diseases (keratoconus et al), eyes after glaucoma surgery, and pterygium.
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Report
(5 results)
Research Products
(48 results)
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[Journal Article] In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe2016
Author(s)
Fukuda S, Okuda K, Kishino G, Hoshi S, Kawano I, Fukuda M, Yamashita T, Beheregaray S, Nagano M, Ohneda O, Nagasawa H, Oshika T
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Journal Title
Graefes Arch Clin Exp Ophthalmol
Volume: 254
Issue: 12
Pages: 2373-2385
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Maximum-a-posteriori birefringence estimator for polarization sensitive optical coherence tomography2015
Author(s)
Kasaragod D, Sugiyama S, Ikuno Y, Caneiro DA, Yamanari M, Fukuda S, Oshika T, Hong YJ, Li1 E, Makita S, Miura M, Yasuno1 Y
Organizer
Optics & Photonics Japan 2015
Place of Presentation
Tokyo, Japan
Year and Date
2015-10-28
Related Report
Int'l Joint Research
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