Development of three-dimensional optical biopsy using Doppler and polarization sensitive optical coherence tomography

• Project/Area Number: 25293353
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Tsukuba
• Principal Investigator: OSHIKA Tetsuro 筑波大学, 医学医療系, 教授 (90194133)
• Co-Investigator(Kenkyū-buntansha): 平岡 孝浩 筑波大学, 医学医療系, 講師 (30359575) ; 加治 優一 筑波大学, 医学医療系, 准教授 (50361332) ; 安野 嘉晃 筑波大学, 数理物質科学研究科(系), 講師 (10344871)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
• Keywords: 光干渉断層計 / OCT / 眼科疾患 / 偏光 / polarization / birefringence / 複屈折 / 偏光感受性 / 偏光位相差 / 血管イメージング

Outline of Final Research Achievements

Optical coherence tomography (OCT) is an instrument widely used in Ophthalmology, which uses near infrared rays and investigates ocular structure in detail. We developed new generation of OCT, polarization sensitive OCT which has several new functions. By detecting and analyzing the polarization caused by the ocular tissues, the new OCT can assess the internal quality and strength of ocular tissues. We tested the safety and effectiveness of this device in normal human subjects and then applied it to several ocular diseases and pathologies such as corneal diseases (keratoconus et al), eyes after glaucoma surgery, and pterygium.

Research Products

• [Journal Article] Objective evaluation of functionality of filtering bleb based on polarization-sensitive optical coherence tomography (2016)
  • Author(s): Kasaragod D, Fukuda S, Ueno Y, Hoshi S, Oshika T, Yasuno Y
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 57 Issue: 4 Pages: 2305-2310
  • DOI: 10.1167/iovs.15-18178
  • NAID: 120007135432
  • Peer Reviewed
• [Journal Article] Apparent accommodation in pseudophakic eyes with refractive against-the-rule, with-the-rule and minimum astigmatism (2016)
  • Author(s): Yamamoto T, Hiraoka T, Oshika T
  • Journal Title: Br J Ophthalmol Volume: 100 Issue: 4 Pages: 565-571
  • DOI: 10.1136/bjophthalmol-2015-307032
  • Peer Reviewed
• [Journal Article] Polyethylene glycol-based synthetic hydrogel sealant for closing vitrectomy wounds: An in vivo and histological study (2016)
  • Author(s): Hoshi S, Okamoto F, Arai M, Hirose T, Fukuda S, Sugiura Y, Oshika T
  • Journal Title: Transl Vis Sci Technol Volume: 5 Issue: 3 Pages: 7-7
  • DOI: 10.1167/tvst.5.3.7
  • NAID: 120007135239
  • Peer Reviewed / Open Access
• [Journal Article] Differences of longitudinal chromatic aberration (LCA) between eyes with intraocular lenses from different manufacturers (2016)
  • Author(s): Nakajima M, Hiraoka T, Yamamoto T, Takagi S, Hirohara Y, Oshika T, Mihashi T
  • Journal Title: PLoS One Volume: 11 Issue: 6 Pages: e0156227-e0156227
  • DOI: 10.1371/journal.pone.0156227
  • NAID: 120007129408
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of phase retardation in filtering blebs using polarization-sensitive optical coherence tomography (2016)
  • Author(s): Fukuda S, Fujita A, Kasaragod D, Ueno Y, Hoshi S, Kishino G, Beheregaray S, Yasuno Y, Oshika T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 57 Issue: 14 Pages: 5919-5925
  • DOI: 10.1167/iovs.16-19548
  • NAID: 120007135103
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe (2016)
  • Author(s): Fukuda S, Okuda K, Kishino G, Hoshi S, Kawano I, Fukuda M, Yamashita T, Beheregaray S, Nagano M, Ohneda O, Nagasawa H, Oshika T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 254 Issue: 12 Pages: 2373-2385
  • DOI: 10.1007/s00417-016-3476-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Repeatability of corneal phase retardation measurements by polarization-sensitive optical coherence tomography (2015)
  • Author(s): Fukuda S, Kishino G, Hoshi S, Beheregaray S, Ueno Y, Fukuda M, Kasaragod D, Yasuno Y, Oshika T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56 Issue: 5 Pages: 3196-3201
  • DOI: 10.1167/iovs.14-16327
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Corneal thickness profile and posterior corneal astigmatism in normal corneas (2015)
  • Author(s): Ueno Y, Hiraoka T, Miyazaki M, Ito M, Oshika T
  • Journal Title: Ophthalmology Volume: 122 Issue: 6 Pages: 1072-1078
  • DOI: 10.1016/j.ophtha.2015.01.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Verification of the lack of correlation between age and longitudinal chromatic aberrations of the human eye from the visible to the infrared (2015)
  • Author(s): Nakajima M, Hiraoka T, Hirohara Y, Oshika T, Mihashi T
  • Journal Title: Biomed Opt Express Volume: 6 Issue: 7 Pages: 2676-2694
  • DOI: 10.1364/boe.6.002676
  • Peer Reviewed
• [Journal Article] Influence of ocular wavefront aberrations on axial length elongation in myopic children treated with overnight orthokeratology (2015)
  • Author(s): Hiraoka T, Kakita T, Okamoto F, Oshika T
  • Journal Title: Ophthalmology Volume: 122 Issue: 1 Pages: 93-100
  • DOI: 10.1016/j.ophtha.2014.07.042
  • Peer Reviewed
• [Journal Article] Multimodal and multiplex spectral imaging of rat cornea ex vivo using a white-light laser source (2015)
  • Author(s): Hiroki Segawa, Yuichi Kaji, Philippe Leproux, Vincent Couderc, Takeaki Ozawa, Tetsuro Oshika and Hideaki Kano
  • Journal Title: Journal of Biophotonics Volume: 8 Issue: 9 Pages: 1-4
  • DOI: 10.1002/jbio.201400059
  • Peer Reviewed / Open Access
• [Journal Article] Scleral birefringence as measured by polarization-sensitive optical coherence tomography and ocular biometric parameters of human eyes in vivo (2014)
  • Author(s): Yamanari M, Nagase S, Fukuda S, Ishi K, Tanaka R, Yasui T, Oshika T, Miura M, Yasuno Y
  • Journal Title: Biomedical Optics Express Volume: 5 Issue: 5 Pages: 1391-1402
  • DOI: 10.1364/boe.5.001391
  • NAID: 120007136704
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Noninvasive evaluation of phase retardation in blebs after glaucoma surgery using anterior segment polarization-sensitive optical coherence tomography (2014)
  • Author(s): Fukuda S, Beheregaray S, Kasaragod D, Hoshi S, Kishino G, Ishii K, Yasuno Y, Oshika T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55 Issue: 8 Pages: 5200-5206
  • DOI: 10.1167/iovs.14-14474
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Bayesian maximum likelihood estimator of phase retardation for quantitative polarization-sensitive optical coherence tomography (2014)
  • Author(s): Deepa Kasaragod, Shuichi Makita, Shinichi Fukuda, Simone Beheregaray, Tetsuro Oshika, and Yoshiaki Yasuno
  • Journal Title: Optics Express Volume: 22 Issue: 13 Pages: 16472-16492
  • DOI: 10.1364/oe.22.016472
  • NAID: 120007136684
  • Peer Reviewed
• [Journal Article] ime course of changes in aniseikonia and foveal microstructure after vitrectomy for epiretinal membrane (2014)
  • Author(s): Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T, Oshika T
  • Journal Title: Ophthalmology Volume: 121 Issue: 11 Pages: 2255-2260
  • DOI: 10.1016/j.ophtha.2014.05.016
  • Peer Reviewed
• [Journal Article] Metamorphopsia and optical coherence tomography findings after rhegmatogenous retinal detachment surgery (2014)
  • Author(s): Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T, Oshika T
  • Journal Title: Am J Ophthalmol Volume: 157 Issue: 1 Pages: 214-220
  • DOI: 10.1016/j.ajo.2013.08.007
  • Peer Reviewed
• [Journal Article] Comparison of three-dimensional optical coherence tomography and combining a rotating Scheimpflug camera with a Placido topography system for forme fruste keratoconus diagnosis (2013)
  • Author(s): Fukuda S, Beheregaray S, Hoshi S, Yamanari M, Lim Y, Hiraoka T, Yasuno Y, Oshika T
  • Journal Title: Br J Ophthalmol Volume: 97 Issue: 12 Pages: 1554-1559
  • DOI: 10.1136/bjophthalmol-2013-303477
  • Peer Reviewed
• [Journal Article] Benzalkonium chloride accelerates the formation of the amyloid fibrils of corneal dystrophy-associated peptides. (2013)
  • Author(s): Kato, Y., Yagi, H., Kaji, Y., Oshika, T. and Goto, Y.
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 35 Pages: 25109-25118
  • DOI: 10.1074/jbc.m113.477695
  • NAID: 120006557640
  • Peer Reviewed
• [Journal Article] Keratoconus diagnosis using anterior segment polarization-sensitive optical coherence tomography (2013)
  • Author(s): Yamanari M, Ishii K, Fukuda S, Lim Y Duan L, Makita S, Miura M, Oshika T, Yasuno Y
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 19 Issue: 2 Pages: 1384-91
  • DOI: 10.1167/iovs.12-10979
  • Peer Reviewed
• [Presentation] Evaluation of filtration surgery outcome using multi contrast anterior eye segment Jones matrix optical coherence tomography (2017)
  • Author(s): Kasaragod D, Makita S, Ueno Y, Hoshi S, Fukuda S, Oshika T, Yasuno Y
  • Organizer: BIOS 2017 - Ophthalmic Technologies XXVII
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2017-01-28
  • Int'l Joint Research
• [Presentation] Comparison of corneal astigmatism axis measurement using anterior segment optical coherent tomography, IOLMaster500, and auto refractokearatometer (2016)
  • Author(s): Nakano S, Hiraoka T, Oshika T
  • Organizer: he 5th Biennial Scientific Meeting Asia Cornea Society 2016, the 5th Asia Orthokeratology and Specialty Lens Conference
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] 偏光OCTによる翼状片の局所複屈折の可視化 (2016)
  • Author(s): 星 崇仁，Kasaragod D，上野勇太，藤田亜佳里，福田慎一，安野嘉晃，大鹿哲郎
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館，京都府，京都市
  • Year and Date: 2016-11-03
• [Presentation] 高深達・前眼部OCTによる水晶体核混濁の定量評価 (2016)
  • Author(s): 森 悠大，上野勇太，平岡孝浩，長谷川優実，萩原希望，藤田亜佳里，大鹿哲郎
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館，京都府，京都市
  • Year and Date: 2016-11-03
• [Presentation] 偏光感受型前眼部OCTによる濾過胞線維化スコアの経時的評価 (2016)
  • Author(s): 大久保智貴，上野勇太，Kasaragod D，星 崇仁，福田慎一，藤田亜佳里，安野嘉晃，大鹿哲郎
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 国立京都国際会館，京都府，京都市
  • Year and Date: 2016-11-03
• [Presentation] Results of toric intraocular lens implantation using surgical guidance and AS-OCT orientation (2016)
  • Author(s): Nakano S, Hiraoka T, Oshika T
  • Organizer: The XXXIV Congress of the European Society of Cataract and Refractive Surgeons (ESCRS)
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-09-10
  • Int'l Joint Research
• [Presentation] A compact Shack-Hartmann wavefront aberrometer: useful tool for clinical and basic research purposes (2016)
  • Author(s): Mihashi T, Hirohara Y, Oshika T, Shah S, Wolffsohn J
  • Organizer: 8th European Meeting on Visual and Physiological Optics
  • Place of Presentation: Antwerp Belgium
  • Year and Date: 2016-08-22
  • Int'l Joint Research
• [Presentation] Evaluation of filtration bleb by multi-contrast anterior-segment optical coherence tomography (2016)
  • Author(s): Kasaragod D, Makita S, Ueno Y, Hoshi S, Oshika T, Yasuno Y
  • Organizer: Association for Research in Vision and Ophthalmology 2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Evaluation of longitudinal chromatic aberration of pseudophakic eyes with a multiwavelength wavefront sensor in pseudophakic eyes (2016)
  • Author(s): Takagi S, Nakajima M, Yamamoto T, Hirohara Y, Mihashi T, Hiraoka T, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology 2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Imaging of crystalline lens using a new anterior segment optical coherence tomography (2016)
  • Author(s): Mori H, Ueno Y, Hiraoka T, Fujita A, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology 2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Measurements of corneal astigmatism axis with anterior segment swept source optical coherent tomography versus auto refractokearatometer (2016)
  • Author(s): Nakano S, Iida M, Hiraoka T, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology 2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Development of a comprehensive evaluation system for anterior segment structure and function (2016)
  • Author(s): Oshika T
  • Organizer: The 31th Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-03-24
  • Int'l Joint Research / Invited
• [Presentation] New anterior segment OCT using polarization sensitive technology (2015)
  • Author(s): Oshika T
  • Organizer: The Annual Meeting of Guangdong Ophthalmological Society held in conjunction with the 11th International Symposium of Ophthalmology
  • Place of Presentation: Guangdong, China
  • Year and Date: 2015-10-30
  • Int'l Joint Research / Invited
• [Presentation] Maximum-a-posteriori birefringence estimator for polarization sensitive optical coherence tomography (2015)
  • Author(s): Kasaragod D, Sugiyama S, Ikuno Y, Caneiro DA, Yamanari M, Fukuda S, Oshika T, Hong YJ, Li1 E, Makita S, Miura M, Yasuno1 Y
  • Organizer: Optics & Photonics Japan 2015
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2015-10-28
  • Int'l Joint Research
• [Presentation] Quantitative evaluation of refractive components of posterior corneal surface using Fourier analysis: an attempt to determine a normal range of values for each Fourier index. (2015)
  • Author(s): Inoue Y, Ueno Y, Hiraoka T, Okamoto F, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] Ultrasound biomicroscopic analysis of normal human ciliary body (2015)
  • Author(s): Terauchi A, Okamoto Y, Okamoto F, Nakano S, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] Bleb analysis of glaucoma filtration surgery using quantitative birefringence imaging of the anterior eye (2015)
  • Author(s): Kasaragod D, Fukuda S, Ueno Y, Oshika T, Yasuno Y
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] A study of short term and long term effects of IOP on scleral ultrastructure using polarization sensitive optical coherence tomography (2014)
  • Author(s): Kasaragod D, Hoshi S, Fukuda S, Beheregaray S, Oshika T, Yasuno Y
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] Evaluation of bleb birefringence after glaucoma surgery using anterior segment polarization-sensitive optical coherence tomography (2014)
  • Author(s): Fukuda S, Beheregaray S, Kasaragod D, Ishii K, Yasuno Y, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] Age related changes in pachymetric mapping of normal corneas (2014)
  • Author(s): Ueno Y, Hiraoka H, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] Repeatability of corneal measurements with anterisegment polarization-sensitive optical coherence tomography (2014)
  • Author(s): Beheregaray S, Fukuda S, Oshika T
  • Organizer: XXXIV World Ophthalmology Congress
  • Place of Presentation: 東京
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] Evaluation of bleb property after trabeculectomy and ex-press tube shunt using anterior segment polarization-sensitive optical coherence tomography (2014)
  • Author(s): Fukuda S, Beheregaray S, Ishii K, Oshika T
  • Organizer: XXXIV World Ophthalmology Congress
  • Place of Presentation: 東京
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] 前眼部OCTによる角膜形状各パラメーターの円錐角膜判別能力の比較 (2014)
  • Author(s): 福田慎一，星 崇仁，山成正宏，Lim Y，Beheregaray S，平岡孝浩，大鹿哲郎，安野嘉晃
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Comparison of three-dimensional optical coherence tomography parameters for early keratoconus diagnosis (2013)
  • Author(s): Fukuda S, Hoshi S, Yamanari M, Beheregaray S, Hiraoka T, Yasuno Y, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Seatlle, Washington, USA
• [Presentation] Influences of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children (2013)
  • Author(s): Hiraoka T, Miyata K, Nakamura Y, Ogata TM, Okamoto F, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Seatlle, Washington, USA
• [Presentation] Benzalkonium chloride accelerates amyloid fibril formation in corneal dystrophies in vitro (2013)
  • Author(s): Kaji1 Y, Yagi H, Kato Y, Goto Y, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Seatlle, Washington, USA
• [Presentation] 前眼部OCTを用いた角膜厚分布と非対称性角膜不正乱視の加齢性変化の検討 (2013)
  • Author(s): 上野勇太，平岡孝浩，宮崎真希，伊藤睦子，大鹿哲郎
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜市
• [Presentation] 前眼部偏光OCTによる緑内障手術濾過胞解析 (2013)
  • Author(s): 大房理恵，福田慎一，Simone Beheregaray，Deepa Kasaragod，石井晃太郎，安野嘉晃，大鹿哲郎
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜市
• [Presentation] Cornea and anterior segment OCT
  • Author(s): Oshika T
  • Organizer: The 10th Japan-Taiwan Joint Meeting of Ophthalmology
  • Place of Presentation: Taipei, Taiwan
  • Invited