Integrated approach to recover vision by electrical stimulation

• Project/Area Number: 25293354
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: Fujikado Takashi 大阪大学, 医学(系)研究科(研究院), 教授 (50243233)
• Co-Investigator(Kenkyū-buntansha): 森本 壮 大阪大学, 医学(系)研究科(研究院), 准教授 (00530198) ; 松下 賢治 大阪大学, 医学(系)研究科(研究院), 講師 (40437405) ; 神田 寛行 大阪大学, 医学(系)研究科(研究院), 助教 (50570248) ; 三好 智満 大阪大学, 医学(系)研究科(研究院), 助教 (70314309) ; 辻川 元一 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70419472)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 電気刺激 / 神経保護 / ラマン分光 / 人工網膜 / 錐体密度 / 補償光学眼底カメラ / ラマン画像 / 経角膜電気刺激 / 神経賦活 / 視神経症 / 軸索再生 / 視覚回復

Outline of Final Research Achievements

In 2 of 3 patients who underwent clinical trial on artificial retina in 2014 - 2015, the residual vision improved 6 months after surgery, suggesting that continuous electrical stimulation is effective to improve neural function. As a basic experiment to elucidate its mechanism, we investigated early changes of neuronal cell death using a Raman microscope and showed that kinetics of mitochondria- related to cell death can be observed in a living state. In retinitis pigmentosa, photoreceptors gradually degenerate. In order to quantify this, we developed an automatic measurement system for cone density using an adaptive optics (AO) fundus camera. We plan to further elucidate the neuronal activation mechanism by electrical stimulation using Raman microscope and AO fundus camera in the future.

Research Products

• [Journal Article] Relationships Between Spatial Contrast Sensitivity and Parafoveal Cone Density in Normal Subjects and Patients With Retinal Degeneration. (2017)
  • Author(s): Hirota M, Morimoto T, Kanda H, Lohmann TK, Miyagawa S, Endo T, Miyoshi T, Fujikado T.
  • Journal Title: Ophthalmic Surg Lasers Imaging Retina. Volume: 48(2) Issue: 2 Pages: 106-113
  • DOI: 10.3928/23258160-20170130-03
  • Peer Reviewed / Open Access
• [Journal Article] One-Year Outcome of 49-Channel Suprachoroidal-Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa. (2016)
  • Author(s): Fujikado T, Kamei M, Sakaguchi H, Kanda H, Endo T, Hirota M, Morimoto T, Nishida K, Kishima H, Terasawa Y, Oosawa K, Ozawa M, Nishida K.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57(14) Issue: 14 Pages: 6147-6157
  • DOI: 10.1167/iovs.16-20367
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] False reaching movements in localization test and effect of auditory feedback in simulated ultra-low vision subjects and patients with retinitis pigmentosa. (2016)
  • Author(s): Endo T, Kanda H, Hirota M, Morimoto T, Nishida K, Fujikado T.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 254(5) Issue: 5 Pages: 947-956
  • DOI: 10.1007/s00417-015-3253-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals. (2016)
  • Author(s): LohmanTK, Kanda H, Morimoto T, Endo T, MiyoshiT, Nishida K, Kamei M, Walter P, Fujikado T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 254 Issue: 4 Pages: 661-673
  • DOI: 10.1007/s00417-015-3104-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between reading performance and saccadic disconjugacy in patients with convergence insufficiency type intermittent exotropia. (2016)
  • Author(s): Hirota M, Kanda H, Endo T, Lohmann TK, Miyoshi T, Morimoto T, Fujikado T.
  • Journal Title: Jpn J Ophthalmol. Volume: 60(4) Issue: 4 Pages: 326-332
  • DOI: 10.1007/s10384-016-0444-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 眼科医の手引 人工網膜 世界の現状は？ (2016)
  • Author(s): 不二門 尚
  • Journal Title: 日本の眼科 Volume: 87(10) Pages: 1347-1348
• [Journal Article] 人工網膜による視覚再生 (2016)
  • Author(s): 神田寛行, 不二門尚
  • Journal Title: 再生医療 Volume: 15(1) Pages: 22-32
  • NAID: 40020759935
• [Journal Article] 感覚のBMI 人工視覚システム (2016)
  • Author(s): 神田寛行, 不二門尚
  • Journal Title: Clinical Neuroscience Volume: 34(2) Pages: 230-234
• [Journal Article] 人工網膜－最近の動向 (2015)
  • Author(s): 神田寛行, 不二門尚
  • Journal Title: 光技術コンタクト Volume: 625(53)
• [Journal Article] Slow Cone Reflectance Changes during Bleaching Determined by Adaptive Optics Scanning Laser Ophthalmoscope in Living Human Eyes. (2015)
  • Author(s): Hirota M, Miyagawa S, Kanda H, Endo T, Lohmann TK, Miyoshi T, Morimoto T, Fujikado T.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0131485-e0131485
  • DOI: 10.1371/journal.pone.0131485
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visual Sensation by Electrical Stimulation Using a New Direct Optic Nerve Electrode Device (2015)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Gonzalez C, Terasawa Y, Montoya R, Fujikado T, Fontan R, Ozawa M, Mercardo H, Nishida K
  • Journal Title: Brain Stimul. Volume: 8 Issue: 3 Pages: 678-681
  • DOI: 10.1016/j.brs.2015.03.001
  • Peer Reviewed
• [Journal Article] 人工網膜~よみがえる光感覚~ (2015)
  • Author(s): 神田寛行, 不二門尚
  • Journal Title: 電子情報通信学会誌 Volume: 98(4) Pages: 266-271
  • Open Access
• [Journal Article] Evaluation of electrochemically treated bulk electrodes for a retinal prosthesis by examination of retinal intrinsic signals in cats (2015)
  • Author(s): Kanda H, Mihashi T, Miyoshi T, Hirohara Y, Morimoto T, Terasawa Y, Fujikado T.
  • Journal Title: Jpn J Ophthalmol Volume: 58(4) Issue: 4 Pages: 309-329
  • DOI: 10.1007/s10384-014-0319-3
  • Peer Reviewed / Open Access
• [Journal Article] Asymmetric wavefront aberrations and pupillary shapes induced by electrical stimulation of ciliary nerve in cats measured with compact wavefront aberrometer (2015)
  • Author(s): Miyagawa S, Mihashi T, Kanda H, Hirohara Y, Endo T, Morimoto T, Miyoshi T, Fujikado T
  • Journal Title: PLoS One Volume: 9(8) Issue: 8 Pages: e105615-e105615
  • DOI: 10.1371/journal.pone.0105615
  • Peer Reviewed / Open Access
• [Journal Article] 【電気信号を用いた神経機能再建】 人工網膜(suprachoroidal-transretinal stimulation:STS) (2015)
  • Author(s): 神田寛行、不二門尚
  • Journal Title: 脳21 Volume: 18（1） Pages: 84-88
• [Journal Article] Characteristics of Retinal Reflectance Changes Induced by Transcorneal Electrical Stimulation in Cat Eyes. (2014)
  • Author(s): Morimoto Takeshi, Kanda H, Miyoshi T, Hirohara Y, Mihashi T, Kitaguchi Y, Nishida K, Fujikado T
  • Journal Title: PLOS ONE Volume: 9-3 Issue: 3 Pages: 1-11
  • DOI: 10.1371/journal.pone.0092186
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration (2014)
  • Author(s): Fuchihata M, Maeda N, Toda R, Koh S, Fujikado T, Nishida K
  • Journal Title: Jpn J Ophthalmol Volume: 58-2 Issue: 2 Pages: 131-138
  • DOI: 10.1007/s10384-013-0291-3
  • Peer Reviewed
• [Journal Article] Feasibility of 2nd generation STS retinal prosthesis in dogs. (2013)
  • Author(s): Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Nishida K, Kishima H, Maruo T, Oosawa K, Ozawa M, Nishida K
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: Jul Pages: 3119-3121
  • DOI: 10.1109/embc.2013.6610201
  • Peer Reviewed
• [Journal Article] Four discriminant models for detecting keratoconus pattern using Zernike coefficients of corneal aberrations. (2013)
  • Author(s): Saika M, Maeda N, Hirohara Y, Mihashi T, Fujikado T, Nishida K
  • Journal Title: Jpn J Ophthalmol Volume: 57-6 Issue: 6 Pages: 503-509
  • DOI: 10.1007/s10384-013-0269-1
  • Peer Reviewed
• [Journal Article] Optical imaging of retina in response to grating stimuli in cats. (2013)
  • Author(s): Hirohara Y, Mihashi T, Kanda H, Morimoto T, Miyoshi T, Wolffsohn JS, Fujikado T
  • Journal Title: Exp Eye Res Volume: 109C Pages: 1-7
  • DOI: 10.1016/j.exer.2013.01.007
  • Peer Reviewed
• [Presentation] Artificial Vision (2016)
  • Author(s): Fujikado Takashi, Kamei M, Kishima H, Morimoto T, KandaH, Sakaguchi H, Nishida K, Endo T, Lohmann TK, Maruo T, Hirota M, Oosawa K, Ozawa M
  • Organizer: The 3rd International Symposium on Cognitive Neuroscience Robotics
  • Place of Presentation: 大阪 千里ライフサイエンスセンター
  • Year and Date: 2016-12-11
  • Int'l Joint Research / Invited
• [Presentation] Development of a second-generation suprachoroidal-transretinal stimulation retinal prosthesis. (2016)
  • Author(s): Kanda H, Kamei M, Sakaguchi H, Endo T, Hirota M, Morimoto T, Nishida K, Kishima H, Miyoshi T, FujikadoT
  • Organizer: medical bionics
  • Place of Presentation: Australia University of Queensland
  • Year and Date: 2016-11-22
  • Int'l Joint Research / Invited
• [Presentation] 脈絡膜上経網膜電気刺激での電極の諸条件が大脳皮質誘発電位に与える影響の検討 (2016)
  • Author(s): 西田健太郎、坂口裕和、瓶井資弘、不二門尚、西田幸二
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 京都 京都国際会館
  • Year and Date: 2016-11-03
• [Presentation] Relationship between retinal damage and current intensity in Suprachoroidal-Transretinal Stimulation. (2016)
  • Author(s): Kanda Hiroyuki
  • Organizer: 2016 Taiwan-Japan Joint Symposium
  • Place of Presentation: 奈良 奈良先端科学技術大学院大学
  • Year and Date: 2016-10-28
  • Int'l Joint Research / Invited
• [Presentation] Clinical Trial of 49-Channel STS Retinal Prosthesis for Advanced RP Patients. (2016)
  • Author(s): Fujikado Takashi, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Endo Takao, Nishida Ke, Kishima H, Hirota M, Oosawa K, Ozawa M, Nishida Ko
  • Organizer: 9th Biennial World Research Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision
  • Place of Presentation: USA(Dearborn)
  • Year and Date: 2016-09-20
  • Int'l Joint Research
• [Presentation] The Shape of the Phosphenes Elicited by Artificial Vision by Direct Optic Nerve (2016)
  • Author(s): Nishida Kentaro, Sakaguchi Hirokazu, Kamei Motohiro, TeresawaYasuo, Fujikado Takashi, Nishida Kohji
  • Organizer: 9th Biennial World Research Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision
  • Place of Presentation: USA(Dearborn)
  • Year and Date: 2016-09-19
  • Int'l Joint Research
• [Presentation] Surgical Feasibility of a Wide-Field Dual-Array Suprachoroidal-Transretinal Stimulation(STS) Prosthesis in Middle-Sized Animals. (2016)
  • Author(s): Morimoto Takeshi, Kanda Hiroyuki, Endo Takao, Lohmann Tibor Karl, Miyoshi Tomomitsu, Nishida Kohji Fujikado Takashi
  • Organizer: 9th Biennial World Research Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision
  • Place of Presentation: USA(Dearborn)
  • Year and Date: 2016-09-19
  • Int'l Joint Research
• [Presentation] 脈絡膜上－経網膜方式人工視覚システムの刺激効率に及ぼす刺激波形形状の影響 (2016)
  • Author(s): 中野由香梨、寺澤靖雄、神田寛行、大澤孝治、三好智満、澤井元
  • Organizer: 第52回日本眼光学学会総会
  • Place of Presentation: 東京 ソラシティカンファレンスセンター
  • Year and Date: 2016-09-04
• [Presentation] ネコ外側膝状体ニューロン単一ユニット記録による人工網膜用刺激電極の評価 (2016)
  • Author(s): 神田寛行、三好智満、森本壮、不二門尚
  • Organizer: 視覚科学フォーラム第20回研究会
  • Place of Presentation: 大阪 CiNet
  • Year and Date: 2016-08-25
• [Presentation] Clinical Trial of 49-Channel STS Retinal Prosthesis for Advanced RP Patients. (2016)
  • Author(s): Fujikado Takashi, Kamei M, Kishima H, Morimoto T, Kanda H, Sakaguchi H, Nishida K, Endo T, Lohmann T.K., Maruo T, Hirota M, Oosawa K, Ozawa M
  • Organizer: Retina Conservation and Regeneration
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2016-07-09
  • Int'l Joint Research
• [Presentation] One-Year Outcomes of 49-Channel Suprachoroidal-Transretinal Stimulation(STS) Retinal Prosthesis in Patients with Adcanced Retinitis Pigmentosa. (2016)
  • Author(s): Fujikado Takashi, Kamei M, Kishima H, Morimoto T, Kanda Hiroyuki, Sakaguchi Hi, Nishida K, Endo T, Osawa K, Ozawa M
  • Organizer: ARVO2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-04
  • Int'l Joint Research
• [Presentation] Surgical feasibility of wide-field dual-array suprachoroidal-transretinal stimulation (STS) prosthesis in middle-sized animals (2016)
  • Author(s): Morimoto Takeshi, Kanda Hiroyuki, Endo Takao, Lohmann TK, Miyoshi Tomomitsu, Kishima Haruhiko, Nishida Kohji, Fujikado Takashi
  • Organizer: ARVO2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-03
  • Int'l Joint Research
• [Presentation] Evaluation of the spatial resolution of electrode arrays for suprachoroidal retinal prosthesis by recording single-unit activities in the lateral geniculate nucleu (2016)
  • Author(s): Kanda Hiroyuki, Miyoshi Tomomitsu, Morimoto Takeshi, FujikdaoTakashi
  • Organizer: ARVO2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-03
  • Int'l Joint Research
• [Presentation] Evaluation of reaching by localization test in a patient with retinal prosthesis by suprachoroidal-transretinal stimulation(STS) (2016)
  • Author(s): EndoTakao, Fujikado Takashi, Hirota Masakazu, Kanda Hiroyuki, Morimoto Takeshi, Nishida Kohji
  • Organizer: ARVO2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-02
  • Int'l Joint Research
• [Presentation] Evaluation of reaching in the artificial vision simulator with the visual feedback (2016)
  • Author(s): Hozumi Kenta, Endo Takao, Hirota Masakazu, Kanda Hiroyuki, Morimoto Takeshi, Fujikado Takashi, Nishida Kohji
  • Organizer: ARVO2016
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-05-02
  • Int'l Joint Research
• [Presentation] 外部カメラ型人工網膜シミュレータにおける視線フィードバック機能の効果 (2016)
  • Author(s): 穂積健太、遠藤高生、広田雅和、神田寛行、森本壮、不二門尚、西田幸二
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-04-08
• [Presentation] 外部カメラ型人工網膜シミュレータにおける視線フィードバック機能の効果 (2016)
  • Author(s): 穂積健太, 遠藤高生, 広田雅和, 神田寛行, 森本壮, 不二門尚, 西田幸二
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-08
• [Presentation] 2枚電極脈絡膜上－経網膜電気刺激（STS）型人工網膜の中型動物への埋植述と生体適合性 (2016)
  • Author(s): 森本壮、神田寛行、三好智満、遠藤高生、Tibor KLohmanｎ、西田幸二、不二門尚
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-04-07
• [Presentation] 外側膝状体単一ユニット活動による人工網膜多極電極の機能評価 (2016)
  • Author(s): 神田寛行、森本壮、三好智満、不二門尚
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-04-07
• [Presentation] 49極STS型人工網膜の慢性臨床研究の結果 (2016)
  • Author(s): 不二門尚、瓶井資弘、貴島晴彦、森本壮、神田寛行、広田雅和、坂口裕和、西田健太郎、遠藤高生、圓尾知之、小澤素生、大澤孝治、西田幸二
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-04-07
• [Presentation] 外側膝状体単一ユニット活動による人工網膜多極電極の機能評価 (2016)
  • Author(s): 神田寛行, 森本壮, 三好智満, 不二門尚
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Presentation] 49極STS型人工網膜の慢性臨床研究の結果 (2016)
  • Author(s): 不二門尚, 瓶井資弘, 貴島晴彦, 森本壮, 神田寛行, 広田雅和, 坂口裕和, 西田健太郎, 遠藤高生, 圓尾知之, 小澤素生, 大澤孝治, 西田幸二
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Presentation] 2枚電極脈絡膜上－経網膜電気刺激（STS）型人工網膜の中型動物への埋植述と生体適合性 (2016)
  • Author(s): 森本壮, 神田寛行, 三好智満, 遠藤高生, Tibor C Lohmanｎ, 西田幸二, 不二門尚
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Presentation] 視細胞変性眼における傍中心窩錐体密度とコントラスト感覚の関係 (2016)
  • Author(s): 広田雅和, 神田寛行, 遠藤高生, 宮川雄, 三好智満, 森本壮, 不二門尚
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Presentation] Waching dying retinal ganglion cells induced by high concentration o f glutaminate by using Raman microscopy. (2015)
  • Author(s): MorimotoTakeshi, chiuLiang-da, Fujita Katsumasa, Kanda Hiroyuki, Fujikado Takashi
  • Organizer: Nanophotonics in Asia 2015
  • Place of Presentation: 大阪
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] Surgical feasibility of wide-field dual-array suprachoroidal-transtretinal stimulation(STS) prosthesis in middle-sized animals. (2015)
  • Author(s): Morimoto Takeshi, Kanda Hiroyuki, Miyoshi Tomomitsu, LohmannT.K.FujikadoTakashi
  • Organizer: Artifitial Vision 2015
  • Place of Presentation: ドイツ アーヘン
  • Year and Date: 2015-11-28
  • Int'l Joint Research
• [Presentation] Suprachoroidal-transretinal stimulation with the VLARS(very large array retina stimulator) device in a cat. (2015)
  • Author(s): Lohman T.K., Kanda Hiroyuki, Morimoto Takeshi, Miyoshi Tomomitsu, Mokwa W, Walter P, Fujikado T
  • Organizer: Artifitial Vision 2015
  • Place of Presentation: ドイツ アーヘン
  • Year and Date: 2015-11-28
  • Int'l Joint Research
• [Presentation] Evaluation of reaching by localization test in a patient with retinal prosthesis by suprachoroidal-transretinal stimulation (STS). (2015)
  • Author(s): EndoTakao, Fujikado Takashi, Hirota Masakazu, Kanda Hiroyuki, Morimoto Takeshi, Nishida Kohji
  • Organizer: Artifitial Vision 2015
  • Place of Presentation: ドイツ アーヘン
  • Year and Date: 2015-11-28
  • Int'l Joint Research
• [Presentation] Clinical Study of Retinal Prosthesis by 49 Channel Suprachoroidal-Transretinal Stimulation (STS) in Patients with Advanced Retinitis Pigmentosa. (2015)
  • Author(s): Fujikado Takashi, Kamei Motohiro, Kishima Haruhiko, Morimoto Takeshi, Kanda Hiroyuki, Sakaguchi H, Nishida K,Endo T, Lohmann T.K., Maruo T, Hirota M, Oosawa K, Ozawa M
  • Organizer: Artifitial Vision 2015
  • Place of Presentation: ドイツ アーヘン
  • Year and Date: 2015-11-28
  • Int'l Joint Research
• [Presentation] Spatial extent of neural responses evaluated by single-unit activities of the lateral geniculate nucleus elicited by suprachoroidal electrical stimulation. (2015)
  • Author(s): Kanda Hiroyuki, Miyoshi Tomomitsu, MorimotoTakeshi, FujikadoTakashi
  • Organizer: Artifitial Vision 2015
  • Place of Presentation: ドイツ アーヘン
  • Year and Date: 2015-11-28
  • Int'l Joint Research
• [Presentation] Relationship between Contrast Sensitivity and Parafoveal Cone Density in Normal Eyes and Eyes with Retinal Degeneration. (2015)
  • Author(s): Hirota Masakazu, Morimoto Takeshi, K.L.Tibor, Miyagawa Suguru, Kanda Hiroyuki, EndoTakao, Miyoshi Tomomitsu, Fujikado Takashi
  • Organizer: Artifitial Vision 2015
  • Place of Presentation: ドイツ アーヘン
  • Year and Date: 2015-11-27
  • Int'l Joint Research
• [Presentation] STS方式人工網膜の開発 (2015)
  • Author(s): 神田寛行, 不二門尚
  • Organizer: 第58回自動制御連合講演会
  • Place of Presentation: 神戸
  • Year and Date: 2015-11-15
• [Presentation] 人工網膜埋植患者に対する術前経角膜電気刺激検査を用いた網膜残存機能の評価 (2015)
  • Author(s): 森本壮, 遠藤高生, 神田寛行, 西田幸二 不二門尚
  • Organizer: 第53回日本神経眼科学会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2015-11-06
• [Presentation] 脈絡膜上経網膜刺激型人工網膜埋植患者のLocalization testによる到達運動の評価 (2015)
  • Author(s): 遠藤高生, 不二門尚, 広田雅和, 神田寛行,森本壮, 西田幸二
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-23
• [Presentation] 新しい『見え方』－最先端技術に対応したロービジョンケアを考える (2015)
  • Author(s): 不二門尚, 瓶井資弘, 坂口裕和, 森本壮, 西田健太郎, 貴島晴彦, 圓尾知之, 神田寛行, 遠藤高生, 大澤孝治, 小澤素生, 西田幸二
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-22
• [Presentation] Image processing using a saliency map for a 49-channel retinal prosthesis. (2015)
  • Author(s): Kanda Hiroyuki, Takaomi Kanda, Yukie Nagai, Takashi Fujikado
  • Organizer: ARVO2015
  • Place of Presentation: アメリカ デンバー
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Presentation] Current intensity-dependent neuroprotection in eyes with traumatic optic neuropathy py transcorneal electrical stimulation. (2015)
  • Author(s): Morimoto Takeshi,EndoTakao, Nishida Kohji, Fujikado Takashi
  • Organizer: ARVO2015
  • Place of Presentation: アメリカ デンバー
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] In situ Densitometry of Cone Photoreceptors in Human Eyes by Adaptive Optics Scanning Laser Ophthalmoscopy. (2015)
  • Author(s): Hirota Masakazu, MiyagawaSuguru, Kanda Hiroyuki, EndoTakao, Lohman Tibor.K, Morimoto Takeshi, FujikadoTakashi
  • Organizer: ARVO2015
  • Place of Presentation: アメリカ デンバー
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] Testing of Chronically Implanted 49-Channel Retinal Prosthesis by Suprachoroidal-Transretinal Stimulation(STS) in Patients with Advanced Retinitis Pigmentosa. (2015)
  • Author(s): Fujiakdo Takashi, Kamei Motohiro, Kishima Haruhiko, Morimoto Takeshi, Kanda Hiroyuki, Sakaguchi Hirokazu, Nishida Kentaro, Endo Takao, OzawaMotoki, Nishida Kohji
  • Organizer: ARVO2015
  • Place of Presentation: アメリカ デンバー
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] 網膜色素変性に対する経角膜電気刺激の治療効果 (2015)
  • Author(s): 森本壮, 遠藤 高生, 西田幸二, 不二門 尚
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-17
• [Presentation] 第2世代49極ＳＴＳ型人工網膜の臨床研究 (2015)
  • Author(s): 不二門尚, 瓶井資弘, 貴島晴彦, 森本壮, 神田寛行, 広田雅和, 坂口裕和, 西田健太郎, 遠藤高生, 圓尾知之, 小澤素生, 大澤孝治, 西田幸二
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16
• [Presentation] 顕著性マップを利用した人工網膜向け画像処理 (2015)
  • Author(s): 神田寛行, 神田嵩臣, 長井志江, 浅田稔, 不二門尚
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16
• [Presentation] 外傷性視神経症に対する経角膜電気刺激の刺激条件による治療効果の検討 (2014)
  • Author(s): 森本壮、遠藤高生、西田幸二、不二門尚
  • Organizer: 第52回日本神経眼科学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2014-12-23
• [Presentation] Feasibility of a Saliency Map for a 49-channel Retinal Prosthesis. (2014)
  • Author(s): Kanda H, Kanda, Takaomi, Nagai Y, Asada M, Fujikado T
  • Organizer: 8th Biennial World Research Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision
  • Place of Presentation: Michigan, USA
  • Year and Date: 2014-09-29
  • Invited
• [Presentation] Feasibility of Retinal Prothesis with Suprachoroidal-transretinal Stimulation. (2014)
  • Author(s): Fujikado Takashi
  • Organizer: 8th The Eye and the Chip World Research Congress
  • Place of Presentation: Michigan, USA
  • Year and Date: 2014-09-28
  • Invited
• [Presentation] Watching dying RGC-5 cells by using Raman microscopy 2. (2014)
  • Author(s): Morimoto T, Kanda H, Endo T, Nishida K, Fujikado T
  • Organizer: ARVO2014
  • Place of Presentation: Orland,USA
  • Year and Date: 2014-05-08
• [Presentation] 次世代人工網膜の展望 (2014)
  • Author(s): 不二門尚
  • Organizer: 第118回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-04
• [Presentation] Clinical application of adaptive optics fundus camera (2014)
  • Author(s): Fujiakdo Takashi
  • Organizer: Japan Taiwan Bilateral Conference on Biomedical and Plasmonic Imaging
  • Place of Presentation: Taipei Taiwan
  • Invited
• [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis in dogs. (2013)
  • Author(s): Fujikado T
  • Organizer: The International Symposium on Visual Prosthetics,
  • Place of Presentation: Aachen, Germany
  • Invited
• [Presentation] Effect of Low‐Additional Soft Contact Lenswith Decentered Optical Design on Myopia Progression inChildren (2013)
  • Author(s): Fujikado Takashi
  • Organizer: Internatinal Myopia Conference
  • Place of Presentation: California, USA
  • Invited
• [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis in Dogs (2013)
  • Author(s): Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Nishida K, Kishima H, Maruo T, Oosawa K, Ozawa M, Nishida K
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka Japan
  • Invited
• [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis with 49 Channel Electrode Array in Dogs (2013)
  • Author(s): Fujikado T, Kamei M, Kishima H, Maruo T, Osawa K, Ozawa M
  • Organizer: ARVO2013
  • Place of Presentation: Seattle, USA
• [Book] Artificial Vision - A Clinical Guide - PartⅡ Retinal Approaches 11.Retinal Prosthesis by Suprachoroidal-Transretinal Stimulation(STS), Japanese Approach (2017)
  • Author(s): Veit Peter Gabel, Fujikado Takashi, et al
  • Total Pages: 232
  • Publisher: Springer International Publishing
• [Book] Cognitive Neuroscience Robotics B - Analytic Approaches to Human Understanding - 10. Brain Machine-Interfaces for Sensory Systems (2016)
  • Author(s): Kasaki Masashi, Ishiguro Hiroshi, Asada Minoru, Osaka Mariko, Fujikado Takashi
  • Total Pages: 275
  • Publisher: Springer Japan
• [Remarks] 大阪大学医学系研究科感覚機能形成学教室
  • URL: http://www.med.osaka-u.ac.jp/pub/sensory/www/index.html