International study to elucidate the pathogenesis and genetic predisposition of SJS / TEN with severe ocular complications

• Project/Area Number: 25293355
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SOTOZONO CHIE 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30216585)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Shigeru 京都府立医科大学, 医学研究科, 教授 (30116024) ; UETA Mayumi 京都府立医科大学, 医学研究科, 准教授 (60398386)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: Stevens-Johnsons症候群 / 遺伝子多型 / HLA / Stevens-Johnson症候群 / 眼合併症型SJS/TEN / 重症薬疹 / 遺伝素因 / 国際共同研究 / 眼合併症

Outline of Final Research Achievements

We performed a genome-wide association study of SJS / TEN with severe ocular complications using Axiom Chip for East Asian ethnics and found the significant association with IKZF1 gene SNPs, and that the significant association with IKZF1 gene SNPs was also observed in Korean people and Indian people. We also found the significant association with HLA-A*02:06 in Japanese and Korean, and the significant association with HLA-B*44:03 in Indian and Brazilian Caucasian. Furthermore, we found the significant association with PTGER3 SNPs and the interaction between PTGER3 SNP and HLA-A*02:06 in Japanese.

Research Products

• [Journal Article] Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. (2016)
  • Author(s): 2.Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J.
  • Journal Title: Ocul Surf. Volume: 14(2) Issue: 2 Pages: 00011-2
  • DOI: 10.1016/j.jtos.2016.02.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stevens Johnsons Syndrome: The Role of an Ophthalmologist. (2016)
  • Author(s): 3.Jain R, Sharma N, Basu S, Iyer G, Ueta M, Sotozono C, Kannibiran C, Rathi VM, Gupta N, Kinoshita S, Gomes JA, Chodosh J, Sangwan VS.
  • Journal Title: Surv Ophthalmol Volume: - Issue: 4 Pages: 168-88
  • DOI: 10.1016/j.survophthal.2016.01.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Analysis of Ocular Manifestation and Genetic Association of Allopurinol-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in South Korea. (2016)
  • Author(s): Lee HS, Ueta M, Kim MK, Seo KY, Sotozono C, Kinoshita S, Yoon KC
  • Journal Title: Cornea Volume: 35(2) Issue: 2 Pages: 199-204
  • DOI: 10.1097/ico.0000000000000708
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease. (2016)
  • Author(s): 4.Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J.
  • Journal Title: Ocul Surf Volume: 14(1) Issue: 1 Pages: 2-19
  • DOI: 10.1016/j.jtos.2015.10.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR) (2015)
  • Author(s): Kano Y, Tohyama M, Aihara M, Matsukura S, Watanabe H, Sueki H, Iijima M, Morita E, Niihara H, Asada H, Kabashima K, Azukizawa H, Hashizume H, Nagao K, Takahashi H, Abe R, Sotozono C, Kurosawa M, Aoyama Y, Chu CY, Chung WH, Shiohara T
  • Journal Title: Journal of Dermatology Volume: 42 Issue: 3 Pages: 276-282
  • DOI: 10.1111/1346-8138.12770
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HLA-A*02:06 and PTGER3 polymorphism exert additive effects in cold medicine-related Stevens-Johnson syndrome with severe ocular complications. (2015)
  • Author(s): Ueta M, Tokunaga K, Sotozono C, Sawai H, Yoon KY, Kim MK, Seo KY, Joo CJ, Tashiro K & Kinoshita S.
  • Journal Title: Human Genome Variation 2 Volume: 15023 Issue: 1
  • DOI: 10.1038/hgv.2015.23
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development of a simple genotyping method for the HLA-A∗31:01-tagging SNP in Japanese (2015)
  • Author(s): Maekawa K, Nakamura R, Kaniwa N, Mizusawa S, Kitamoto A, Kitamoto T, Ukaji M, Matsuzawa Y, Sugiyama E, Uchida Y, Kurose K, Ueta M, Sotozono C, Ikeda H, Yagami A, Matsukura S, Kinoshita S, Muramatsu M, Ikezawa Z, Sekine A, Furuya H, Takahashi Y, Matsunaga K, Aihara M, Saito Y
  • Journal Title: Pharmacogenomics. Volume: 16 Issue: 15 Pages: 1689
  • DOI: 10.2217/pgs.15.115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Drugs causing severe ocular surface involvements in Japanese patients with StevenseJohnson syndrome/toxic epidermal necrolysis (2015)
  • Author(s): Kaniwa N, Ueta M, Nakamura R, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y.
  • Journal Title: Allergology International Volume: 64 Issue: 4 Pages: 379-381
  • DOI: 10.1016/j.alit.2015.05.002
  • NAID: 130005290406
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Predictive Factors associated with Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. (2015)
  • Author(s): Sotozono C, Ueta M, Nakatani E, Kitami A, Watanabe H, Sueki H, Iijima M, Aihara M, Ikezawa Z, Aihara Y, Kano Y, Shiohara T, Tohyama M, Shirakata Y, Kaneda H, Fukushima M, Kinoshita S, Hashimoto K
  • Journal Title: Am J Ophthalmol Volume: 160(2) Issue: 2 Pages: 228-237
  • DOI: 10.1016/j.ajo.2015.05.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement (2015)
  • Author(s): Ueta M, Sawai H, Sotozono C, Hitomi Y, Kaniwa N, Kim MK, Seo KY, Yoon KC, Joo CK, Kannabiran C, Wakamatsu TH, Sangwan V, Rathi V, Basu S, Ozeki T, Mushiroda T, Sugiyama E, Maekawa K, Nakamura R, Aihara M, Matsunaga K, Sekine A, Gomes JÁP, Hamuro J, Saito Y, Kubo M, Kinoshita S, Tokunaga K.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 135 Issue: 6 Pages: 1538
  • DOI: 10.1016/j.jaci.2014.12.1916
  • Peer Reviewed / Open Access
• [Journal Article] The Role of Systemic Immunomodulatory Treatment and Prognostic Factors on Chronic Ocular Complications in Stevens-Johnson Syndrome. Ophthalmology. (2015)
  • Author(s): Kim DH, Yoon KC, Seo KY, Lee HS, Yoon SC, Sotozono C, Ueta M, Kim MK.
  • Journal Title: Ophthalmology. Volume: 122(2) Issue: 2 Pages: 254-264
  • DOI: 10.1016/j.ophtha.2014.08.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ocular surface reconstruction using stem cell and tissue engineering. (2015)
  • Author(s): Nakamura T, Inatomi T, Sotozono C, Koizumi N, Kinoshita S
  • Journal Title: Prog Retin Eye Res Volume: 51 Pages: 187-207
  • DOI: 10.1016/j.preteyeres.2015.07.003
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. (2014)
  • Author(s): Ueta M, Kannabiran C, Wakamatsu TH, Kim MK, Yoon K-C, Seo KY, Joo C-K, Sangwan V, Rathi V, Basu S, Shamaila A, Lee HS, Yoon S, Sotozono C, Gomes JAP, Tokunaga K, Kinoshita S.
  • Journal Title: Sci. Rep. Volume: 4 Issue: 1 Pages: 5981-5981
  • DOI: 10.1038/srep05981
  • Peer Reviewed / Open Access
• [Journal Article] Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity. (2014)
  • Author(s): Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Kaneda H, Fukushima M, Kinoshita S
  • Journal Title: Acta Ophthalmol. Volume: 92(6) Issue: 6
  • DOI: 10.1111/aos.12397
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement (2014)
  • Author(s): Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H, Miyadera H, Sugiyama E, Maekawa K, Nakamura R, Nagato M, Aihara M, Matsunaga K, Takahashi Y, Furuya H, Muramatsu M, Ikezawa Z, Kinoshita S.
  • Journal Title: Sci Rep. Volume: 4 Issue: 1 Pages: 4862-4862
  • DOI: 10.1038/srep04862
  • Peer Reviewed / Open Access
• [Journal Article] Upregulation of Toll-like receptor 5 expression in the conjunctival epithelium of various human ocular surface diseases. (2014)
  • Author(s): Yamada K, Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S.
  • Journal Title: Br J Ophthalmol. Volume: in press
  • Peer Reviewed
• [Journal Article] Usefulness of a New Therapy Using Rebamipide Eyedrops in Patients with VKC/AKC Refractory to Conventional Anti-Allergic Treatments (2014)
  • Author(s): Ueta M, Sotozono C, Koga A, Yokoi N, Kinoshita S.
  • Journal Title: Allergology International Volume: 63 Issue: 1 Pages: 75-81
  • DOI: 10.2332/allergolint.13-OA-0605
  • NAID: 130004873110
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] In silico risk assessment of HLA-A*02:06-associated Stevens-Johnson syndrome and toxic epidermal necrolysis caused by cold medicine ingredients. (2013)
  • Author(s): Isogai H, Miyadera H, Ueta M, Sotozono C, Kinoshita S, Tokunaga K, Hirayama N
  • Journal Title: J Toxicol. Volume: Article ID 514068 Pages: 514068-514068
  • DOI: 10.1155/2013/514068
  • Peer Reviewed / Open Access
• [Journal Article] Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. (2013)
  • Author(s): Kaniwa N, Sugiyama E, Saito Y, Kurose K, Maekawa K, Hasegawa R, Furuya H, Ikeda H, Takahashi Y, Muramatsu M, Tohkin M, Ozeki T, Mushiroda T, Kubo M, Kamatani N, Abe M, Yagami A, Ueta M, Sotozono C, Kinoshita S, Ikezawa Z, Matsunaga K, Aihara M.
  • Journal Title: Pharmacogenomics. Volume: 14 Issue: 15 Pages: 1821-31
  • DOI: 10.2217/pgs.13.180
  • Peer Reviewed
• [Journal Article] The effect of a hydrocolloid dressing containing ceramide-2 on split-thickness wounds in a laser-induced erosion model (2013)
  • Author(s): Tsuchiya S, Ichioka S, Sekiya N, Tajima S, Iwasaki T, Numata S
  • Journal Title: Adv Skin Wound Care Volume: 26(5) Issue: 5 Pages: 224-9
  • DOI: 10.1097/01
  • Peer Reviewed
• [Journal Article] Rebamipide Suppresses PolyI:C-Stimulated Cytokine Production in Human Conjunctival Epithelial Cells. (2013)
  • Author(s): Ueta M, Sotozono C, Yokoi N, Kinoshita S
  • Journal Title: J Ocul Pharmacol Ther. Volume: 29 Issue: 7 Pages: 688-93
  • DOI: 10.1089/jop.2012.0054
  • Peer Reviewed
• [Journal Article] Visual Improvement after Cultivated Oral Mucosal Epithelial Transplantatio (2013)
  • Author(s): Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S
  • Journal Title: Ophthalmol, Peer-Reviewed papers Volume: 120(1) Issue: 1 Pages: 193-200
  • DOI: 10.1016/j.ophtha.2012.07.053
  • Peer Reviewed
• [Presentation] IKZF1 Expression and Upregulation by polyI:C in Human Epidermal Keratinocytes. (2016)
  • Author(s): Mayumi Ueta, Hiromi Nishigaki, Shigeru Kinoshita
  • Organizer: Keystone Symposium Immunity in Skin Development, Homeostasis and Disease
  • Place of Presentation: Tahoe City, California, USA
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Stevens-Johnson syndrome with severe ocular surface complications might be associated with disordered innate immune response. (2016)
  • Author(s): Mayumi Ueta, Chie Sotosono, Shigeru Kinoshita.
  • Organizer: 19th ANNUAL IOSS (International Ocular Surface Society) MEETING. Seattle
  • Place of Presentation: WA, USA
  • Year and Date: 2016-04-30
  • Int'l Joint Research
• [Presentation] Genetic Predisposition of Cold medicine related SJS/TEN with severe ocular complications. (2016)
  • Author(s): Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Katushi Tokunaga, Shigeru Kinoshita
  • Organizer: The 7th International Drug Hypersensitivity Meeting
  • Place of Presentation: Malaga, Spain
  • Year and Date: 2016-04-22
  • Int'l Joint Research
• [Presentation] Regulation of Mucocutaneous Inflammation by Cold Medicine–Related Stevens-Johnson Syndrome susceptibility gene, IKZF1. (2016)
  • Author(s): Mayumi Ueta, Hiromi Sawai, Junji Hamuro, Yuki Hitomi, Chie Sotozono, Katsushi Tokunaga, Shigeru Kinoshita
  • Organizer: The 13th International Congressof Human Genetics.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-04-05
  • Int'l Joint Research
• [Presentation] 感冒薬関連Stevens-Johnson症候群発症に関わる遺伝子間相互作用 (2016)
  • Author(s): 上田真由美、徳永勝士、外園千恵、澤井裕美、木下茂
  • Organizer: 角膜カンファランス2016
  • Place of Presentation: 軽井沢、長野県
  • Year and Date: 2016-02-20
• [Presentation] The Role of Ophthalmologist in the Management of Acute SJS/TEN. (2015)
  • Author(s): Sotozono C
  • Organizer: The 56th annual meeting of the Ophthalmological Society
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-29
  • Int'l Joint Research / Invited
• [Presentation] Strategies for Visual Improvement in Chronic SJS/TEN. (2015)
  • Author(s): Sotozono C
  • Organizer: The 56th annual meeting of the Ophthalmological Society
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-29
  • Int'l Joint Research / Invited
• [Presentation] Genetic predisposition of Cold medicine-Related Stevens-Johnson Syndrome with Ocular Surface Complications. (2015)
  • Author(s): Mayumi Ueta
  • Organizer: the 56th Annual meeting of the Ophthalmological Society of Taiwan.
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-29
  • Int'l Joint Research / Invited
• [Presentation] Contribution of combination of multiple gene polymorphisms to the onset of cold medicine-related Stevens-Johnson syndrome with severe ocular complications. (2015)
  • Author(s): Mayumi Ueta, Katsushi Tokunaga, Chie Sotozono, Hiromi Sawai, Shigeru Kinoshita
  • Organizer: 2015 American Academy of Ophthalmology
  • Place of Presentation: LasVegas, USA
  • Year and Date: 2015-11-15
  • Int'l Joint Research
• [Presentation] Predictive Factors Associated with Long-Term Ocular Sequelae of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. (2015)
  • Author(s): Chie Sotozono, Mayumi Ueta, Eiji Nakatani, Hideaki Kaneda, Masanori Fukushima, Yoko Kano, Tetsuo Shiohara, and Shigeru Kinoshita
  • Organizer: 2015 American Academy of Ophthalmology
  • Place of Presentation: LasVegas, USA
  • Year and Date: 2015-11-14
  • Int'l Joint Research
• [Presentation] 感冒薬関連Stevens-Johnson症候群発症におけるEP3遺伝子多型とHLA-A*02:06の相互作用 (2015)
  • Author(s): 上田真由美、徳永勝士、外園千恵、澤井裕美、木下茂
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-25
• [Presentation] 重症多形滲出性紅斑の眼後遺症に対する新規医療器具の医師主導治験 (2015)
  • Author(s): 外園千恵、上田真由美、今井浩二郎、手良向聡、羽室淳爾、角栄里子、荻野 顕、吉村長久、小泉範子、木下茂
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-23
• [Presentation] 感冒薬関連Stevens-Johnson症候群のHLAならびに遺伝素因 (2015)
  • Author(s): 上田真由美
  • Organizer: 日本人類遺伝学会 第60回大会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-17
• [Presentation] 感冒薬関連Stevens-Johnson症候群発症におけるHLA-A*02:06とEP3遺伝子多型の相互作用 (2015)
  • Author(s): 上田真由美、徳永勝士、外園千恵、澤井裕美、木下茂
  • Organizer: 日本人類遺伝学会 第60回大会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-16
• [Presentation] HLA-A*02:06 and PTGER3 polymorphism exerts additive effects in cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Japanese and Korean populations. (2015)
  • Author(s): Ueta M, Tokunaga K, Sotozono C, Sawai H, Yoon KC, Kim MK, Seo KY, Joo CK, Kinoshita S
  • Organizer: European Association for Vision and Eye Research (EVER) 2015
  • Place of Presentation: Nice, France
  • Year and Date: 2015-10-07
• [Presentation] Etiology and HLA of Stevens-Johnson Syndrome with Severe Ocular Complications in a Brazilian population. (2015)
  • Author(s): 上田真由美、Tais Hitomi Wakamatsu, 徳永勝士、Renata Ruoco Loureiro, Karita Antunes Costa, Juliana Maria Ferraz Sallum, José Arthur Milhomens, 外園千恵、José Álvaro Pereira Gomes, 木下茂
  • Organizer: 第24回日本組織適合性学会大会
  • Place of Presentation: 水戸、茨城
  • Year and Date: 2015-09-10
• [Presentation] Genetic predisposition of Stevens-Johnson Syndrome with Severe Ocular Complications. (2015)
  • Author(s): Ueta M
  • Organizer: Chulalongkorn Eye Center-Kyoto Prefectural University of Medicine Joint meeting.
  • Place of Presentation: Chulalongkorn University, Bangkok, Thailand
  • Year and Date: 2015-08-18
  • Int'l Joint Research / Invited
• [Presentation] Genetic predisposition and Immunopathogenesis of Stevens-Johnson Syndrome (SJS) with severe ocular complications - How much do we understand the disease? (2015)
  • Author(s): Ueta M
  • Organizer: OSKON2015
  • Place of Presentation: Chennai, India
  • Year and Date: 2015-07-10
  • Int'l Joint Research / Invited
• [Presentation] HLA-A*02:06 and PTGER3 polymorphism exerts additive effects in cold medicine-related Stevens-Johnson syndrome with severe ocular complications. (2015)
  • Author(s): Ueta M, Tokunaga T, Sotozono C, Sawai H, Kinoshita S
  • Organizer: The European Academy of Allergy and Clinical Immunology (EAACI)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-06-09
  • Int'l Joint Research
• [Presentation] IKZF1 SNPs associated with Cold Medicine–Related Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis with Severe Mucosal Involvement. (2015)
  • Author(s): Mayumi Ueta, Hiromi Sawai, Yuki Hitomi, Chie Sotozono, Norihiko Yokoi, Junji Hamuro, Katsushi Tokunaga, Shigeru Kinoshita.
  • Organizer: 第64回日本アレルギー学会学術大会、英語セッション
  • Place of Presentation: 東京
  • Year and Date: 2015-05-27
• [Presentation] PTGER3 SNPs associated with Cold Medicine–Related Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis with Severe Ocular complications. (2015)
  • Author(s): Mayumi Ueta, Chie Sotozono, Hiromi Sawai, Katsushi Tokunaga, Shigeru Kinoshita
  • Organizer: 2015 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO). Denver
  • Place of Presentation: CO, USA
  • Year and Date: 2015-05-05
  • Int'l Joint Research
• [Presentation] Stevens-Johnson症候群および中毒性表皮壊死融解症における急性期眼障害のリスク因子 (2015)
  • Author(s): 外園千恵、松山琴音、中谷英仁、狩野葉子、塩原哲夫、上田真由美、木下茂
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-17
• [Presentation] Clinical finding of Stevens-Johnson Syndrome with severe ocular complications. (2015)
  • Author(s): Ueta Mayumi
  • Organizer: 38 SIMASP
  • Place of Presentation: SaoPaulo, Brazil
  • Year and Date: 2015-03-05
  • Invited
• [Presentation] New Susceptibility Gene IKZF1 for Cold MedicineRelated Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis with Severe Mucosal Involvement. (2014)
  • Author(s): Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Yuki Hitomi, Nahoko Kaniwa, Mee Kum Kim, Kyoung Yul Seo, Kyung-Chul Yoon, Shigeru Kinoshita, Katsushi Tokunaga.et al
  • Organizer: The American Society of Human Genetics (ASHG) 2014
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-10-21
• [Presentation] HLA-A*0206 with TLR3 Polymorphism Exerts more than Additive Effects in Cold medicine related Stevens-Johnson Syndrome with Severe Ocular Complications. (2014)
  • Author(s): Ueta M, Tokunaga K, Sotozono C, Sawai H, Kinoshita K.
  • Organizer: 2014 ISER (The International Society for Eye Research) XXI Biennial Meeting,
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2014-07-21
  • Invited
• [Presentation] HLA markers of cold medicine-related Stevens-Johnson syndrome with severe mucosal involvements in the Japanese. (2014)
  • Author(s): Mayumi Ueta, Chie Sotozono, Shigeru Kinoshita.
  • Organizer: 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Orland, FL, USA
  • Year and Date: 2014-05-07
• [Presentation] Strong association between HLA-A*02:06 and Acetaminophen-related Stevens-Johnson syndrome with severe mucosal involvements in the Japanese. (2014)
  • Author(s): Mayumi Ueta, Chie Sotozono, Hiromi Sawai, Katsushi Tokunaga, Shigeru Kinoshita
  • Organizer: The 6th International Drug Hypersensitivity Meeting
  • Place of Presentation: Bern, Switzerland
  • Year and Date: 2014-04-10
• [Presentation] HLA association with antipyretic analgesics-induced Stevens-Johnson syndrome / toxic epidermal necrolysis with severe ocular surface complications in Japanese patients. (2014)
  • Author(s): Ryosuke Nakamura, Nahoko Kaniwa, Mayumi Ueta, Chie Sotozono, Emiko Sugiyama, Keiko Maekawa, Akiko Yagami, Setsuko Matsukura, Zenro Ikezawa, Kayoko Matsunaga, Tokunaga Katsushi, Michiko Aihara, Shigeru Kinoshita, Yoshiro Saito.
  • Organizer: The 6th International Drug Hypersensitivity Meeting
  • Place of Presentation: Bern, Switzerland
• [Presentation] Medication tendencies for inducing severe ocular surface symptoms in Japanese Stevens-Johnson syndrome / toxic epidermal necrolysis patients. (2014)
  • Author(s): Nahoko Kaniwa, Mayumi Ueta, Ryosuke Nakamura, Emiko Sugiyama, Keiko Maekawa, Yukitoshi Takahashi, Hirokazu Furuya, Akiko Yagami, Setsuko Matsukura, Zenro Ikezawa, Kayoko Matsunaga, Chie Sotozono, Michiko Aihara, Shigeru Kinoshita, Yoshiro Saito.
  • Organizer: The 6th International Drug Hypersensitivity Meeting
  • Place of Presentation: Bern, Switzerland
• [Presentation] Anti-inflammatory effects of rebamipide eye drops on allergic conjunctivitis with and without giant papillae. (2014)
  • Author(s): Mayumi Ueta, Jun Shoji, Chie Sotozono, Norihiko Yokoi, Shigeru Kinoshita
  • Organizer: 2014 World Ophthalmology Congress of the International Council of Ophthalmology.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Etiologic Features of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) with Ocular Involvement. (2014)
  • Author(s): Sotozono C, Kano Y, Shiohara T, Sakabayashi S, Kinoshita S.
  • Organizer: WOC2014 , APAO2014,
  • Place of Presentation: Tokyo, Japan
  • Invited
• [Presentation] HLA MARKERS OF COLD MEDICINE RELATED STEVENS-JOHNSON SYNDROME (2013)
  • Author(s): Ueta M, Sotozono C, Tokunaga K, Kinoshita S
  • Organizer: 8th International Cutaneous ADR Congress (ISCAR 2013)
  • Place of Presentation: 桃園、台湾
• [Presentation] HLA analysis of cold medicine related Stevens-Johnson syndrome with ocular complication in Japan. (2013)
  • Author(s): Ueta M, Sotozono C, Kinoshita S
  • Organizer: 2013 Annual Meeting of the Asian Association for Research in Vision and Ophthalmology (Asian ARVO)
  • Place of Presentation: New Delhi, India
• [Presentation] Anti-inflammatory effects of rebamipide eye drops on allergic conjunctivitis. (2013)
  • Author(s): Ueta M, Sotozono C, Koga A, Yokoi N, Kinoshita S
  • Organizer: 2013 TFOS (7th International Conference on the Tear Film & Ocular Surface)
  • Place of Presentation: Taormina, Sicily、Italy
• [Presentation] The effect of rebamipide eye drops on allergic conjunctivitis with giant papilla. (2013)
  • Author(s): Ueta M, Sotozono C, Yokoi N, Kinoshita K.
  • Organizer: The EAACI (European Academy of Allergy and Clinical Immunology)-WAO (World Allergy Organization) Congress 2013
  • Place of Presentation: Milano, Italy
• [Presentation] Etiologic Features Of Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis With Ocular Involvement. (2013)
  • Author(s): Sotozono C, Kinoshita S, Kitami A, Iijima M, Aihara M, Ikezawa Z, Kano Y, Shiohara T, Shirakata Y, Hashimoto K.
  • Organizer: 8th International Cutaneous ADR Congress
  • Place of Presentation: Tao-Yuan, Taiwan
  • Invited
• [Presentation] 自己免疫性眼表面疾患 (2013)
  • Author(s): 外園千恵、上田真由美、福本暁子、稲富勉、横井則彦、木下茂
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Stevens-Johnson症候群後遺症患者の発症背景と初期診断 (2013)
  • Author(s): 外園千恵、上田真由美、宮崎冴子、稲富勉、木下茂
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜
• [Presentation] 感冒薬誘因性Stevens-Johnson症候群/中毒性表皮壊死症のHLA解析 (2013)
  • Author(s): 上田真由美、外園千恵、宮寺浩子、徳永勝士、木下茂
  • Organizer: 第５８回日本人類遺伝学会
  • Place of Presentation: 仙台
• [Book] Stevens-Johnson症候群. 眼科疾患 最新の治療2016-2018第１版 (2016)
  • Author(s): 上田真由美
  • Total Pages: 111
  • Publisher: 南江堂
• [Book] Stevens-Johnson症候群. 一目でわかる眼疾患の見分け方. 角結膜疾患, 緑内障. 第１版 (2016)
  • Author(s): 上田真由美
  • Publisher: メジカルビュー社.
• [Book] 重篤な眼合併症と伴うStevens-Johnson症候群の発症予測. 特集・眼の先制医療. 2016あたらしい眼科 (2016)
  • Author(s): 上田真由美
  • Publisher: メディカル葵出版社
• [Book] ドライアイリサーチアワード、ドライアイベストリサーチアワード受賞論文、感冒薬に関連した発症した眼合併型Stevens-Johnson症候群の発症関連遺伝子IKZF1. Frontiers in Dry Eye, 2016, Vol.11 No.1 (2016)
  • Author(s): 上田真由美
  • Publisher: メディカルレビュー社
• [Book] 難治性角結膜疾患に対する培養自家口腔粘膜上皮シート移植に関する臨床試験 (2015)
  • Author(s): 外園千恵、稲富勉、中村隆宏、小泉範子、羽室淳爾、木下茂
  • Publisher: 日本臨床
• [Book] 重症多形滲出性紅斑の眼後遺症に対する新医療機器の臨床試験 (2015)
  • Author(s): 外園千恵
  • Publisher: Biophilia
• [Book] 重症多形滲出性紅斑の眼後遺症に対する輪部支持型ハードコンタクトレンズCS-100の臨床試験 (2015)
  • Author(s): 外園千恵
  • Publisher: 日本評価
• [Book] tevens-Johnson症候群の眼障害、、皮膚科・眼科連携マニュアル、目のまわりの病気とその治療、第１版 (2015)
  • Author(s): 上田真由美、外園千恵
  • Publisher: 秀潤社
• [Book] 全身疾患と関連する角膜異常. 第１０章前眼部疾患, 小児眼科学 第１版 (2015)
  • Author(s): 上田真由美, 外園千恵
  • Publisher: 三輪書店
• [Book] Stevens-Johnson症候群の眼症状には点眼液？眼軟膏？、ヴィジュアルでみるステロイド外用薬の使い方ガイド、第１版 (2015)
  • Author(s): 上田真由美, 外園千恵
  • Publisher: 学研メディカル秀潤社
• [Book] 眼科におけるStevens-Johnson症候群の病型ならびに遺伝素因.あたらしい眼科 (2015)
  • Author(s): 上田真由美
  • Publisher: メディカル葵出版社