Elucidation of the mechanism to control tear secretion by anti-aging approach
| Project/Area Number |
25293356
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
Tsubota Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | ドライアイ / 涙腺 / 涙液 |
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| Outline of Final Research Achievements |
A purpose of this study is to contribute to condition of a patient elucidation of dry eye syndrome caused by aging and a lifestyle-related disease. By using life style-related disease developing mice, we examined the elucidation of age related molecules and effect of the functional foods factor which had the antioxidant action in the lacrimal glands. As a result, aging-related molecules significantly showed a low value in a lifestyle-related disease developing mice. In addition, it became clear that increase in tear secretion volume and secretion-related molecules by giving a functional foods factor. We demonstrated that the aging and dry eye syndrome are a close relationship to a lifestyle-related disease. Our findings should be crucial in condition of a patient elucidation and therapeutic treatment of dry eye syndrome.
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Report
(4 results)
Research Products
(2 results)
