Molecular analysis for new therapeutic strategies in global cooperative clinical study for childhood hepatic tumors

• Project/Area Number: 25293359
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Hamamatsu University School of Medicine (2014-2015); Hiroshima University (2013)
• Principal Investigator: OGURA Kaoru 浜松医科大学, 医学部附属病院, 講師 (10346653)
• Co-Investigator(Kenkyū-buntansha): HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744) ; UEDA Yuka 広島大学, 病院, 医科診療医 (70624641) ; ONITAKE Yoshiyuki 広島大学, 病院(医), 病院助教 (10448269) ; KURIHARA Sho 広島大学, 病院(医), 医科診療医 (40724894)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2013: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 小児 / 癌 / トランスレーショナルリサーチ / 薬剤反応性 / ゲノム / トランレーショナルリサーチ

Outline of Final Research Achievements

About 200 Tissue samples of the cases treated by JPLT-2 protocol and several hepatoblastoma cell lines were used. SNP array analysis revealed the high frequency of gain and loss at chromosomes 1p. 1q and 2q. Whole genome expression analysis using microarray detected 12 significantly upregulated genes located the aberrant chromosomes in poor prognostic cases. Among them, fluorescent real-time PCR confirmed 3 genes significantly upregulated in these unfavorable cases and these were involved in Wnt and MAPK signals and correlated with activation of mucin and AFP production. These genes inserted into hepatoblastoma cell lines and 2 of them showed upregulated cell growth, suggesting that these genes might be molecular targets of hepatoblastoma.

Research Products

• [Journal Article] Clinical prognostic value of DNA methylation in hepatoblastoma: Four novel tumor suppressor candidates (2016)
  • Author(s): Honda S, Minato M, Suzuki H, Fujiyoshi M, Miyagi H, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
  • Journal Title: Cancer Science Volume: in press Issue: 6 Pages: 812-819
  • DOI: 10.1111/cas.12928
  • NAID: 120005828475
  • Peer Reviewed / Open Access
• [Journal Article] Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumors (2015)
  • Author(s): Kurihara S, Ueda Y, Onitake Y, Sueda T, Ohta E, Morihara N, Hirano S, Irisuna F, Hiyama E
  • Journal Title: Journal of Pediatric Surgery Volume: 50 Issue: 12 Pages: 2094-2097
  • DOI: 10.1016/j.jpedsurg.2015.08.033
  • Peer Reviewed / Open Access
• [Journal Article] Mortality and morbidity in primarily resected hepatoblastomas in Japan: Experience of the JPLT (Japanese Study Group for Pediatric Liver Tumor) trials (2015)
  • Author(s): Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S, Ueda Y, Onitake Y
  • Journal Title: Journal of Pediatric Surgery Volume: 50 Issue: 12 Pages: 2098-2101
  • DOI: 10.1016/j.jpedsurg.2015.08.035
  • Peer Reviewed / Open Access
• [Journal Article] The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model (2015)
  • Author(s): Czauderna P, Haeberle B, Hiyama E, Rangaswami A, Krailo M, Maibach R, Rinaldi E, Feng Y, Aronson D, Malogolowkin M, Yoshimura K, Leuschner I, Lopez-Terrada D, Hishiki T, Perilongo G, von Schweinitz D, Schmid I, Watanabe K, Derosa M, Meyers R
  • Journal Title: European Journal of Cancer Volume: 1 Pages: 92-101
  • DOI: 10.1016/j.ejca.2015.09.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 肝芽腫の分子生物学 (2015)
  • Author(s): 檜山英三, 上田祐華, 栗原 将
  • Journal Title: 小児外科 Volume: 47 Pages: 181-188
  • Peer Reviewed
• [Journal Article] The Children’s Hepatic tumors International Collaboration (CHIC): novel global rare tumor database yields new prognostic factors in hepatoblastoma (2015)
  • Author(s): Czauderna P, Haeberle B, Hiyama E
  • Journal Title: Lancet Volume: in press
• [Journal Article] Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy (2014)
  • Author(s): Czauderna P, Lopez-Terrada D, Hiyama E, Häberle B, Malogolowkin MH, Meyers RL
  • Journal Title: Current Opinion in Pediatrics Volume: 26 Issue: 1 Pages: 19-28
  • DOI: 10.1097/mop.0000000000000046
  • Peer Reviewed / Open Access
• [Journal Article] Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium (2014)
  • Author(s): Lopez-Terrada D, Alaggio R, de Davila MT, Czauderna P, Hiyama E, Katzenstein H, Leuschner I, Malogolowkin M, Meyers R, Ranganathan S, Tanaka Y, Tomlinson G, Fabre M, Zimmermann A, Finegold MJ; Children's Oncology Group Liver Tumor Committee
  • Journal Title: Modern Pathology Volume: 27 Issue: 3 Pages: 472-491
  • DOI: 10.1038/modpathol.2013.80
  • Peer Reviewed / Open Access
• [Journal Article] FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions (2014)
  • Author(s): Tokumasu D, Sakuma T, Hayashi Y, Hosoi S, Hiyama E, Yamamoto T
  • Journal Title: Genes to Cells Volume: 19 Issue: 5 Pages: 419-431
  • DOI: 10.1111/gtc.12142
  • Peer Reviewed / Open Access
• [Journal Article] Pediatric Hepatoblastoma: diagnosis and treatment (2014)
  • Author(s): Hiyama E
  • Journal Title: Translational Pediatrics Volume: 3 Pages: 293-299
  • Peer Reviewed / Open Access
• [Journal Article] RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients (2013)
  • Author(s): Honda S, Miyagi H, Suzuki H, Minato M, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
  • Journal Title: Pediatric Surgery International Volume: 29 Issue: 11 Pages: 1147-1152
  • DOI: 10.1007/s00383-013-3371-z
  • Peer Reviewed / Open Access
• [Journal Article] Detection of MYCN amplification using blood plasma: noninvasive therapy evaluation and prediction of prognosis in neuroblastoma (2013)
  • Author(s): Kojima M, Hiyama E, Fukuba I, Yamaoka E, Ueda Y, Onitake Y, Kurihara S, Sueda T
  • Journal Title: Pediatric Surgery International Volume: 29 Issue: 11 Pages: 1139-1145
  • DOI: 10.1007/s00383-013-3374-9
  • Peer Reviewed / Open Access
• [Journal Article] A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT) (2013)
  • Author(s): Hiyama E, Ueda Y, Onitake Y, Kurihara S, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T; Japanese Study Group for Pediatric Liver Tumor
  • Journal Title: Pediatric Surgery International Volume: 29 Issue: 10 Pages: 1071-1075
  • DOI: 10.1007/s00383-013-3399-0
  • Peer Reviewed / Open Access
• [Journal Article] Current therapeutic strategies for childhood hepatic malignant tumors (2013)
  • Author(s): Hiyama E
  • Journal Title: International Journal of Clinical Oncology Volume: 18 Issue: 6 Pages: 943-945
  • DOI: 10.1007/s10147-013-0607-9
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells (2013)
  • Author(s): Kanda A, Sotomaru Y, Nobukiyo A, Yamaoka E, Hiyama E
  • Journal Title: Folia Histochemica et Cytobiologica Volume: 51 Issue: 4 Pages: 292-299
  • DOI: 10.5603/fhc.2013.0040
  • Peer Reviewed
• [Presentation] Exome sequencing of hepatoblastoma identifies biological signatures and protential therapeutic targets (2016)
  • Author(s): Hiyama E
  • Organizer: International Pediatric Liver Tumor Symposium
  • Place of Presentation: Texas, USA.
  • Year and Date: 2016-02-25
  • Int'l Joint Research
• [Presentation] 肝芽腫の化学療法抵抗性に関わるDNAメチル化異常解析 (2015)
  • Author(s): 本多昌平, 湊 雅嗣, 宮城久之, 檜山英三, 武冨紹信
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2015-11-27
• [Presentation] 思春期早発症を契機に発見された副腎皮質がんの1 例 (2015)
  • Author(s): 小倉 薫, 川原 央好, 坂口 公祥, 川上 領太, 松永 真由美, 小野 裕之, 藤澤 泰子, 中西 俊樹, 緒方 勤
  • Organizer: 第57回日本小児血液がん学会学術集会
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2015-11-27
• [Presentation] Prediction of prognosis by preoperative chemotherapy response in hepatoblastoma patients treated by JPLT-2 protocol (2015)
  • Author(s): Hiyama E, Hishiki T, Ida K, Watanabe K, Oue T, Yano M, Hoshino K, Iehara T, Koh K, Tanaka Y, Kurihara S, Ueda Y
  • Organizer: SIOP 2015
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] Integrated exome analysis in childhood hepatoblastoma: Biological approach for molecular targeting (2015)
  • Author(s): Hiyama E, Kurihara S, Onitake Y, Ueda Y, Morihara N, Fukuba I, Komatsu R
  • Organizer: SIOP 2015
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] Congenital hepatoblastoma in JPLT-2 study (2015)
  • Author(s): Watanabe K, Hishiki T, Ida K, Oue T, Yano M, Hoshino K, Iehara T, Koh K, Tanaka Y, Hiyama E
  • Organizer: SIOP 2015
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] AFP高値を認めた肝限局性か過形成の1症例 (2015)
  • Author(s): 栗原 将
  • Organizer: 第54回日本小児外科学会中国四国地方会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2015-09-26
• [Presentation] SIOPEL-4 regimenを用いて治療を行った両側肺転移を伴う肝芽腫の1例 (2015)
  • Author(s): 小松 和幸, 北形 綾一, 川上 領太, 坂口 公祥, 坂口 孝宣, 川原 央好, 小倉 薫
  • Organizer: 第51回静岡小児血液・がん研究会
  • Place of Presentation: 静岡県静岡市
  • Year and Date: 2015-07-04
• [Presentation] Survival and late effects in the risk-stratified hepatoblastoma patients treated by JPLT-2 protocol (2015)
  • Author(s): Hiyama E, Kurihara S, Ueda Y, Hishiki T, Ida K, Iehara T, Oue T, Yano M, Watanabe K, Hoshino K, Ko K, Tanaka Y
  • Organizer: 2015 ASCO Annual Meeting
  • Place of Presentation: Chicago, U.S.A
  • Year and Date: 2015-05-29
• [Presentation] OCIAD2はDNAメチル化により制御される肝芽腫の新規癌抑制遺伝子である (2015)
  • Author(s): 湊 雅嗣, 本多 昌平, 小林 希, 三次 早香, 鈴木 拓, 岡田 忠雄, 宮城 久之, 檜山 英三, 武冨 紹信
  • Organizer: 第52回日本小児外科学会学術集会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-05-28
• [Presentation] 新生児期に手術を行った後腹膜腫瘍の2例 (2015)
  • Author(s): 小倉 薫, 川原央好, 大石 彰, 上野大蔵, 飯嶋重雄, 坂口公祥, 緒方 勤, 伊東宏晃
  • Organizer: 第52回日本小児外科学会学術集会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-05-28
• [Presentation] 小児期発症肝細胞がんの現状と切除不能例に対する治療戦略の展望～JPLT2登録症例の後方視的解析を通して (2015)
  • Author(s): 菱木 知郎, 家原 知子, 井田 孔明, 大植 孝治, 康 勝好, 田中 祐吉, 星野 健, 矢野 道広, 渡邉 健一郎, 檜山 英三, 日本小児肝癌スタディグループ(JPLT)
  • Organizer: 第52回日本小児外科学会学術集会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-05-28
• [Presentation] Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumors (2015)
  • Author(s): Kurihara S, Ueda Y, Onitake Y, Sueda T, Ohta E, Morihara N, Hirano S, Irisuna F, Hiyama E
  • Organizer: 48th Annual Meeting of the Pacific Association of Pediatric Surgeons
  • Place of Presentation: Jeju, South Kore
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Presentation] Mortality and morbidity in primarily resected hepatoblastomas in Japan: experience of JPLT (Japanese study group for pediatric liver tumor) trials (2015)
  • Author(s): Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S, Ueda Y, Onitake Y.
  • Organizer: 48th Annual Meeting of the Pacific Association of Pediatric Surgeons
  • Place of Presentation: Jeju, South Kore
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Presentation] Outcome and morbidity of primary resection of hepatoblastoma in JPLT-1 and 2 protocols (2014)
  • Author(s): Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S
  • Organizer: SIOP2014
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] 小児固形腫瘍における循環遊離DNAと循環がん細胞のがん診断への応用 (2014)
  • Author(s): 檜山英三, 檜山桂子, 林 陽子, 森原なぎさ, 平野尚子, 福場郁子, 山岡絵美, 栗原 将
  • Organizer: 第73回日本癌学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-27
• [Presentation] DNAメチル化解析による肝芽腫の新規予後予測マーカーの確立 (2014)
  • Author(s): 本多昌平, 湊 雅嗣, 鈴木 拓, 春田雅之, 金子安比古, 檜山英三, 武冨紹信
  • Organizer: 第73回日本癌学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-25
• [Presentation] Surgical managements for refractory neuroblastoma in young children (2014)
  • Author(s): Hiyama E, Kurihara S, Onitake Y, Ueda Y, Miki M, Kawaguchi H, Nakamura K, Kobayashi M
  • Organizer: BAPS61st Annual Congress
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2014-07-22 – 2014-07-25
• [Presentation] Central venous catheter-related complications in children with malignancy (2014)
  • Author(s): Kurihara S, Hiyama E, Onitake Y, Miki M, Nakamura K, Kawaguchi H, Kobayashi M
  • Organizer: PAPS2014
  • Place of Presentation: Calgary, Canada
  • Year and Date: 2014-05-25 – 2014-05-29
• [Presentation] Clinical feature of ATRX or DAXX mutated neuroblastoma (2014)
  • Author(s): Hiyama E, Kurihara S, Onitake Y, Yamaoka E, Fukuba I, Hiyama K
  • Organizer: PAPS2014
  • Place of Presentation: Calgary, Canada
  • Year and Date: 2014-05-25 – 2014-05-29
• [Presentation] Telomere Biology in Neuroblastoma: Focusing on ATRX/DAXX Genes and Alternative-Strengthening of Telomere(ALT) (2014)
  • Author(s): Hiyama E
  • Organizer: ANR Congress 2014.
  • Place of Presentation: Cologne, Germany
  • Year and Date: 2014-05-13 – 2014-05-16
• [Presentation] 肝芽腫の縦隔再発に対してICG蛍光法を使用した経験 (2014)
  • Author(s): 栗原 将, 鬼武美幸, 小倉 薫, 檜山英三
  • Organizer: 第55回日本中国四国小児がん研究会
  • Place of Presentation: 広島県福山市
  • Year and Date: 2014-04-26
• [Presentation] 希少小児がんである肝芽腫に対する薬剤開発戦略としての国際共同臨床試験に関する研究 (2014)
  • Author(s): 檜山 英三
  • Organizer: 平成25年度厚生労働科学研究がん臨床研究成果発表会（研究者向け）
  • Place of Presentation: 国際研究交流会館国際会議場（東京都中央区）
• [Presentation] 小児肝腫瘍に対する診断と治療 (2014)
  • Author(s): 檜山 英三
  • Organizer: 第39回北海道小児がん研究会
  • Place of Presentation: 京王プラザ（北海道札幌市）
  • Invited
• [Presentation] Wnt Signaling and telomerase activation in hepatoblastoma (2013)
  • Author(s): Hiyama E, Ueda Y, Kamimatsuse A, Onitake Y, Ogura K, Hiyama K
  • Organizer: AACR Annual Meeintg2013
  • Place of Presentation: Walter E. Washington Convention Center（アメリカ ワシントン）
• [Presentation] 2度の再発を来した脂肪芽腫の1例 (2013)
  • Author(s): 小倉 薫, 檜山 英三, 鬼武 美幸, 上田 祐華, 谷 守通
  • Organizer: 第54回中国四国小児がん研究会
  • Place of Presentation: 岩国医療センター（山口県岩国市）
• [Presentation] 小児がん (2013)
  • Author(s): 檜山 英三
  • Organizer: がん政策サミット2013春～県計画の好事例を共有し実践していこう～
  • Place of Presentation: ベルサール九段（東京都千代田区）
  • Invited
• [Presentation] 網羅的メチル化解析による肝芽腫の分化度からみた予後予測マーカーを確立する取組み (2013)
  • Author(s): 本多 昌平, 岡田 忠雄，宮城 久之，檜山 英三, 武冨 紹信
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
• [Presentation] 血中DNA を用いた神経芽腫の分子診断：予後予測と治療効果判定 (2013)
  • Author(s): 檜山 英三，児島 正人，河島 茉澄，上田 祐華，鬼武 美幸，上松瀬 新，小倉 薫，末田 泰二郎
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
• [Presentation] 18 トリソミーに合併した肝芽腫の1 例―染色体異常を合併したJPLT 登録症例の検討を併せて― (2013)
  • Author(s): 鬼武 美幸，檜山 英三，小倉 薫，上松瀬 新, 中村 和洋，古江 綾
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
• [Presentation] 術後に心不全の改善を認めた静脈管開存症の1 例 (2013)
  • Author(s): 小倉 薫，檜山 英三，上松瀬 新，鬼武 美幸，上田 祐華
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
• [Presentation] Survival, surgical respectability, and late effects in the hepatoblastoma patients treated by cisplatin plus pirarubicin(CITA) chemotherapy. (Abstract 10038) (2013)
  • Author(s): Hiyama E, Kamimatsuse A, Onitake Y, Ueda Y, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T.
  • Organizer: ASCO Annual ’ 13 Meeting
  • Place of Presentation: McComick Place（アメリカ シカゴ）
• [Presentation] CHILDREN'S HEPATIC TUMOR INTERNATIONAL COLLABORATION (CHIC): NEW HEPATOBLASTOMA INTERNATIONAL RISK GROUPS (HB-IRG) (2013)
  • Author(s): Meyers R, Haberle B, Hiyama E, Maibach R, Krailo M, Feng Y, Yoshimura K, Rinaldi E, Ortali M, Saraceno D, Rangaswami A, Malogolowkin M, Perilongo G, Watanabe K, Schmid I, Aronson D, Von Schweinitz D, Leuschner I, Lopez-Terrada D, Tanaka Y, Czauderna P
  • Organizer: 45th Congress of the International Society of Pediatric Oncology
  • Place of Presentation: Hong Kong Convention and Exhibition Centre(中国 香港）
• [Presentation] FURTHER STUDY: IDENTIFICATION OF NEW CANDIDATE GENES IN PROGRESSION OF HEPATOBLASTOMA USING GENOME-WIDE ASSOCIATION STUDY (2013)
  • Author(s): Hiyama E, Ueda Y, Onitake Y, Ida K, Ogura K, Kondo S, Kamijyo T, Watanabe K, Oue T, Hishiki T, Tajiri T, Horie H, Inoue T, Tanaka Y.
  • Organizer: 45th Congress of the International Society of Pediatric Oncology
  • Place of Presentation: Hong Kong Convention and Exhibition Centre(中国 香港）
• [Presentation] Epigenetic analyses to establish a molecular-genetic marker for treatment outcome in hepatoblastomas (2013)
  • Author(s): Honda S, Okada T, Suzuki H, Minato M, Haruta M, Kaneko Y, Hiyama E, Taketomi A
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] 肺転移巣手術のタイミングに苦慮した高リスク肝芽腫の一例 (2013)
  • Author(s): 栗原 将, 鬼武 美幸, 小倉 薫, 上田 祐華, 檜山 英三, 世羅 康彦, 三木 瑞香, 中村 和洋, 小林 正夫
  • Organizer: 第2回せとうち小児がんセミナー
  • Place of Presentation: ホテルグランヴィア岡山（岡山県岡山市）
• [Presentation] 高用量シスプラチン療法後に腫瘍全摘を行った門脈浸潤を伴う肝芽腫の一例 (2013)
  • Author(s): 江藤 昌平, 古江 綾, 千々松 郁枝, 三木 瑞香, 世羅 康彦, 川口 浩史, 中村 和洋, 上田 祐華, 鬼武 美幸, 小倉 薫, 檜山 英三, 小林 正夫
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県福岡市）
• [Presentation] 次世代シーケンサーを用いた肝芽腫のメチル化解析による予後予測マーカー確立の試み (2013)
  • Author(s): 本多 昌平, 岡田 忠雄, 湊 雅嗣, 春田 雅之, 金子 安比古, 檜山 英三, 武冨 紹信
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県福岡市）
• [Presentation] Wilms腫瘍を合併した縦隔奇形腫の１例 (2013)
  • Author(s): 小倉 薫, 檜山 英三, 鬼武 美幸, 上田 祐華, 千々松 郁枝, 世羅 康彦, 小林 正夫
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県福岡市）
• [Book] 肝芽腫の診断と治療. 「最新肝癌学」 (2015)
  • Author(s): 上條岳彦, 檜山英三
  • Total Pages: 8
  • Publisher: 日本臨牀社