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Study of nerve plasticity after nerve corssing using three dementional imaging reconstruction

Research Project

Project/Area Number 25293362
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionNiigata University

Principal Investigator

Shibata Minoru  新潟大学, 医歯(薬)学総合研究科, 研究員 (50196432)

Co-Investigator(Kenkyū-buntansha) 松田 健  新潟大学, 医歯学系, 教授 (50423166)
Research Collaborator SATO Noboru  新潟大学, 医歯学系, 教授 (00254756)
USHIKI Tatsuo  新潟大学, 医歯学系, 教授 (40184999)
SHIBUKI Katsuei  新潟大学, 脳研究所, 教授 (40146163)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords神経交叉 / 神経可塑性 / 脊髄髄節 / 支配レベル / 脊髄前根 / 脊髄後根 / 末梢神経 / 立体三次元 / 再構築 / 神経再生 / 神経再生経路 / 3次元解析
Outline of Final Research Achievements

Nerve crossing recently become useful nerve repairing method, however, this procedure should theoretically invites unusefull missreinnervation. We anticipated unknown nerve purposeful neural plasticity worked after nerve crossing. We established nerve crossing technique in the extremely small peripheral nerve in the upper arm to allow hole mount brachial plexus observation. Retrograding tracing of ulnar and musculocutaneous nerve revealed spinal neuron innervation and there was almost no overlapping innervation between ulnar and musculocutaneous nerve. It was found that after crossing of proximal ulna and distal musculocutaneous nerve retrograde tracing from distal to the crossing site identified participation of musculocutaneous nerve innervating neuron tracing in addition to the ulnar innervating neurons. Electrophysiological study demostrated useful reinnervation by this type of crossing procedure. Observation of whole mounting brachial plexus is proceeding.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] マウス腕神経叢神経移行術モデルを用いた末梢神経再生経路の解析2017

    • Author(s)
      若槻華子 渡辺啓介 千葉映奈 柴田 実 松田 健 佐藤 昇
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウス腕神経叢神経移行術モデルを用いた末梢神経再生経路の解析2016

    • Author(s)
      若槻華子 渡辺啓介 千葉映奈 柴田 実 松田 健 佐藤 昇
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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